LOCUS       NM_001108114            4822 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus tensin 2 (Tns2), mRNA.
ACCESSION   NM_001108114 XM_001066149 XM_001066207 XM_001066264 XM_235710
VERSION     NM_001108114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4822)
  AUTHORS   Eom,T., Muslimov,I.A., Tsokas,P., Berardi,V., Zhong,J.,
            Sacktor,T.C. and Tiedge,H.
  TITLE     Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent
            translational control
  JOURNAL   J Cell Biol 207 (2), 237-252 (2014)
   PUBMED   25332164
REFERENCE   2  (bases 1 to 4822)
  AUTHORS   Koh,A., Lee,M.N., Yang,Y.R., Jeong,H., Ghim,J., Noh,J., Kim,J.,
            Ryu,D., Park,S., Song,P., Koo,S.H., Leslie,N.R., Berggren,P.O.,
            Choi,J.H., Suh,P.G. and Ryu,S.H.
  TITLE     C1-Ten is a protein tyrosine phosphatase of insulin receptor
            substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy
  JOURNAL   Mol Cell Biol 33 (8), 1608-1620 (2013)
   PUBMED   23401856
REFERENCE   3  (bases 1 to 4822)
  AUTHORS   Moon,K.D., Zhang,X., Zhou,Q. and Geahlen,R.L.
  TITLE     The protein-tyrosine kinase Syk interacts with the C-terminal
            region of tensin2
  JOURNAL   Biochim Biophys Acta 1823 (2), 199-205 (2012)
   PUBMED   22019427
REFERENCE   4  (bases 1 to 4822)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 4822)
  AUTHORS   Yam,J.W., Ko,F.C., Chan,C.Y., Jin,D.Y. and Ng,I.O.
  TITLE     Interaction of deleted in liver cancer 1 with tensin2 in caveolae
            and implications in tumor suppression
  JOURNAL   Cancer Res 66 (17), 8367-8372 (2006)
   PUBMED   16951145
REFERENCE   6  (bases 1 to 4822)
  AUTHORS   Tamura,K., Manabe,N., Uchio,K., Miyamoto,M., Yamaguchi,M.,
            Ogura,A., Yamamoto,Y., Nagano,N., Furuya,Y. and Miyamoto,H.
  TITLE     Characteristic changes in carbohydrate profile in the kidneys of
            hereditary nephrotic mice (ICGN strain)
  JOURNAL   J Vet Med Sci 62 (4), 379-390 (2000)
   PUBMED   10823724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1 and BF419140.1.
            
            On Aug 21, 2019 this sequence version replaced NM_001108114.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This record is based on transcript
            alignments from orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.30453.1,
                                           SRR26643296.21035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000007.1  135112559-135112835
            278-386             JAXUCZ010000007.1  135114262-135114370
            387-424             JAXUCZ010000007.1  135114796-135114833
            425-463             JAXUCZ010000007.1  135115693-135115731
            464-502             JAXUCZ010000007.1  135116035-135116073
            503-552             JAXUCZ010000007.1  135116237-135116286
            553-724             JAXUCZ010000007.1  135116503-135116674
            725-775             JAXUCZ010000007.1  135116964-135117014
            776-898             JAXUCZ010000007.1  135117310-135117432
            899-963             JAXUCZ010000007.1  135117519-135117583
            964-1047            JAXUCZ010000007.1  135118683-135118766
            1048-1160           JAXUCZ010000007.1  135119156-135119268
            1161-1221           JAXUCZ010000007.1  135119348-135119408
            1222-1297           JAXUCZ010000007.1  135119564-135119639
            1298-1427           JAXUCZ010000007.1  135120172-135120301
            1428-1493           JAXUCZ010000007.1  135120387-135120452
            1494-1607           JAXUCZ010000007.1  135120529-135120642
            1608-2819           JAXUCZ010000007.1  135120742-135121953
            2820-2967           JAXUCZ010000007.1  135122091-135122238
