LOCUS       NM_001253859            2289 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus target of myb1 like 1 membrane trafficking
            protein (Tom1l1), mRNA.
ACCESSION   NM_001253859 XM_002724537 XM_002727790
VERSION     NM_001253859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Zhang,J., Suzuki,K., Hitomi,T. and Siraganian,R.P.
  TITLE     TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast
            cells
  JOURNAL   J Biol Chem 282 (52), 37669-37677 (2007)
   PUBMED   17977829
  REMARK    GeneRIF: TOM1L1 is a novel protein involved in the FcepsilonRI
            signal transduction for the generation of cytokines that acts as a
            Lyn substrate
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Katoh,Y., Imakagura,H., Futatsumori,M. and Nakayama,K.
  TITLE     Recruitment of clathrin onto endosomes by the Tom1-Tollip complex
  JOURNAL   Biochem Biophys Res Commun 341 (1), 143-149 (2006)
   PUBMED   16412388
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Franco,M., Furstoss,O., Simon,V., Benistant,C., Hong,W.J. and
            Roche,S.
  TITLE     The adaptor protein Tom1L1 is a negative regulator of Src mitogenic
            signaling induced by growth factors
  JOURNAL   Mol Cell Biol 26 (5), 1932-1947 (2006)
   PUBMED   16479011
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Puertollano,R.
  TITLE     Interactions of TOM1L1 with the multivesicular body sorting
            machinery
  JOURNAL   J Biol Chem 280 (10), 9258-9264 (2005)
   PUBMED   15611048
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Seykora,J.T., Mei,L., Dotto,G.P. and Stein,P.L.
  TITLE     'Srcasm: a novel Src activating and signaling molecule
  JOURNAL   J Biol Chem 277 (4), 2812-2822 (2002)
   PUBMED   11711534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK596986.1, BC169112.1 and CO568886.1.
            
            On or before Dec 9, 2011 this sequence version replaced
            XM_002727790.1, XM_002724537.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169112.1, SRR8487231.32738.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CK596986.1         15-16
            3-2073              BC169112.1         1-2071
            2074-2289           CO568886.1         1-216               c
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2289
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /note="target of myb1 like 1 membrane trafficking protein"
                     /db_xref="GeneID:287622"
                     /db_xref="RGD:1562626"
     CDS             1..1425
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /note="target of myb1-like 1; Target of Myb-like protein
                     1; Src-activating and signaling molecule protein"
                     /codon_start=1
                     /product="TOM1-like protein 1"
                     /protein_id="NP_001240788.1"
                     /db_xref="GeneID:287622"
                     /db_xref="RGD:1562626"
                     /translation="MAFGKSHRDPYATSLGHLIEKATFAGVQTEDWGQFMHICDIINT
                     TQDGPKDAVKALKKRISKNYNHKEIQLSLSLIDMCMQNCGPSFQSLIVKKEFVKDTLV
                     KLLNPRYTLPLETQNRILSFIKMWSQGFPGGVDVSEVKEVYLDLLKKGVQFPPLDGEP
                     ETKQEAGQISPSRPTSVPTAPALSSIIAPKNPTISLVPEQIGKLHSELDMVKMNVKVM
                     TAILMENTPGSENHEDIELLRKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLN
                     NAILGYERFTRNQQRLLEQKRNPTEANTSSEPSAPSCDLLNLGPVAPVPVSSEGPLNS
                     VNAQLSGLNVSSQSPVITNNLYPSLQPQMDLLASEDTEVPTLFPQRTSQNLASSHTYD
                     NFPDHSSSVLLQPVSLHTAPAAPSSQRLPPLPSNHPVLKNSALQPPSYYEVMEFDPLA
                     PTTEAIYEEIDASHKKGAQSHSEC"
     exon            1..58
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            59..143
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            144..222
