LOCUS       NM_001399051            1928 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus target of EGR1, exonuclease (Toe1), transcript
            variant 1, mRNA.
ACCESSION   NM_001399051 XM_006238651
VERSION     NM_001399051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1928)
  AUTHORS   Lardelli,R.M., Schaffer,A.E., Eggens,V.R., Zaki,M.S., Grainger,S.,
            Sathe,S., Van Nostrand,E.L., Schlachetzki,Z., Rosti,B., Akizu,N.,
            Scott,E., Silhavy,J.L., Heckman,L.D., Rosti,R.O., Dikoglu,E.,
            Gregor,A., Guemez-Gamboa,A., Musaev,D., Mande,R., Widjaja,A.,
            Shaw,T.L., Markmiller,S., Marin-Valencia,I., Davies,J.H., de
            Meirleir,L., Kayserili,H., Altunoglu,U., Freckmann,M.L.,
            Warwick,L., Chitayat,D., Blaser,S., Caglayan,A.O., Bilguvar,K.,
            Per,H., Fagerberg,C., Christesen,H.T., Kibaek,M., Aldinger,K.A.,
            Manchester,D., Matsumoto,N., Muramatsu,K., Saitsu,H., Shiina,M.,
            Ogata,K., Foulds,N., Dobyns,W.B., Chi,N.C., Traver,D., Spaccini,L.,
            Bova,S.M., Gabriel,S.B., Gunel,M., Valente,E.M., Nassogne,M.C.,
            Bennett,E.J., Yeo,G.W., Baas,F., Lykke-Andersen,J. and Gleeson,J.G.
  TITLE     Biallelic mutations in the 3' exonuclease TOE1 cause
            pontocerebellar hypoplasia and uncover a role in snRNA processing
  JOURNAL   Nat Genet 49 (3), 457-464 (2017)
   PUBMED   28092684
REFERENCE   2  (bases 1 to 1928)
  AUTHORS   Wagner,E., Clement,S.L. and Lykke-Andersen,J.
  TITLE     An unconventional human Ccr4-Caf1 deadenylase complex in nuclear
            cajal bodies
  JOURNAL   Mol Cell Biol 27 (5), 1686-1695 (2007)
   PUBMED   17178830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 30, 2021 this sequence version replaced XM_006238651.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.17714.1,
                                           SRR26360176.527154.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000005.1  135510503-135510626 c
            125-267             JAXUCZ010000005.1  135509645-135509787 c
            268-308             JAXUCZ010000005.1  135509514-135509554 c
            309-405             JAXUCZ010000005.1  135509287-135509383 c
            406-564             JAXUCZ010000005.1  135509012-135509170 c
            565-824             JAXUCZ010000005.1  135508495-135508754 c
            825-987             JAXUCZ010000005.1  135508136-135508298 c
            988-1928            JAXUCZ010000005.1  135507116-135508056 c
FEATURES             Location/Qualifiers
     source          1..1928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1928
                     /gene="Toe1"
                     /note="target of EGR1, exonuclease"
                     /db_xref="GeneID:298443"
                     /db_xref="RGD:1309094"
     exon            1..124
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1587
                     /gene="Toe1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     target of EGR1 protein 1; target of EGR1, member 1
                     (nuclear)"
                     /codon_start=1
                     /product="target of EGR1 protein 1 isoform 1"
                     /protein_id="NP_001385980.1"
                     /db_xref="GeneID:298443"
                     /db_xref="RGD:1309094"
                     /translation="MAADSDDGVPSVPTPSDGGVNRTTQSAEEFVVRVPVVDVQSDNF
                     KEIWPSLLLALKTASFVAVDTELSGLGDRKSLLNQCIEERYKAVCHAARTRSVLSLGL