            2968-3533           JAXUCZ010000007.1  135122325-135122890
            3534-3623           JAXUCZ010000007.1  135122993-135123082
            3624-3749           JAXUCZ010000007.1  135123374-135123499
            3750-3842           JAXUCZ010000007.1  135123708-135123800
            3843-3920           JAXUCZ010000007.1  135123918-135123995
            3921-3998           JAXUCZ010000007.1  135124084-135124161
            3999-4167           JAXUCZ010000007.1  135124600-135124768
            4168-4236           JAXUCZ010000007.1  135125677-135125745
            4237-4266           JAXUCZ010000007.1  135125846-135125875
            4267-4804           JAXUCZ010000007.1  135125967-135126504
            4805-4822           BF419140.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4822
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /note="tensin 2"
                     /db_xref="GeneID:315326"
                     /db_xref="RGD:1310917"
     exon            1..277
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..4405
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /EC_number="3.1.3.48"
                     /note="tensin-like C1 domain-containing phosphatase;
                     tensin like C1 domain containing phosphatase (tensin 2)"
                     /codon_start=1
                     /product="tensin-2"
                     /protein_id="NP_001101584.2"
                     /db_xref="GeneID:315326"
                     /db_xref="RGD:1310917"
                     /translation="MKSSGPVERLLRALGRRDSSRATSRPRKAEPHSFREKVFRKKAP
                     VCAVCKVTIDGTGVSCRVCKVATHRKCEAKVTSSCQALPPAELRRNTAPVRRIEHLGS
                     TKSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRE
                     LAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVHDFGWPELHAPPLDKLCSICKAMETW
                     LSADPQHVVVLYCKGSKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKAAMEL
                     QPSQHRYVGYFSGLLSGSIRMNSSPLFLHYVFVPVLPAFEPNTGFQPFLKIYQSMQLV
                     YTSGVYHITGPGPRQICISLEPALLLKGDVMVTCYHKGGQGTDRTLVFRVQFHTCTIH
                     GPRLNFPKDQLDEAWADERFPFQASVEFVFSSSPEKVKGNTPRNDPSVSVDYNMTEPA
                     VRWDSYENFNQHHEDSVDGSLAHTRGPLDGSPYAQVQRVPRQTPPAPSPELPPPPMLS
                     VSSDSGHSSTLTTEHTAESPGRPPPTAAERQELDRLLGGCGVASAGRGAGRETAILDD
                     EEQPSVGGGLHLGMYPGHRPGLSRRCSCRQGLREPCGVPNGGYYRPEGTLERRRPPYG
                     GYEGHPQGYTEASVEKRRLCRSLSEGPYPYAPELGKPANGDFGYRPAGYREVVILEDP
                     GVPALCSCPACEEKMALPTAALYGLRLEREAGEGWSSEVGKPLLHPVRPGHPLPLLVP
                     ACGHHHAPVPDYGCLKSPKVGEEGHEGCSYAVCPEGRYGHPGYPALVTYGYGGAVPSY
                     CPAYGRAPHSCGSPSEGRGYPSPGAHSPQAGSVSPGSPPYLQSRKLGYEAPAEDGRDK
                     YSLPGPLASAGPLASTESPEPSWRDGSSGHSTLPRSPRDAQCSASSELSGPSTPLHTS
                     SPVQGKESTRRQDTTRSPSLAPTQRLSPGEALPSVVQGVTEKTPELLASSRPEPLDPS
                     PFSQTSTPSSPNGWPQERSPGGHTNSASPRSPVPTTLPGLRHAPWQGPQGPSDSPDGS
                     PLTPVPTQMPWLVGSPEPPQSSPTPAFPLATSYETNGPTQPPLPEKRHLPGSGQQSSP
                     PARGTNQHVTFASPLPDVTQPPEHPLQENQSSVKFVQDTSKFWYKPHLSRDQAIALLK
                     DKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPSEQLVRHFLIETGPKGVKI
                     KGCPTEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETSEAPVPTNMSTAADLLR
                     QGAACSVLYLTSVETESLTGPQAVARASSAALSCSPVPVPAIVHFKVSAQGITLTDNQ
                     RKVFFRRHYPVNSITFSSTDPQDRRWTNPDGTTSKIFGFVAKKPGSPWENVCHLFAEL
                     DPDQPASAIVTFITKVLLGQRK"
     exon            278..386
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..424
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..463
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..502
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..552
