LOCUS       NM_001191810           10134 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus tensin 1 (Tns1), mRNA.
ACCESSION   NM_001191810 XM_237286
VERSION     NM_001191810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10134)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 10134)
  AUTHORS   Kuo JC, Han X, Hsiao CT, Yates JR 3rd and Waterman CM.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 10134)
  AUTHORS   Chen H, Duncan IC, Bozorgchami H and Lo SH.
  TITLE     Tensin1 and a previously undocumented family member, tensin2,
            positively regulate cell migration
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 733-738 (2002)
   PUBMED   11792844
REFERENCE   4  (bases 1 to 10134)
  AUTHORS   Chen H, Ishii A, Wong WK, Chen LB and Lo SH.
  TITLE     Molecular characterization of human tensin
  JOURNAL   Biochem J 351 Pt 2 (Pt 2), 403-411 (2000)
   PUBMED   11023826
REFERENCE   5  (bases 1 to 10134)
  AUTHORS   Lo SH, Yu QC, Degenstein L, Chen LB and Fuchs E.
  TITLE     Progressive kidney degeneration in mice lacking tensin
  JOURNAL   J Cell Biol 136 (6), 1349-1361 (1997)
   PUBMED   9087448
REFERENCE   6  (bases 1 to 10134)
  AUTHORS   Jankowski SA and Gumucio DL.
  TITLE     Genes for tensin, villin and desmin are linked on mouse chromosome
            1
  JOURNAL   Mamm Genome 6 (10), 744-745 (1995)
   PUBMED   8563175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000215.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001191810.3.
            
            On Nov 8, 2022 this sequence version replaced NM_001191810.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JACYVU010000215.1  8772294-8772542     c
            250-364             JACYVU010000215.1  8727394-8727508     c
            365-402             JACYVU010000215.1  8716442-8716479     c
            403-444             JACYVU010000215.1  8664471-8664512     c
            445-486             JACYVU010000215.1  8652994-8653035     c
            487-537             JACYVU010000215.1  8651752-8651802     c
            538-599             JACYVU010000215.1  8646486-8646547     c
            600-780             JACYVU010000215.1  8644648-8644828     c
            781-831             JACYVU010000215.1  8642848-8642898     c
            832-954             JACYVU010000215.1  8641779-8641901     c
            955-1019            JACYVU010000215.1  8641354-8641418     c
            1020-1103           JACYVU010000215.1  8639913-8639996     c
            1104-1216           JACYVU010000215.1  8635723-8635835     c
            1217-1277           JACYVU010000215.1  8635314-8635374     c
            1278-1353           JACYVU010000215.1  8635143-8635218     c
            1354-1483           JACYVU010000215.1  8634506-8634635     c
            1484-1549           JACYVU010000215.1  8631119-8631184     c
            1550-1666           JACYVU010000215.1  8629721-8629837     c
            1667-3247           JACYVU010000215.1  8603424-8605004     c
            3248-3444           JACYVU010000215.1  8593490-8593686     c
            3445-3520           JACYVU010000215.1  8592595-8592670     c
            3521-3613           JACYVU010000215.1  8588729-8588821     c
