LOCUS       NM_022615               3706 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DNA topoisomerase I (Top1), mRNA.
ACCESSION   NM_022615
VERSION     NM_022615.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3706)
  AUTHORS   Huelsenbeck,S.C., Schorr,A., Roos,W.P., Huelsenbeck,J.,
            Henninger,C., Kaina,B. and Fritz,G.
  TITLE     Rac1 protein signaling is required for DNA damage response
            stimulated by topoisomerase II poisons
  JOURNAL   J Biol Chem 287 (46), 38590-38599 (2012)
   PUBMED   23012366
  REMARK    GeneRIF: Rac1-regulated mechanisms are required for DNA damage
            induction and subsequent activation of the DDR following treatment
            with topo II but not topo I poisons
REFERENCE   2  (bases 1 to 3706)
  AUTHORS   Onishi,Y. and Kawano,Y.
  TITLE     Rhythmic binding of Topoisomerase I impacts on the transcription of
            Bmal1 and circadian period
  JOURNAL   Nucleic Acids Res 40 (19), 9482-9492 (2012)
   PUBMED   22904072
REFERENCE   3  (bases 1 to 3706)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3706)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3706)
  AUTHORS   Casafont,I., Bengoechea,R., Navascues,J., Pena,E., Berciano,M.T.
            and Lafarga,M.
  TITLE     The giant fibrillar center: a nucleolar structure enriched in
            upstream binding factor (UBF) that appears in transcriptionally
            more active sensory ganglia neurons
  JOURNAL   J Struct Biol 159 (3), 451-461 (2007)
   PUBMED   17587596
REFERENCE   6  (bases 1 to 3706)
  AUTHORS   Tournier,M.F., Sobczak,J., de Nechaud,B. and Duguet,M.
  TITLE     Comparison of biochemical properties of DNA-topoisomerase I from
            normal and regenerating liver
  JOURNAL   Eur J Biochem 210 (1), 359-364 (1992)
   PUBMED   1332866
REFERENCE   7  (bases 1 to 3706)
  AUTHORS   Ivanov,V.A.
  TITLE     Variations in DNA topoisomerase I activity after gamma irradiation
            of mature neurons
  JOURNAL   Neurosci Lett 94 (1-2), 99-103 (1988)
   PUBMED   2853856
REFERENCE   8  (bases 1 to 3706)
  AUTHORS   Rose,K.M., Szopa,J., Han,F.S., Cheng,Y.C., Richter,A. and Scheer,U.
  TITLE     Association of DNA topoisomerase I and RNA polymerase I: a possible
            role for topoisomerase I in ribosomal gene transcription
  JOURNAL   Chromosoma 96 (6), 411-416 (1988)
   PUBMED   2851418
REFERENCE   9  (bases 1 to 3706)
  AUTHORS   Crespi,M.D., Radicella,J.P., Baldi,A., Charreau,E.H. and Calvo,J.C.
  TITLE     DNA topoisomerase I from Leydig cells is modulated by luteinizing
            hormone and cyclic adenosine monophosphate
  JOURNAL   Mol Cell Endocrinol 53 (3), 221-226 (1987)
   PUBMED   2822514
REFERENCE   10 (bases 1 to 3706)
  AUTHORS   Ivanov,V.A., Melnikov,A.A. and Terpilovska,O.N.