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            223..372
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            373..495
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            496..600
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            601..717
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            718..851
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            852..909
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1027
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1127
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1179
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1285
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1361
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1426
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..2289
                     /gene="Tom1l1"
                     /gene_synonym="RGD1562626; Srcasm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgtttg ggaagagtca ccgcgatccc tacgctacct ctctgggtca cctcatagaa
       61 aaggccacct ttgctggagt tcagacagaa gactggggcc agttcatgca tatctgtgac
      121 ataattaaca ccacacaaga cgggccaaaa gatgcagtaa aagctttgaa gaaaaggatc
      181 tccaaaaact acaaccacaa agaaatccaa ctttccttat cactcattga catgtgcatg
      241 cagaactgtg ggccgagttt ccaatctctg attgtgaaga aggagttcgt taaagatact
      301 ctagttaagc tgctgaaccc cagatacacc ttaccgttgg agactcagaa cagaatcttg
      361 agtttcatta agatgtggtc ccagggcttc ccgggaggtg tagatgtcag tgaagtgaag
      421 gaagtgtacc tcgacctgct gaagaaaggg gttcaattcc cacccttgga tggagagcct
      481 gagacaaaac aggaggctgg tcagatctca ccaagtcgac cgacatctgt ccccactgcg
      541 cctgctcttt cttctataat tgctcccaag aacccgacta tttccttagt ccctgaacag
      601 atcgggaaac tgcacagtga actggacatg gtgaaaatga acgtgaaagt gatgacagcc
      661 atattgatgg agaacactcc tggctccgaa aaccatgaag acatagagct cctgaggaaa
      721 ctttacaaga cgggtcggga gatgcaggag aggatcatgg acctgctggt ggtagttgag
      781 aatgaagacg tgacagtgga actgattcaa gtgaacgagg atctgaataa tgccatcctc
      841 ggatacgaga ggtttactcg aaaccagcaa aggcttttgg aacagaagag gaacccgacg
      901 gaagccaata cttccagcga accctctgct ccttcctgcg atctcctcaa cctaggtccc
      961 gtggcgccag tgcctgtgtc cagtgaggga ccactcaact ccgtgaacgc tcagctttcc
     1021 ggcctaaatg tcagctctca gagtcctgtt ataacaaaca acttgtatcc cagtcttcag
     1081 ccacagatgg atttactagc atcagaagat acagaagtac ccaccttgtt tccccagagg
     1141 accagccaaa acctcgcctc aagccacaca tatgataact ttccggatca ctccagttca
     1201 gtattgctac agccagttag cctacacact gccccggcag cgccgtcgag ccagaggctg
     1261 ccacccttgc cgagcaatca tccagtgtta aaaaacagtg ctctccaacc acccagttac
     1321 tacgaggtaa tggagtttga tcccttagct cccactacag aagctattta tgaagaaatt
     1381 gatgcttccc acaagaaagg agctcaaagc catagtgaat gctgagacaa atgaactaag
     1441 catcataaag ggtcagctct ctaaagtagt ccctgatcaa cggaggcctg gaagacaaga
     1501 cctgccaaca gggaaagcca cagtggatca tttctctgct ggaaacttca acataaaagc
     1561 taacactttt tgggcaacac tgctgttcct cacaatggct caagatttca ggaaaatctg
     1621 gttgtaacaa cttcagcaga aggaaaactg cctagtacta gaccacttgg ttaaactgta
     1681 gactcttatg ttgtgcaggc ttgcacccag tgcaaatcat gacagaccta tgacagggtt
     1741 actttaagac cctattagaa aacattgtaa acagatgggg gaaggaagaa aatgagtgcc
     1801 tttattgaac tgaatctgaa tgtagagttc agtttgtact tgtttataaa taacattttg
     1861 gtttagaatg gcttgaaaga cttgatgact ttaattgtat ttcaagtgcc tgaggaggcc
     1921 actgcatcag gcggccttta ggtgtagtta gttctttata atgttaaaca ttcttgcctt
     1981 ttattataat tcacattctg atttgaaaca aagattactg gaaaacaggg caatgcatca
     2041 ttcacgtaaa attaaattac tattaatttg tcagagttgt gttgttcttg ttctgtcttc
     2101 tagtttaatg agcttttatg ccagtaagtc ttcacaattt cacccttcca atgataatgt
     2161 taatgaactt ggaattatgg tggtaaatgc tagcttagcc agcaggtgta attctgttag
     2221 atcatgatac catcatttcc atgttatcat ctattttcag tactctgaat aaaacagcac
     2281 tcaagccta
//
