LOCUS       NM_001105861            2966 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus DNA topoisomerase III beta (Top3b), mRNA.
ACCESSION   NM_001105861 XM_001067804 XM_213564
VERSION     NM_001105861.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2966)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2966)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 2966)
  AUTHORS   Kwan KY, Moens PB and Wang JC.
  TITLE     Infertility and aneuploidy in mice lacking a type IA DNA
            topoisomerase III beta
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2526-2531 (2003)
   PUBMED   12591952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213564.4, XM_001067804.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2966
                     /gene="Top3b"
                     /note="DNA topoisomerase III beta"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
     exon            1..74
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            75..158
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            159..337
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2856
                     /gene="Top3b"
                     /EC_number="5.6.2.2"
                     /note="topoisomerase (DNA) III beta"
                     /codon_start=1
                     /product="DNA topoisomerase 3-beta-1"
                     /protein_id="NP_001099331.1"
                     /db_xref="GeneID:287930"
                     /db_xref="RGD:1309468"
                     /translation="MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGT
                     FAGQPVHFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFL
                     QVEGRGCDYVVLWLDCDKEGENICFEVLDAVLPVLNNAHNGEKTVFRARFSSITDTDI
                     CNAMTRLTEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQ
                     TPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWDRVRVFDREIAQMFLNM
                     TKLEKEAWVEATSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQVAERLYTQGYI
                     SYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPPITP
                     MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISP
                     GFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGI
                     GTDASIPVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYHKIDAELVLPTIRSAVEK
                     QLNLIAQGKANYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRC
                     GKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRG
                     KSYPLCPYCYNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCVECENGVLVLDPTS
                     GPKWKVACNTCSVVAHCFDNAHRVRVSADTCNTCEAALLDVDFNKAKSPLPGNETQHT
                     GCIFCDTVFQELVELKHAASCHPMHRGGPGRRQGRGRARGRRPPGKPNPRRPKDKMSA
                     LAAYFV"
     exon            338..469
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            470..576
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            577..651
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            652..848
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1005
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1119
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1210
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1365
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1471
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1618
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1792
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1921
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2071
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2172
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2374
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2966
