LOCUS       NM_138845              17543 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus trinucleotide repeat containing adaptor 6B
            (Tnrc6b), mRNA.
ACCESSION   NM_138845 XM_001077084 XM_576311
VERSION     NM_138845.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 17543)
  AUTHORS   Edwards TL, Hartmann KE and Velez Edwards DR.
  TITLE     Variants in BET1L and TNRC6B associate with increasing fibroid
            volume and fibroid type among European Americans
  JOURNAL   Hum Genet 132 (12), 1361-1369 (2013)
   PUBMED   23892540
REFERENCE   2  (bases 1 to 17543)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 17543)
  AUTHORS   Ender C and Meister G.
  TITLE     Argonaute proteins at a glance
  JOURNAL   J Cell Sci 123 (Pt 11), 1819-1823 (2010)
   PUBMED   20484662
  REMARK    Review article
REFERENCE   4  (bases 1 to 17543)
  AUTHORS   Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT,
            Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY,
            Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF and
            Sonenberg N.
  TITLE     Mammalian miRNA RISC recruits CAF1 and PABP to affect
            PABP-dependent deadenylation
  JOURNAL   Mol Cell 35 (6), 868-880 (2009)
   PUBMED   19716330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000186.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_138845.5.
            
            On Feb 10, 2021 this sequence version replaced NM_138845.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132285,
                              SAMD00132291 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JACYVU010000186.1  5495135-5495334
            201-269             JACYVU010000186.1  5535797-5535865
            270-360             JACYVU010000186.1  5548886-5548976
            361-428             JACYVU010000186.1  5569584-5569651
            429-516             JACYVU010000186.1  5639181-5639268
            517-538             JACYVU010000186.1  5645136-5645157
            539-880             JACYVU010000186.1  5653296-5653637
            881-3223            JACYVU010000186.1  5655650-5657992
            3224-3382           JACYVU010000186.1  5659715-5659873
            3383-3558           JACYVU010000186.1  5661008-5661183
            3559-3630           JACYVU010000186.1  5663746-5663817
            3631-3676           JACYVU010000186.1  5664657-5664702
            3677-3813           JACYVU010000186.1  5665954-5666090
            3814-3939           JACYVU010000186.1  5671157-5671282
            3940-4071           JACYVU010000186.1  5678361-5678492
            4072-4167           JACYVU010000186.1  5678756-5678851
            4168-4390           JACYVU010000186.1  5678984-5679206
            4391-4528           JACYVU010000186.1  5684638-5684775
            4529-4705           JACYVU010000186.1  5687767-5687943
            4706-4852           JACYVU010000186.1  5689115-5689261
            4853-4948           JACYVU010000186.1  5689509-5689604
            4949-5173           JACYVU010000186.1  5695578-5695802
            5174-5244           JACYVU010000186.1  5696216-5696286
            5245-5384           JACYVU010000186.1  5699063-5699202
            5385-17543          JACYVU010000186.1  5700414-5712572
FEATURES             Location/Qualifiers
     source          1..17543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..17543
