LOCUS       XM_056985179            2354 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus TOP6B like initiator of meiotic double
            strand breaks (Top6bl), mRNA.
ACCESSION   XM_056985179
VERSION     XM_056985179.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq; corrected model.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by
            NM_001426986.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            frameshifts :: corrected 2 indels
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               JACYVU010000045.1  761625-762002       c
            379-432             JACYVU010000045.1  761569-761622       c
            433-489             JACYVU010000045.1  761511-761567       c
            490-628             JACYVU010000045.1  759164-759302       c
            629-682             JACYVU010000045.1  754423-754476       c
            683-792             JACYVU010000045.1  723693-723802       c
            793-876             JACYVU010000045.1  708642-708725       c
            877-932             JACYVU010000045.1  705479-705534       c
            933-1004            JACYVU010000045.1  704748-704819       c
            1005-1200           JACYVU010000045.1  703740-703935       c
            1201-1351           JACYVU010000045.1  700694-700844       c
            1352-1492           JACYVU010000045.1  698297-698437       c
            1493-1614           JACYVU010000045.1  693737-693858       c
            1615-1725           JACYVU010000045.1  689619-689729       c
            1726-1824           JACYVU010000045.1  685206-685304       c
            1825-1903           JACYVU010000045.1  676016-676094       c
            1904-2354           JACYVU010000045.1  674621-675071       c
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..2354
                     /gene="Top6bl"
                     /note="TOP6B like initiator of meiotic double strand
                     breaks; The sequence of the model RefSeq transcript was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: deleted 3 bases in 2 codons;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 Proteins, and 90% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     3 samples with support for all annotated introns"
                     /db_xref="GeneID:361702"
                     /db_xref="RGD:1563323"
     CDS             1..2253
                     /gene="Top6bl"
                     /note="The sequence of the model RefSeq protein was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: deleted 3 bases in 2 codons"
                     /codon_start=1
                     /product="LOW QUALITY PROTEIN: type 2 DNA topoisomerase 6
                     subunit B-like"
                     /protein_id="XP_056841159.1"
                     /db_xref="GeneID:361702"
                     /db_xref="RGD:1563323"
                     /translation="MWEAEPDPRHRPQNRRQSHLGSRASLGILHYAAAAFQGPALENA
                     EGGQSALKRAEGRVLARPWESLRSHRLASSRLASNLGSCATCTPAHPPTEASRLRQLP
                     QCAGARAGGGASARSGGKGLPGRGLFTVEALAEEEVVTNWQTESCSRSPYGMERTALA
                     VCEILRYLIIHWKCEAGIPKGALLDGQLAISIEALPSKHLPDSLRCIITIASAGNVDG
                     GLDFKKLLQDIQPALPRLSAKLTLASEEGGHSQDTSVKAPCQMTFEVDENSRSLMTDC
                     LVIKHFLRKIIIVHHKLKFNFSVTVNGILSAEIFGAENEPVLRLSNGISLAVGFQHYV
                     SKPQFNWTEPHCSRLHPVLGHPAPLSIPGAKANMGLLGELTLTPAAALCPSPKGFSSQ
                     LNRISSVSIFLYGPLGLPLVASDQEQPSTAVFRDASYFIDWKKHNLFMLPNLDLNLDT
