LOCUS       NP_001002798             593 aa            linear   ROD 03-APR-2024
DEFINITION  DNA topoisomerase I, mitochondrial [Rattus norvegicus].
ACCESSION   NP_001002798 XP_216972
VERSION     NP_001002798.1
DBSOURCE    REFSEQ: accession NM_001002798.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 593)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   2  (residues 1 to 593)
  AUTHORS   Zhang,H., Meng,L.H., Zimonjic,D.B., Popescu,N.C. and Pommier,Y.
  TITLE     Thirteen-exon-motif signature for vertebrate nuclear and
            mitochondrial type IB topoisomerases
  JOURNAL   Nucleic Acids Res 32 (7), 2087-2092 (2004)
   PUBMED   15096574
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001786.1.
            
            On Aug 30, 2004 this sequence version replaced XP_216972.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..593
                     /product="DNA topoisomerase I, mitochondrial"
                     /EC_number="5.6.2.1"
                     /note="mitochondrial topoisomerase I; DNA topoisomerase 1,
                     mitochondrial; topoisomerase (DNA) I, mitochondrial"
                     /calculated_mol_wt=64077
     transit_peptide 1..43
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q6IM78.1)"
                     /calculated_mol_wt=4953
     mat_peptide     44..593
                     /product="DNA topoisomerase I, mitochondrial.
                     /id=PRO_0000384395"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
                     /calculated_mol_wt=64077
     Region          44..258
                     /region_name="Topoisom_I_N"
                     /note="Eukaryotic DNA topoisomerase I, DNA binding
                     fragment; pfam02919"
                     /db_xref="CDD:460746"
     Site            145
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Region          189..565
                     /region_name="TOPEUc"
                     /note="DNA Topoisomerase I (eukaryota); smart00435"
                     /db_xref="CDD:214661"
     Site            193
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Site            241
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Region          254..255
                     /region_name="Interaction with DNA. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Site            272
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Region          317..322
                     /region_name="Interaction with DNA. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Site            330
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Site            361
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Site            403
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Region          414..416
                     /region_name="Interaction with DNA. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Site            461
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     Site            479
                     /site_type="other"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q6IM78.1)"
     CDS             1..593
                     /gene="Top1mt"
                     /coded_by="NM_001002798.1:34..1815"
                     /db_xref="GeneID:300029"
                     /db_xref="RGD:1303177"
ORIGIN      
        1 mlllwlralc rrfqhvprrv psrqvsrgsk asragwgets kssvkwkqle hkgpcfapay
       61 eplpdgvrff ydgkpvrlsl aaeevatfyg kmlhlecttk evfrrnffsd wqkemtaeer
      121 klithldkcd fseihrhfme raearrtlpr eqkqklkeea eklqqefgyc ildghrekig
      181 nfkteppglf rgrgdhpkmg mlkrrvmped vvincsrdsk ipeppaghqw kevrsdntvm
      241 wlaawveniq nsfkyiilnp sskpkgemdw qkyevarrlk gvvdkiraqy qadwkspemk
      301 krqlavalyf idklalrtgn ekeegetadt vgccslrveh vrlhtpadgq ehvveldflg
      361 kdsiryknhv tveklvfqnl qhfmedkdpr ddlfdaltts slnkhlqdlm egltakvfrt
      421 ynasitlqeq lrvltraeds ltckvlaynr anravavlcn hqraipktfe esmqtlqkki
      481 etkkaqvaea qvelqkaetd lrmrgdsksk sflqkqqrll kleeqlarlc tkatdkeenk
      541 qvalgtakln yldprisiaw ckrfgvpvek iynktqrerf awafnqaged fef
//
