LOCUS       NM_212519               2298 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus translocase of outer mitochondrial membrane 70
            (Tomm70), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_212519 XM_221530
VERSION     NM_212519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Kang,C., Qin,J., Osei,W. and Hu,K.
  TITLE     Regulation of protein kinase C-epsilon and its age-dependence
  JOURNAL   Biochem Biophys Res Commun 482 (4), 1201-1206 (2017)
   PUBMED   27919679
  REMARK    GeneRIF: adenosine-induced translocation of PKCepsilon to
            mitochondria is mediated by a caveolin-3-dependent mechanism and
            this process is age-related, possibly in part, through regulation
            of HSP90 and TOM70 expression
REFERENCE   2  (bases 1 to 2298)
  AUTHORS   Ellenrieder,L., Martensson,C.U. and Becker,T.
  TITLE     Biogenesis of mitochondrial outer membrane proteins, problems and
            diseases
  JOURNAL   Biol Chem 396 (11), 1199-1213 (2015)
   PUBMED   25980382
  REMARK    Review article
REFERENCE   3  (bases 1 to 2298)
  AUTHORS   Wenz,L.S., Opalinski,L., Wiedemann,N. and Becker,T.
  TITLE     Cooperation of protein machineries in mitochondrial protein sorting
  JOURNAL   Biochim Biophys Acta 1853 (5), 1119-1129 (2015)
   PUBMED   25633533
  REMARK    Review article
REFERENCE   4  (bases 1 to 2298)
  AUTHORS   Schulz,C., Schendzielorz,A. and Rehling,P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   5  (bases 1 to 2298)
  AUTHORS   Hohr,A.I., Straub,S.P., Warscheid,B., Becker,T. and Wiedemann,N.
  TITLE     Assembly of beta-barrel proteins in the mitochondrial outer
            membrane
  JOURNAL   Biochim Biophys Acta 1853 (1), 74-88 (2015)
   PUBMED   25305573
  REMARK    Review article
REFERENCE   6  (bases 1 to 2298)
  AUTHORS   Anandatheerthavarada,H.K., Sepuri,N.B.V. and Avadhani,N.G.
  TITLE     Mitochondrial targeting of cytochrome P450 proteins containing
            NH2-terminal chimeric signals involves an unusual TOM20/TOM22
            bypass mechanism
  JOURNAL   J Biol Chem 284 (25), 17352-17363 (2009)
   PUBMED   19401463
REFERENCE   7  (bases 1 to 2298)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   8  (bases 1 to 2298)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2298)
  AUTHORS   Suzuki,H., Maeda,M. and Mihara,K.
  TITLE     Characterization of rat TOM70 as a receptor of the preprotein
            translocase of the mitochondrial outer membrane
  JOURNAL   J Cell Sci 115 (Pt 9), 1895-1905 (2002)
   PUBMED   11956321
REFERENCE   10 (bases 1 to 2298)
  AUTHORS   Alvarez-Dolado,M., Gonzalez-Moreno,M., Valencia,A., Zenke,M.,
            Bernal,J. and Munoz,A.
  TITLE     Identification of a mammalian homologue of the fungal Tom70
            mitochondrial precursor protein import receptor as a thyroid
            hormone-regulated gene in specific brain regions
  JOURNAL   J Neurochem 73 (6), 2240-2249 (1999)
   PUBMED   10582581
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098640.1.
