LOCUS       NM_001108658            3887 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus TOP1 binding arginine/serine rich protein, E3
            ubiquitin ligase (Topors), mRNA.
ACCESSION   NM_001108658 XM_001058041 XM_342819
VERSION     NM_001108658.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3887)
  AUTHORS   Czub B, Shah AZ, Alfano G, Kruczek PM, Chakarova CF and
            Bhattacharya SS.
  TITLE     TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S
            Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene
  JOURNAL   PLoS One 11 (2), e0148678 (2016)
   PUBMED   26872363
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3887)
  AUTHORS   Chakarova CF, Khanna H, Shah AZ, Patil SB, Sedmak T, Murga-Zamalloa
            CA, Papaioannou MG, Nagel-Wolfrum K, Lopez I, Munro P, Cheetham M,
            Koenekoop RK, Rios RM, Matter K, Wolfrum U, Swaroop A and
            Bhattacharya SS.
  TITLE     TOPORS, implicated in retinal degeneration, is a cilia-centrosomal
            protein
  JOURNAL   Hum Mol Genet 20 (5), 975-987 (2011)
   PUBMED   21159800
REFERENCE   3  (bases 1 to 3887)
  AUTHORS   Renner F, Moreno R and Schmitz ML.
  TITLE     SUMOylation-dependent localization of IKKepsilon in PML nuclear
            bodies is essential for protection against DNA-damage-triggered
            cell death
  JOURNAL   Mol Cell 37 (4), 503-515 (2010)
   PUBMED   20188669
REFERENCE   4  (bases 1 to 3887)
  AUTHORS   Yang X, Li H, Zhou Z, Wang WH, Deng A, Andrisani O and Liu X.
  TITLE     Plk1-mediated phosphorylation of Topors regulates p53 stability
  JOURNAL   J Biol Chem 284 (28), 18588-18592 (2009)
   PUBMED   19473992
REFERENCE   5  (bases 1 to 3887)
  AUTHORS   Guan B, Pungaliya P, Li X, Uquillas C, Mutton LN, Rubin EH and
            Bieberich CJ.
  TITLE     Ubiquitination by TOPORS regulates the prostate tumor suppressor
            NKX3.1
  JOURNAL   J Biol Chem 283 (8), 4834-4840 (2008)
   PUBMED   18077445
REFERENCE   6  (bases 1 to 3887)
  AUTHORS   Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z,
            Brownell J, Liu LF, Lutzker S, Saleem A and Rubin EH.
  TITLE     Topors functions as an E3 ubiquitin ligase with specific E2 enzymes
            and ubiquitinates p53
  JOURNAL   J Biol Chem 279 (35), 36440-36444 (2004)
   PUBMED   15247280
REFERENCE   7  (bases 1 to 3887)
  AUTHORS   Weger S, Hammer E and Engstler M.
  TITLE     The DNA topoisomerase I binding protein topors as a novel cellular
            target for SUMO-1 modification: characterization of domains
            necessary for subcellular localization and sumolation
  JOURNAL   Exp Cell Res 290 (1), 13-27 (2003)
   PUBMED   14516784
REFERENCE   8  (bases 1 to 3887)
  AUTHORS   Chu D, Kakazu N, Gorrin-Rivas MJ, Lu HP, Kawata M, Abe T, Ueda K
            and Adachi Y.
  TITLE     Cloning and characterization of LUN, a novel ring finger protein
            that is highly expressed in lung and specifically binds to a
            palindromic sequence
  JOURNAL   J Biol Chem 276 (17), 14004-14013 (2001)
   PUBMED   11278651
REFERENCE   9  (bases 1 to 3887)
  AUTHORS   Zhou R, Wen H and Ao SZ.
  TITLE     Identification of a novel gene encoding a p53-associated protein
  JOURNAL   Gene 235 (1-2), 93-101 (1999)
   PUBMED   10415337
REFERENCE   10 (bases 1 to 3887)
  AUTHORS   Haluska P Jr, Saleem A, Rasheed Z, Ahmed F, Su EW, Liu LF and Rubin
            EH.
