LOCUS       NM_001130572            4246 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tonsoku-like, DNA repair protein (Tonsl), mRNA.
ACCESSION   NM_001130572 XM_001075280 XM_345850
VERSION     NM_001130572.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4246)
  AUTHORS   Chang,H.R., Cho,S.Y., Lee,J.H., Lee,E., Seo,J., Lee,H.R.,
            Cavalcanti,D.P., Makitie,O., Valta,H., Girisha,K.M., Lee,C.,
            Neethukrishna,K., Bhavani,G.S., Shukla,A., Nampoothiri,S.,
            Phadke,S.R., Park,M.J., Ikegawa,S., Wang,Z., Higgs,M.R.,
            Stewart,G.S., Jung,E., Lee,M.S., Park,J.H., Lee,E.A., Kim,H.,
            Myung,K., Jeon,W., Lee,K., Kim,D., Kim,O.H., Choi,M., Lee,H.W.,
            Kim,Y. and Cho,T.J.
  TITLE     Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia
  JOURNAL   Am J Hum Genet 104 (3), 439-453 (2019)
   PUBMED   30773278
REFERENCE   2  (bases 1 to 4246)
  AUTHORS   O'Connell,B.C., Adamson,B., Lydeard,J.R., Sowa,M.E., Ciccia,A.,
            Bredemeyer,A.L., Schlabach,M., Gygi,S.P., Elledge,S.J. and
            Harper,J.W.
  TITLE     A genome-wide camptothecin sensitivity screen identifies a
            mammalian MMS22L-NFKBIL2 complex required for genomic stability
  JOURNAL   Mol Cell 40 (4), 645-657 (2010)
   PUBMED   21055985
REFERENCE   3  (bases 1 to 4246)
  AUTHORS   Duro,E., Lundin,C., Ask,K., Sanchez-Pulido,L., MacArtney,T.J.,
            Toth,R., Ponting,C.P., Groth,A., Helleday,T. and Rouse,J.
  TITLE     Identification of the MMS22L-TONSL complex that promotes homologous
            recombination
  JOURNAL   Mol Cell 40 (4), 632-644 (2010)
   PUBMED   21055984
REFERENCE   4  (bases 1 to 4246)
  AUTHORS   O'Donnell,L., Panier,S., Wildenhain,J., Tkach,J.M., Al-Hakim,A.,
            Landry,M.C., Escribano-Diaz,C., Szilard,R.K., Young,J.T., Munro,M.,
            Canny,M.D., Kolas,N.K., Zhang,W., Harding,S.M., Ylanko,J.,
            Mendez,M., Mullin,M., Sun,T., Habermann,B., Datti,A., Bristow,R.G.,
            Gingras,A.C., Tyers,M.D., Brown,G.W. and Durocher,D.
  TITLE     The MMS22L-TONSL complex mediates recovery from replication stress
            and homologous recombination
  JOURNAL   Mol Cell 40 (4), 619-631 (2010)
   PUBMED   21055983
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_345850.3, XM_001075280.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4246
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4246
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /note="tonsoku-like, DNA repair protein"
                     /db_xref="GeneID:366953"
                     /db_xref="RGD:1307483"
     exon            1..92
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..4171
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /note="ikappaBR; I-kappa-B-related protein; inhibitor of
                     kappa B-related protein; NF-kappa-B inhibitor-like protein
                     2; nuclear factor of kappa light polypeptide gene enhancer
                     in B-cells inhibitor-like 2"
                     /codon_start=1
                     /product="tonsoku-like protein"
                     /protein_id="NP_001124044.1"
                     /db_xref="GeneID:366953"
                     /db_xref="RGD:1307483"
                     /translation="MTLEQELRQLSKAKARAQRNGQLCEEAVCCHQLGELLASHGRFQ
                     EALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSN
                     HTELQRAWATIGRTHLDVYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEM
                     RTRLYLNLGLTCESLQQTAQCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQH
                     SQAMRCLEGARECARAMKMRFMESECCMLVSQVLQDLGDFLAAKRALKKAYRLGSQKP
                     NQRVAICQSLKYVLAVVRLQQQLQEAEGNDLQGAMAICEQLGDLFSKADDFPKASEAY
                     QKQLHFAELLNRPDLELAVIHESLATTLGDMKDYHKAVHHYEEELRLRKGNALEEAKT
                     WFNIGLAREEAGDAYELLAPCFQKAFGCAQQAQRYQLQRQILQHLYTVQLKLQPQEAR
                     DTEIRLQELSMAKDTEEEEEEEEEEEEEASEALETSEMELSESEDDADGLSQQLEEEE
                     ELQGCVGRRKINKWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