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /note="trinucleotide repeat containing adaptor 6B"
                     /db_xref="GeneID:192178"
                     /db_xref="RGD:621428"
     exon            1..200
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            201..269
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            270..360
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..5772
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /note="androgen receptor-related apoptosis-associated
                     protein CBL27; trinucleotide repeat containing 6B"
                     /codon_start=1
                     /product="trinucleotide repeat-containing gene 6B protein"
                     /protein_id="NP_620200.2"
                     /db_xref="GeneID:192178"
                     /db_xref="RGD:621428"
                     /translation="MHTNEGEVEEESSSQVEQEDFVMEGHGKTPPPGEESKQEKEQER
                     EEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSPSPPVNG
                     GNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGGGAGP
                     PPCTAPGANPNNAQVTGALLQSESGTAPESTLGGAAASNYANSTWGPGASSNNGASPN
                     PIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSALPGSTTSNKG
                     KGSQCQSASSGNECNLGVWKSDPKAKSVQSPNSTSDSNNGLGTWRSTSGQDRIGPGSG
                     FSNFNPNSNPSAWPALVQEGTCRKGVLEAEGSSSSAQVSTVGQASREQQSKMENAGVN
                     FVVSGREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQST
                     GDRKTGSVGSWGAARGPSGADTVSGQSNSGNNGNNGKDREDSWKGASVPKPTGSQSDS
                     WDNNNRSTGGSWNFGPQDSNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQ
                     PNSSTGAWDNQKGHPLPENQGNAQAPCWGRSSSSAGSEVGGQSTGSNHKAGSSDSHNS
                     GRRSYRPAHPDCQAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKS
                     DKGTEGWESAATQTKNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKSTGGWNDYKNN
                     NSSNWGGGRADEKTPSSWNESSCKDQGWGGGRQPNQGWTSGKNGWGEEVDQVKNNNWE
                     SSANKPVSGWGEGGQSEIGTWGNGGNTNLASKGGWEDCKRSPAWNETGRQPNSWNKQH
                     QQQQQQPPPPQPEASGSWGGPPPPPQGNVRPSNSNWSSGPQPATPKDDEPSGWEEPSP
                     QSISRKMDIDDGTSAWGDPNSYNYKNVNLWDKNSQGGPAPREPNLPTPMTGKSASVWS
                     KSTPPAPDNGTSAWGEPNESSPGWGEMDDAGASATGWGNTPASAPNAMKPNSKSMQDG
                     WGESDGPVTGARHPSWEEEDDGGVWNTAGSQGSTSSHNSASWGQGGKKQMKCSIKGNN
                     DSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVDKKFDVDKRTMNLGDFNDIMRKDRPG
                     FRPPNSKDLGTTDSGPYFEKGGSHGLFGNSTAQSRGLHTPVQPLSSSPGLRAQVPPQF
                     ISPQVSASMLKQFPNSGLNPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQ
                     QQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQQQQQQQQQQQQQQRQPSMKH
                     SPSHPVGPKPHLDNMVPNTLNVGLPDLPTKGPIPGYGSGFSSGGMDYGMVGGKEAGTE
                     SRFKQWTSMMEGLPSVATQEATMHKNGAIVAPGKTRGGSPYNQFDIIPGDTLGGHTGP
                     AGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGT
                     ATSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKS
                     TWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGLTNPKPASPWSSTAPRSVRGW
                     GTQDSRIASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQ
                     GTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATEDEVSRFLAQAQPPTPAATPSA
                     PATGWQSLETSQNQADPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGTSLWGPPNYS
