LOCUS       NP_001094328            1614 aa            linear   ROD 31-MAR-2024
DEFINITION  DNA topoisomerase 2-beta [Rattus norvegicus].
ACCESSION   NP_001094328 XP_001067768 XP_341387
VERSION     NP_001094328.2
DBSOURCE    REFSEQ: accession NM_001100858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1614)
  AUTHORS   Hu,H.L., Shiflett,L.A., Kobayashi,M., Chao,M.V., Wilson,A.C.,
            Mohr,I. and Huang,T.T.
  TITLE     TOP2beta-Dependent Nuclear DNA Damage Shapes Extracellular Growth
            Factor Responses via Dynamic AKT Phosphorylation to Control Virus
            Latency
  JOURNAL   Mol Cell 74 (3), 466-480 (2019)
   PUBMED   30930055
  REMARK    GeneRIF: Suppression of host DNA-repair pathways that remove
            TOP2bcc trigger HSV-1 reactivation. Moreover, perturbation of AKT
            phosphorylation dynamics by downregulating the PHLPP1 phosphatase
            led to AKT mis-localization and disruption of DSB-induced HSV-1
            reactivation.
REFERENCE   2  (residues 1 to 1614)
  AUTHORS   Rochette,L., Guenancia,C., Gudjoncik,A., Hachet,O., Zeller,M.,
            Cottin,Y. and Vergely,C.
  TITLE     Anthracyclines/trastuzumab: new aspects of cardiotoxicity and
            molecular mechanisms
  JOURNAL   Trends Pharmacol Sci 36 (6), 326-348 (2015)
   PUBMED   25895646
  REMARK    Review article
REFERENCE   3  (residues 1 to 1614)
  AUTHORS   Onoda,A., Hosoya,O., Sano,K., Kiyama,K., Kimura,H., Kawano,S.,
            Furuta,R., Miyaji,M., Tsutsui,K. and Tsutsui,K.M.
  TITLE     Nuclear dynamics of topoisomerase IIbeta reflects its catalytic
            activity that is regulated by binding of RNA to the C-terminal
            domain
  JOURNAL   Nucleic Acids Res 42 (14), 9005-9020 (2014)
   PUBMED   25034690
REFERENCE   4  (residues 1 to 1614)
  AUTHORS   Yang,F., Teves,S.S., Kemp,C.J. and Henikoff,S.
  TITLE     Doxorubicin, DNA torsion, and chromatin dynamics
  JOURNAL   Biochim Biophys Acta 1845 (1), 84-89 (2014)
   PUBMED   24361676
  REMARK    Review article
REFERENCE   5  (residues 1 to 1614)
  AUTHORS   Vavrova,A., Jansova,H., Mackova,E., Machacek,M., Haskova,P.,
            Tichotova,L., Sterba,M. and Simunek,T.
  TITLE     Catalytic inhibitors of topoisomerase II differently modulate the
            toxicity of anthracyclines in cardiac and cancer cells
  JOURNAL   PLoS One 8 (10), e76676 (2013)
   PUBMED   24116135
  REMARK    GeneRIF: Data indicate that dexrazoxane may protect cardiomyocytes
            via its catalytic topoisomerase II (TOP2) inhibitory activity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1614)
  AUTHORS   Yang,X., Li,W., Prescott,E.D., Burden,S.J. and Wang,J.C.
  TITLE     DNA topoisomerase IIbeta and neural development
  JOURNAL   Science 287 (5450), 131-134 (2000)
   PUBMED   10615047
REFERENCE   7  (residues 1 to 1614)
  AUTHORS   Bjergbaek,L., Jensen,S., Westergaard,O. and Andersen,A.H.
  TITLE     Using a biochemical approach to identify the primary dimerization
            regions in human DNA topoisomerase IIalpha
  JOURNAL   J Biol Chem 274 (37), 26529-26536 (1999)
   PUBMED   10473615
REFERENCE   8  (residues 1 to 1614)
  AUTHORS   Adachi,N., Miyaike,M., Kato,S., Kanamaru,R., Koyama,H. and
            Kikuchi,A.
  TITLE     Cellular distribution of mammalian DNA topoisomerase II is
            determined by its catalytically dispensable C-terminal domain
  JOURNAL   Nucleic Acids Res 25 (15), 3135-3142 (1997)
   PUBMED   9224616
REFERENCE   9  (residues 1 to 1614)
  AUTHORS   Meyer,K.N., Kjeldsen,E., Straub,T., Knudsen,B.R., Hickson,I.D.,
            Kikuchi,A., Kreipe,H. and Boege,F.