  TITLE     Interaction between human topoisomerase I and a novel RING
            finger/arginine-serine protein
  JOURNAL   Nucleic Acids Res 27 (12), 2538-2544 (1999)
   PUBMED   10352183
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342819.3, XM_001058041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB577097.1, CB715562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3887
                     /gene="Topors"
                     /note="TOP1 binding arginine/serine rich protein, E3
                     ubiquitin ligase"
                     /db_xref="GeneID:362501"
                     /db_xref="RGD:1305270"
     exon            1..177
                     /gene="Topors"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3303
                     /gene="Topors"
                     /EC_number="2.3.2.27"
                     /note="topoisomerase I binding, arginine/serine-rich, E3
                     ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Topors"
                     /protein_id="NP_001102128.1"
                     /db_xref="GeneID:362501"
                     /db_xref="RGD:1305270"
                     /translation="MGSQPPPLGSPLSREEGEAPPLAPAEEGRRRSRRVRLRGSCRHR
                     PSLLGRRELASSGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDS
                     KCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFK
                     EYVLRPSYNGSFTAPEVRRFRYRTTMTRERNASLYSPSSTVSRRTSTPPDSGVLFEGL
                     GISTRPRDVDIPQFMRHMALRGPTATDERSLRKVQEQDIINFRRTLYRAGVRVRSIED
                     GGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLE
                     SQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSV
                     ITISPDEAEAQELDVNVSTIRQAPWDDETPGPSYSNSEQVHVGVSSLLNSSDSSDEEL
                     VSGGAASQIQGVQANDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGSY
                     EKMETVKTQEQEQSYSSGDSDASRASSPRSVLGKDEQMGKSHCDSDTRINSKKEEKRS
                     TSLSTPRDSSSTRGDRACSPYNHRHRKGGRSRSSDSRSQSRSGHDQRNHRKHHGKKRL
                     KNKRSRSRESSSKPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRR
                     SRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEF
                     RIQSFSERTNARRKNHSERKYYYYERHRSRSVSSNRSRTTSAVPDRMRNEKPGGKRKY
                     KTRHLEDTNEEAQPSRAFASRVKESHYQKPSKLDGGSKDESDSFSDSRPSDRETKHKR
                     RKRRARSLSVEIVYEGKATDTSKHHKKKKKKHKKKHRKHHGDNTSRSPVVITIDSDSD
                     GDAGVKASVECSQSSLPQPGQDEVSTPSSEAFETKDVVTIEDELAVEDKECDVTALTN
                     DLSTSQAVESSESPPVSVEQTLDVREDSTFASDVESQSSNASIPTEPSRPLPSPRTSL
                     SSVSPGRDCDMS"
     exon            178..375
                     /gene="Topors"
                     /inference="alignment:Splign:2.1.0"
     exon            376..3887
                     /gene="Topors"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagggca gggcgtgaac gatcaattta ggaatgggtt ttggagttcc aagctgcgag
       61 caaactgcct gccttcggct tgcgggtcct gggatggggc actctagagc tcccctgttc
      121 ccggtaccta ccgaggagta agtccagtcc aggtttcggc gactcaccgg catcatgggg
      181 tcgcagccgc cgccactggg gtctccgctg tctcgcgagg agggtgaagc gccccctctg
      241 gcgcctgccg aggaggggag gcgcagaagc cgccgggtac gccttcgcgg atcctgccgc
      301 caccgaccga gcctcctggg ccggcgggag ctggcttcta gcggcccagc ggtccctgcc
      361 accgcgtcct cggagataat ggcctcagct gccaaggaat ttaaaatgga caacttttca
      421 cctaaagctg gcactagcaa actgcagcag acagtaccgg ccgatgcatc tcctgattct
      481 aagtgtccta tatgcttgga tagatttgat aatgtgtctt acttagatcg ctgcctacat
      541 aagttctgtt tccgctgtgt acaagagtgg tcaaaaaaca aagccgagtg cccactgtgt
      601 aagcagccct ttgattccat tttccattct gtgagggctg aagatgactt caaggagtat
      661 gtgctaaggc cttcctacaa tggttctttt accgcccctg aggttcgaag attccgctac
      721 cggacaacta tgacgagaga acggaacgcc tctctttact ctcccagtag cactgtcagt
      781 agaagaacaa gcactccgcc agacagtgga gtgctgtttg aagggttagg catctcaaca
