LOCUS       NM_001109668            3795 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus toll interacting protein (Tollip), mRNA.
ACCESSION   NM_001109668 XM_001063419 XM_341961
VERSION     NM_001109668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3795)
  AUTHORS   Tian,Y., Shu,R., Lei,Y., Xu,Y., Zhang,X. and Luo,H.
  TITLE     Somatostatin attenuates intestinal epithelial barrier injury during
            acute intestinal ischemia-reperfusion through
            Tollip/Myeloiddifferentiationfactor 88/Nuclear factor kappa-B
            signaling
  JOURNAL   Bioengineered 13 (3), 5005-5020 (2022)
   PUBMED   35164650
  REMARK    GeneRIF: Somatostatin attenuates intestinal epithelial barrier
            injury during acute intestinal ischemia-reperfusion through
            Tollip/Myeloiddifferentiationfactor 88/Nuclear factor kappa-B
            signaling.
REFERENCE   2  (bases 1 to 3795)
  AUTHORS   Saikia,P., Roychowdhury,S., Bellos,D., Pollard,K.A., McMullen,M.R.,
            McCullough,R.L., McCullough,A.J., Gholam,P., de la Motte,C. and
            Nagy,L.E.
  TITLE     Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from
            ethanol-fed rats via regulation of microRNA291b and its target
            Tollip
  JOURNAL   Sci Rep 7 (1), 15671 (2017)
   PUBMED   29142263
  REMARK    GeneRIF: we have identified miR291b as a critical miRNA
            up-regulated by ethanol. Normalization of the miR291b --> Tollip
            pathway by HA35 ameliorated ethanol-induced sensitization of TLR4
            signaling in macrophages/monocytes, suggesting that HA35 may be a
            novel therapeutic agent in the treatment of Alcoholic liver
            disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3795)
  AUTHORS   Wu,W., Wang,Y., Zou,J., Long,F., Yan,H., Zeng,L. and Chen,Y.
  TITLE     Bifidobacterium adolescentis protects against necrotizing
            enterocolitis and upregulates TOLLIP and SIGIRR in premature
            neonatal rats
  JOURNAL   BMC Pediatr 17 (1), 1 (2017)
   PUBMED   28056921
  REMARK    GeneRIF: This study demonstrated B. adolescentis prevents NEC in
            preterm neonatal rats and that the mechanism for this action might
            be associated with the alteration of TLR4, TOLLIP, and SIGIRR
            expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3795)
  AUTHORS   Li,M., Feng,B., Wang,L., Guo,S., Zhang,P., Gong,J., Zhang,Y.,
            Zheng,A. and Li,H.
  TITLE     Tollip is a critical mediator of cerebral ischaemia-reperfusion
            injury
  JOURNAL   J Pathol 237 (2), 249-262 (2015)
   PUBMED   26011492
  REMARK    GeneRIF: Tollip acts as a novel modulator of I/R injury by
            promoting neuronal apoptosis and ischaemic inflammation, which are
            largely mediated by suppression of Akt signalling.
REFERENCE   5  (bases 1 to 3795)
  AUTHORS   Liu,M.W., Wang,Y.H., Qian,C.Y. and Li,H.
  TITLE     Xuebijing exerts protective effects on lung permeability leakage
            and lung injury by upregulating Toll-interacting protein expression
            in rats with sepsis
  JOURNAL   Int J Mol Med 34 (6), 1492-1504 (2014)
   PUBMED   25269519
  REMARK    GeneRIF: Daata indicate that Xuebijing (XBJ) significantly reduced
            ligation and puncture (CLP)-induced lung permeability by
            upregulating Toll-interacting protein (Tollip) expression.
REFERENCE   6  (bases 1 to 3795)
  AUTHORS   Verstrepen,L., Bekaert,T., Chau,T.L., Tavernier,J., Chariot,A. and
            Beyaert,R.
  TITLE     TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a
            common theme
  JOURNAL   Cell Mol Life Sci 65 (19), 2964-2978 (2008)
   PUBMED   18535784
  REMARK    Review article
REFERENCE   7  (bases 1 to 3795)
  AUTHORS   Katoh,Y., Imakagura,H., Futatsumori,M. and Nakayama,K.
  TITLE     Recruitment of clathrin onto endosomes by the Tom1-Tollip complex
  JOURNAL   Biochem Biophys Res Commun 341 (1), 143-149 (2006)
   PUBMED   16412388
REFERENCE   8  (bases 1 to 3795)
  AUTHORS   Bulut,Y., Faure,E., Thomas,L., Equils,O. and Arditi,M.
