LOCUS       NM_133317               2039 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus transducer of ErbB-2.1 (Tob1), mRNA.
ACCESSION   NM_133317
VERSION     NM_133317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Perez,R.C., Yang,X., Familari,M., Martinez,G., Lovicu,F.J.,
            Hime,G.R. and de Iongh,R.U.
  TITLE     TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells
  JOURNAL   J Mol Histol 55 (1), 121-138 (2024)
   PUBMED   38165569
  REMARK    GeneRIF: TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells.
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Doidge,R., Mittal,S., Aslam,A. and Winkler,G.S.
  TITLE     The anti-proliferative activity of BTG/TOB proteins is mediated via
            the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the
            Ccr4-not complex
  JOURNAL   PLoS One 7 (12), e51331 (2012)
   PUBMED   23236473
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Hosoda,N., Funakoshi,Y., Hirasawa,M., Yamagishi,R., Asano,Y.,
            Miyagawa,R., Ogami,K., Tsujimoto,M. and Hoshino,S.
  TITLE     Anti-proliferative protein Tob negatively regulates CPEB3 target by
            recruiting Caf1 deadenylase
  JOURNAL   EMBO J 30 (7), 1311-1323 (2011)
   PUBMED   21336257
REFERENCE   4  (bases 1 to 2039)
  AUTHORS   Horiuchi,M., Takeuchi,K., Noda,N., Muroya,N., Suzuki,T.,
            Nakamura,T., Kawamura-Tsuzuku,J., Takahasi,K., Yamamoto,T. and
            Inagaki,F.
  TITLE     Structural basis for the antiproliferative activity of the
            Tob-hCaf1 complex
  JOURNAL   J Biol Chem 284 (19), 13244-13255 (2009)
   PUBMED   19276069
REFERENCE   5  (bases 1 to 2039)
  AUTHORS   Miyasaka,T., Morita,M., Ito,K., Suzuki,T., Fukuda,H., Takeda,S.,
            Inoue,J., Semba,K. and Yamamoto,T.
  TITLE     Interaction of antiproliferative protein Tob with the CCR4-NOT
            deadenylase complex
  JOURNAL   Cancer Sci 99 (4), 755-761 (2008)
   PUBMED   18377426
REFERENCE   6  (bases 1 to 2039)
  AUTHORS   Jin,M., Wang,X.M., Tu,Y., Zhang,X.H., Gao,X., Guo,N., Xie,Z.,
            Zhao,G., Jing,N., Li,B.M. and Yu,L.
  TITLE     The negative cell cycle regulator, Tob (transducer of ErbB-2), is a
            multifunctional protein involved in hippocampus-dependent learning
            and memory
  JOURNAL   Neuroscience 131 (3), 647-659 (2005)
   PUBMED   15730870
REFERENCE   7  (bases 1 to 2039)
  AUTHORS   Maekawa,M., Nishida,E. and Tanoue,T.
  TITLE     Identification of the Anti-proliferative protein Tob as a MAPK
            substrate
  JOURNAL   J Biol Chem 277 (40), 37783-37787 (2002)
   PUBMED   12151396
REFERENCE   8  (bases 1 to 2039)
  AUTHORS   Yoshida,Y., Tanaka,S., Umemori,H., Minowa,O., Usui,M., Ikematsu,N.,
            Hosoda,E., Imamura,T., Kuno,J., Yamashita,T., Miyazono,K., Noda,M.,
            Noda,T. and Yamamoto,T.
  TITLE     Negative regulation of BMP/Smad signaling by Tob in osteoblasts
  JOURNAL   Cell 103 (7), 1085-1097 (2000)
   PUBMED   11163184
REFERENCE   9  (bases 1 to 2039)
  AUTHORS   Matsuda,S., Kawamura-Tsuzuku,J., Ohsugi,M., Yoshida,M., Emi,M.,
            Nakamura,Y., Onda,M., Yoshida,Y., Nishiyama,A. and Yamamoto,T.
