LOCUS       NM_152935                980 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus translocase of outer mitochondrial membrane 20
            (Tomm20), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_152935
VERSION     NM_152935.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 980)
  AUTHORS   Di Maio,R., Barrett,P.J., Hoffman,E.K., Barrett,C.W., Zharikov,A.,
            Borah,A., Hu,X., McCoy,J., Chu,C.T., Burton,E.A., Hastings,T.G. and
            Greenamyre,J.T.
  TITLE     alpha-Synuclein binds to TOM20 and inhibits mitochondrial protein
            import in Parkinson's disease
  JOURNAL   Sci Transl Med 8 (342), 342ra78 (2016)
   PUBMED   27280685
  REMARK    GeneRIF: alpha-Synuclein binds to TOM20 and inhibits mitochondrial
            protein import in Parkinson's disease
REFERENCE   2  (bases 1 to 980)
  AUTHORS   Ellenrieder,L., Martensson,C.U. and Becker,T.
  TITLE     Biogenesis of mitochondrial outer membrane proteins, problems and
            diseases
  JOURNAL   Biol Chem 396 (11), 1199-1213 (2015)
   PUBMED   25980382
  REMARK    Review article
REFERENCE   3  (bases 1 to 980)
  AUTHORS   Guarani,V., McNeill,E.M., Paulo,J.A., Huttlin,E.L., Frohlich,F.,
            Gygi,S.P., Van Vactor,D. and Harper,J.W.
  TITLE     QIL1 is a novel mitochondrial protein required for MICOS complex
            stability and cristae morphology
  JOURNAL   Elife 4, e06265 (2015)
   PUBMED   25997101
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 980)
  AUTHORS   Wenz,L.S., Opalinski,L., Wiedemann,N. and Becker,T.
  TITLE     Cooperation of protein machineries in mitochondrial protein sorting
  JOURNAL   Biochim Biophys Acta 1853 (5), 1119-1129 (2015)
   PUBMED   25633533
  REMARK    Review article
REFERENCE   5  (bases 1 to 980)
  AUTHORS   Schulz,C., Schendzielorz,A. and Rehling,P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   6  (bases 1 to 980)
  AUTHORS   Suzuki,H., Maeda,M. and Mihara,K.
  TITLE     Characterization of rat TOM70 as a receptor of the preprotein
            translocase of the mitochondrial outer membrane
  JOURNAL   J Cell Sci 115 (Pt 9), 1895-1905 (2002)
   PUBMED   11956321
REFERENCE   7  (bases 1 to 980)
  AUTHORS   Kanaji,S., Iwahashi,J., Kida,Y., Sakaguchi,M. and Mihara,K.
  TITLE     Characterization of the signal that directs Tom20 to the
            mitochondrial outer membrane
  JOURNAL   J Cell Biol 151 (2), 277-288 (2000)
   PUBMED   11038175
REFERENCE   8  (bases 1 to 980)
  AUTHORS   Abe,Y., Shodai,T., Muto,T., Mihara,K., Torii,H., Nishikawa,S.,
            Endo,T. and Kohda,D.
  TITLE     Structural basis of presequence recognition by the mitochondrial
            protein import receptor Tom20
  JOURNAL   Cell 100 (5), 551-560 (2000)
   PUBMED   10721992
REFERENCE   9  (bases 1 to 980)
  AUTHORS   Craig,E.E., Chesley,A. and Hood,D.A.
  TITLE     Thyroid hormone modifies mitochondrial phenotype by increasing
            protein import without altering degradation
  JOURNAL   Am J Physiol 275 (6), C1508-C1515 (1998)
   PUBMED   9843712
REFERENCE   10 (bases 1 to 980)
  AUTHORS   Takahashi,M., Chesley,A., Freyssenet,D. and Hood,D.A.
  TITLE     Contractile activity-induced adaptations in the mitochondrial
            protein import system
  JOURNAL   Am J Physiol 274 (5), C1380-C1387 (1998)
   PUBMED   9612226
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_152935.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U21871.1, EV777319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000019.1  71832190-71832420   c
            232-278             JAXUCZ010000019.1  71828341-71828387   c
            279-360             JAXUCZ010000019.1  71826946-71827027   c
            361-503             JAXUCZ010000019.1  71824161-71824303   c
            504-980             JAXUCZ010000019.1  71822429-71822905   c
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..980
                     /gene="Tomm20"
                     /note="translocase of outer mitochondrial membrane 20"
                     /db_xref="GeneID:266601"
                     /db_xref="RGD:708467"
     exon            1..231
                     /gene="Tomm20"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..548
                     /gene="Tomm20"
                     /note="mitochondrial 20 kDa outer membrane protein; outer
                     mitochondrial membrane receptor Tom20; outer mitochondrial
                     membrane receptor rTOM20; translocase of outer
                     mitochondrial membrane 20 homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM20
                     homolog"
                     /protein_id="NP_690918.2"
                     /db_xref="GeneID:266601"
                     /db_xref="RGD:708467"
                     /translation="MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKK
                     QKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGDYEKGVDHLTNAIAVCGQ
                     PQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE"
     exon            232..278
                     /gene="Tomm20"
                     /inference="alignment:Splign:2.1.0"
     exon            279..360
                     /gene="Tomm20"
                     /inference="alignment:Splign:2.1.0"
     exon            361..503
                     /gene="Tomm20"
                     /inference="alignment:Splign:2.1.0"
     exon            504..980
                     /gene="Tomm20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctggactg cagacaggcg gcagcgagag accggcgagc tccgatcggt cggagctaac
       61 cgctgccagg cgggctgccg cggccccgca cacgccccag tcgagcgaag atggtgggcc
      121 ggaacagcgc catcgccgcg ggcgtgtgcg gtgccctctt catagggtac tgcatctact
      181 ttgaccgcaa aaggcggagt gaccccaact tcaagaacag gcttcgagaa cgaagaaaga
      241 aacagaagct tgctaaggag agagctgggc tttccaagtt acctgattta aaagatgctg
      301 aagctgttca gaaattcttc cttgaagaga tacagcttgg tgaagagtta ttagcacaag
      361 gtgactatga gaagggtgtg gaccacctga caaatgcaat cgctgtgtgt ggacagcctc
      421 agcagttgct gcaagtgtta caacagactc ttccaccacc agtgttccag atgcttctga
      481 ccaagcttcc aaccattagt cagagaattg tcagtgctca gagcttggct gaggatgatg
      541 tggaatgagc cagacaccaa catgataaaa tctcagtaaa atgataacag ttagctgcag
      601 gctgctctgc tcggggggat aagggcaaac tgtgcttgtc atgaactgtc tcacactgac
      661 atctccaaag tgaacctgaa ctttggtaga gccattgtct gttctattta tttttccagt
      721 gagaagtatt ttgatagctt ttcattttat aaatacactg cgttaaccaa aagatcatgg
      781 atttcgtttg ttcttgacat gcagttcaat gtaaatacag tagtattagg tagagactcc
      841 tggtgatttt aaaggattgg aaaagactga ggaatagttg aataatgcac attttaaaga
      901 ctagaacatt ttattgtacg ttgtaaaatt gagtagaaac ttgtgtttgt gaaaactgag
      961 cattaaaacc ttacagagac
//