            3614-3637           JACYVU010000215.1  8587889-8587912     c
            3638-3676           JACYVU010000215.1  8587458-8587496     c
            3677-3875           JACYVU010000215.1  8579479-8579677     c
            3876-4945           JACYVU010000215.1  8576182-8577251     c
            4946-5032           JACYVU010000215.1  8573258-8573344     c
            5033-5164           JACYVU010000215.1  8572374-8572505     c
            5165-5257           JACYVU010000215.1  8571926-8572018     c
            5258-5335           JACYVU010000215.1  8571072-8571149     c
            5336-5407           JACYVU010000215.1  8569412-8569483     c
            5408-5576           JACYVU010000215.1  8569013-8569181     c
            5577-5645           JACYVU010000215.1  8568185-8568253     c
            5646-5678           JACYVU010000215.1  8567813-8567845     c
            5679-10134          JACYVU010000215.1  8561577-8566032     c
FEATURES             Location/Qualifiers
     source          1..10134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..10134
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /note="tensin 1"
                     /db_xref="GeneID:301509"
                     /db_xref="RGD:68427"
     exon            1..249
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..5823
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /codon_start=1
                     /product="tensin-1"
                     /protein_id="NP_001178739.1"
                     /db_xref="GeneID:301509"
                     /db_xref="RGD:68427"
                     /translation="MGCTVSLVCCEALEPLPSCGPQPPGTPPGPARPERSEPGGAASI
                     QRRRLLLQPEDLEAPKTHHFKVKAFKKVKPCGVCRQAITREGCICKVCSFSCHRKCQA
                     KVAAPCVPPSSHELVPIATESVPKNVVDVGEGDCRGGSTPKNLEEAGSMRVSPSIQPQ
                     PQPQPQPISLSRNLSVSRAMEDSCELDLVYITERIIAVSFPSTANEENFRSNLREVAQ
                     MLKSKHGGNYLLFNLSEQRPDITKLHAKVLEFGWPDLHTPALEKICSVCKAMDTWLNA
                     DPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPS
                     QRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTS
                     GIYNIPGDSQASICITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLG
                     VVFGKEDLDEAFKDDRFPDYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIR
                     WDSYDNFNGHREDGMEEVVGHTQGPLDGSLYAKVKKKDSLNGSSGPITTARPALSATP
                     NHVEHTLSVSSDSGNSTASTKTDKTDEPVSGAAIAPAALSPQEKKELDRLLSGFGVDR
                     EKQGAMYRAQQLRSHPGGGPTVSSPGRHIVPAQVHVNGGALASERETDILDDELPIQD
                     GQSGGSMGTLSSLDGVTNTSEGGYPETLSPLTNGLDKPYPTEPILNGGGYPYESANRV
                     VPVHSSHSAPIRPSYSAQEGLGGYQREGPHPAWSKQVTSAHRGYDPSGLFRSQSFPDV
                     EPQLPQAPARGGSSREAVQRGLNSWQQQQQQQQQQQQQQQQQQQQQPHPPPRQQERSP
                     LQSLACSKPSPHLSAETPIPALPEFPRAASQQEIEQSIETLNMLMLDLEPASAAAPLH
                     KSQSVPGAWPGASPLSSQPLLGSSCQSHPLTQSRSGYIPSGDTLGAPELLSSGRSYSP
                     YDYQLHPAASNQSFRPKSPASSTFLPSPHSSAGPQEPPASLPGLIAEPQLPLKETTSD
                     TSRTPEEEPLNLEGLVAHRVAGVQARERQPAEPPAPLRRRAASDGQYENQSPEATSPR
                     SPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSVARSP