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..724
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..775
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..898
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..963
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1047
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1160
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1221
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1297
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1427
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1493
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1607
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..2819
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2967
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3533
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3623
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3749
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3842
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3920
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..3998
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4167
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4236
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4266
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4805
                     /gene="Tns2"
                     /gene_synonym="Tenc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacttcctgg agcagcgacc tgcccccttc ccgcctgcac ttccctccac ttccagggcc
       61 aggcttctcc acacaccagc cagacagcct cccctccacc caagggaagc ggctgcctcg
      121 gccaggctgc ttccaggaag ccccgggcca ggccccagca ttgttcaggc ccagcaacca
      181 agagcccagc cagccagaca ccatgaagtc cagcggccct gtggaaaggt tgctcagagc
      241 cctggggagg agggacagca gccgggccac cagcaggcct aggaaagcag aaccgcacag
      301 cttccgggag aaggttttcc ggaagaaggc tccagtgtgt gcagtgtgta aggtgaccat
      361 cgatgggacc ggtgtctcgt gccgagtctg caaggtggcc acacacagaa aatgtgaagc
      421 aaaggtgact tcatcctgtc aggccttgcc ccccgcggag ctgcggagaa acacagcccc
      481 agtccggcgc atagaacacc tggggtccac caagtctctg aaccactcaa agcaacgcag
      541 tactctaccc aggagcttca gcctggatcc gctcatggag cgtcgctggg acttggacct
      601 cacctatgta acagagcgga tcctggccgc agcttttcct gcacgaccag acgagcagcg
      661 acaccgaggc cacttgcgag agctggccca tgtgcttcaa tccaagcacc gagacaagta
      721 cctgctcttc aacctttcag agaaacggca tgacttgacc cgcctgaacc ccaaggtaca
      781 tgactttggc tggccggaat tacatgcccc acctctggac aagttgtgtt ccatctgcaa
      841 agccatggag acgtggctca gtgccgaccc tcagcatgtg gtcgtgttat actgcaaggg
      901 tagcaaaggc aagcttggag tcatcgtctc tgcctatatg cactatagca agatctctgc
      961 aggggcagac caagcgctgg caaccctcac catgaggaaa ttctgtgagg acaaggcggc
     1021 catggaactg cagccctccc agcaccgcta tgtcggctat ttcagcgggc tgctgtcagg
     1081 ctccatcaga atgaacagca gccctctctt cctgcactat gtgtttgtac ccgtgctgcc
     1141 agcctttgag cccaacacag gcttccaacc cttcctcaag atctaccagt ctatgcagct
     1201 ggtctacaca tctggagtct accacatcac aggtccaggg ccccgccaga tttgcatcag
     1261 cctggagcca gcccttctcc tcaaaggcga cgtcatggtg acctgctacc acaagggtgg
     1321 tcaggggaca gaccggaccc ttgtgttccg agttcagttc cacacgtgta ccatccatgg
     1381 gccacggctc aacttcccca aggaccagct agatgaggcc tgggctgatg agcggttccc
     1441 tttccaagcc tcggtggagt ttgtcttctc ctccagccct gagaaggtca aaggcaacac
     1501 cccacggaat gatccctctg tctcagtgga ttacaacatg acagagcctg ctgtacgctg
     1561 ggactcctat gaaaacttca accagcacca tgaggacagt gtggacggct ccttggccca
     1621 cacaaggggc cccctggatg gcagtcctta tgcccaggtg cagcgggtcc cccgacagac
     1681 accaccggca ccttctccag agcttccccc acccccgatg ctctctgtca gcagtgactc
     1741 cggccactca tccacactta ccacagaaca cacagcagaa tcccctggcc ggccgccccc
     1801 gactgctgct gagagacagg agctagatcg tctgctggga ggctgtggag tggccagtgc