                     QFILPDVNYKVELPEENQSQNAQGPVLLLFLFVDFQSGVPVHQGEIWGLHTLLTTHLS
                     TILSESRSTVQDSIQSAVDQVLELHHQAAKTHQRLQASLSVAVTSIMSVLTGSTSSSF
                     RKTCLQALEAVDTQEFSAKLHRIFYDITQHQFLNHCSCDTEQHLTPEKKISAQNTKDQ
                     HKNIGLEFPAESSGQAENKRLKRSSPNQGREESRTLGPARDLSPPESVTRDCDPTEAS
                     LTARGSQTQVANDGVQAADAASPLGGLEVPQGAQGGCGPKLPPPGPHHRLRCSRRTCG
                     YRRSPTCPSG"
ORIGIN      
        1 atgtgggaag cagagcctga tcccaggcac cgcccgcaga acagaaggca aagccatctg
       61 gggtctagag ccagcttggg aatcctgcac tacgcagccg cagctttcca gggaccagcc
      121 ctggaaaacg ccgagggcgg tcagagcgct ttgaaaaggg ccgagggccg cgtcttggcg
      181 agaccgtggg aaagtctcag gagtcaccgc ctggcctctt cccggctcgc ctccaacctt
      241 ggcagctgcg ccacctgtac tcccgcccat ccgcctactg aagcgagccg cctcaggcag
      301 ctcccgcagt gcgcaggcgc gagggctggg ggcggggcga gcgcacggtc gggcgggaag
      361 ggactgccgg gccgtgggct cttcaccgtc gaagccctag ctgaggagga ggttgtgacc
      421 aactggcaaa ccgagagctg cagccgctct ccttacggaa tggagaggac ggctttggct
      481 gtctgcgaga ttttaagata tttaataatt cactggaagt gtgaagcagg aataccaaag
      541 ggagcattgc tagatgggca gctagcgatt tccatagaag cattgccttc taagcaccta
      601 ccagattctc tacgttgtat aataactatt gcttctgcag gaaatgttga tggtggcttg
      661 gacttcaaga agcttctaca agacatacag cctgcactgc ccaggctgtc tgcaaagctg
      721 actctggctt cagaggaagg gggccattct caagatacat cagtcaaggc gccctgccag
      781 atgacttttg aggttgatga aaattctcga agtttgatga cagactgtct ggtgataaag
      841 cattttctac ggaaaatcat catagttcat cacaagctca agtttaattt cagtgtaacg
      901 gtgaatggga tcctctctgc agagattttt ggggcagaga atgaacctgt tttgaggctg
      961 tccaatggga tctctcttgc tgtgggcttt cagcactatg tcagtaaacc acaattcaat
     1021 tggactgaac cacactgcag cagactccac cctgtgctag gacatccggc accactgtcc
     1081 atccctggtg ccaaggctaa catgggcctg ttgggagagt tgaccctgac tccagccgct
     1141 gctctgtgcc ccagccccaa gggcttctcc agccaactga acaggatttc ttctgtttcc
     1201 atatttctat atggcccttt gggtctgcct ctggtagcat cagatcagga gcagccaagt
     1261 actgctgtct tcagagatgc ctcttatttc attgactgga agaaacacaa tttgtttatg
     1321 ttgcccaatt tggatctcaa tttggataca cagtttatac ttccagatgt gaattataaa
     1381 gtggagttgc ctgaggagaa tcagtctcag aacgcacagg gaccagttct gctacttttc
     1441 ctatttgtgg atttccaaag tggagtccca gtacaccaag gggaaatctg gggactccat
     1501 actttgctca caactcatct cagcaccatc ctctcggaga gccgcagcac ggtacaagac
     1561 tccatccagt cagctgtgga ccaggtcttg gagctgcacc accaagctgc caagactcac
     1621 cagagactgc aggcctccct ctctgtggct gtgacttcca tcatgagtgt gctgactgga
     1681 agcacaagca gcagcttcag gaagacatgc ctccaggctc tcgaggcagt tgacacacag
     1741 gaatttagtg ccaaactgca cagaatattt tatgatatca cccagcacca atttctgaac
     1801 cactgctcat gtgacacaga gcagcacctg actccagaga aaaagatttc agcccagaac
     1861 accaaagacc agcacaagaa tattggtcta gagttccctg cagaatctag cgggcaagca
     1921 gaaaacaaga ggctcaagag gagcagcccc aaccagggca gggaagaatc gcgaactctg
     1981 ggcccagcca gggacctgag cccgccagaa tccgtcacgc gcgactgcga tcctaccgag
     2041 gcctccctca ctgctagagg atcacagacc caagtggcca acgacggagt tcaggcggca
     2101 gacgcagcga gccctctggg cggcctggag gtaccgcagg gagcacaggg cgggtgcggg
     2161 cctaagctac cgccgccggg ccctcaccac cgcctccgct gctcccgcag gacttgtggc
     2221 tacaggaggt ctccaacctg tccgagtggc tgagtccggg acacaggtcc taagcgcccg
     2281 ctcctgagac tcacagcaag gcaaggaagc ccgggacgcg tgtgttatat atttcaataa
     2341 agctgctcca agca
//