                     PGLAKTPLSALGLKPHNPADILLHPTGVARRLIQPEEDEGEEVAKPPEEPRSYVESVA
                     RTAVAGPRAQDVEPKSFSAPATHAYGHETPLRNGTPGGSFVSPSPLSTSSPILSADST
                     SVGSFPSAGSSDQGPRTPIQPMLDSSIRSGSLGQPSPAALSYQSSSPVPVGGSSYSSP
                     DYSLQPFSSSPESQGQPHFSAASVHMVPGSPQARHRTVGTNTPPSPGFGRRAINPTMA
                     APGSPSLSHRQVMGPSGPGFHGNVVSGHPTSATVAPGSPSLGRHPVGSHQVPGLHSGV
                     VTTPGSPSLGRHPGAHQGNLVSSLHGNAVISPGSPSLGRHLGGSGSVVPGSPSLDRHV
                     AYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQ
                     GSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSSPVANGMASPSGSSTVSFSHTLPD
                     FSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFR
                     GAYGLAMKVSSPPPTITQQGKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSA
                     LVYQHSVIPLALPCKLVIPSRDPTDESKDSSGPANSTTDLLKQGAACNVLFINSVDME
                     SLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTF
                     CDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSK
                     VMLSAGQKR"
     exon            250..364
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            365..402
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            403..444
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            445..486
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            487..537
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            538..599
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            600..780
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            781..831
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            832..954
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1019
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1103
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1216
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1277
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1353
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1483
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1549
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1666
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..3247
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3444
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3520
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3613
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3637
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3676
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3875
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..4945
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5032
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5164
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5257
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5335
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5336..5407
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5576
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5577..5645
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5646..5678
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
     exon            5679..10134
                     /gene="Tns1"