     1861 gggccgtggt gctgggcgag agacagccat cctagatgat gaagagcagc cctctgtggg
     1921 tggaggcctg caccttggga tgtatccggg ccacaggcct ggcctcagtc gccgctgctc
     1981 ctgccgtcag ggcctccggg agccttgtgg ggtccccaat gggggctact accgacctga
     2041 gggaacccta gagagacgaa gaccacccta tgggggctat gagggacacc cccagggcta
     2101 cacagaagcc tctgtggaga agaggcgtct ctgcaggtca ctatcagaag gaccgtaccc
     2161 ctatgcacct gagctgggga aaccagccaa tggagacttt ggctaccgcc cagcaggcta
     2221 ccgggaggtg gtgatcctag aggaccccgg agtgcctgct ttatgctcat gccctgcctg
     2281 tgaggagaag atggcactgc ccactgcagc cctgtatgga ctgcgactag agagagaggc
     2341 tggagagggg tggtccagtg aggttggcaa gcctctcctg cacccagtga ggcctggaca
     2401 cccattgcct ctgctggtgc ctgcctgtgg gcaccaccat gctccagtgc ctgactatgg
     2461 ctgcctgaag tcacccaagg tgggtgagga agggcatgag ggctgctcct atgccgtgtg
     2521 ccctgaaggc aggtacgggc atccagggta ccctgccctg gtaacctatg gctacggagg
     2581 agcagttccc agctactgcc cagcatatgg ccgggcgcct cacagttgtg ggtccccaag
     2641 tgaaggcaga gggtacccca gccctggtgc ccactcacca caggctggtt ctgtgtcccc
     2701 gggaagtcca ccctacctgc aatccaggaa gctgggttat gaggctcctg ccgaggatgg
     2761 gagagacaag tactcacttc ctgggcccct ggcctcagca ggacccttgg cttctacaga
     2821 gtcccctgaa ccatcctgga gggatggctc cagtggacac agcacactgc ctcgttctcc
     2881 ccgagatgcc cagtgcagtg cctcttcaga gctgtccggt ccctccacac ccttgcacac
     2941 cagcagccca gttcagggca aggagagcac ccgacggcaa gacaccacca ggtctccctc
     3001 cttggcaccc actcagagac tgagtcctgg cgaggccttg ccctctgttg tacagggagt
     3061 cactgaaaag actcctgagc tgttggcaag cagcaggcct gagccactgg accctagccc
     3121 cttttcccag acctctacac ccagctcacc caatggctgg cctcaagaaa ggagcccagg
     3181 gggccacacc aacagtgcca gtcctcggag ccctgtgcca accaccctgc ccggactccg
     3241 ccatgcccca tggcagggcc ctcagggccc ctcagatagc ccagatggct cccctcttac
     3301 tcctgtgcct acccagatgc cctggcttgt gggcagccca gaaccacctc agagctcacc
     3361 cacccctgcg tttcccctgg ctacctccta cgagaccaac ggtcccactc agcctccact
     3421 tcctgaaaaa cgacacctgc cggggtctgg gcagcagtca tcgccaccag ccagaggcac
     3481 caatcagcat gtcacctttg catctcctct cccagatgtc acccaacccc cagagcaccc
     3541 tttacaagag aaccaaagca gtgtcaagtt tgtccaggat acatcaaagt tctggtacaa
     3601 gcctcacctt tcccgagacc aagccattgc cctgctgaaa gacaaggatc ctggggcctt
     3661 cctgatcaga gacagtcact ctttccaggg agcctatggg ttagccctca aagtggccac
     3721 acccccaccc agcgcccagc catggaaagg ggacccctca gaacagctgg tccgccattt
     3781 cctcattgag actggaccca aaggtgtgaa gatcaagggt tgtcccactg agccctattt
     3841 tggaagcctg tctgccctgg tctcacagca ctccatttct cccatctccc tgccctgctg
     3901 tctgcgaatt cctagtaaag atcctctgga agaaacctca gaggccccag tgcccaccaa
     3961 catgagcacg gcagcagacc tcctacgcca gggagcagcc tgcagtgtgc tctacctgac
     4021 ctcggtggag acagagtcat tgactggccc tcaagctgtg gccagggcca gctctgcagc
     4081 tctgagctgc agccctgtcc cagtgccagc cattgtccac ttcaaggtct cagctcaagg
     4141 catcacactg acagacaacc agagaaaggt cttctttcgc cgccattacc cagtgaacag
     4201 catcactttc tctagcactg acccccagga ccgcagatgg accaacccag atgggaccac
     4261 ctccaagatc tttggtttcg tggccaagaa gccaggaagt ccctgggaaa atgtgtgtca
     4321 cctctttgcg gagcttgacc cagaccaacc tgcaagtgcc attgtcacct tcatcaccaa
     4381 agttctactg ggccagagaa aatgaagcca ccagctccaa gtccacatca acactgcacc
     4441 ctcccagcat cacagccctc actaccctgg cctggcccct atgagaaaga gtggcagcag
     4501 tggggccact gctctttcct gccctttgcc tgctaagcta atgaatgggc ccctgagatg
     4561 acctggcacg tgagcggatg gcagagacag gtgtgagggg tgaggaggca tcagtaagtg
     4621 gagccctgga ggggaatgac cctgccagct ccacccagct tgcagggccc atcatggagg
     4681 gagaggggag aggcttggga gcttcctgcc tcccctctaa acagagacca gagtggggtc
     4741 acataaacag agggaagaga gagtctattt ttgtgtaata ataaagaatt tctataaact
     4801 cttgaaaaaa aaaaaaaaaa aa
//
