LOCUS       XM_039087265            2461 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DNA topoisomerase III alpha (Top3a),
            transcript variant X3, mRNA.
ACCESSION   XM_039087265
VERSION     XM_039087265.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051345.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039087265.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..2461
                     /gene="Top3a"
                     /note="DNA topoisomerase III alpha; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 176 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:303194"
                     /db_xref="RGD:1309320"
     CDS             184..2328
                     /gene="Top3a"
                     /codon_start=1
                     /product="DNA topoisomerase 3-alpha isoform X3"
                     /protein_id="XP_038943193.1"
                     /db_xref="GeneID:303194"
                     /db_xref="RGD:1309320"
                     /translation="MIFPVTLLAFQWQRRPGGRALSRAAMEVAFRGVRKVLCVAEKND
                     AAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQF
                     RKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETQHCQALVIWTDCDREGENIGFEI
                     IHVCKAVKPNLQVLRARFSEITHHAVRAACEHLTEPDQRVSDAVDVRQELDLRIGAAF
                     TRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHRIKVTHDH
                     KDGTVEFNWKRYRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEK
                     LASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPKDLNLVTLVEQQTQDPHWGAF
                     AQNILERGGPTPRNGNKSDQAHPPIHPTKYTSSLQGDDRRLYEFIVRHFLACCSQDAQ
                     GQETTVEIDIAQERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGFRFQPSTVEMV
                     DGETSPPQLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGM
                     GLVEGYDSMGYEMSKPNLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKA
                     KKLDEALSQYLGERTEVAQQEEIYPAMPEPVRKCPQCNKDMVLKTKKSGSTLAARGSQ
                     NVAQPCGFLTRCWRPAGTAVYVPFVSQPLCTG"
ORIGIN      
        1 ggaagttgtc tgtgagcgcg agtttaagcg ggactcggag gtgtgggttt ctgatccagg
       61 aggcagtttc ctggaaaaaa atgcattatt aaagtggctc tcagagggct gcctcgtggc
      121 tttaactctg ggtgctccaa catgcatggg cgcccgtgga gttgctggcg cactgtctag
      181 ggaatgatct tcccagtcac cctcttagcg tttcagtggc agcgacggcc tggaggccgt
      241 gccctgtccc gcgctgccat ggaagtagcc ttccgaggag tgcgaaaagt cctctgcgtg
      301 gcggagaaaa acgacgctgc caaaggaatc gccgacttgc tatccaacgg tcgtatgagg
      361 cggaaagaag gcctttctaa attcaacaag atttatgaat ttgactatca tctgtatggc
      421 cagaatgtta ctatgataat gacttcagtc tctggacatt tgctggctca tgacttccag
      481 atgcagtttc ggaaatggca gagctgcaat ccccttgtcc tctttgaagc agaaattgaa
      541 aagtattgcc cagaaaattt tatagacatc aagaaaactc tggaacgaga gacacagcat
      601 tgtcaggcat tggtgatctg gactgactgt gacagagaag gtgaaaacat cgggtttgag
      661 attatccatg tatgcaaggc tgtaaagccc aatctacagg tgctgagggc ccgcttctct
      721 gagatcacac accatgctgt cagggcagcc tgtgagcatc tgactgagcc tgaccagaga
      781 gtaagtgacg cagtggatgt gaggcaagag ctggatctga ggatcggggc tgccttcaca
      841 aggttccaga ccctgcggct ccagaggatt ttccctgagg tgctggcgga gcagctcatc
      901 agctatggca gctgccagtt cccaacactg gggtttgtgg tggaaaggtt caaggccatt
      961 caggcttttg tgccggaagt cttccacaga attaaagtaa ctcatgacca caaagatggg
     1021 actgtagagt tcaactggaa aagataccgt ctctttaacc acacagcttg tcttgtcctt
     1081 tatcagttgt gtatggagga tcccatggca accgtggtag aggtcaggtc caagccaaag
     1141 agcaagtggc ggcctcaagc gttggacact gtggagctag agaaactggc gtctcgaaaa
     1201 ttgagaataa atgccaaaga aaccatgagg attgcggaaa agctctatac acaagggtac
     1261 atcagctatc ccaggacaga aacaaacatc ttccccaaag acttaaacct ggttacattg
     1321 gtggaacagc agacccagga tccacactgg ggggcttttg ctcagaacat tctagagcga
     1381 ggcggcccca ctccacgaaa tgggaacaaa tctgatcaag ctcaccctcc cattcacccc
     1441 accaaataca ccagcagcct gcagggagat gatcggcgac tgtatgagtt catcgttcgc
     1501 catttcctgg cttgctgctc tcaggatgct caggggcaag agactaccgt ggagatcgac
     1561 attgcccagg agcgctttgt agcccatggc ctcataatcc tggcccgtaa ctatctagat
     1621 gtgtatccgt atgaccactg gagtgacaag ctcctccctg tctatgagca aggcttccgc
     1681 tttcagccca gcactgtgga aatggtggat ggggagacta gcccacccca actgcttacc
     1741 gaagctgacc tcatcgccct catggagaaa catggtattg gtactgatgc aactcatgca
     1801 gaacacatcg agaccatcaa agcccggatg tatgtgggac tcacctcaga caagcggttc
     1861 ctccctgggc acctgggcat gggacttgtg gaaggttatg attccatggg ttacgagatg
     1921 tccaagccta acctccgtgc cgagctggaa gctgatctca agctgatctg tgagggcaag
     1981 aaggataagt ttcaggttct aaggcagcaa gtgcagaaat acaagcaggt gttcattgaa
     2041 gcagtggcga aggcaaagaa gctggatgag gccttatctc agtacttagg agaaaggaca
     2101 gaggtggctc agcaagaaga gatctaccca gccatgccag agcctgttcg gaagtgccca
     2161 cagtgtaaca aggatatggt cctcaagacc aagaagagtg gttctacctt agctgcacgg
     2221 ggttcccaga atgtcgctca gccgtgtggt ttcctgactc ggtgctggag gccagcaggg
     2281 acagcagtgt atgttccgtt tgtcagccag cccctgtgta caggttgaag ttgaagttta
     2341 agcgtggtag ccttccccca tctatgcccc tggagtttgt cggctgcata ggtggatgtg
     2401 atgagacctt gaaggaaatc ttcggcctgc gattttcacg ggctccacca agagcgagcc
     2461 a
//