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagagccgg aagtgcgttc gtgagtggcc accgggaaag cacggccgga gcgagaggtg
       61 cagcggcacg gcgggtttca agtgatatac cctgcccaga aagctacagc agaggccaac
      121 agtggtccag ctatgaaatt tgcatgtcct cttgcaagga gtcagcatcg gcagtcctgt
      181 tgaactacag agaagacatt tctaagcttt tgtattgctg ctcttctggg tgccacagtc
      241 tgtgggccct gacagcctgg agcaggaatg aagacggtgc tcatggtagc agaaaagcca
      301 tccctggcac aatccattgc caaaatcctc tcccgaggaa acatgtcctc acacaaaggg
      361 ctaaatgggg cgtgttcagt gcacaaatac acaggaacct ttgctggcca gcccgtccac
      421 ttcaagatga catctgtctg tggtcatgtg atgacactgg attttctggg aaagtacaac
      481 aagtgggata aggtagatcc tgcagagtta ttcagccaag ctccaacaga gaaaaaggaa
      541 gcaaacccca agctgaacat ggtcaagttc ctgcaggtgg agggcagagg ctgtgactac
      601 gtcgtgctgt ggctggactg tgacaaggaa ggcgagaata tttgctttga ggtccttgat
      661 gccgttctgc ctgtcctgaa taatgcccac aatggtgaga agacagtgtt ccgggccagg
      721 ttcagttcca tcacagacac ggacatctgc aatgccatga cccgcctgac tgagccagac
      781 cacaatgagg cactctcggt ggatgcccgc caggagctag acctgcgcat cggctgtgcg
      841 ttcactaggt ttcaaacaaa gtatttccag ggaaaatatg gcgacttaga cagctctctc
      901 atctcctttg ggccttgtca gactccaacc ctgggattct gtgtagaaag acatgataaa
      961 atccagtcct tcaaaccaga gacctactgg gtacttcagg ccaaggttca tactgataaa
     1021 gaggagtcac tccttttgga ctgggaccga gttagagttt tcgaccggga gattgcacag
     1081 atgtttttaa acatgacaaa gctagaaaaa gaagcttggg tggaggctac aagcaagaaa
     1141 gaaaaagcca agcagagacc acttgctctg aacactgtgg agatgttgcg tgtggccagt
     1201 tcagctctgg gtatgggacc acagcatgcc atgcaagtag ctgagagatt atacacacag
     1261 ggctacatca gctacccacg gacagaaacc acacactatc ccgagaactt tgacctgaag
     1321 ggctctttac gacaacaggc caatcaccca tactgggcag actcggtaaa gcagttgtta
     1381 gcagaaggca tcaaccgccc tcggaaaggt cacgatgctg gtgaccatcc tccgatcaca
     1441 ccaatgaagt cagctacaga ggctgaatta ggaggtgacg cttggcgact ctacgagtac
     1501 atcaccagac acttcatcgc cacagtgagc catgactgca agtatctcca gagcaccatc
     1561 tccttcagga tcgggcccga gcacttcaca tgcatgggaa agacagttat ttccccaggc
     1621 ttcacagaga tcatgccttg gcagagcgtg cccctggaag agagtctgcc cacatgccag
     1681 aagggcgata ccttcactgt gggtgaggtg aagatgctag agaagcagac gagccccccg
     1741 gactatctga ctgaggctga gctcatcacc ctcatggaga agcatggcat cgggacggat
     1801 gccagtatcc ctgtgcacat caacaacatc tgccagcgca actacgtcac agtggagaac
     1861 ggccgccggc tcaagcccac caacctcggc atagttctgg tgcacggcta ccacaagatt
     1921 gatgcagagc tggtgctccc caccatccgc agcgcagtgg agaagcagct gaaccttatt
     1981 gcccagggca aagccaacta ccaccaggtg ctgggccaca ccctggatat cttcaagaga
     2041 aagttccact actttgttga ttctattgct ggcatggacg agttaatgga ggtatccttt
     2101 tcacccctgg ctgccactgg caagcccctc tcgcgctgtg ggaagtgcca tcgatttatg
     2161 aagtatatcc aggccaagcc aagccgcctg cactgctccc actgcgatga gacctacacc
     2221 ctcccccaga atggtaccat caagctctac aaggagctgc ggtgcccatt ggatgacttt
     2281 gaactggtct tgtggtcctc aggctcccgg ggcaagagct accccctctg tccctactgc
     2341 tataaccacc cacccttccg agacatgaag aaaggcatgg gctgcaatga gtgcacacac
     2401 cctacgtgcc agcactcact gagtatgctg ggcattggcc agtgcgtgga gtgcgagaat
     2461 ggagtcctgg ttctggaccc cacctccggt cccaagtgga aggtggcctg caatacatgc
     2521 agcgtagtgg cacactgctt tgacaatgcc caccgagtac gggtgtctgc tgacacctgc
     2581 aacacctgcg aggctgcctt gctcgatgta gacttcaaca aggccaagtc tccccttcct
     2641 ggcaacgaga cacagcacac aggctgcatc ttctgtgaca ccgtcttcca ggagctggtg
     2701 gagctgaagc atgcagcctc ctgccacccc atgcaccgag gtggtcctgg aaggaggcag
     2761 ggtcgtgggc gggcccgggg ccggagacct ccaggaaagc ccaaccccag gcggccaaaa
     2821 gacaagatgt cagccctggc tgcttacttt gtataactac ccaccttgcc ccactctagc
     2881 ccccgttgat gtagacatgt cgtggtgatc tttgagccac tgaaaccatt aaaatgcttt
     2941 ttattttgta ttctctggaa caaaaa
//
