LOCUS       XM_017597896            3031 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DNA topoisomerase III beta (Top3b),
            transcript variant X3, mRNA.
ACCESSION   XM_017597896
VERSION     XM_017597896.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051346.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_017597896.3.
            
            On Jan 21, 2021 this sequence version replaced XM_017597896.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..3031
                     /gene="Top3b"
                     /note="DNA topoisomerase III beta; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 26
                     ESTs, 3 long SRA reads, 14 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 114 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
     CDS             339..2927
                     /gene="Top3b"
                     /codon_start=1
                     /product="DNA topoisomerase 3-beta-1 isoform X1"
                     /protein_id="XP_017453385.1"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
                     /translation="MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGT
                     FAGQPVHFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFL
                     QVEGRGCDYVVLWLDCDKEGENICFEVLDAVLPVLNNAHNGEKTVFRARFSSITDTDI
                     CNAMTRLTEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQ
                     TPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWDRVRVFDREIAQMFLNM
                     TKLEKEAWVEATSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQVAERLYTQGYI
                     SYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPPITP
                     MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISP
                     GFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGI
                     GTDASIPVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYHKIDAELVLPTIRSAVEK
                     QLNLIAQGKANYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRC
                     GKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRG
                     KSYPLCPYCYNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCVECENGVLVLDPTS
                     GPKWKVACNTCSVVAHCFDNAHRVRVSADTCNTCEAALLDVDFNKAKSPLPGNETQHT
                     GCIFCDTVFQELVELKHAASCHPMHRGGPGRRQGRGRARGRRPPGKPNPRRPKDKMSA
                     LAAYFV"
ORIGIN      
        1 gctcagggaa gccttgctgc ccacaaaagc tcgggcctgc ggtccgcgtt cttagtcgaa
       61 ggttctactt gctgccggcc ggagcctgct ctgtctggag acccgggctg ttctctgttt
      121 tgatctccac aggtttggag aaaacgtttc aagtgatata ccctgcccag aaagctacag
      181 cagaggccaa cagtggtcca gctatgaaat ttgcatgtcc tcttgcaagg agtcagcatc
      241 ggcagtcctg ttgaactaca gagaagacat ttctaagctt ttgtattgct gctcttctgg
      301 gtgccacagt ctgtgggccc tgacagcctg gagcaggaat gaagacggtg ctcatggtag
      361 cagaaaagcc atccctggca caatccattg ccaaaatcct ctcccgagga aacatgtcct
      421 cacacaaagg gctaaatggg gcgtgttcag tgcacaaata cacaggaacc tttgctggcc
      481 agcccgtcca cttcaagatg acatctgtct gtggtcatgt gatgacactg gattttctgg
      541 gaaagtacaa caagtgggat aaggtagatc ctgcagagtt attcagccaa gctccaacag
      601 agaaaaagga agcaaacccc aagctgaaca tggtcaagtt cctgcaggtg gagggcagag
      661 gctgtgacta cgtcgtgctg tggctggact gtgacaagga aggcgagaat atttgctttg
      721 aggtccttga tgccgttctg cctgtcctga ataatgccca caatggtgag aagacagtgt
      781 tccgggccag gttcagttcc atcacagaca cggacatctg caatgccatg acccgcctga
      841 ctgagccaga ccacaatgag gcactctcgg tggatgcccg ccaggagcta gacctgcgca
      901 tcggctgtgc gttcactagg tttcaaacaa agtatttcca gggaaaatat ggcgacttag
      961 acagctctct catctccttt gggccttgtc agactccaac cctgggattc tgtgtagaaa
     1021 gacatgataa aatccagtcc ttcaaaccag agacctactg ggtacttcag gccaaggttc
     1081 atactgataa agaggagtca ctccttttgg actgggaccg agttagagtt ttcgaccggg
     1141 agattgcaca gatgttttta aacatgacaa agctagaaaa agaagcttgg gtggaggcta
     1201 caagcaagaa agaaaaagcc aagcagagac cacttgctct gaacactgtg gagatgttgc
     1261 gtgtggccag ttcagctctg ggtatgggac cacagcatgc catgcaagta gctgagagat
     1321 tatacacaca gggctacatc agctacccac ggacagaaac cacacactat cccgagaact
     1381 ttgacctgaa gggctcttta cgacaacagg ccaatcaccc atactgggca gactcggtaa
     1441 agcagttgtt agcagaaggc atcaaccgcc ctcggaaagg tcacgatgct ggtgaccatc
     1501 ctccgatcac accaatgaag tcagctacag aggctgaatt aggaggtgac gcttggcgac
     1561 tctacgagta catcaccaga cacttcatcg ccacagtgag ccatgactgc aagtatctcc
     1621 agagcaccat ctccttcagg atcgggcccg agcacttcac atgcatggga aagacagtta
     1681 tttccccagg cttcacagag atcatgcctt ggcagagcgt gcccctggaa gagagtctgc
     1741 ccacatgcca gaagggcgat accttcactg tgggtgaggt gaagatgcta gagaagcaga
     1801 cgagcccccc ggactatctg actgaggctg agctcatcac cctcatggag aagcatggca
     1861 tcgggacgga tgccagtatc cctgtgcaca tcaacaacat ctgccagcgc aactacgtca
     1921 cagtggagaa cggccgccgg ctcaagccca ccaacctcgg catagttctg gtgcacggct
     1981 accacaagat tgatgcagag ctggtgctcc ccaccatccg cagcgcagtg gagaagcagc
     2041 tgaaccttat tgcccagggc aaagccaact accaccaggt gctgggccac accctggata
     2101 tcttcaagag aaagttccac tactttgttg attctattgc tggcatggac gagttaatgg
     2161 aggtatcctt ttcacccctg gctgccactg gcaagcccct ctcgcgctgt gggaagtgcc
     2221 atcgatttat gaagtatatc caggccaagc caagccgcct gcactgctcc cactgcgatg
     2281 agacctacac cctcccccag aatggtacca tcaagctcta caaggagctg cggtgcccat
     2341 tggatgactt tgaactggtc ttgtggtcct caggctcccg gggcaagagc taccccctct
     2401 gtccctactg ctataaccac ccacccttcc gagacatgaa gaaaggcatg ggctgcaatg
     2461 agtgcacaca ccctacgtgc cagcactcac tgagtatgct gggcattggc cagtgcgtgg
     2521 agtgcgagaa tggagtcctg gttctggacc ccacctccgg tcccaagtgg aaggtggcct
     2581 gcaatacatg cagcgtagtg gcacactgct ttgacaatgc ccaccgagta cgggtgtctg
     2641 ctgacacctg caacacctgc gaggctgcct tgctcgatgt agacttcaac aaggccaagt
     2701 ctccccttcc tggcaacgag acacagcaca caggctgcat cttctgtgac accgtcttcc
     2761 aggagctggt ggagctgaag catgcagcct cctgccaccc catgcaccga ggtggtcctg
     2821 gaaggaggca gggtcgtggg cgggcccggg gccggagacc tccaggaaag cccaacccca
     2881 ggcggccaaa agacaagatg tcagccctgg ctgcttactt tgtataacta cccaccttgc
     2941 cccactctag cccccgttga tgtagacatg tcgtggtgat ctttgagcca ctgaaaccat
     3001 taaaatgctt tttattttgt attctctgga a
//