  TITLE     Cooperation of Toll-like receptor 2 and 6 for cellular activation
            by soluble tuberculosis factor and Borrelia burgdorferi outer
            surface protein A lipoprotein: role of Toll-interacting protein and
            IL-1 receptor signaling molecules in Toll-like receptor 2 signaling
  JOURNAL   J Immunol 167 (2), 987-994 (2001)
   PUBMED   11441107
REFERENCE   9  (bases 1 to 3795)
  AUTHORS   Burns,K., Clatworthy,J., Martin,L., Martinon,F., Plumpton,C.,
            Maschera,B., Lewis,A., Ray,K., Tschopp,J. and Volpe,F.
  TITLE     Tollip, a new component of the IL-1RI pathway, links IRAK to the
            IL-1 receptor
  JOURNAL   Nat Cell Biol 2 (6), 346-351 (2000)
   PUBMED   10854325
REFERENCE   10 (bases 1 to 3795)
  AUTHORS   Nilsen,K.H.
  TITLE     Malignant lymphoma and rheumatic symptoms
  JOURNAL   N Z Med J 83 (563), 320-322 (1976)
   PUBMED   1085432
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341961.3, XM_001063419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133067.1, FQ186868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3795
                     /gene="Tollip"
                     /note="toll interacting protein"
                     /db_xref="GeneID:361677"
                     /db_xref="RGD:1304676"
     exon            1..226
                     /gene="Tollip"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1018
                     /gene="Tollip"
                     /codon_start=1
                     /product="toll-interacting protein"
                     /protein_id="NP_001103138.1"
                     /db_xref="GeneID:361677"
                     /db_xref="RGD:1304676"
                     /translation="MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQ
                     YGGAVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNK
                     VIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGD
                     DKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAM
                     PPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES"
     exon            227..376
                     /gene="Tollip"
                     /inference="alignment:Splign:2.1.0"
     exon            377..559
                     /gene="Tollip"
                     /inference="alignment:Splign:2.1.0"
     exon            560..712
                     /gene="Tollip"
                     /inference="alignment:Splign:2.1.0"
     exon            713..803
                     /gene="Tollip"
                     /inference="alignment:Splign:2.1.0"
     exon            804..3795
                     /gene="Tollip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggtcg gctactgccg agctctgtgc ttgggggaac gccgaggtgg ggcgaggcgg
       61 ggcgactgtc agctgactaa agagccgatt gcctcgcggg acaacggtca gcgacgcagg
      121 ttgtggtggg aacggaagag ctctcccggc gggtctctgt gcagtcggtg aggcagaggg
      181 ccgccgcagc accatggcga ccaccgtcag cacgcagcgc gggccggtat acattggtga
      241 gctcccccag gactttctcc gtataacgcc cacacagcag cagcagcaga tacagctgga
      301 tgcccaggca gcccagcagc tgcagtatgg aggagcagtt ggcactgtgg gtcgtctcag
      361 catcactgta gtacaggcca aattggcaaa gaattatggc atgactcgta tggaccctta
      421 ctgccgcctg cgtctgggct atgctgttta tgaaactccc acagcacaca atggcgccaa
      481 gaaccctcga tggaacaagg ttattcagtg cacagtgccc ccaggtgtgg actcgttcta
      541 ccttgagatc ttcgatgagc gagccttctc catggacgac cgcatagctt ggacccacat
      601 cactatcccc gagtccctga agcagggcca agtggaggac gagtggtata gcctgagtgg
      661 gaggcagggc gacgacaagg agggcatgat taacctggtc atgtcctata cgtcccttcc
      721 agctgccatg atgatgccgc ctcagcctgt ggttctgatg ccaactgtgt accagcaggg
      781 tgttggctat gtgcccattg cagggatgcc tgctgtctgc agccctggca tggtgcctat
