LOCUS       XM_017597900            2953 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DNA topoisomerase III beta (Top3b),
            transcript variant X10, mRNA.
ACCESSION   XM_017597900
VERSION     XM_017597900.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051346.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_017597900.3.
            
            On Jan 21, 2021 this sequence version replaced XM_017597900.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2953
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..2953
                     /gene="Top3b"
                     /note="DNA topoisomerase III beta; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 28 ESTs, 3 long SRA reads, 14 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 180 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
     CDS             261..2849
                     /gene="Top3b"
                     /codon_start=1
                     /product="DNA topoisomerase 3-beta-1 isoform X1"
                     /protein_id="XP_017453389.1"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
                     /translation="MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGT
                     FAGQPVHFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFL
                     QVEGRGCDYVVLWLDCDKEGENICFEVLDAVLPVLNNAHNGEKTVFRARFSSITDTDI
                     CNAMTRLTEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQ
                     TPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWDRVRVFDREIAQMFLNM
                     TKLEKEAWVEATSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQVAERLYTQGYI
                     SYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPPITP
                     MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISP
                     GFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGI
                     GTDASIPVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYHKIDAELVLPTIRSAVEK
                     QLNLIAQGKANYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRC
                     GKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRG
                     KSYPLCPYCYNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCVECENGVLVLDPTS
                     GPKWKVACNTCSVVAHCFDNAHRVRVSADTCNTCEAALLDVDFNKAKSPLPGNETQHT
                     GCIFCDTVFQELVELKHAASCHPMHRGGPGRRQGRGRARGRRPPGKPNPRRPKDKMSA
                     LAAYFV"
ORIGIN      
        1 acaagcggac agagccggaa gtgcgttcgt gagtggccac cgggaaagca cggccggagc
       61 gagaggtgca gcggcacggc gggtgagcag tgggttgctg gctgctcgag gaagcggaag
      121 acgctggctt tcttcgggca tttccggaat ggagtcagca tcggcagtcc tgttgaacta
      181 cagagaagac atttctaagc ttttgtattg ctgctcttct gggtgccaca gtctgtgggc
      241 cctgacagcc tggagcagga atgaagacgg tgctcatggt agcagaaaag ccatccctgg
      301 cacaatccat tgccaaaatc ctctcccgag gaaacatgtc ctcacacaaa gggctaaatg
      361 gggcgtgttc agtgcacaaa tacacaggaa cctttgctgg ccagcccgtc cacttcaaga
      421 tgacatctgt ctgtggtcat gtgatgacac tggattttct gggaaagtac aacaagtggg
      481 ataaggtaga tcctgcagag ttattcagcc aagctccaac agagaaaaag gaagcaaacc
      541 ccaagctgaa catggtcaag ttcctgcagg tggagggcag aggctgtgac tacgtcgtgc
      601 tgtggctgga ctgtgacaag gaaggcgaga atatttgctt tgaggtcctt gatgccgttc
      661 tgcctgtcct gaataatgcc cacaatggtg agaagacagt gttccgggcc aggttcagtt
      721 ccatcacaga cacggacatc tgcaatgcca tgacccgcct gactgagcca gaccacaatg
      781 aggcactctc ggtggatgcc cgccaggagc tagacctgcg catcggctgt gcgttcacta
      841 ggtttcaaac aaagtatttc cagggaaaat atggcgactt agacagctct ctcatctcct
      901 ttgggccttg tcagactcca accctgggat tctgtgtaga aagacatgat aaaatccagt
      961 ccttcaaacc agagacctac tgggtacttc aggccaaggt tcatactgat aaagaggagt
     1021 cactcctttt ggactgggac cgagttagag ttttcgaccg ggagattgca cagatgtttt
     1081 taaacatgac aaagctagaa aaagaagctt gggtggaggc tacaagcaag aaagaaaaag
     1141 ccaagcagag accacttgct ctgaacactg tggagatgtt gcgtgtggcc agttcagctc
     1201 tgggtatggg accacagcat gccatgcaag tagctgagag attatacaca cagggctaca
     1261 tcagctaccc acggacagaa accacacact atcccgagaa ctttgacctg aagggctctt
     1321 tacgacaaca ggccaatcac ccatactggg cagactcggt aaagcagttg ttagcagaag
     1381 gcatcaaccg ccctcggaaa ggtcacgatg ctggtgacca tcctccgatc acaccaatga
     1441 agtcagctac agaggctgaa ttaggaggtg acgcttggcg actctacgag tacatcacca
     1501 gacacttcat cgccacagtg agccatgact gcaagtatct ccagagcacc atctccttca
     1561 ggatcgggcc cgagcacttc acatgcatgg gaaagacagt tatttcccca ggcttcacag
     1621 agatcatgcc ttggcagagc gtgcccctgg aagagagtct gcccacatgc cagaagggcg
     1681 ataccttcac tgtgggtgag gtgaagatgc tagagaagca gacgagcccc ccggactatc
     1741 tgactgaggc tgagctcatc accctcatgg agaagcatgg catcgggacg gatgccagta
     1801 tccctgtgca catcaacaac atctgccagc gcaactacgt cacagtggag aacggccgcc
     1861 ggctcaagcc caccaacctc ggcatagttc tggtgcacgg ctaccacaag attgatgcag
     1921 agctggtgct ccccaccatc cgcagcgcag tggagaagca gctgaacctt attgcccagg
     1981 gcaaagccaa ctaccaccag gtgctgggcc acaccctgga tatcttcaag agaaagttcc
     2041 actactttgt tgattctatt gctggcatgg acgagttaat ggaggtatcc ttttcacccc
     2101 tggctgccac tggcaagccc ctctcgcgct gtgggaagtg ccatcgattt atgaagtata
     2161 tccaggccaa gccaagccgc ctgcactgct cccactgcga tgagacctac accctccccc
     2221 agaatggtac catcaagctc tacaaggagc tgcggtgccc attggatgac tttgaactgg
     2281 tcttgtggtc ctcaggctcc cggggcaaga gctaccccct ctgtccctac tgctataacc
     2341 acccaccctt ccgagacatg aagaaaggca tgggctgcaa tgagtgcaca caccctacgt
     2401 gccagcactc actgagtatg ctgggcattg gccagtgcgt ggagtgcgag aatggagtcc
     2461 tggttctgga ccccacctcc ggtcccaagt ggaaggtggc ctgcaataca tgcagcgtag
     2521 tggcacactg ctttgacaat gcccaccgag tacgggtgtc tgctgacacc tgcaacacct
     2581 gcgaggctgc cttgctcgat gtagacttca acaaggccaa gtctcccctt cctggcaacg
     2641 agacacagca cacaggctgc atcttctgtg acaccgtctt ccaggagctg gtggagctga
     2701 agcatgcagc ctcctgccac cccatgcacc gaggtggtcc tggaaggagg cagggtcgtg
     2761 ggcgggcccg gggccggaga cctccaggaa agcccaaccc caggcggcca aaagacaaga
     2821 tgtcagccct ggctgcttac tttgtataac tacccacctt gccccactct agcccccgtt
     2881 gatgtagaca tgtcgtggtg atctttgagc cactgaaacc attaaaatgc tttttatttt
     2941 gtattctctg gaa
//