            
            On Apr 20, 2006 this sequence version replaced NM_212519.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098640.1, FQ228582.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..2298
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /note="translocase of outer mitochondrial membrane 70"
                     /db_xref="GeneID:304017"
                     /db_xref="RGD:1303049"
     exon            1..467
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1970
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /note="translocase of outer membrane 70 kDa subunit;
                     mitochondrial precursor proteins import receptor;
                     translocase of outer mitochondrial membrane protein 70"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM70"
                     /protein_id="NP_997684.1"
                     /db_xref="GeneID:304017"
                     /db_xref="RGD:1303049"
                     /translation="MAASKPVEAAMAAAAAPASGNGVGSSGGTAAPGSGAGTLPRWHV
                     ALAIGAPLLLGAGAMYLWSRRRRRREAGGRGDASGLKRNSERKTPEGRASPALGSGPD
                     GSGDSLEMSSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNADLSTFYQN
                     RAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCIL
                     EGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPML
                     KGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAQGKYMAEAL
                     LLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLSTQDF
                     NMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYRQ
                     AYTANNSSQVQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE
                     PDNATTYVHKGLLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKA
                     IDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL"
     exon            468..641
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            642..768
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            769..878
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1027
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1235
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1370
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1478
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1595
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1693
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1816
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2264
                     /gene="Tomm70"
                     /gene_synonym="TOM70; Tomm70a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttttctgt cgtccgctcc tgctgcttag cgtgctcgct cgcgcgttgc tttcctccac
       61 gctcccggct tcctctccac gctgcccggt gaccgtggcg cccgcgaccg gcgcggcggc
      121 ggcggaggac agtcgtcatg gccgcctcta agcccgtaga ggcggcgatg gcggcggctg
      181 ctgcgcccgc ttctggaaat ggagtgggca gtagcggtgg gactgcggcc cccggctcgg
      241 gcgcggggac cctgccgcga tggcacgtgg cgctggccat cggggcgccc ctgttgctgg
      301 gtgctggggc catgtacctg tggagccgaa gacggaggcg ccgggaagcc ggaggccggg
      361 gcgacgccag cggcctgaag cgcaacagcg aacgaaagac cccagagggc agggccagtc
      421 cggccctggg cagtggcccc gacggttctg gtgactccct ggaaatgagc tctctggata
      481 gagcccaagc agccaaaaat aaaggcaaca aatatttcaa agcaggaaaa tatgagcaag
      541 ctattcagtg ctataccgag gctattagtc tgtgccctac tgagaagaat gcagacctct
      601 ctacatttta tcagaacaga gctgctgcct ttgaacagtt gcaaaaatgg aaagaagtgg
      661 cccaagattg tacaaaggcc gttgaactta atcccaaata tgtgaaagct ctctttagac
      721 gtgcaaaagc ccatgagaag ctagacaata agaaggagtg tttagaagat gtcactgctg
      781 tgtgtatatt agaagggttt caaaatgagc agagcatgct gttagctgat aaagttctta
      841 aacttctcgg gaaagagaat gccaaagaaa aatataagaa ccgggaacct ctgatgccat
      901 ctccacagtt tattaaatct tacttcagtt ctttcacgga tgacataatt tctcagccaa
      961 tgcttaaagg agagaagtct gacgaagata aggacaagga gggagaagcg ttagaagtaa
     1021 aagaaaattc tggatattta aaagctaaac aatatatgga agaagaaaac tatgacaaaa
     1081 tcataagtga atgctcaaag gaaatagatg ctcaaggcaa atacatggca gaggcattac
     1141 tactacgagc caccttctac ttgcttattg gcagtgccaa cgcggccaag cctgacttag
     1201 ataaggtcat cagtttgaag gaagctaacg tgaagcttcg agcaaatgcc cttatcaaaa
     1261 gaggcaccat gtgcatgcag cagcagcagc ctatgctgtc tactcaggac ttcaacatgg
     1321 ctgctgagat tgaccctatg aactcggatg tttatcacca ccgaggacag ctgaaaatcc
     1381 tgctggatct agttgaagaa gcagtggcag attttgatgc atgtatcaga ctaagaccga
     1441 agtttgcttt ggcacaggct cagaagtgtt ttgcattgta tcggcaggca tatacagcaa
     1501 acaattcttc gcaagtccag gcagctatga aaggttttga agaagtcata aagaaatttc
     1561 caaggtgtgc tgaaggctat gcactttatg cccaggcatt aacagatcaa caacaatttg
     1621 gtaaagctga tgaaatgtat gataaatgta ttgatttgga accagataat gctacaactt
     1681 atgttcataa aggtttactt caacttcagt ggaagcaaga tttggataaa ggtttggagc
     1741 ttatcagcaa agctattgaa attgacaaca aatgtgactt tgcgtatgag accatgggga
     1801 ctattgaagt gcagagagga aacatggaga aagccattga catgttcaac aaagctatca
     1861 acctggccaa gtcggaaatg gagatggctc atctgtactc actttgtgat gctgcccatg
     1921 cccagacaga agtagcaaag aaatacggat taaaaccacc gacattataa gcaccagggg
     1981 aaacagactg actcttttaa aagaagttta ccccctcttc aactgaatcc tgaagacact
     2041 gtcatgaatt gttgaatggt ggaactcagt attccctttg tgatgttgtc attacatctg
     2101 tttcatgttt aggtgtagtg ggcgtggcct tcaaggaagt ttgcagtctt gcagctttta
     2161 ttccctgtgc aacaaaagct tagaacctgt taaagggata ttaaaacaaa gttgtagaat
     2221 acaaacagta attggccatg caaataaaaa ctttgatttg ttgaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaa
//
