LOCUS       NM_001002798            1887 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA topoisomerase I mitochondrial (Top1mt), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001002798 XM_216972
VERSION     NM_001002798.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Zhang,H., Meng,L.H., Zimonjic,D.B., Popescu,N.C. and Pommier,Y.
  TITLE     Thirteen-exon-motif signature for vertebrate nuclear and
            mitochondrial type IB topoisomerases
  JOURNAL   Nucleic Acids Res 32 (7), 2087-2092 (2004)
   PUBMED   15096574
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001786.1.
            
            On Aug 30, 2004 this sequence version replaced XM_216972.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1887
                     /gene="Top1mt"
                     /note="DNA topoisomerase I mitochondrial"
                     /db_xref="GeneID:300029"
                     /db_xref="RGD:1303177"
     exon            1..137
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1815
                     /gene="Top1mt"
                     /EC_number="5.6.2.1"
                     /note="mitochondrial topoisomerase I; DNA topoisomerase 1,
                     mitochondrial; topoisomerase (DNA) I, mitochondrial"
                     /codon_start=1
                     /product="DNA topoisomerase I, mitochondrial"
                     /protein_id="NP_001002798.1"
                     /db_xref="GeneID:300029"
                     /db_xref="RGD:1303177"
                     /translation="MLLLWLRALCRRFQHVPRRVPSRQVSRGSKASRAGWGETSKSSV
                     KWKQLEHKGPCFAPAYEPLPDGVRFFYDGKPVRLSLAAEEVATFYGKMLHLECTTKEV
                     FRRNFFSDWQKEMTAEERKLITHLDKCDFSEIHRHFMERAEARRTLPREQKQKLKEEA
                     EKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRD
                     SKIPEPPAGHQWKEVRSDNTVMWLAAWVENIQNSFKYIILNPSSKPKGEMDWQKYEVA
                     RRLKGVVDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCC
                     SLRVEHVRLHTPADGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDD
                     LFDALTTSSLNKHLQDLMEGLTAKVFRTYNASITLQEQLRVLTRAEDSLTCKVLAYNR
                     ANRAVAVLCNHQRAIPKTFEESMQTLQKKIETKKAQVAEAQVELQKAETDLRMRGDSK
                     SKSFLQKQQRLLKLEEQLARLCTKATDKEENKQVALGTAKLNYLDPRISIAWCKRFGV
                     PVEKIYNKTQRERFAWAFNQAGEDFEF"
     exon            138..250
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            251..372
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            373..495
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            496..683
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            684..828
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            829..972
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1158
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1227
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1342
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1470
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1565
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1712
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1887
                     /gene="Top1mt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcgggct gagcccacgc acgacgcaca cgcatgctgc tgctatggct cagagctctg
       61 tgccggcgtt tccagcatgt cccccgccgc gtccccagcc gccaagtgtc ccggggctcg
      121 aaggcgagca gagccgggtg gggagagacg agcaagagca gtgtgaagtg gaagcaactg
      181 gagcacaagg gtccgtgctt cgccccagcc tatgagcccc ttcctgatgg agtacgtttc
      241 ttctatgatg gcaagccagt gaggctgagc ttggcagcgg aggaggttgc tactttctat
      301 gggaaaatgc tgcatctcga gtgtacgacc aaggaagtct tccggaggaa cttcttcagc
      361 gactggcaga aggaaatgac agctgaggag aggaagctca tcacacacct ggacaagtgc
      421 gacttctcgg agatccatag gcacttcatg gaaagagctg aggcccgcag gacccttccc
      481 agggagcaga agcagaaact aaaagaagag gcagagaagc ttcagcagga gtttggctac
      541 tgtattttag atggccacag agagaaaata ggcaatttca agacggaacc acccggcttg
      601 ttccgcggcc gaggcgacca tcccaagatg gggatgttga agaggagggt catgccagag
      661 gatgtggtca ttaactgtag cagagattcc aagatcccag agcccccggc tggtcatcag
      721 tggaaagagg tccgctcgga taacacagtc atgtggctgg ctgcctgggt ggagaacatc
      781 cagaactcct tcaagtacat catactgaac cccagctcca agccgaaggg agagatggat
      841 tggcagaagt atgaggtagc acgacgcttg aagggggttg tggacaagat ccgtgctcag
      901 tatcaggctg actggaagtc accagaaatg aagaaaaggc agctggctgt agccctttat
      961 tttattgata agctggcact gcgaacagga aatgagaagg aagagggtga gacggccgac
     1021 accgtgggct gctgttcgct ccgagtggag cacgtccgac tgcacacgcc cgcagatggc
     1081 caggagcatg tggtagagct ggacttcttg gggaaggatt ccatccgtta taagaatcac
     1141 gtgacggtgg agaagcttgt gttccagaac cttcagcact tcatggaaga caaggaccct
     1201 agggacgacc tcttcgatgc actgactact tccagcctga acaagcactt gcaggacttg
     1261 atggaggggc tgacagccaa ggtgtttcgg acctacaatg cctccatcac tctgcaggag
     1321 cagctgcggg tgctgacccg tgctgaagac agcctaacct gcaaagtctt agcttacaac
     1381 cgggcaaacc gggctgtggc ggtcctctgt aaccatcaga gagcaattcc taagaccttc
     1441 gaggagtcca tgcagacact gcagaaaaag attgagacaa agaaggcaca ggtggctgag
     1501 gcacaggtgg agctgcagaa ggcagagact gaccttagaa tgagagggga cagcaagtcc
     1561 aaaagtttcc ttcagaagca gcagcggctg ctgaagctgg aggagcagct ggctcgactg
     1621 tgcacgaagg ccacagacaa ggaggagaat aagcaagtgg ccctgggcac cgccaagctc
     1681 aactacctgg acccccggat cagcattgca tggtgtaaga gatttggtgt gcccgtagag
     1741 aagatctaca acaagaccca gagagagagg tttgcttggg ccttcaacca ggcaggtgaa
     1801 gactttgaat tttaagtagc ctctttgcca ctggaacttt cttactgtga agcaatattg
     1861 tggttttcta taataaaatg ctggggg
//