                     /gene_synonym="Tns"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgcctggg gccgagaggt cgctggggct gggggtgggc cggttcgttg gtagtccgcg
       61 tccccgcccc gggcccgccg ggtgccgggc cggatgggct gcaccgtgag cctggtgtgc
      121 tgcgaggcgc tcgagcctct gccttcttgt ggcccgcagc cccccgggac tccgccgggc
      181 cccgcgcggc ccgagcgctc tgagcccggg ggtgcggcat ccatccagag gaggaggctg
      241 ctgcttcagc cagaagacct ggaggccccc aagacccacc acttcaaggt gaaggccttc
      301 aagaaggtga agccctgtgg tgtctgccgg caggccatca ctcgggaagg ctgtatttgc
      361 aaagtctgca gcttctcctg tcatcggaaa tgccaggcca aggtggctgc cccttgcgtt
      421 cctccatcca gccatgaact ggtgcccatc gccacggaga gtgtgcccaa gaatgtagta
      481 gatgtggggg aaggagactg ccggggtgga agtactccga aaaacctgga ggaggccggc
      541 tccatgagag tttctccaag catacagcca cagccacagc cacagccaca gcctatcagt
      601 ctctctagaa acctgagtgt gagccgagcc atggaagaca gctgtgagct ggacctggtg
      661 tatatcaccg aacgcatcat cgccgtgtcc ttccccagca cagctaatga ggagaacttc
      721 cgcagcaacc tccgtgaagt ggctcagatg ctgaagtcca agcatggggg caactacctg
      781 ctattcaacc tctctgagca gaggcctgac atcacaaagc tccatgctaa ggtcctggaa
      841 tttggctggc ctgacctgca cacaccagct ctggagaaga tatgcagtgt ctgtaaggcc
      901 atggacacct ggctcaatgc agacccccac aatgtcgtcg ttctccacaa caagggaaac
      961 cgaggaagga ttggggtcgt cattgcagca tatatgcact acagcaacat ttcagccagt
     1021 gctgaccagg ctcttgacag gtttgcaatg aagagattct atgaggacaa gatcgtgccc
     1081 attggccagc catcccagag gagatatgtg cactacttca gcggcctgct ctccggctcc
     1141 atcaaaatga acaacaagcc tttgtttctg caccatgtta tcatgcacgg catccccaac
     1201 tttgagtcta aaggagggtg ccggcccttt cttcgcatct accaagccat gcaacctgtg
     1261 tacacatctg gcatttacaa catccctgga gacagccagg ccagcatctg tatcaccatc
     1321 gaaccagggc tgctcctgaa aggagacatc ttgctgaagt gttatcataa gaagttccgg
     1381 agcccggctc gagacgtcat cttccgagtg cagttccaca cctgtgccat ccatgacttg
     1441 ggggtcgttt ttgggaagga agatctggat gaggccttca aagatgatcg atttcctgac
     1501 tatggcaaag tggagtttgt cttttcctat ggaccagaga aaatccaagg catggagcac
     1561 ctggagaacg ggcccagtgt atctgtagac tataacactt ccgaccccct catccgatgg
     1621 gattcctatg acaacttcaa tgggcatcgt gaggatggca tggaagaagt ggtgggacac
     1681 acccaagggc cgctggatgg gagcctgtat gccaaagtga agaagaagga ctccctgaat
     1741 ggcagttcgg ggcctatcac caccgcaagg cctgccctgt cagccactcc caaccatgtg
     1801 gaacacacac tgtctgtgag cagcgactcc ggcaactcca cagcctccac taagacagac
     1861 aagactgacg agccagtctc tggggctgcc attgcccctg ctgccctgag tcctcaggag
     1921 aagaaagagc tggatcgcct actaagtggc ttcggtgtag atagagagaa gcaaggtgcc
     1981 atgtaccggg ctcagcaact cagatcccac ccaggcgggg gcccgactgt gtcctcccct
     2041 ggccgccaca ttgtcccagc tcaggttcat gtcaatggtg gggccctggc atctgagcgg
     2101 gagacggaca ttctggatga tgagctgccc atccaggatg ggcagagtgg gggcagcatg
     2161 ggaacgctgt cttccctgga tggggtcacc aacaccagcg aaggtggcta cccagagacc
     2221 ctgtccccac tgaccaatgg tctggacaaa ccctatccca cagaacctat tctcaacggg
     2281 ggaggctacc cctatgagtc tgccaaccgg gtggtacctg ttcatagcag tcactcggct
     2341 cccattcgac cctcctactc tgctcaggag ggtttaggtg gctaccagcg tgagggaccc
     2401 cacccggcct ggtcaaaaca agtgaccagc gctcaccgtg gctatgaccc cagtggtcta
     2461 ttccgatccc agtcctttcc agatgtggag cctcagctgc cccaagctcc agcccgtggg