                     SSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI"
     exon            361..428
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            429..516
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            517..538
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            539..880
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            881..3223
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3382
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3558
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3630
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3676
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3813
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..3939
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4071
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4167
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4390
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4528
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            4529..4705
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4852
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            4853..4948
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            4949..5173
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            5174..5244
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            5245..5384
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
     exon            5385..17543
                     /gene="Tnrc6b"
                     /gene_synonym="Cbl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaggggaa agtttgttta ttttgttttt agtttctggg gtccccgagc ttcgggaagg
       61 tgaagcgagc gacagtgacc cccctagcct ctcagcctcc ccgcgacgtc gcctctacag
      121 cttgcggaga agcggagacc gcggtcaccg ctgggctcca cagcggaacg acgcgctctc
      181 ggagccggcg cggctcagcg ggtcttgggt tttttgcact gaatgtaacc tagactgatc
      241 gtctcagttg ccccaggata ctgtcagagg cagtgtctgt gtgtgtctgc agagctttgc
      301 acagaatctg ttcccatgca caccaatgag ggagaagtag aggaagagag cagctcccag
      361 gtggaacagg aggattttgt aatggaaggg catggcaaga ctccacctcc tggagaagaa
      421 agcaaacaag agaaggagca agaaagggaa gaacagttaa tggaagacaa gaaaaggaag
      481 aaagaggata aaaagaaaaa agaagccacc cagaaggtca cggaacaaaa aaccaaagtg
      541 cccgaagtga cgaaaccaag tttaagccaa ccaacggccg ccagcccaat tggcagctct
      601 ccatcgccac cagtcaatgg tggcaacaat gccaaaaggg tggcagtgcc gaacggacaa
      661 ccgccaagcg ccgcccgcta catgcctcgg gaggtgccac cgcgattccg ttgccagcag
      721 gaccacaaag tgttactaaa acgtgggcag ccccctccac cgtcctgcat gctcctaggg
      781 ggtggggcgg ggcctcctcc ctgcacagca cctggagcaa accccaacaa cgcacaagtg
      841 acaggagcgc tgctgcagag cgagagtggg acggcaccag agtcaaccct tggaggtgct
      901 gctgcttcaa attatgcaaa ttccacttgg ggcccgggag cctcctccaa caacggcgcc
      961 tcccccaacc caattcacat ctgggacaag gtgattgtag acgggtctga catggaagag
     1021 tggccttgta ttgccagcaa agacactgaa tcttcttccg aaaacaccac cgataacaac
     1081 agtgcctcga accctggctc tgagaagagc gctctgccag gaagcaccac tagtaacaaa
     1141 ggcaaaggga gccagtgcca gtctgcaagt tctgggaatg aatgtaatct tggggtctgg
     1201 aaatctgacc ctaaggctaa atctgttcag tctcccaact ctacttcaga tagcaacaat
     1261 ggactaggaa cctggaggag taccagtggt caagatagaa ttggacctgg ctctggcttc
     1321 agcaacttta acccaaatag caacccatct gcctggccag cattggtcca agaaggaact
     1381 tgtaggaaag gggtgttgga ggcagaaggt agcagttcca gtgcacaagt cagcacagta