  TITLE     DNA topoisomerase I from rat brain neurons
  JOURNAL   Biochim Biophys Acta 866 (2-3), 154-160 (1986)
   PUBMED   3006775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 27, 2022 this sequence version replaced NM_022615.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.16230.1,
                                           SRR26643285.14146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000003.1  169713195-169713416
            223-247             JAXUCZ010000003.1  169713730-169713754
            248-350             JAXUCZ010000003.1  169739258-169739360
            351-474             JAXUCZ010000003.1  169748739-169748862
            475-530             JAXUCZ010000003.1  169750374-169750429
            531-626             JAXUCZ010000003.1  169753434-169753529
            627-702             JAXUCZ010000003.1  169755637-169755712
            703-809             JAXUCZ010000003.1  169760523-169760629
            810-925             JAXUCZ010000003.1  169768341-169768456
            926-1047            JAXUCZ010000003.1  169772805-169772926
            1048-1170           JAXUCZ010000003.1  169773805-169773927
            1171-1358           JAXUCZ010000003.1  169776343-169776530
            1359-1503           JAXUCZ010000003.1  169776752-169776896
            1504-1647           JAXUCZ010000003.1  169784899-169785042
            1648-1833           JAXUCZ010000003.1  169785885-169786070
            1834-1902           JAXUCZ010000003.1  169786703-169786771
            1903-2017           JAXUCZ010000003.1  169787362-169787476
            2018-2145           JAXUCZ010000003.1  169789122-169789249
            2146-2240           JAXUCZ010000003.1  169792253-169792347
            2241-2390           JAXUCZ010000003.1  169792609-169792758
            2391-3706           JAXUCZ010000003.1  169795015-169796330
FEATURES             Location/Qualifiers
     source          1..3706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3706
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /note="DNA topoisomerase I"
                     /db_xref="GeneID:64550"
                     /db_xref="RGD:621246"
     exon            1..222
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2493
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /EC_number="5.6.2.1"
                     /note="topoisomerase (DNA) I"
                     /codon_start=1
                     /product="DNA topoisomerase 1"
                     /protein_id="NP_072137.1"
                     /db_xref="GeneID:64550"
                     /db_xref="RGD:621246"
                     /translation="MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDK
                     DREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSDKHKDKHKDRDKEKRKEEKIRAAGDA
                     KIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRPRDEDDADYKPKKIKTEDIK
                     KEKKRKLEEEEDGKLKKPKNKDKDKKVAEPDNKKKKAKKEEEQKWKWWEEERYPEGIK
                     WKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIF
                     RKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENE
                     KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDA
                     KVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETAR
                     RLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCS
                     LRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL
                     FDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRA
                     NRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARKDLKSAKADAKVMKDAKT
                     KKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGV
                     PIEKIYNKTQREKFAWAIDMTDEDYEF"
     exon            223..247
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            248..350
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            351..474
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            475..530
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            531..626
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            627..702
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            703..809
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            810..925
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1047
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1170
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1358
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1503
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1647
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1833
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1902
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2017
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2145
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2240