      841 ggctatgccc ccaccagctg tggctcctca gccccgctgt aatgaggagg acctcaaggc
      901 tatccaggac atgtttccca acatggacag ggaagtaatc cgttctgtgc ttgaagccca
      961 aagagggaac aaagatgctg ccatcaactc cttactgcaa atgggcgaag agtcctagac
     1021 ccacctgtgg cccttggctt cacagcactg acccttggac ttgtccaccc ggggctcccc
     1081 agggtcacca tccccacaag attccaatga aagaccatcc acataccctt tccttggaca
     1141 tctgcgccgc cccttcccac atattttggg gatgcatgtg gattttcggt tctaggcagg
     1201 cagtcctctt caatgttgct gggggacagg gttgggggac agttctctcc ctgtctctag
     1261 ctgggtgatg gtggcatggc cctgttattg cacagaccag tcgtcctgtt tggggacctg
     1321 catctcctgt cctcacccta ttctggaaag cattcttata gaaagcaagc tgcctctgcc
     1381 aggatagagg tgattgtaca gcgtccttct gagttgatgg atggcatgga gttactcagc
     1441 ccagctggga tggttgttga cggtgcactg agttcatgtg cacttactta caggttattt
     1501 ttagaacttt caagctaaaa cctccttccc tcctctgatg ttgtatgtga acctgggccc
     1561 ctcagctagt cctgggccag gagatatgct tcccagccat atccagcagg tctctaacct
     1621 cctgtcttgc ttacctgcca ctgtctggct aggcttcagc cacagaaatc catcttggaa
     1681 acagaaggta tccagacttg gtgcttggct agcaaggccc caccttggcc cttactgctg
     1741 aaggctgctt tccacctctt ctttagtcca gcattgtggg tcttactcca ggggctgttc
     1801 ttgttgatag accttcatca cagagttcag agtcaagtga aggagatggg cgggtgtggc
     1861 actgcgtgct tactactaaa attcaagcat cgtgacacta ctgacctgca gtacactcta
     1921 tggacccaca ctgtagattg gcttgagtaa taaaaatcca tgcttaaatt aaaccttcat
     1981 ggaggtagag gtgcctgtac ctgaccagtg gatattgtgc attgtatttt gagttacaaa
     2041 cctatgagcc catggcctgg ctatagacct gtttagggga aagatgggtg gcaccttgtc
     2101 ctaagattca gaccttgaaa gctttctcag aatcgatcca ctgtacaggt actgttaaga
     2161 agctatcaca cattgtcacg tgtttatggt gttacagttt tgccttacat tgcagttgct
     2221 ttttgttttt ctgagaattt gcacacccag tgtttgaata tgtgatgcac caatatgggc
     2281 gtgaaggtga ctcctagcag tttggactat tgaaatacga aaactagtac ttcagttttg
     2341 atctttgcct cctaaaaaag cagtgagata tactactttc tgttatccgt ggggtgcttt
     2401 ttgtcagatg tattgttcat aagtatttat ttttgtaagc ctaaaggcag tatgtggtga
     2461 cggtgagcat gggatggtgg taacaagcac ttttctgtag ttgtagctct ttaaaccttt
     2521 taactgcaaa acagagaaga aagaccaatg tttgttaaat agattcaacc actcacttta
     2581 acacaaccag gcactggaag tctccattct agaccgttgt gtggccttgt tctgggtaag
     2641 cagatgccct cttatagggt ggatgagtca agcaggcagg acctcctcaa gtggtctgct
     2701 tagtgtcacc agcagactcg agacactgca gagcagggac ctcagtacct gtctctaggt
     2761 ctcagtgtgg ctgtgcgcat cagcctctgc cttaggaggt gtggtctgag cacagggcca
     2821 ctttgctctt gtgaggctct gtagggagcc cctgagcagc ccccacagca ctcagaggca
     2881 gcattcacta acttgtgctt gctcgaatga ggaagaggga tggttttaag acagatttaa
     2941 gacttgagct aaacacagac tcttcccttg gtcatgaaca ttttattttt ttaatagatt
     3001 aaaggaagat cacgttttat aaggcctgag tgatatccca ctctcctagg ttttatgcta
     3061 ttttgtcttg gaatttcatg tcagtaccca tgtagtacaa ggaaagaggc agtgcttgtc
     3121 ggcgcctgtg tagggactaa ggcatcagag catggcttgc ttggccttcc atcgcatcct
     3181 gaatcttctc aaggtgagaa gtcacccctg gaaggagctc aaaggcagag gccacagcag
     3241 agacagacaa gcttctgcgt ggggaccagg ctctttctgg gtatcattgc tgctcttgcc
     3301 aagtttgaag attgatgttg gtagcaaaat ttcacaaggt gttcattgga ggccctgccc
     3361 tcaaggtgtt cactggggcc cctgccctca ggccaactcc agggtaggta ggtatgggtc
     3421 tagggatggc ctgcgctgtt ctcttctctg cacatgttgg ttggctgaag ttgtaacctg
     3481 ctgcacattt gtggtctgac atggccagtg gctttcatct cacctgtgag taacgcctgc
     3541 ccaattgaca gaagtgtggt gcgatgggct ctgccctcgc cctcccaggc cactctttac
     3601 agacactggc atcatccgac acactgtcta gaggttggtg ggaatagttc tcagaaccct
     3661 gtctgtggtt attttgggga tgggggtcca tgtccagatt tttctttgat tatatgatat
     3721 atttttactt tcagccttct aatttaataa gtggtctata taaaatagaa aaataaagcc
     3781 ctctgaggaa atgtt
//