  TITLE     Tob, a novel protein that interacts with p185erbB2, is associated
            with anti-proliferative activity
  JOURNAL   Oncogene 12 (4), 705-713 (1996)
   PUBMED   8632892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 23, 2005 this sequence version replaced NM_133317.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF349723.1, SRR26643291.28998.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2039              JAXUCZ010000010.1  79659993-79662031
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2039
                     /gene="Tob1"
                     /note="transducer of ErbB-2.1"
                     /db_xref="GeneID:170842"
                     /db_xref="RGD:621126"
     exon            1..2039
                     /gene="Tob1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1251
                     /gene="Tob1"
                     /note="transducer of ERBB2, 1"
                     /codon_start=1
                     /product="protein Tob1"
                     /protein_id="NP_579851.2"
                     /db_xref="GeneID:170842"
                     /db_xref="RGD:621126"
                     /translation="MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKQKYEGHW
                     YPEKPYKGSGFRCIHVGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQ
                     IGEKGPVKVLYVDDSNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHS
                     AAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSSKVARTSPISLGLNVNVNDL
                     LKQKAISSSMHSLYGLGLGSQQQPQPQPQQPPSQPPPPPPPPQQQQQQQQQQQQQQQQ
                     QQQQPQQQTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAY
                     GGLNEKSFVDGLNFSLNNIQYSNQQFQPVMAN"
ORIGIN      
        1 gaacaagacc acggaaggtt gaaggataat cttctagtac cagcactttg aatgagaatt
       61 tgtttctctg ccacaaactg attttttttt taaattttat ttttctggtg gaggagttga
      121 aacaaaccta ccttttgtgg catcgcagct atgcagcttg aaattcaagt agcactaaat
      181 tttattattt cctatttgta caataagctt cccaggagac gtgtcaacat ttttggtgaa
      241 gaacttgaaa gacttcttaa acagaaatat gaagggcatt ggtatcctga gaagccatac
      301 aaaggctcag ggtttagatg catacacgta ggggagaagg tggacccggt gatcgagcaa
      361 gcgtccaaag agagtggtct ggacattgac gatgttcgtg gcaatctgcc gcaggatctg
      421 agcgtgtgga tcgacccgtt tgaggtttcc taccaaatcg gtgagaaggg accagtgaag
      481 gtgctgtacg tagatgacag taatgagaac gggtgtgagc tggataagga gatcaagaac
      541 agctttaacc ctgaggccca ggttttcatg cccataagcg acccagcctc ctctgtgtcc
      601 agctcgccgt cgcctccctt tggccattct gctgccgtca gccccacctt catgccccgg
      661 tccactcagc ctttaacctt taccactgcc acttttgctg ccaccaagtt tggctccacc
      721 aaaatgaaga acagtggccg tagcagcaag gtagcacgca cttctcccat cagcctgggc
      781 ctgaatgtca atgtgaacga cctcctgaag cagaaagcca tctcttcctc aatgcactct
      841 ctgtacgggc tgggcctggg cagccagcag cagcctcagc cgcagccgca gcagccgcca
      901 tcccagccac caccgccgcc accacctcca cagcagcagc agcagcagca gcagcagcag
      961 cagcagcagc agcaacagca gcagcagcag ccgcagcagc aaacctctgc tctttctccc
     1021 aatgccaagg aatttatttt tcctaacatg cagggtcaag gtagtagtac caatggaatg
     1081 ttcccaggtg acagccccct taacctcagt cccctccagt acagtaatgc ctttgatgtg
     1141 tttgcggcct acggaggcct caacgagaag tctttcgtag acggcttgaa ttttagctta
     1201 aataacattc agtattctaa ccagcagttc cagcccgtaa tggctaacta aaaaaacagg
     1261 aaaagagaga acatgtgtcg tacaagttaa aatgcatcgg cccaaggggg actttttttt
     1321 ttttttttgc ctccttgaga tttttttttt aagcttatag taaggataca ttcaagcttg
     1381 gtcacaaaat aaaacatgca tcttttttca tttgccaacc aagcacaatg ttattttata
     1441 ctgactgtat attttaaagt atactttcag atatggcctc ttacagtatt taagatatag
     1501 caaggacatg gctgattttt ttttatatat atatataaaa aattggcact aataagtggg
     1561 tttattggtc ttttctaatt gtataattta atttagtaca aagtttgtaa actatcagag
     1621 gatatatata tatatacata tatatattgt ttctacgaca cggtattgca tttctatctt
     1681 tttactacag tgatctgtgg cagcggcttc atgttgtatt ttttttactg aaattgtaaa
     1741 atatccatct taaagacatc aactattctg aaaattgtgt acaggatatt cctttagtgg
     1801 tggaattaaa atgtacgaat atttgctttt tcaaaaaaat gtattttctg ttaaaggttt
     1861 aaagattttt gctatatatt atggaagaaa atgtaatcgt aaatattaat tttgtaccta
     1921 tattgtgcaa tacttgaaaa aaaaacggta taaaagtatt ttgagtcagt gtcttacatg
     1981 ttaagaggga ctgaaatagt ttatattaag tttgtattaa aattctttaa aattaaaaa
//