                     ACFKQQPDKGDSSYLAQVFNLTLLCMEEYVIEPKSVQFLVQHGFNFNRQYAQGIPYHK
                     GNDKGDESQSQSVRTLFLELIRARRPLVLHNGLIDLVFLYQNFYAHLPENLGTFTADL
                     CEMFPAGIYDTKYAAEFHARFVASYLEYAFRKCERENGKQRAAGSPHVALEFCSYPSS
                     MRGHIDYRCCMSPVSCRHSHTTGICDKFSAYGWCPLGPQCPQSHDIDLIIDTDEAVAE
                     DKRRRRRRKDKRKRALQSQPETQTLEEAEDGPPTKQVCEDSLKTEKIEQKVAEGDQLG
                     STQGHKDSLEMACKRTADVPTSELLVNQASPNPVPGDGLHRAGFDAFMTGYVMAYVGL
                     SKGLQLCSSEPWLPECHNKVYLSGKTVPLTVAKSQFSRPSKAHNQKMKLAWGSS"
     exon            125..267
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..308
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..405
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..564
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..824
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..987
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1928
                     /gene="Toe1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacttgctc ggggaagact aagcggaagt ctctacgttc ctatagaaag ctggctaggg
       61 gcgaggggtg tcatggcggc ggacagtgac gatggtgtgc cttcagttcc aacgccctct
      121 gacggtggtg tcaacagaac cacacaatct gcagaggagt ttgtagttcg ggttcccgtg
      181 gtagatgtgc agagtgacaa cttcaaggag atatggccat cactcttgct agccttaaag
      241 acagctagct ttgtggcggt ggacacggag ctgagtggcc ttggggatag gaagagtttg
      301 ctgaaccagt gcatcgagga acgttataag gccgtgtgtc atgctgccag gacccgttct
      361 gtcctgtccc tgggcctcgc ctgcttcaag cagcaaccag ataagggtga cagttcttac
      421 ttggctcaag tgttcaatct caccctactg tgcatggagg agtatgttat agaaccgaag
      481 tcagtacagt tcctggtaca gcatggcttc aacttcaacc ggcagtatgc tcaggggatc
      541 ccctaccata aaggcaatga caagggagat gaaagccaga gccagtcagt acggacactg
      601 ttccttgaac taattcgagc ccggcggccg ctggtgctgc acaatgggct tatagacttg
      661 gtgttcctgt accagaattt ctacgctcac ttgcctgaga acttgggaac cttcactgct
      721 gacctgtgtg agatgttccc ggcaggcatt tatgacacca aatatgctgc agagttccac
      781 gctcgatttg tggcttccta cttagaatac gctttccgga aatgtgagcg cgaaaatggg
      841 aagcagcggg cagctggcag cccacatgtt gccctggaat tctgcagcta tccttctagc
      901 atgagaggcc acattgacta ccgctgctgt atgtcccctg tgagctgccg tcattctcat
      961 accactggca tctgtgacaa gttctcggcc tatggctggt gccctctagg accacagtgt
     1021 cctcagtcac acgatattga ccttataatt gacacggatg aggctgtggc agaggacaag
     1081 cggagacggc ggcgacgtaa ggacaaacgg aagagggctt tgcagagtca accagagaca
     1141 cagaccttgg aggaagctga agatggtcct cccacaaagc aggtctgtga agatagcctc
     1201 aagactgaga aaattgaaca aaaagtggca gaaggtgatc agcttggctc cacacaaggt
     1261 cacaaagata gcttggagat ggcgtgtaag aggacagctg atgtgcctac ctcagagctg
     1321 ctggtgaacc aagccagtcc taatcctgta cccggggatg ggctgcaccg tgctgggttt
     1381 gatgccttca tgacaggtta tgtgatggcc tatgtgggcc tgagcaaggg acttcaactc
     1441 tgcagctctg aaccttggct tcctgaatgt cacaacaagg tatatctaag cggcaaaact
     1501 gtgcccctca cagtggccaa gagccagttt tcccgtcctt ccaaagccca caaccagaag
     1561 atgaagctgg cttggggcag cagctgactc caatatctgc ctgtgtttgt catcccagga
     1621 acctacatag tgaattctaa gtcgggcaga gctatgtagc aaaatagtat ttcaaataga
     1681 agtcatttga gtctttactc tatgtatgtc cgtttaactg cttacagagt tgacaagcag
     1741 gtcctgacag acacagagta ctgttttctt tgtaaactca gaggcctggg tacaagggta
     1801 aaaataaggc taactagcac ctgcaatatc aactttatta tttttttaat ctgaaagtgt
     1861 tttggggaaa gtttttttta aaaaaaaaat caacagaaat gaattatgaa aatatttgac
     1921 caacttca
//