     2521 ggcagcagcc gagaggctgt gcagaggggc ctgaattcat ggcagcagca gcagcagcag
     2581 cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcccca cccacctccc
     2641 cgccagcagg agcgatcccc actgcagagt ctagcctgca gcaagcctag cccccatctg
     2701 tcagcagaga cccccatacc agctctccca gagttcccaa gggcagcctc ccagcaggag
     2761 attgagcagt ccatcgaaac tctcaatatg ttgatgctgg acttggagcc agcctcagct
     2821 gctgcccctc ttcataagtc ccagagtgtc cctggggcct ggccaggggc ttccccactc
     2881 tcttcccagc ccctcttggg gtcttcctgc cagtcccacc cactgaccca gtccagatct
     2941 ggctatatcc ccagtgggga caccctggga gccccggagc tgctctcttc tggaaggtct
     3001 tactcacctt acgattatca gctgcatcca gctgcatcca accagagttt ccggccaaaa
     3061 agtccagcct cttccacctt ccttccaagc cctcatagct ctgcagggcc tcaggagccc
     3121 ccagcctctc tccctggtct catcgccgag cctcagctcc cactgaagga aactacttca
     3181 gatacctccc gaactccaga ggaggagccg ctgaacctgg aagggctggt agcccatcgg
     3241 gtagcagggg ttcaggctcg ggagaggcag cctgcagagc ccccagcccc actccggagg
     3301 cgagcagcca gtgatggaca gtatgagaac cagtctccgg aggccacatc cccccgtagt
     3361 cctggggtcc gctcccccgt ccagtgcgtc tcccctgagt tggctcttac cattgccctc
     3421 aatcctggag ggcgccccaa agagccccat ttgcatagct acaaggaggc ctttgaggag
     3481 atggagggga cctccccaag cagcccacca cccagcgtgg cacgttctcc tccaggtctg
     3541 gctaagacac ccctgtctgc tctgggcctg aaaccccaca acccagcgga catcttgctg
     3601 caccccacgg gtgttgccag aagactgatc cagccagagg aagatgaggg agaggaggta
     3661 gctaagcctc cagaagagcc ccggagctat gtggagtctg ttgcaaggac agcagtggca
     3721 ggccctcgag ctcaggacgt ggagcctaag agcttcagtg caccagccac tcatgcctat
     3781 ggccacgaga cacccctgag aaacgggact cccggaggct cctttgtctc ccccagcccc
     3841 ctttccacaa gcagtcccat cctcagtgct gacagcactt ccgtgggcag tttcccatca
     3901 gcgggaagca gtgaccaggg tccccggaca cccatccagc ccatgctgga ctccagcatt
     3961 cgctcaggca gcttggggca gccgagccct gcagccttga gttatcagag ctcctcacct
     4021 gtccctgttg gtggcagcag ctacagcagc cctgactact cccttcaacc attcagctct
     4081 tctccagaaa gccagggcca gccacatttc agtgcggcca gcgtccacat ggtgcctggg
     4141 agccctcagg cacgacacag gacagtgggc accaacactc cacctagtcc cggctttggc
     4201 cggcgggcca tcaaccccac catggctgcc cctggtagtc ccagtttgag ccaccgacag
     4261 gtgatgggtc catctggtcc aggtttccat ggtaacgtgg tttctggcca cccaaccagt
     4321 gcaacggttg ctcctggaag tcccagcttg ggccggcacc cagtgggaag ccatcaagtt
     4381 ccaggtctcc acagcggtgt ggtcactact ccagggagcc caagcctggg ccgacaccct
     4441 ggggcccacc aagggaatct ggtctccagt ctccatggca atgcagtcat tagccctggg
     4501 agccccagtt tgggccggca cctgggtggg tctggatctg tggttcctgg aagccccagc
     4561 ttggaccggc atgtagctta tggtggctac tctacccctg aggaccgaag accaacactg
     4621 tcccggcaaa gcagtgcctc aggctaccag gctccttcca caccgtcatt ccctgtttct
     4681 cctgcctact accctggcct gagcagccct gccacctcac cctcgccaga ctcagcagcc
     4741 ttccggcaag ggagccccac accagcctta ccagagaagc ggaggatgtc agtgggagac
     4801 cgggcaggca gtctccccaa ctatgctacc atcaatggga aagtgtcctc ctcgcctgtc
     4861 gccaatggca tggccagccc cagtgggagc agcaccgttt ccttctctca cacgcttcca
     4921 gacttttcca agtactcgat gccagataat agtccggaga cacgggctaa agtgaagttt
     4981 gtccaggata cttccaagta ttggtacaag cctgagatct ccagagagca ggccattgca
