LOCUS       NM_212520               1549 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus translocase of outer mitochondrial membrane 40
            (Tomm40), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_212520 XM_006228420 XM_218426
VERSION     NM_212520.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Wang,X., Wang,S., Liu,W., Wang,T., Wang,J., Gao,X., Duan,R., Li,Y.,
            Pu,L., Deng,B. and Chen,Z.
  TITLE     Epigenetic upregulation of miR-126 induced by heat stress
            contributes to apoptosis of rat cardiomyocytes by promoting Tomm40
            transcription
  JOURNAL   J Mol Cell Cardiol 129, 39-48 (2019)
   PUBMED   30296408
  REMARK    GeneRIF: the role of miR-126 and TOMM40 in heat stressed
            cardiomyocytes, is reported.
REFERENCE   2  (bases 1 to 1549)
  AUTHORS   Feng,W., Li,J., Liang,Y., Zhang,Y. and Li,S.J.
  TITLE     Structural characterisation of a full-length mitochondrial outer
            membrane TOM40 preprotein translocase: implications for its
            interaction with presequence peptides
  JOURNAL   Eur Biophys J 48 (1), 35-43 (2019)
   PUBMED   30121780
  REMARK    GeneRIF: interaction between Tom40 and presequence peptides is
            mainly electrostatic in nature
REFERENCE   3  (bases 1 to 1549)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1549)
  AUTHORS   Ellenrieder,L., Martensson,C.U. and Becker,T.
  TITLE     Biogenesis of mitochondrial outer membrane proteins, problems and
            diseases
  JOURNAL   Biol Chem 396 (11), 1199-1213 (2015)
   PUBMED   25980382
  REMARK    Review article
REFERENCE   5  (bases 1 to 1549)
  AUTHORS   Yamase,Y., Horibe,H., Ueyama,C., Fujimaki,T., Oguri,M., Kato,K.,
            Arai,M., Watanabe,S. and Yamada,Y.
  TITLE     Association of TOMM40 and SLC22A4 polymorphisms with ischemic
            stroke
  JOURNAL   Biomed Rep 3 (4), 491-498 (2015)
   PUBMED   26171154
REFERENCE   6  (bases 1 to 1549)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1549)
  AUTHORS   Danial,N.N., Gramm,C.F., Scorrano,L., Zhang,C.Y., Krauss,S.,
            Ranger,A.M., Datta,S.R., Greenberg,M.E., Licklider,L.J.,
            Lowell,B.B., Gygi,S.P. and Korsmeyer,S.J.
  TITLE     BAD and glucokinase reside in a mitochondrial complex that
            integrates glycolysis and apoptosis
  JOURNAL   Nature 424 (6951), 952-956 (2003)
   PUBMED   12931191
REFERENCE   8  (bases 1 to 1549)
  AUTHORS   Johnston,A.J., Hoogenraad,J., Dougan,D.A., Truscott,K.N., Yano,M.,
            Mori,M., Hoogenraad,N.J. and Ryan,M.T.
  TITLE     Insertion and assembly of human tom7 into the preprotein
            translocase complex of the outer mitochondrial membrane
  JOURNAL   J Biol Chem 277 (44), 42197-42204 (2002)
   PUBMED   12198123
REFERENCE   9  (bases 1 to 1549)
  AUTHORS   Das,B., Tao,S.Z., Mushnitsky,R. and Norin,A.J.
  TITLE     Genetic identity and differential expression of p38.5 (Haymaker) in
            human malignant and nonmalignant cells
  JOURNAL   Int J Cancer 94 (6), 800-806 (2001)
   PUBMED   11745481
REFERENCE   10 (bases 1 to 1549)
  AUTHORS   Suzuki,H., Okazawa,Y., Komiya,T., Saeki,K., Mekada,E., Kitada,S.,
            Ito,A. and Mihara,K.