                     HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASV
                     TLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAASMERRLQMASSGQASHSSPALQTI
                     PNNHLFDPETSPPSSPCPKPPSYTPRPPEASPAPAKVFLEETVSAVCRPRKNRHRPAS
                     SSSSSEDDDDNTNPCRPSQKRLRHSTQQGEAKTPDPSKSRETAISSACRAAYQAAIRG
                     VGSAQSRRLVPSLPRGSNEVPAPKTALIPEEEFLAEEWLEVDTPLTRSSSSSRPSTSI
                     SDYERCPARPRTRAKQSRPASLDGWCTRTKAADASLTAEPTENSSMPRTTGPNKENCA
                     AGQPLLLVQPPPIRVRVQIQDNLFLIPVPHSDVHSVAWLAEQAAQRYFQTCGLLPRLT
                     LRKDGALLAPQDPIPDVLQSNDEVMAEVTSWDLPPLKDRYRRACQSLGQGEHQQVLQA
                     MEHQSSSPSFSACSLALCQAQLTPLLRALKLHTALRELRLSGNRLGDPCATELLATLG
                     TMPNLVLLDLSSNHLGPEGLRQLVEGSLGQTAFQNVEELDLSMNPLGDGCAQALASLL
                     RTCPVLRTLRLQACGFSPSFFLSHQAALGSAFKDAEHLKTLSLSYNTLGAPALARVLQ
                     SLPTCTLLHLELSSVAASKSNSSLIEPVIKYLTKEGCALAHLTLSANCLSDKAVRELS
                     RCLPSCPSLTSLDLSANPEVSCAGLEELLSALQERPQGLSFFDLSGCSIQGPLNSDLW
                     DKILSQLQELQLCSKDLTTKDRDTLCQRLPAGACTLNQGSKLFFKCL"
     exon            93..188
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            189..331
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..515
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..645
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..817
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..932
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1078
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1231
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1357
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1547
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1630
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1720
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1793
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1957
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2081
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2824
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2901
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3052
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3131
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3433
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3605
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3781
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3855
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..3989
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4246
                     /gene="Tonsl"
                     /gene_synonym="Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcagaga agcgcgggaa gtccagattt tcgcggcggc ggcggcggcg gcggtggctg
       61 tgtgaatatg acgctggaac aggagcttcg ccagctgagc aaggcgaagg ccagggccca
      121 gaggaatgga cagctgtgcg aggaggcggt ctgctgccac cagctggggg agctgctagc
      181 tagccacggt cgcttccagg aagctttaga ggagcaccag caggagctac atctgctaga
      241 gagtgtccag gacaccctag gctgcgctgt ggcccaccgc aagatcggag agcggctggc
      301 tgaaatggag aactactctg ctgctctgaa gcaccagcat ctctacctgg atctagctgg
      361 ttccctgtcc aaccacactg aattgcagag agcctgggcc accattggcc gcacccatct
      421 ggatgtatat gaccactgcc aatcaagaga ttccttgctg caggcacagg ctgcctttga
      481 gaagagtttg gctattgtgg atgagaaact agaggggatg ctgacccagc gggaactgag
      541 tgagatgagg acccgtctct acctcaatct gggcctcacc tgtgagagcc tgcagcagac
      601 agcccagtgc aacaactact tcaaaaagag catctttctc gctgagcaga accatctgta
      661 tgaagatctg ttccgggccc gatacaacct gggtgccatc cactggcgcg gagggcagca
      721 ctctcaggcc atgcgctgct tggagggggc ccgggaatgt gcacgtgcca tgaagatgag
      781 attcatggaa agcgaatgtt gcatgctagt gtctcaggtg ctccaagatc tgggggactt
      841 tctggctgcc aaacgagccc tgaagaaggc ctataggttg ggctctcaga agcctaacca
      901 gagagtggct atctgtcaga gtctcaagta tgtattggcc gtggtccggc tgcagcagca
      961 gctgcaagag gctgagggca atgatcttca aggtgccatg gctatctgtg aacagttggg
     1021 ggaccttttc tccaaagccg atgacttccc caaggcatct gaggcttacc agaagcagct