     1441 ggtcaggcat ccagggaaca gcagtcaaag atggagaatg cgggtgttaa ttttgttgtc
     1501 tctggcagag aacaggctca gattcataac actgatggac caaaaaacgg aaacactaac
     1561 tccttgaact taagttcacc aaaccccatg gaaaataagg gaatgccctt tggaatgggc
     1621 ttggggaaca cctccaggag cactgatgcc ccttcacaaa gcactggaga tcgaaagact
     1681 gggagtgttg ggtcttgggg cgcagctagg gggccttctg gagctgacac agtctctgga
     1741 caaagcaatt ctggaaacaa tgggaacaat ggaaaagaca gagaggactc ctggaaagga
     1801 gcttccgttc caaaaccaac tgggtcacaa agtgactctt gggacaacaa taacaggtct
     1861 acgggtgggt cctggaattt tggccctcag gactctaatg acaacaaatg gggtgaaggg
     1921 aacaaaatga catctggggt ctctcaggga gaatggaaac agccgactgg gtctgatgag
     1981 ttgaaaattg gagaatggag tggtccaaac caaccaaatt ctagcactgg agcatgggac
     2041 aatcaaaagg gccaccccct cccagaaaac caaggcaatg cccaggctcc ctgttgggga
     2101 agatcttcca gctccgcagg aagtgaagtt ggaggtcaaa gcactggaag caaccacaaa
     2161 gcaggaagta gcgacagtca taattctggt cgtcggtcat acaggcccgc acatcctgat
     2221 tgccaggctg tcttgcagac tcttttgagc cggactgatt tggaccctag ggtgctctca
     2281 aacactggct ggggccaaac tcaaattaag caggacacag tgtgggatat tgaagaggtg
     2341 ccaaggcctg aggggaaatc tgacaaagga actgaggggt gggagagcgc tgccacacag
     2401 accaagaact cagggggctg gggagatgca cccagccaaa gcaatcaaat gaagtctgga
     2461 tggggggagc tctcagcctc aacagagtgg aaagacccca agagtacagg aggctggaat
     2521 gactacaaga acaacaactc ttctaactgg ggaggaggac gagcggatga aaagacacct
     2581 tcctcttgga atgagagttc ttgtaaggat caggggtggg gaggtgggcg ccagcccaac
     2641 caaggatgga cttctgggaa gaatggttgg ggcgaggagg ttgatcaagt gaaaaataac
     2701 aattgggaaa gttctgccaa taagcctgtg tctgggtggg gtgaaggagg gcagagtgaa
     2761 attggaactt ggggcaatgg tgggaataca aacctcgctt caaaaggtgg gtgggaagat
     2821 tgcaaaagat cccctgcatg gaatgagact ggcagacagc ctaattcctg gaataaacaa
     2881 caccaacagc agcagcagca gccaccgcca ccacagccag aggcttctgg ttcatgggga
     2941 ggcccacccc caccacctca aggcaatgtt cgaccttcta attccaactg gagcagtggg
     3001 ccccaacctg caacccctaa ggatgatgaa cccagtggtt gggaggagcc atccccacag
     3061 tcaattagtc gaaaaatgga catcgatgat ggcacttcag cttggggaga ccctaacagt
     3121 tataactaca agaatgtgaa cctttgggat aagaattctc aagggggccc agcacctcga
     3181 gaaccaaacc tgcctacccc gatgaccgga aaatcagcat cagtctggag caaaagcaca
     3241 ccacctgctc cagataatgg gacttcagcc tggggtgagc caaatgaaag cagtcctggg
     3301 tggggtgaga tggatgatgc aggagcatca gccacaggct ggggaaacac acctgccagc
     3361 gctcccaatg ccatgaaacc caattccaaa tctatgcaag acggctgggg ggagagtgat
     3421 ggcccagtca caggagctcg ccatcctagc tgggaagagg aagatgatgg aggagtctgg
     3481 aacaccgccg gctctcaggg aagcacttcc tcccacaact cagcaagctg gggacaagga
     3541 ggaaagaaac aaatgaagtg ctcgataaaa ggaaacaatg attcgtggat gaatcctctt
     3601 gccaaacagt tttcaaatat gggattgctg agtcaaactg aggataaccc aagcagcaaa
     3661 atggatttgt ctgtagataa gaaatttgat gtggacaaga gaacaatgaa tctcggggat
     3721 tttaatgata tcatgaggaa ggatcgacct gggttccgtc cacctaattc caaagacttg
     3781 ggaaccacag acagtgggcc ttattttgag aagggcggca gtcatggttt gtttggaaac
     3841 agcacagcac agtcaagagg cctgcacact ccagtgcagc cactgagttc ttctcctggt
     3901 ctccgggcgc aagtgcctcc ccagtttatc tccccccagg tttctgcctc aatgctcaag
     3961 cagttcccca acagtggcct gaatccaggt ctctttaatg tggggcccca gttatctcct
     4021 caacaaattg ccatgctgag ccagcttcca cagattcccc agtttcagtt ggcttgtcag
     4081 cttcttctgc agcagcagca gcagcagcag ttgctacaga accagagaaa gatctctcaa