  TITLE     Cell cycle-coupled relocation of types I and II topoisomerases and
            modulation of catalytic enzyme activities
  JOURNAL   J Cell Biol 136 (4), 775-788 (1997)
   PUBMED   9049244
REFERENCE   10 (residues 1 to 1614)
  AUTHORS   Tsutsui,K., Tsutsui,K., Okada,S., Watanabe,M., Shohmori,T., Seki,S.
            and Inoue,Y.
  TITLE     Molecular cloning of partial cDNAs for rat DNA topoisomerase II
            isoforms and their differential expression in brain development
  JOURNAL   J Biol Chem 268 (25), 19076-19083 (1993)
   PUBMED   8395528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 14, 2022 this sequence version replaced NP_001094328.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB262979.1, SRR26643296.33985.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     Protein         1..1614
                     /product="DNA topoisomerase 2-beta"
                     /EC_number="5.6.2.3"
                     /note="topoisomerase II beta; topoisomerase (DNA) II beta"
                     /calculated_mol_wt=181863
     Region          34..1457
                     /region_name="PTZ00108"
                     /note="DNA topoisomerase 2-like protein; Provisional"
                     /db_xref="CDD:240271"
     Region          1503..1599
                     /region_name="DTHCT"
                     /note="DTHCT (NUC029) region; pfam08070"
                     /db_xref="CDD:462355"
     CDS             1..1614
                     /gene="Top2b"
                     /coded_by="NM_001100858.2:502..5346"
                     /db_xref="GeneID:361100"
                     /db_xref="RGD:1586156"
ORIGIN      
        1 maksslagvd galtwvnnaa kkeeletank ndsskklsve rvyqkktqle hillrpdtyi
       61 gsvepltqlm wvydedvgmn crevtfvpgl ykifdeilvn aadnkqrdkn mtcikvsidp
      121 esniisiwnn gkgipvvehk vekvyvpali fgqlltssny dddekkvtgg rngygaklcn
      181 ifstkftvet ackeykhsfk qtwmnnmmkt seakikhfdg edytcitfqp dlakfkmekl
      241 dkdivalmtr raydlagsck gvkvmfngkk lpvngfrsyv dlyvkdklde tgvalkvihe
      301 lanerwdvcl tlsekgfqqi sfvnsiattk ggrhvdyvvd qvvgklievv kkknkagvsv
      361 kpfqvknhiw vfinclienp tfdsqtkenm tlqpksfgsk cqlsekffka asncgivesi
      421 lnwvkfkaqt qlnkkcssvk yskikgipkl ddandaggkh slectlilte gdsakslavs
      481 glgvigrdry gvfplrgkil nvreashkqi menaeinnii kivglqykks yddaeslktl
      541 rygkimimtd qdqdgshikg llinfihhnw psllkhgfle efitpivkas knkqelsfys
      601 ipefdewkkh ienqkawkik yykglgtsta keakeyfadm erhrilfrya gpeddaaitl
      661 afskkkiddr kewltnfmed rrqrrlhglp eqflygtatk hltyndfink elilfsnsdn
      721 ersipslvdg fkpgqrkvlf tcfkrndkre vkvaqlagsv aemsayhhge qalmmtivnl
      781 aqnfvgsnni nllqpigqfg trlhggkdaa spryiftmls slarllfpav ddnllkflyd
      841 dnqrvepewy ipiipmvlin gaegigtgwa cklpnydare ivnnvrrmle gldphpmlpn
      901 yknfkgtiqe lgqnqyavsg eifvvdrntv eitelpvrtw tqvykeqvle pmlngtdktp
      961 alisdykeyh tdttvkfvvk mteeklaqae aaglhkvfkl qttltcnsmv lfdhmgclkk
     1021 yetvqdilke ffdlrlsyyg lrkewlvgml gaestklnnq arfilekiqg kitienrskk
     1081 dliqmlvqrg yesdpvkawk eaqekaaeee daqnphddss sdsgtpsgpd fnyilnmslw
     1141 sltkekveel ikqrdtkgre vndlkrksps dlwkedlaaf veeldkveaq eredilagms
     1201 gkavkgkvgk akvkklqlee tmpspygrri vpeitamkad asrkllkkkk gdpdttvvkv
     1261 efdeefsgtp aegtgeetlt psapvnkgpk pkrekkepgt rvrktpastg kpntkkvkkr
     1321 npwsddesks esdleeaepv viprdsllrr aaaerpkytf dfseeeedda dddddnndle
     1381 elkvkaspit ndgedefvps dgidkdeyaf spgkskatpe ksshdkksqd fgnlfsfpsy
     1441 sqkseddsak fdsneedtts vfapsfglkq tdkvpsqtva akkgkapsda aapkakrapr
     1501 qrkvvepans dsdselgnip kktaapkgkg rgakkrkasg senegdynpg rkpsktaskk
     1561 pkktsfdqds dvdifpsdft seppalprtg rarkevkyfa esdeeedvdf amfn
//