     1081 gcactttgct gagctgctga acagaccgga cctcgagctg gctgtcatcc acgaatccct
     1141 ggccaccacg ctgggagaca tgaaggatta ccacaaggct gtacaccact atgaagagga
     1201 actgaggcta cgcaaaggca atgccctgga ggaagctaag acttggttca acattggact
     1261 ggcccgtgag gaagctggag atgcatatga gctgctagct ccatgcttcc agaaggcttt
     1321 cggctgtgct cagcaggccc agcggtacca actgcagagg cagatcttac agcatcttta
     1381 cactgtgcaa ctgaagttgc agccccaaga agcccgtgac actgaaatca gactgcagga
     1441 gctgagtatg gcaaaagaca cagaggaaga ggaggaagaa gaggaggagg aagaggaaga
     1501 agccagtgag gccctggaga ccagtgaaat ggagctctca gagagcgagg atgatgctga
     1561 cggcctgtct cagcagctgg aggaagagga ggagcttcag ggctgtgtgg ggcggcggaa
     1621 gataaacaag tggaaccggc gcaatgacat gggagagacc ctgttgcacc gagcttgcat
     1681 cgaaggccaa ctgcgccgtg tccaggatct tgtgaagcag ggccatcccc tgaatccccg
     1741 agactactgt ggctggactc ctctacatga agcttgcaac tatggacatc ttgagattgt
     1801 gcgcttcctt ctggaccatg gagcagcagt ggatgacccg ggtggccagg ggtgtgatgg
     1861 catcaccccc ctgcatgatg ccctcaactg tggccacttt gaggtagctg agctcctcat
     1921 tgagcgaggg gcgtccgtaa ctctccgcac caggaagggc ctcagcccac tggagacact
     1981 gcagcagtgg gtgaagctgt acttcaggga tcttgacctt gagacaagac agaaggccgc
     2041 atccatggag aggaggctcc agatggcctc ctcaggccaa gcttcccaca gctcccctgc
     2101 cctccagacc attccaaata atcatctctt cgaccctgag acctctcctc cctcaagccc
     2161 ctgtccaaaa cccccctcgt atactcctag acctccagag gcctctccag cccctgctaa
     2221 ggtctttctg gaggaaactg tgtctgcagt gtgcagacct cgaaagaaca ggcacaggcc
     2281 agccagcagc agtagcagct cggaggacga tgacgacaac acaaacccct gcaggccatc
     2341 tcagaaaaga ctgagacaca gcacacagca gggtgaagcc aagacacctg acccatccaa
     2401 aagtagagag acagccattt caagcgcttg ccgggctgct taccaagcag ccatccgagg
     2461 cgtggggagt gcccagagcc gtcgcttggt acctagcctg cctcggggct caaatgaagt
     2521 ccctgccccc aaaacagcac tcattcctga ggaggaattc ctggctgagg aatggctgga
     2581 ggtagataca cctctgaccc gcagcagcag cagcagcagg cccagtacct ccatatcaga
     2641 ctatgagcga tgccctgcaa ggccccggac tcgtgccaag cagagtcgcc cagcaagtct
     2701 tgatggttgg tgtacacgga ctaaagcagc agatgccagc ttgactgcag agcctacgga
     2761 gaactccagc atgccaagga ccacaggacc caacaaagaa aattgtgcag caggccagcc
     2821 tttgcttctg gtccagcccc ctcctatccg ggttcgagtt caaattcagg acaacctttt
     2881 cctcatcccc gtcccacaca gcgatgtcca ttctgtggct tggctagcag agcaagcggc
     2941 ccagcgctac ttccaaactt gcgggctact cccaaggctc accctacgga aggatggagc
     3001 actactggcc ccacaggacc ccatccctga tgtgctgcaa agtaacgacg aggtgatggc
     3061 tgaagtaacg tcatgggacc ttcctccact aaaggaccgc taccgtaggg cctgccagag
     3121 cctggggcaa ggggagcacc agcaagtgct gcaggccatg gagcaccaga gttcgagccc
     3181 ttcgtttagt gcctgttctc tggccttgtg ccaagcccag ctcacacccc tgctgagggc
     3241 cctcaagtta cacacagcac tccgggagct acgcctttct gggaaccgac tgggtgaccc
     3301 atgtgctact gagctactgg ctaccctggg caccatgcct aacctggtcc tcctcgatct
     3361 ctcttccaat cacttgggcc cggaaggcct gcgtcagctt gttgaaggct ccttgggcca
     3421 gactgctttc cagaacgtgg aggaactaga cttgagtatg aatccactgg gagatggctg
     3481 tgctcaggcc ctggcctccc ttctgcggac ctgccccgtg ctcaggacct tgcgtctaca
     3541 agcctgtggt ttcagcccca gcttcttcct gagccaccag gctgccctgg gtagtgcctt
     3601 caaagatgct gagcacctca agaccttgtc cctatcttac aatactctcg gcgctcctgc
     3661 cctggcaagg gtgctgcaga gcttacccac ctgtaccctc ctacatttgg agcttagctc
     3721 cgtggcagcc agcaagagca actcgagtct catagagcct gttatcaaat acttgaccaa
     3781 ggaaggctgt gctctggccc acctaaccct gtctgcaaac tgcctgagtg acaaggctgt
     3841 gagagaactg agcagatgtc tccctagctg cccctcactc acctctctgg acctgtccgc
     3901 caaccctgag gtcagctgtg ccggtctgga ggagctcctg tctgccctac aggagcggcc
     3961 ccaaggcctc agcttctttg acttgtcagg ctgctccatt caggggcccc tgaactctga
     4021 cctctgggac aagatcctct cgcagttgca ggagctgcag ttgtgcagca aagacctgac
     4081 cacaaaagac cgagacaccc tgtgtcagag actgccggcg ggtgcgtgca cactgaacca
     4141 aggttccaag ctcttcttta aatgcctctg accctggccc tgccgtttct gccaaaaaaa
     4201 aaaaaaagaa aaaaaaaaac cttaataaat tatgctgcta tctcat
//