     4141 gcagtgcgcc agcagcaaga gcagcagctg gcaagaatgg tgagtgctct ccagcagcag
     4201 cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagaggcaa
     4261 cctagcatga agcattcacc ttctcatcct gttgggccta agccacattt ggacaacatg
     4321 gtacccaaca cgctgaatgt ggggctccca gaccttccga ccaaaggacc aatccctgga
     4381 tatggttctg gctttagctc tggtggaatg gactatggta tggttggtgg caaggaggct
     4441 ggaactgagt ctcgcttcaa acagtggacc tccatgatgg aagggctgcc atctgtggcc
     4501 acacaagaag ctaccatgca caaaaacggc gctatagtgg cccctggtaa gacccgagga
     4561 gggtcaccat acaaccagtt tgatataatc ccaggtgaca cactgggtgg ccatacgggt
     4621 cctgctggtg atagctggtt acctgccaaa tctccaccga ctaataaaat cggaagtaaa
     4681 tccagcaatg ccagttggcc tccagaattc caaccaggag tgccatggaa aggtatccaa
     4741 aatatcgacc ctgaatctga cccctatgtc accccaggaa gtgtgctggg gggcacagcc
     4801 acatcgccca ttgtagatac tgaccaccaa ctgctgcggg ataacaccac agggtctaat
     4861 tcttccctca acacctcgct gccttcacct ggtgcctggc cctacagtgc ctctgacaac
     4921 tcctttacca acgttcatag cacttcagca aagttccctg attacaaatc cacgtggtcc
     4981 ccagatccca taggacacaa ccccactcat ctctccaaca agatgtggaa aaaccacatc
     5041 tcctccagga acactacacc gctgccccgc ccacctcctg gcctgaccaa ccccaaaccg
     5101 gcatctcctt ggagcagcac agcacccaga tcggtcaggg ggtggggaac acaggactcc
     5161 cggattgcct cagcctctac ctggagtgat ggtggctctg ttcgtcctag ttactggctg
     5221 gttcttcaca atctcactcc acagattgat gggtcaacct tgagaacgat ctgcatgcag
     5281 catggcccac tgctgacatt ccatctgaac ctaacccagg gcacagccct gatccgatat
     5341 agcaccaaac aagaggcagc caaggcccag actgcactgc acatgtgtgt gttgggaaac
     5401 actaccatcc tggccgagtt tgccactgag gatgaagtca gccgctttct ggctcaagct
     5461 cagcccccta cacctgcagc aaccccgagt gcacctgcca cagggtggca gtcactggag
     5521 accagccaga accaagcaga ccccgttgga cctgcgctga accttttcgg tgggtccacc
     5581 gggctcgggc agtggagcag cagcgctggt ggcagcagtg gggccgatct tgccggcact
     5641 tccttatggg gccccccaaa ctattcttct agcttgtggg gagtcccgac ggtggaagat
     5701 ccccatagga tgggcagccc tgctccttta ctacctggtg accttctggg aggagggtcg
     5761 gattcaatct gaacttagaa ctttcaactc tgacctcgtg accttttttg gaacagcagc
     5821 agcactaact tgaccttttc gttttttttt tcaacttgca ataaatacat ttttaaaagg
     5881 aaaaaagaaa acggagagag aaaaaaggtg ggtcattgac agactgtctg agcacatagt
     5941 tgcctccctt aaaacttcag ttttttcgtt tggaatatga atccaaaaag agaacatatc
     6001 acacttgaaa tacttgaatc atgaacgcca acctagaaag acaatgtgaa gcaagtacac
     6061 ataccattta aatttaaaca caaaaaaaaa ttaaaaaaat tagtttctag tttttcactt
     6121 ttttcatgtt atatggaagt tgttgctaag aaacatatat actgaaaaaa tagcttttta
     6181 actttgtttg cactgggtgt gtttccgtcc ttaggtctac catgtttggg tgggagggaa
     6241 attcaaaaga attgttgggg gaggggggag ggaagacttg acggagcctc actttaaaaa
     6301 caaaaacaaa aaaaacttta aaaaaaaagg aaaaattttg tgattggctg gttgataaat
     6361 accagtgtgt tctggcacat gtaactgccc aggcatgctc gttctggtat gtgtgtgcac
     6421 gtgtgttcat gtgcatttgc gtgcatcctc ctctctgtct ctttgtgtgt gtgcctgcgt
     6481 cctgccctcc tcgtccctcc ccaccctgat ttctcagaaa gctgcattgc tgacagtttg
     6541 caggctggct ggccggccat ccgcttttta ttatttttga ctatgagaac acaggagcgc
     6601 agggagccgc tgcaactcaa gcacttcttc cggctgcatg gagatgaagg gtgcttttca
     6661 gtgatgagag cagcagccag tgagggtccc cagcttcctg ttgacctagc cgcagagcag
     6721 agcactgcca agcccagcgg gaggtgcctc agagaagctg ctgctcacct ctgtgctgtg
     6781 aaataagcag ctgctgggcc actgagcacg tgggggtcta agtcctgagc aggctgattt
     6841 gctacttgga atgggaatag atgattcaat aatttttaaa tcacgtgatg ttttaaaagc
