LOCUS       NM_001007146            2291 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Rattus norvegicus transducer of ERBB2, 2 (Tob2), mRNA.
ACCESSION   NM_001007146 XM_235503
VERSION     NM_001007146.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Perez,R.C., Yang,X., Familari,M., Martinez,G., Lovicu,F.J.,
            Hime,G.R. and de Iongh,R.U.
  TITLE     TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells
  JOURNAL   J Mol Histol 55 (1), 121-138 (2024)
   PUBMED   38165569
  REMARK    GeneRIF: TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells.
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Ajima,R., Akiyama,T., Usui,M., Yoneda,M., Yoshida,Y., Nakamura,T.,
            Minowa,O., Noda,M., Tanaka,S., Noda,T. and Yamamoto,T.
  TITLE     Osteoporotic bone formation in mice lacking tob2; involvement of
            Tob2 in RANK ligand expression and osteoclasts differentiation
  JOURNAL   FEBS Lett 582 (9), 1313-1318 (2008)
   PUBMED   18358842
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Ikematsu,N., Yoshida,Y., Kawamura-Tsuzuku,J., Ohsugi,M., Onda,M.,
            Hirai,M., Fujimoto,J. and Yamamoto,T.
  TITLE     Tob2, a novel anti-proliferative Tob/BTG1 family member, associates
            with a component of the CCR4 transcriptional regulatory complex
            capable of binding cyclin-dependent kinases
  JOURNAL   Oncogene 18 (52), 7432-7441 (1999)
   PUBMED   10602502
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085117.1.
            
            On Nov 22, 2004 this sequence version replaced XM_235503.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            39 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085117.1, CK480859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2291              BC085117.1         40-2330
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2291
                     /gene="Tob2"
                     /note="transducer of ERBB2, 2"
                     /db_xref="GeneID:315159"
                     /db_xref="RGD:1359722"
     exon            1..153
                     /gene="Tob2"
                     /inference="alignment:Splign:2.1.0"
     exon            154..2286
                     /gene="Tob2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1286
                     /gene="Tob2"
                     /codon_start=1
                     /product="protein Tob2"
                     /protein_id="NP_001007147.1"
                     /db_xref="GeneID:315159"
                     /db_xref="RGD:1359722"
                     /translation="MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHW
                     YPEKPLRGSGFRCVHIGEVVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQ
                     IGEKGAVKVLYLGDGEVGGAQELDKEIKSSFNPDAQVFVPIGSQDSSLSSSPSPSFGQ
                     SPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGASSGVSVSGSGAGGQQPPSQQP
                     RLARSPTNNLLKHKSLSLSMHSLNFITANPGPQSQLSPNAKEFVYNGGGSPSSLFFDG
                     VDGPGTSAAAPFGSSGASTCNSSSFDVAQVFGGGANSLFLEKTPFVEGLSYNLNTMQY
                     PNQPFQPVVLAN"
ORIGIN      
        1 agcggaaaga atcacatgag ctcggtcctc gtctctctct accctcaacg acgtaaaagg
       61 acaccgtggc cctcagcctc gcggcgcccg ggaagctgag agggagagac ctccgtcccg
      121 cggcctgcag agcgaccctt cgcggagacc cgaaagcctc tggaccccag gatcactctc
      181 ctttcctgct gctgcccttg gcctgtgccc gtggcctgtg cgggttctca gcctagaaga
      241 ggatcatgca gctggagatc aaagtggccc taaacttcat catctcctac ttatacaaca
      301 agctgccccg tcgcagggca gatctgttcg gggaggagct agagcggctt ttgaagaaga
      361 aatatgaagg ccactggtac cctgagaagc cgctgagggg ttccggcttc cgctgcgtcc
      421 acattgggga agtcgtagac cctgtggtgg agctggctgc caagcggagt ggcctggcag
      481 tggaggatgt gcgcgccaac gtgcccgaag agctgagtgt ctggattgac cctttcgagg
      541 tatcctacca gattggtgag aagggagctg tgaaggtcct gtacctgggg gacggtgagg
      601 tgggcggtgc ccaagagctg gacaaggaga tcaagagcag cttcaatccc gacgcccagg
      661 tgtttgtgcc catcggcagc caggacagct ccctgtccag ctctccctca ccatcctttg
      721 gccagtcccc cagccccacc ttcatccccc ggtctgccca gcccatcacc ttcactactg
      781 cctcctttgc tgccaccaag tttggttcca ccaagatgaa gaagggtggt ggggcctcaa
      841 gcggtgtgag tgtgagcggc agcggggcag gcggccagca gccaccgtcc cagcagcctc
      901 gcctggcccg ctcccccaca aataacctgc tgaagcacaa gagcctctct ttgtctatgc
      961 attcactgaa cttcatcaca gccaacccgg gcccccagtc ccagctctcc cccaatgcca
     1021 aggagtttgt gtacaacggt ggtggttcgc ccagcagcct cttcttcgac ggggtggatg
     1081 gcccgggcac cagtgctgcc gccccctttg ggagtagcgg tgccagcact tgcaacagca
     1141 gcagcttcga cgtggcccag gtgtttggag gtggtgctaa cagcctgttc ctggagaaaa
     1201 cgcccttcgt agaaggcctc agctacaacc tgaacaccat gcagtatccc aaccagccct
     1261 tccagcctgt cgtgctggcc aactgaccat cttcctgtct gccaggccag gagcccccac
     1321 cgccacagga aagagaaagg aaagaccaac cgaaagaggg gaagcaaact atagaaaagg
     1381 atcccagtct tctcattctc ccggctagga aaacagttcg cccaggcacg gagtaggagg
     1441 ggctctggaa gcacggagcg ttgaacttgc tcgccctgac tctttccctg cctgcctctg
     1501 atttcatcgg gttggtttgg attttgtaac ttttttttac atgtagtttt ctatatgaca
     1561 tctttaatga gtggtttcct gtgctaagag tggcccagat gtgaatcact gctccctcct
     1621 ccatgctccc tggggttggc ttgggcaaaa gctggagtgg ggagaggctg gccccgcatc
     1681 cacggccccc accctagctg tcttctcagg ccctgccacc aaataggtct ggccctagcc
     1741 tcaattccct ctcaggctgg gccacaggaa gctgctgact ggccgcttga caccctcccc
     1801 ttaaagctac tatctgtgat tataggaagg ttagcacttt ctctaatgga agtctttgtc
     1861 ttgtggcccc atcccttacc ggctcttggc ctggacgaga tctatgcagc cccttcctcc
     1921 agtgcagcct ttccctgagc ctgaggtgag ggcagagttt agagtagggc taagtgtatg
     1981 ttttcatgtg tgcattcatg cctgtgcgtg tgtggcttgc tgtcatggtc tcaaggattc
     2041 cgagccactc ggatcttccc tctgtagatg tgaccctggg ttgtatcaag tgcttattta
     2101 tgtaccaggt tgggggatgg acccagggtg ggttgatagt ccatttgtaa ggcagtatat
     2161 gtgtggggat gacaagtggc taagccgaag aaaccccagg ggaaagcgct gcataaggaa
     2221 ctgggtttcc agactgcaga gggatctgca cttttgtttg tttttgacca aaaaaaaaaa
     2281 aaaaaaaaaa a
//
