LOCUS       XM_017597898            3040 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DNA topoisomerase III beta (Top3b),
            transcript variant X8, mRNA.
ACCESSION   XM_017597898
VERSION     XM_017597898.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051346.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_017597898.3.
            
            On Jan 21, 2021 this sequence version replaced XM_017597898.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..3040
                     /gene="Top3b"
                     /note="DNA topoisomerase III beta; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 27
                     ESTs, 4 long SRA reads, 14 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 95 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
     CDS             348..2936
                     /gene="Top3b"
                     /codon_start=1
                     /product="DNA topoisomerase 3-beta-1 isoform X1"
                     /protein_id="XP_017453387.1"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
                     /translation="MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGT
                     FAGQPVHFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFL
                     QVEGRGCDYVVLWLDCDKEGENICFEVLDAVLPVLNNAHNGEKTVFRARFSSITDTDI
                     CNAMTRLTEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQ
                     TPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWDRVRVFDREIAQMFLNM
                     TKLEKEAWVEATSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQVAERLYTQGYI
                     SYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPPITP
                     MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISP
                     GFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGI
                     GTDASIPVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYHKIDAELVLPTIRSAVEK
                     QLNLIAQGKANYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRC
                     GKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRG
                     KSYPLCPYCYNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCVECENGVLVLDPTS
                     GPKWKVACNTCSVVAHCFDNAHRVRVSADTCNTCEAALLDVDFNKAKSPLPGNETQHT
                     GCIFCDTVFQELVELKHAASCHPMHRGGPGRRQGRGRARGRRPPGKPNPRRPKDKMSA
                     LAAYFV"
ORIGIN      
        1 tccgacccgg gtgggggcgt gggggagggt ccttgcctgg tgcggctttt tcccggtccc
       61 gccctcgctt cgggtgggac cgagtttagt gggcgactgt cgctccaccg agctccccgc
      121 ggccccgcga tgagatgttt ctccctaatt gagggtttca agtgatatac cctgcccaga
      181 aagctacagc agaggccaac agtggtccag ctatgaaatt tgcatgtcct cttgcaagga
      241 gtcagcatcg gcagtcctgt tgaactacag agaagacatt tctaagcttt tgtattgctg
      301 ctcttctggg tgccacagtc tgtgggccct gacagcctgg agcaggaatg aagacggtgc
      361 tcatggtagc agaaaagcca tccctggcac aatccattgc caaaatcctc tcccgaggaa
      421 acatgtcctc acacaaaggg ctaaatgggg cgtgttcagt gcacaaatac acaggaacct
      481 ttgctggcca gcccgtccac ttcaagatga catctgtctg tggtcatgtg atgacactgg
      541 attttctggg aaagtacaac aagtgggata aggtagatcc tgcagagtta ttcagccaag
      601 ctccaacaga gaaaaaggaa gcaaacccca agctgaacat ggtcaagttc ctgcaggtgg
      661 agggcagagg ctgtgactac gtcgtgctgt ggctggactg tgacaaggaa ggcgagaata
      721 tttgctttga ggtccttgat gccgttctgc ctgtcctgaa taatgcccac aatggtgaga
      781 agacagtgtt ccgggccagg ttcagttcca tcacagacac ggacatctgc aatgccatga
      841 cccgcctgac tgagccagac cacaatgagg cactctcggt ggatgcccgc caggagctag
      901 acctgcgcat cggctgtgcg ttcactaggt ttcaaacaaa gtatttccag ggaaaatatg
      961 gcgacttaga cagctctctc atctcctttg ggccttgtca gactccaacc ctgggattct
     1021 gtgtagaaag acatgataaa atccagtcct tcaaaccaga gacctactgg gtacttcagg
     1081 ccaaggttca tactgataaa gaggagtcac tccttttgga ctgggaccga gttagagttt
     1141 tcgaccggga gattgcacag atgtttttaa acatgacaaa gctagaaaaa gaagcttggg
     1201 tggaggctac aagcaagaaa gaaaaagcca agcagagacc acttgctctg aacactgtgg
     1261 agatgttgcg tgtggccagt tcagctctgg gtatgggacc acagcatgcc atgcaagtag
     1321 ctgagagatt atacacacag ggctacatca gctacccacg gacagaaacc acacactatc
     1381 ccgagaactt tgacctgaag ggctctttac gacaacaggc caatcaccca tactgggcag
     1441 actcggtaaa gcagttgtta gcagaaggca tcaaccgccc tcggaaaggt cacgatgctg
     1501 gtgaccatcc tccgatcaca ccaatgaagt cagctacaga ggctgaatta ggaggtgacg
     1561 cttggcgact ctacgagtac atcaccagac acttcatcgc cacagtgagc catgactgca
     1621 agtatctcca gagcaccatc tccttcagga tcgggcccga gcacttcaca tgcatgggaa
     1681 agacagttat ttccccaggc ttcacagaga tcatgccttg gcagagcgtg cccctggaag
     1741 agagtctgcc cacatgccag aagggcgata ccttcactgt gggtgaggtg aagatgctag
     1801 agaagcagac gagccccccg gactatctga ctgaggctga gctcatcacc ctcatggaga
     1861 agcatggcat cgggacggat gccagtatcc ctgtgcacat caacaacatc tgccagcgca
     1921 actacgtcac agtggagaac ggccgccggc tcaagcccac caacctcggc atagttctgg
     1981 tgcacggcta ccacaagatt gatgcagagc tggtgctccc caccatccgc agcgcagtgg
     2041 agaagcagct gaaccttatt gcccagggca aagccaacta ccaccaggtg ctgggccaca
     2101 ccctggatat cttcaagaga aagttccact actttgttga ttctattgct ggcatggacg
     2161 agttaatgga ggtatccttt tcacccctgg ctgccactgg caagcccctc tcgcgctgtg
     2221 ggaagtgcca tcgatttatg aagtatatcc aggccaagcc aagccgcctg cactgctccc
     2281 actgcgatga gacctacacc ctcccccaga atggtaccat caagctctac aaggagctgc
     2341 ggtgcccatt ggatgacttt gaactggtct tgtggtcctc aggctcccgg ggcaagagct
     2401 accccctctg tccctactgc tataaccacc cacccttccg agacatgaag aaaggcatgg
     2461 gctgcaatga gtgcacacac cctacgtgcc agcactcact gagtatgctg ggcattggcc
     2521 agtgcgtgga gtgcgagaat ggagtcctgg ttctggaccc cacctccggt cccaagtgga
     2581 aggtggcctg caatacatgc agcgtagtgg cacactgctt tgacaatgcc caccgagtac
     2641 gggtgtctgc tgacacctgc aacacctgcg aggctgcctt gctcgatgta gacttcaaca
     2701 aggccaagtc tccccttcct ggcaacgaga cacagcacac aggctgcatc ttctgtgaca
     2761 ccgtcttcca ggagctggtg gagctgaagc atgcagcctc ctgccacccc atgcaccgag
     2821 gtggtcctgg aaggaggcag ggtcgtgggc gggcccgggg ccggagacct ccaggaaagc
     2881 ccaaccccag gcggccaaaa gacaagatgt cagccctggc tgcttacttt gtataactac
     2941 ccaccttgcc ccactctagc ccccgttgat gtagacatgt cgtggtgatc tttgagccac
     3001 tgaaaccatt aaaatgcttt ttattttgta ttctctggaa
//