     6901 agaaataccg ttcctacttt gctgtgtcat caggtgtgat cattttttaa aggattcagg
     6961 taatgcaaat taaattatat ctattagttc tcatgatcat ttgaggaaaa ctgcagtaaa
     7021 ttatgagcag cctcctggaa gcatcgcagc tcctctctct cggctcctct cgctgagcat
     7081 tacctgtgcc aggccatggc gtgttacagc accaggccat cactgacaga aacgtttact
     7141 taacgaatgt tcttaaacca gtgtgtactt caagtgtctc cctttgtttc tctgtgttgt
     7201 ttcctgtgta tgtggttttg cttaggcaga aataacttag caaagactta agtattgcac
     7261 cttgttttgg ttttgacctc ttttttttct ttccttgtaa tgttggggtt ttttttattt
     7321 tggtatttaa agactttttt ttaaaaagca tcaatgtagt agttctctgg gccgaacagg
     7381 aggcaatgtt taatccagtt atcatcaata cgtatgtact atgttggaat caaaatatat
     7441 cacatttctt attgtgaaga gagtgaaagt aaacctgaag gggatcctta cttactaaat
     7501 agacggcggg tgggcgggcg ggcgggggag atgtgtgcgg gtaacatgct agcactgtgt
     7561 ggatatccca gtctgcatcg tactgtctgt tcaacatgaa gtgccgacat tctgtaccag
     7621 caattacctg cccattccaa cccctgatgg gagcagacct ctgctgtcct ctgtgacttg
     7681 ctgctattga ggacaaggga gtttttcttt agcatcttca gtgaaggata caacaatgcc
     7741 taatgtattt aactttcagc ttgtgtcttt tgtgtaggtg tgtaggtggg tagaggggta
     7801 tggataggaa aaagcaaaca aacaaacaaa aaaacccaaa attgcatgta agtggctttg
     7861 taagacagtg agtgggaagt tctgtagtcg tcttggctta ccttgttgga tataaaccta
     7921 gcttcagagg agactgatgg caccattccc aggagcactt gtgtttgcca atctgggtgc
     7981 ctttggcagg tgggtgggca aatgagtttg gagttctggt ttgttcctgc aacaccttgt
     8041 tctcatggac tctgccttcc tcctgctctc tggtttccat caccaccatc ccctctcacc
     8101 tctgccctac aaaatgtctc cttccagccc cactgactct cagtgttgga gcagagctct
     8161 gtcacaggtg atgacgtcca cgtgaggcgc agcttatatt cagacatctg caggctgaag
     8221 gctgaatctt agcgtcccca gaatcctggg agcctgtggg gactgtccac tgccgctctt
     8281 ggttcatggc cctgcctacc ttctcttccc ctgctcctct ttctgcctgt tgggtccttg
     8341 acctgcacta tggcttagtt gagttcctta tgatactacg gtgaaagccg ggtgctagag
     8401 cccctcttgt ttacaagaca taaatgaggg atttgaaata tgtaaaaata aacacgagaa
     8461 gctaaaatgt tcttccatca tagcttaaag ggaaaaaaac taaaaactta aaaaaaaaga
     8521 ccaaaaagtg cgtatatata tatatataca tataaatata tattttagat gaagactaac
     8581 tctgggagca tttaacagtg tttttgtttt ttatttttaa cattattttc ctgctttaaa
     8641 atttgcaagc attctcagga attctagggt aggaagccag ttttttgaag atggtttatt
     8701 taatcgtatc ttatcctaga tagacagctg tttctttcct gttagtaaac ttttacaagt
     8761 tcctgaaact tcaaaaagtt taaacgattt ttacttacaa aaatgtaaaa agaaaagtct
     8821 ccaaacatta ttatcataca ggggatcaca cattttaaaa tacatagaaa tattttttaa
     8881 aaattaccaa tttagcagca acaggtaaat tcattatctt aacaactgtg ggagaaggct
     8941 cagatgttct gagtgttgtc accgccatgc ttgagattgt gatgacttac tgggggaagt
     9001 gtttgttcaa ttagtaggct tgccacctcg ctgttccttc tgtatgaggc tggactgacc
     9061 acctccccgt catgtctctg ttctccagtg cagcccttct tctccctggc tctccagccc
     9121 catcaacaaa agaaaggaat aaagaaagaa acaatagctt aagctaaagg attggctcta
     9181 aactgtggta gtgccgttgt tggattgctg agaatctctg taaagagtta ggaaatatag
     9241 gttagtaatt tttaagcaaa atttaaatgt aagcattact aaaggaaaat tacctatgga
     9301 ctgttctgtt tatgaagagt gtgcgtctcg cctccaccgg ttacaggagg aaaaagcaga
     9361 agagtctaat gaggaacaag tggttttact tttttttttt ttttagctcc cagctactgt
     9421 ttgcttgttt taaatgctgt tttgaagatc tgctgcttac tatccccatc ctgggaggca
     9481 gagatgtgga gtgtttcctt ttgattttgg taatgttgaa ttctgctttt gtattccctc
     9541 ctggggccag aggtcatggc cacagctcct ttcaaacttt aagcttccca gtgggaaaga