  TITLE     Characterization of rat TOM40, a central component of the
            preprotein translocase of the mitochondrial outer membrane
  JOURNAL   J Biol Chem 275 (48), 37930-37936 (2000)
   PUBMED   10980201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_006228420.4, NM_212520.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2448502.1,
                                           SRR26360172.82535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000001.1  88498781-88498833   c
            54-332              JAXUCZ010000001.1  88498402-88498680   c
            333-400             JAXUCZ010000001.1  88497671-88497738   c
            401-493             JAXUCZ010000001.1  88497044-88497136   c
            494-595             JAXUCZ010000001.1  88494867-88494968   c
            596-701             JAXUCZ010000001.1  88494681-88494786   c
            702-824             JAXUCZ010000001.1  88488784-88488906   c
            825-901             JAXUCZ010000001.1  88488576-88488652   c
            902-1004            JAXUCZ010000001.1  88488367-88488469   c
            1005-1549           JAXUCZ010000001.1  88486745-88487289   c
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1549
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /note="translocase of outer mitochondrial membrane 40"
                     /db_xref="GeneID:308416"
                     /db_xref="RGD:1303022"
     exon            1..53
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            54..332
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1144
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /note="mitochondrial outer membrane protein of 38 kDa;
                     translocase of outer membrane 40 kDa subunit homolog;
                     outer membrane protein 38 kDa; translocase of outer
                     mitochondrial membrane 40 homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM40
                     homolog"
                     /protein_id="NP_997685.2"
                     /db_xref="GeneID:308416"
                     /db_xref="RGD:1303022"
                     /translation="MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGL
                     GTGSNAGRGSERTPGAAASGAAASSNDGNCGCLPNPGTFEECHRKCKELFPVQMEGVK
                     LTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSL
                     NAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILV
                     AHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYH
                     KASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPP
                     LPLTLSLCAFLNHRKNKFLCGFGLTIG"
     exon            333..400
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            401..493
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            494..595
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            596..701
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            702..824
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            825..901
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1004
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1549
                     /gene="Tomm40"
                     /gene_synonym="OM38; TOM40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacggggta ggagcggagc ccaggccggg aacaggcgcc gcagctgccg ccaataccat
       61 ggggaacgtg ttggctgcta gctctccgcc cgcagggcca ccgccgcctc ctacgccgtc
      121 cctcgtgggg ctcccgccgc cgcctccttc gccgccaggc ttcacgctgc cgccacttgg
      181 aggtggcctg ggcactgggt caaacgctgg tcgcggttcg gaacggactc ccggggccgc
      241 ggcgagcggc gctgcggcgt cctcgaacga tgggaactgc ggctgcctgc ccaacccggg
      301 gacgttcgag gagtgccacc ggaagtgcaa ggagctgttt ccagttcaga tggaaggtgt
      361 caaacttaca gtcaacaaag ggttaagcaa tcgtttccag gtgacccata cagtagccct
      421 cggcacaatt ggggagtcca actaccactt cggggttaca tacgtgggga caaaacagct
      481 gagtcccaca gaggcgttcc ccgtgctggt gggtgacatg gacaatagtg gcagcctcaa
      541 tgcacaggtc atccaccagc tgagcccagg cctcaggtcc aagatggcca tccagaccca
      601 gcagtccaag ttcgtgaact ggcaggtgga tggcgagtac cgtggctccg acttcacggc
      661 tgctgtcacc ctgggcaacc cagatgtctt ggtgggttca ggaatcctcg tggctcacta
      721 cctccagagc atcacaccgt gtctggccct aggtggcgag ctcgtctacc accggcggcc
      781 tggagaagag ggcactgtca tgtctctagc tgggaaatac acactgaaca actggttggc
      841 tacagtaacg ctgggtcagg caggcatgca tgcgacgtat taccacaaag ccagtgacca
      901 gctgcaggtg ggtgtggagt ttgaggccag caccaggatg caggacacca gtgcctcctt
      961 tgggtatcag ctggacctgc ccaaggccaa cttcctcttc aaaggctctg tgaacagtaa
     1021 ctggatcgtg ggtgccacgc tggagaagaa gcttccgccc ttgcccctga cactgtcgct
     1081 ctgcgccttc ctgaaccacc gcaagaataa gttcctgtgt ggctttggcc tcaccatcgg
     1141 ctgagtcctc ctggccttcc tctgcagacc actgctgggc cagctgccct cccctcctcc
     1201 ctctctcttg gggttggggc agtgggaagg aggggaccta ccccatgccc gaggatccca
     1261 gcgccagggg acagtgtctg gaggcctggg gtccccgagg gagttctggg atctgaaggg
     1321 cattcgattg tgagcgccca ggcaggggca cagaggcggc tgtacaggct cagggaggaa
     1381 agacttgatg tccccgtcct cctgagggca gcagaggagc gccgggccgc ctgtcacttt
     1441 cccctccacc cctccataga aatcatgttt ataagttatg gaaaaccggg acattttaca
     1501 gaaaaaaaaa acttaaaaaa caaaaaatac acacggaaaa aaaatagga
//