      841 agacctagag atgttgacat tcctcaattt atgagacaca tggcattaag ggggccaact
      901 gctacagatg agaggtcttt gcggaaagtt caagaacaag atattattaa ttttaggcgc
      961 actctttatc gtgctggtgt tcgagttaga agtatcgaag acggtggccg ctacagggat
     1021 atttcagctg agttcttccg tagaaatcca gcttgccttc acagattagt tccttggtta
     1081 aaacgtgagc ttaccgttct ttttggagcc catggctcgt tagtcaatat tgtccagcac
     1141 atcatcatga gtaatgtcac tcgctatgat ttggagagtc aggcatttgt gtcggaccta
     1201 agaccatttt tgcttaatcg aactgagcat tttatacacg agtttatcag ttttgctaga
     1261 tctcccttca atatggcagc ttttgaccag catgctaatt atgattgccc tccttcatct
     1321 gaagaaggca gccgttctga ttcttcagtt attacaatat caccagatga ggctgaagcc
     1381 caagagctag atgtgaatgt atccaccatc aggcaggcac catgggatga tgaaactcct
     1441 ggaccgtcat attcaaattc agagcaagtg catgttggcg tgtcttccct tttaaattct
     1501 tcggacagtt cagatgaaga acttgtttct ggaggagccg catctcagat acaaggagta
     1561 caggccaatg acgacgtaaa caatgacagc gattcatcat cagataattg tgtcattgtt
     1621 gggtttgtta agccattagc tgaacggacc ccagaacttg ttgaactgtc ttctgattct
     1681 gaggagttgg gctcttatga aaaaatggaa acagtgaaga cacaagaaca ggagcagtct
     1741 tacagttcag gtgatagtga tgctagtcga gcttcatctc cgcgttctgt ccttggaaaa
     1801 gatgagcaga tgggtaaaag ccattgtgat tcggacacaa gaataaactc aaagaaagaa
     1861 gagaaacgat ctacgtcatt gtcaactccc agggacagct catctacaag aggtgacagg
     1921 gcatgttccc catataacca tcgacatagg aagggaggaa gatccaggag ttcagattcc
     1981 cgttcccaaa gtagaagtgg acatgatcag aggaatcaca ggaagcatca tgggaagaaa
     2041 agattgaaga ataagagatc cagaagcagg gagagtagta gcaaacctag agcgagaaag
     2101 gacaaaaaga gatcaagaac tagagatagc agctggtcaa gaagaagcca gaccctttct
     2161 ctaagtagtg gaagcactag tagatcaagg tctcgtagca gtgatcatgg caagcgaaga
     2221 tcacgaagca gaaatcgaga tcgctattat ttaagaaata attatggaag caaatacaag
     2281 tgggaatata cttactatag ccgaaacaag gacagagatg gttatgagtc gtcatacagg
     2341 aggaggactc tttcaagagc ccattattct agacaatctt caagtccaga atttagaatt
     2401 cagtcttttt ctgaaagaac aaatgccagg aggaagaacc acagtgaaag gaaatactac
     2461 tactatgaga ggcaccgatc gaggagcgtg tcgagtaata ggtcgaggac tacgtcagct
     2521 gtccctgacc ggatgagaaa tgagaagcct ggagggaagc ggaagtacaa gacccgccat
     2581 ttggaagaca ctaatgagga ggcacaaccg tctcgtgcat ttgcttccag agtgaaggag
     2641 agtcattacc aaaagccatc aaaattggac ggaggttcta aagacgagag cgatagcttt
     2701 tcagatagca gaccatcaga cagagagaca aaacacaaga ggaggaaaag gagggcacgg
     2761 agcctaagtg tagagatagt ttatgaagga aaagctacag acacaagcaa acaccataag
     2821 aagaagaaga agaaacataa gaagaagcat aggaaacacc atggagataa cacttcacgg
     2881 tccccggtgg ttataaccat cgacagtgac agcgacgggg atgctggagt gaaggcaagt
     2941 gttgagtgta gccagagcag tcttcctcag cctggacagg atgaagtctc cactccatcc
     3001 tcggaagcat ttgaaactaa agatgtcgtc acgatagagg atgagcttgc tgtcgaggac
     3061 aaggagtgcg atgttacggc acttactaat gacttgagta ccagccaagc tgtggagagc
     3121 agtgagtcac cgccagtctc agttgaacag actcttgacg tacgagaaga tagcaccttc
     3181 gcctctgatg tggagagcca gtccagtaat gcgtctattc ccaccgagcc atcaagacca
     3241 ttgccatctc cacggacctc attatcctca gtgtctcctg gtagagactg tgacatgtcc
     3301 tgaaactgcc aaagcatctc cttgataatc cagaggctat agagagaaag aggtgaaagg
     3361 tcatctattg cagtctagat gactttttct ggaaaaactt tgcctcttag aatattttaa
     3421 gtgttcgtgt gtgttaattt gtaaaattat ttgttcaaaa agttatgtat gtcccattcc
     3481 cagatatatg cacttttaag tgaagaaaat gttgctagct gtttatttaa aacttgggaa
     3541 cctttttaaa taaaaatcaa aaaatttaga agttatttca taaagccata cggtattgac
     3601 atatttttat ggtagtattt ttgaattttt tttggggggg ggagttattc tgaaaatgtg
     3661 ttaagctggg agaatgcttt tggacagtta tttttcataa aagatttgta tgattcaaaa
     3721 ccatttctta gactgaagta agtcatttta atctgcacag gttatcttga cttctgccaa
     3781 aagcaaagtt tagtattttc tttataaact tgtttatctg gactggcagt aaaacaaatg
     3841 tgtattcaaa agacaataaa actgtacact caaaaaaaat gaagaca
//