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2390
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..3706
                     /gene="Top1"
                     /gene_synonym="Ab2-086"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgtcag cagcgtcgcc gccgccgtcg ccgcctcctc agctgtcccg gggagtcttg
       61 ggcccttggt tgctgtcgcc gtctgttcgt gcctctcagg agctccgtcc gcctgttcag
      121 gccgccccga ccgtccgcct ctcttccccg cgctgcctct gagcccgcag cgttcgcacg
      181 ccggccgaca tgagcgggga ccatctccac aacgactccc agatcgaagc ggatttccga
      241 ttgaatgatt ctcataaaca caaagataaa cacaaagatc gagaacaccg gcataaggag
      301 cacaagaagg ataaggataa ggaccgggaa aagtctaaac atagcaacag tgaacataaa
      361 gattctgaaa agaaacacaa agagaaagag aaaaccaaac acaaagatgg aagctcagac
      421 aaacataaag acaaacataa agacagagac aaggaaaaac gaaaggagga aaagattaga
      481 gctgctgggg atgcaaaaat aaagaaggag aaggaaaatg gcttctctag tccaccacga
      541 attaaagacg agcctgaaga tgatggctat tttgctcctc caaaagagga tataaagcca
      601 ctgaagaggc ctcgggatga agatgatgct gattataagc ctaagaaaat taagacagaa
      661 gatatcaaga aggagaagaa acgaaaacta gaagaagaag aggatggcaa acttaaaaag
      721 cccaagaata aagataaaga taaaaaggtt gctgagccag ataataagaa gaagaaggcg
      781 aaaaaggaag aggagcagaa gtggaaatgg tgggaagaag aacgctatcc agaaggcatc
      841 aagtggaaat tcctagaaca taaagggcct gttttcgctc caccgtatga gcctctgcca
      901 gagggtgtca agttttacta tgatggtaaa gttatgaagc tgagtcccaa agcagaagaa
      961 gtagctacat tctttgcaaa aatgcttgac catgaatata ctactaagga aatattcagg
     1021 aaaaatttct ttaaagactg gagaaaggaa atgactaatg atgaaaaaaa tacgattacc
     1081 aacctaagca aatgcgactt tacacagatg agccagtact tcaaagctca atcagaagct
     1141 cggaaacaga tgagcaagga agaaaaattg aaaatcaaag aagaaaatga aaaattattg
     1201 aaagaatatg gcttttgtgt aatggataat catagagagc ggattgccaa cttcaagata
     1261 gagcctccag ggctcttccg aggccgtggc aaccacccca agatgggtat gctgaagaga
     1321 aggatcatgc ctgaggacat catcatcaac tgtagcaaag atgccaaggt tccttctcct
     1381 cctcctggac ataaatggaa ggaagttcga catgataaca aggttacttg gctggtctcc
     1441 tggacagaga atatccaagg ttctatcaaa tatatcatgc tgaatcccag ttcacgaatc
     1501 aagggtgaga aagactggca gaagtatgag actgctcggc gactgaagaa gtgtgtggac
     1561 aagatccgaa atcagtatcg ggaagactgg aagtccaaag aaatgaaagt tcggcagaga
     1621 gctgtagcac tgtacttcat tgataagctt gctctgagag caggcaatga gaaggaagaa
     1681 ggagagacag cagacactgt gggttgctgt tcacttagag tggaacacat caatctacac
     1741 ccagaattgg atggtcagga gtacgtggtg gagtttgact ttcctgggaa ggactcaatc
     1801 agatactaca acaaagtccc agttgagaaa cgagttttta aaaacttaca actatttatg
     1861 gagaacaagc agcctgagga tgatcttttt gatcgactta atactggtat tctaaataag
     1921 catcttcaag atctcatgga gggcttgact gccaaggtgt tccgtaccta caatgcctcc
     1981 atcacgctgc agcagcagct taaagagctc acagcccctg atgagaatgt accagcaaag
     2041 attctatctt ataaccgtgc caatcgcgct gttgcaattc tttgtaacca ccagagggcg
     2101 ccaccaaaga cctttgagaa gtcaatgatg aacttgcagt ctaagattga tgccaagaaa
     2161 gatcagctag cagatgctcg aaaggacctg aaaagcgcta aggctgatgc caaagtcatg
     2221 aaggatgcaa agaccaagaa ggtagtagag tcaaaaaaga aggctgtaca gagattagaa
     2281 gagcagctga tgaagctgga ggttcaagcc acagaccgag aggagaacaa acaaattgcc
     2341 ttggggacct ccaaactcaa ttacctggac cctaggatca cagtggcttg gtgcaaaaaa
     2401 tggggggtcc caatcgagaa gatttacaac aaaacccaga gagagaagtt tgcttgggcc
     2461 attgatatga ctgatgagga ctacgagttt tgaccagtct cggcaggggt tctgtgaaag
     2521 gaacagtgtg gtttggggaa gatggataaa ctgagcctca cttgccctca caccggaggg
     2581 agaggccaca agtcttaaca aaccaacatc tttgcaaaaa gatagacctg gagatattat
     2641 aagggagagc tgagccagtt gtcctatgga caacttattt aaaaatattt cagatgtcaa
     2701 aattctagct gtatgatttg ttttgaattt tgtttttatt ttcaagagag caagtggatg
     2761 ggaatttgtt ggcatcctgc caggcaaatt cagttttgct gcaatgtttg gattctctca
     2821 gctactgtat gcgaagtctg attatattgg tgcgttttta cagttagggt tttgcaataa
     2881 cttctatatt ttaatagaaa cgaattccta aaatccctcc tctccccaat ttcaggaatt
     2941 taaaattaag tagaacaaaa caaaaaccca gcgcacctat tacagctgtc atccaccgtc
     3001 atgggaatca gttttcatta aacttgaagc agttgtggca tcatcggcag tgttttggtt
     3061 cagacaccta ttcacagaaa agcatgatgg gaaaatattt cctgacttga gtgttccttt
     3121 ttaaatgtga atttttattt cgttttaatt attttaaaat atttaagcct tcttcttgat
     3181 cttaaagatc gtgtagcttg gggttgggga gggatgaagg gcgagtgagt ctaaggataa
     3241 tgaaataatc agtgactgaa accattttcc catcatcctt tgttctgacc attctttgta
     3301 ccctttaaga aatccatctt tttctttgga aaccccagtc tttcatttga aagattttat
     3361 tgtataaaaa cttccacagg tcaataaatt tagaggaaaa tgagcatttg gtccaaggaa
     3421 aacaaaaaca aaaacaaaac aaaaaggaaa aaataatcaa gattttaggg cttttatttt
     3481 tttttctttt gtaattgtgt aaaaaatgga aaaaaccata aaaaggaaaa ttttaatgtg
     3541 aagacttttt ttttgctata atcattagtt ttagaggcat tgttagttta gtgtgtgtgc
     3601 agagtccatt cccacatctt tcctcaagta tcttctattt ttatcatgaa ttccctttta
     3661 atcaactgta ggttatttaa aataaactcc tacaacttaa cggaaa
//
