LOCUS       NM_212514               1056 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus translocase of outer mitochondrial membrane 22
            (Tomm22), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_212514 XM_216977
VERSION     NM_212514.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Bose,H.S., Whittal,R.M., Marshall,B., Rajapaksha,M., Wang,N.P.,
            Bose,M., Perry,E.W., Zhao,Z.Q. and Miller,W.L.
  TITLE     A Novel Mitochondrial Complex of Aldosterone Synthase,
            Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes
            Aldosterone in the Rat Heart
  JOURNAL   J Pharmacol Exp Ther 377 (1), 108-120 (2021)
   PUBMED   33526603
  REMARK    GeneRIF: A Novel Mitochondrial Complex of Aldosterone Synthase,
            Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes
            Aldosterone in the Rat Heart.
            Erratum:[J Pharmacol Exp Ther. 2021 Apr;377(1):200. doi:
            10.1124/jpet.120.000365err.. PMID: 33757981]
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Ellenrieder,L., Martensson,C.U. and Becker,T.
  TITLE     Biogenesis of mitochondrial outer membrane proteins, problems and
            diseases
  JOURNAL   Biol Chem 396 (11), 1199-1213 (2015)
   PUBMED   25980382
  REMARK    Review article
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Wenz,L.S., Opalinski,L., Wiedemann,N. and Becker,T.
  TITLE     Cooperation of protein machineries in mitochondrial protein sorting
  JOURNAL   Biochim Biophys Acta 1853 (5), 1119-1129 (2015)
   PUBMED   25633533
  REMARK    Review article
REFERENCE   4  (bases 1 to 1056)
  AUTHORS   Schulz,C., Schendzielorz,A. and Rehling,P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   5  (bases 1 to 1056)
  AUTHORS   Hohr,A.I., Straub,S.P., Warscheid,B., Becker,T. and Wiedemann,N.
  TITLE     Assembly of beta-barrel proteins in the mitochondrial outer
            membrane
  JOURNAL   Biochim Biophys Acta 1853 (1), 74-88 (2015)
   PUBMED   25305573
  REMARK    Review article
REFERENCE   6  (bases 1 to 1056)
  AUTHORS   Humphries,A.D., Streimann,I.C., Stojanovski,D., Johnston,A.J.,
            Yano,M., Hoogenraad,N.J. and Ryan,M.T.
  TITLE     Dissection of the mitochondrial import and assembly pathway for
            human Tom40
  JOURNAL   J Biol Chem 280 (12), 11535-11543 (2005)
   PUBMED   15644312
REFERENCE   7  (bases 1 to 1056)
  AUTHORS   Nakamura,Y., Suzuki,H., Sakaguchi,M. and Mihara,K.
  TITLE     Targeting and assembly of rat mitochondrial translocase of outer
            membrane 22 (TOM22) into the TOM complex
  JOURNAL   J Biol Chem 279 (20), 21223-21232 (2004)
   PUBMED   14985332
  REMARK    GeneRIF: Analysis of signals that target rat TOM22 to the
            mitochondrial outer membrane and assembly into the TOM complex in
            cultured mammalian cells.
REFERENCE   8  (bases 1 to 1056)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1056)
  AUTHORS   Johnston,A.J., Hoogenraad,J., Dougan,D.A., Truscott,K.N., Yano,M.,
            Mori,M., Hoogenraad,N.J. and Ryan,M.T.
  TITLE     Insertion and assembly of human tom7 into the preprotein
            translocase complex of the outer mitochondrial membrane
  JOURNAL   J Biol Chem 277 (44), 42197-42204 (2002)
   PUBMED   12198123
REFERENCE   10 (bases 1 to 1056)
  AUTHORS   Suzuki,H., Maeda,M. and Mihara,K.
  TITLE     Characterization of rat TOM70 as a receptor of the preprotein
            translocase of the mitochondrial outer membrane
  JOURNAL   J Cell Sci 115 (Pt 9), 1895-1905 (2002)
   PUBMED   11956321
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098639.1.
            
            On Jul 31, 2005 this sequence version replaced NM_212514.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098639.1, EV776729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1056
                     /gene="Tomm22"
                     /gene_synonym="rTOM22; TOM22"
                     /note="translocase of outer mitochondrial membrane 22"
                     /db_xref="GeneID:300075"
                     /db_xref="RGD:1303260"
     exon            1..130
                     /gene="Tomm22"
                     /gene_synonym="rTOM22; TOM22"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..442
                     /gene="Tomm22"
                     /gene_synonym="rTOM22; TOM22"
                     /note="translocase of outer membrane 22 kDa subunit
                     homolog; translocase of outer mitochondrial membrane 22
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM22
                     homolog"
                     /protein_id="NP_997679.1"
                     /db_xref="GeneID:300075"
                     /db_xref="RGD:1303260"
                     /translation="MAAAVAAAGAGEPLSPEELVPKAEAEKAEEDLEEDDDDELDETL
                     SERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFE
                     TEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPPLPGKI"
     exon            131..249
                     /gene="Tomm22"
                     /gene_synonym="rTOM22; TOM22"
                     /inference="alignment:Splign:2.1.0"
     exon            250..367
                     /gene="Tomm22"
                     /gene_synonym="rTOM22; TOM22"
                     /inference="alignment:Splign:2.1.0"
     exon            368..1030
                     /gene="Tomm22"
                     /gene_synonym="rTOM22; TOM22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtcctaca gccatggccg ccgccgtcgc tgcagccggc gctggggagc ctctgtcccc
       61 cgaagaattg gtcccgaaag ccgaggcaga gaaagctgag gaggacctgg aagaagacga
      121 cgacgacgag ctagatgaga ccctatcgga gagactctgg ggtctgacgg agatgtttcc
      181 cgagagggtc cggtcagccg ctggagccac ctttgatctc tcgctcttcg tggctcagaa
      241 gatgtacaga ttttccaggg cagctttgtg gattgggacc acttccttca tgatcctggt
      301 tcttcctgtt gtctttgaga cagaaaagtt gcaaatggag caacaacagc aactgcagca
      361 aaggcagata cttttagggc ctaacacagg actgtcagga ggaatgccag gggctctacc
      421 tccacttcct ggaaagatct agattcttat ttcggtattt gtccgtgtgg gagaactttg
      481 aaattcattt gtgtttgaac tgctgattgt ttgaactttt tattcttttt tttaaccttg
      541 gcacatggat ctctttgaac atagtgggaa ctttctccgt ttctcgtgga gggaccccag
      601 gtaaacctgt gcccttcata atgaatgccc tcatttactt cctgttctca ctccgatgct
      661 ggagtacagc catttggaag gttatcccac tctcctttaa taaattgctc ctaagaagtt
      721 cttacatgcc catagtggga aagaagttaa gtacccctga ctataaggac ttttttttta
      781 atggaaatgt ctaggacgtg ttaaacagtg tgggactgac aaaatccatt acacctgtag
      841 tacagcagcc accagggatc cggtgtgtgc cagggaaaag ggtggctggc tgtagctttg
      901 gccaggggga gactgggcag agcagacact catttcctct gcacatttcg gctcttagac
      961 cttcatgtgt atacaaaaga agtcagcgct cactttttgt atttaaatat taaaagaact
     1021 tgaaccgaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