     5041 ctcctgaagg atcaggagcc aggggccttc atcatccgag acagccactc cttccgaggg
     5101 gcttatggac tggccatgaa ggtgtcctca ccccctccaa ccattactca gcagggcaag
     5161 aaaggagaca tgacccatga gctggtgagg cactttctga tcgagacagg ccctagagga
     5221 gtcaagctca agggctgtcc caatgagcca aactttggct ccctttctgc cctcgtctat
     5281 cagcactccg tcatcccact ggccctgccc tgtaagctgg tcattccaag ccgagacccc
     5341 acagatgaat caaaagatag ctcaggccct gccaactcaa ccactgacct gctgaagcaa
     5401 ggagcagctt gcaatgtgct cttcatcaat tctgtggata tggagtcact caccgggcca
     5461 caggcaattt ccaaagccac atctgagact ttggctgctg accccacgcc agctgccacc
     5521 attgttcact tcaaggtctc tgcccaagga atcacactga ctgacaatca aagaaagctc
     5581 ttcttcagac gacattaccc cctcaacact gtcaccttct gtgacctgga tccacaagaa
     5641 aggaagtgga tgaagacaga gggaggtgcc cctgctaagc tcttcggctt cgtggcccgg
     5701 aagcagggca gcaccacaga caacgcttgc cacctcttcg cagagcttga ccccaaccag
     5761 cctgcgtctg ccattgtcaa cttcgtctcc aaggtcatgc tgagtgctgg ccaaaagaga
     5821 tgaacgaatc ctggagccct tgcccaaggc tggggcactg gggacggggt gtgtggggag
     5881 ggatctgcga atcctgacca ccttgaatcc agaacgaggg ctttgggtcg accgtggaga
     5941 aggagagaag aaagtgcaat gctgggagag ggaagtgaat tgtggaggga gggaggggaa
     6001 caggaggaag aggaaggaag gaagaagaga ggaactcgaa atcccctgta cagatggaag
     6061 ccacacctcc caaagcctct ccagctagct ggggcccctc cccctcacct cccaaagcct
     6121 ctccagctag ctggggcccc tccccctccg agagaattga gctcccacag gcacacagcc
     6181 cttgggggga ccctatttca tggagcaaca aaaaagctcg ttctccctaa cgctcctgct
     6241 ttgagaagaa gtcgaactga ggcttcttct ctggaggtaa ggttgctggt ggccagctta
     6301 tgacatcaag cagtgacact ttttcacatt ttgctcaccc gaggcacccc tggtctgtgc
     6361 ttgctctgac tccttgttgc agggtccaaa tgtactccca cacgctgatc gatacctgcc
     6421 tgtgtccact caactcagat tacaaacagc tctgctttgt ctgtgtcccc tgtgatacac
     6481 atatacacac tgcccaaaga aggctaggga tatagggtgg caggaccccc ccccccccgg
     6541 tcagatgaca agctgtctcc tgcaggagtc tagcttatgg gtacagagtt ctctccgcac
     6601 ctgccctcta gtggctctgg gggcctccag cctgtcctcc gcagagactc tggtacagag
     6661 ggcatggccg ctagcagcat tcgagctgtt ctgtctcctg gagactgaag ttggcttgga
     6721 ggaagaggtg atggccacag tctggggaag aatacccgtt aggaagggtg gcatcttttt
     6781 ttgcgatgtg gggctcacgg tgaattgggc aggcgcactg tgctgtgggc tcatgagttg
     6841 ggcatgcgca ctgacaatgc ccaggactgc cttactccct tccctcagcc caattctggg
     6901 ccagcactat ccttgcactt gctcatcttc ttgaagcgta ctgggggata ggggccgtgc
     6961 ctttctgacc tatcctgtcc taaagagtcc tcatgttcgc ttatcccagg agcctgcttc
     7021 ccgaagtcct gcctagggca cctgggggag cccctcccct ctgttttccc ctctgtaagt
     7081 gttttggagt ctgatattgc agacactctc tgtctgggct gctcagggtg acatcagagc
     7141 acctctggga atgctgctgg agaactacat ggtcctccca cagtaccaaa gcttccctgt
     7201 ttccccttct gcctcggtct ccccagcaga accatgctgt ctgtgggaca ggggacagaa
     7261 ggtatgaatt taggccaaag gtcctatggt ccatttgcgg ggttgcgaag gctcctgcca
     7321 ctgctcgggc ctccatttaa gcgcatgggg gtcctcaggg gtggcattgt actgatatat
     7381 aaatatatat aatatataca tgagacatac tgatagaatc tgtaagctaa taaaaaatat
     7441 aagaaaaagg ttaaaaaaag aataggtaaa ttgacaagaa atatttattg ttttcccata
     7501 ttgctttatt gtccctggcc acaaactgtt cctacctgtt ttctaacagt aagtagtgcc
     7561 tgacctgcag ggggtcttta tattccaaac aacccagggc tagccttggc cttggccctg
     7621 gccttggctg ccctaggcta catctgtggg atggcatgct ccagttctgg caaacggcag
     7681 cacagttgcc aacatcccgt atgcgtggac agctagccac ttccaacccc tcaggcctga
     7741 gccagggtgt atttggagat cagggtgtgt gtggccatgg tgtggcgtct cttggattgt
     7801 tttcctcctc cagggagctt tgactgtgtg gacattgttt aaggagctaa agaaggccgg
     7861 tgaggatcag gagccctcac ttcccaaaga ataaatgggc tgagtgatca aggctcttcc
     7921 aagtgtcctt ccctctgaga tactcaaggc aaatgtctgg atttcccatt tcctcatccc
     7981 cctaacgaat tgtacttctc cccacgatag aaggagctgc ttctcatccc tttctttgta
     8041 aatgaaagac tcccatgtag tctggggagt ctcctcctag ctggaatgtt gttcacttga
     8101 gccttggaga agcatcagag cctctgcatc ctgccctgga ccagactcaa gtctaggatc
     8161 agccttcatg gatggtctca ccttcccatg ctgtgctcag gcccaagcca cgtgtgagtc
     8221 gagtgaatga ccaaggcaga tgctagcaag cgggcgcctc cttctcagcc tgcctctagg
     8281 aagaatggac accagagttt ggcttttctg gaagaatggt ggaggggacc tcacttctca
     8341 cagtgggaac cacactgttg tctgtcccct tcctaagtgt gattctcaca gatgggctcc
     8401 tgcacactca catacgtgcg catgcacaca cacacacaca tacacacaga gagaccacat
     8461 gcacacagag cactccgtat gcaactctgt attcttgcca aagacttcct ttaaacgaga
     8521 gcacttttac ccactgctct tttgtgaatg atctgttttg ttgttgttta ttgttgaatc
     8581 tctatatcaa cagggagagt gttgtccatt cttagacagg aatgaaagag ggggaggggt
     8641 gacaggagaa catggcggcc agtgatgccc ttaacaagac cccttaggaa cagcccaggt
     8701 acaaacagcc tccggccact cggaagatct gaggttggag gtgagatggc agagaagggc
     8761 actgatggag ccaggattgg tgcctaggga agtccccgat ggctctgggg gtggggacag
     8821 gtgtgaagag ctgggttgga acagggtgga catgaagact gggaaaatta acagttgcat
     8881 actgaagttg ttactgtgga cccctggtta ccttgccctg ccatgtttta ggaaagaatc
     8941 caaattttag ttttgaaagg gggcatttga gtcttctcac cttaccgatt cctagcagct
     9001 tagatagcct caggcatgag tgccaggatt cctgataggc cctggctttg gagagtccct
     9061 agggatagcc cctctggggg tgtagggagg acactgtggc tgtgcatccc tctaatgagg
     9121 ggctttcagg agagagaacc ctcctgctgc agggaagtgc aggagagaca agtgagtggg
     9181 ccgcatcctc ctgcctctgg gttttcttca tcctacctcc cgggacatct gacccccttt
     9241 tcccagcttc agatctcggg gagatccatc taagggaatc agccctctcc tgcctccatg
     9301 gcttgggtcc ctgaagagct tggaacccaa agctagggcc cacccctgca cttaggcctt
     9361 ggacgaagat cttgagactg gtgtttctgt ggtcactggt ggacaggatg tatgtgcgtg
     9421 cgcgtgtgtg taagtgtggg tgtgtgtgcg tgctctgctc atctctaggg aacttcgagg
     9481 tgggaagtgg gaggtgggag gtggagggac ccagtagtga gaagaactag gaggtgaggc
     9541 ctaatgggcc gcagattggt catgttttgg tgctgatgac agaggggcca gtcccagggg
     9601 aggaggcttg gcgggccact ttcttgtctc ctgtctcatc aaacttggag cgtctcagtc
     9661 attttccatg cctgggcccc tcacagcagc aaggccacag aagttcgaca cacccagtgt
     9721 gtgtcagtgt tcacagtcca gccctccctg aggacccaca tttggctcgt atgtgtgtga
     9781 gcacgttggg gtgcgcatga ggtatctccc cagtctcttc ccttctgtca cccgaatcaa
     9841 atgtaagacg tccctcacat cctgatcatc ccaactctgc ctcccaggcc ctctgctggg
     9901 aaacccatat ccggagtcca tgccctgccc ctgcccccgg ctgtgtattt atagatggaa
     9961 atatacttta tattttgtat cattgtgcct atagcctctg ccaccttgta taaaccctga
    10021 tgtatgctaa gtgttctgga catgaatgta tgtacactga tgctgtcccc tctgtacagc
    10081 tgcttactct caccatccat gtatggcttt ataaaggata aagttaaaca caaa
//