     9601 aaatccagct ccacaggtaa agtgaatggg tggggttgtt gcctgcattc tctaaaaccg
     9661 ctttagtgcc ttcgtacata caccggactc ctaaacagga tgagtgtgtg tgcatgtggt
     9721 ccagccattc cacagttggt atgatgcttg cctgtaaagg aaatgggatt ggttctggac
     9781 aggccccaaa ggcagtgggc taaatcaaaa taaacaaaaa tcgaggaagt taaatatgtt
     9841 gttttgtctt gataatgtgg gatgccaagt tccttcctat gttgtgtgcc ctccataggt
     9901 gctgacttct ccatgtgtag aagggtgaca gttacagtca tggggaaagt ctctttgtgc
     9961 cgggccagtg gaggaaggct cctgcttctc agctcctgtt ttctgtcttc tccctgcctc
    10021 tccccttggc ccatttgtca tcctgttgga agcttttgtt attgatgggc tatgacctga
    10081 gaagaggttg tggtgggggt gtcttgaagg tggaaagccc ttccctcccc atggtattca
    10141 gcaagaactc tgtctcccga gacattaggt gacttcgttc attatacatg gaaaaattca
    10201 atacgcatat ccttccagca cattctggca tatatacaga ggcttgctag tcaccattat
    10261 atagatttgt tttatacaca ttataagcat gtaagtatga actttctgtt ttacactagg
    10321 tttttttttt ttttaactct tataggtaga catgtatgtg tctcatgagc atcacaggcg
    10381 tgtttctgtc tgccctccat gaatagccaa aagaaaagca cgggtgtggg aaagagttgt
    10441 cttctaccac ttgggagagc tctactgtgt gagaccccgt gctgttaccc catttaaggg
    10501 ttgagatgca ctcgggtctc tgaaacctct ttaaaacaaa cagaagaagg aggacagccc
    10561 catggcctct ctccttccag cccctaatcc ttgaacttac tttccatttc cagcatttac
    10621 aggaatgaac ttagcagtac agcactgctg gtccacaaaa caactcaaaa ccatattctc
    10681 ccctcagtgt ccccatgaaa cgtcccctgt gcttccccat tcagtcagtt actttgtact
    10741 gaaatggctt gtgttgtaag aattttccca cttctgttgt gactgtagca ttgggaattg
    10801 aatcaagatt cagtgtgatg tggaagataa tatgtaaggg ggagaaagaa aagggagagg
    10861 aattcctgct aagaatttgg aagggctttt actagtgtgc ctaccaaaaa ctggacatta
    10921 ccttactgca gacacttcac tccctgtttg tagttcattg tgctggggag gaaacccagg
    10981 actttgccca tggtagtgag cacgctctgt gcctgagcca cacagcccta tgctgttgct
    11041 gtccccgtcc cctcttgtaa gggaaatggg tttatagggt taacagctag gttctacttt
    11101 gacttcagat gctgtgtact tttaaattat tttctcacct tctgccattt tgactcttaa
    11161 gtgtctgtgc tgagcaaaat gcttaagaca agcctgctct cctctccagt gtcagcagga
    11221 tgctctcagc aggtctggct gagatagcca acgctaggat caaggcacaa ctgagtggtc
    11281 ccattcttcc ctgccctcaa aggtaaaact caccatacac tgctctgaca gttgttactt
    11341 tgttagctct aagtataagg tcttcaacta gaagaagaga cacattttta gctgatttta
    11401 aaacaaacaa acaaaaaccc ccaaacttta ttctccatgt ttttgccaag ccttgtcata
    11461 gttttgtgtc cgtgaattag ctacacttct taatatcact gcaaagagaa accttgttct
    11521 gcgatcatgt ttttcttcta tgagtgcagc taggcctact ctagcctgtg tgtaagtgaa
    11581 ctgtccaccc ttagatttca aggaccacac agagccccct ttgctcttta cctacaagga
    11641 cagggtcttg aagacatcat cagcctataa gagaaacaag aaaacaaaaa caaaaaccca
    11701 gaatatcctc aaatttgtta cacttcataa gaacgctcta gaggcttacg gccagggcaa
    11761 aggtgtgcgg tcatcagaga gggctccagt tgtcaacagt cgtattcttc ttcttgacct
    11821 taactttgac aaaggggtag ccactgcatt ctttagattt gaaaaaattg tcaacttcag
    11881 caatctaaac aaaagatagt aataaaaatt gaatattgga ctagacttgg tggcacacac
    11941 ttttaatccc agcacttgag gggcagaagc aagttgacct ctgaggagtt caaggccagc
    12001 ctgttctaca tagcaagttt gagaaagacc ctgtctcata gagcagaatc cgagtatcag
    12061 tcctctctaa actgcccaca acatctcccc cacttcacac ggccacaagg aggccatgaa
    12121 caagatacaa gacggtgtga aaaaggagtt atgagtcaga gtagaaagct aactcttgcc
    12181 agcccagtgt cccctctgcc tctcatgtat gtggccctcc tgactaggtc ctgagcagat
    12241 gggaaatatt tccatcattt gaatggtttc tcaaatagta gcagagtgac agagaatgcc
    12301 aatgtggatg tttgcctctc tgattttaaa tagctctttc tggtccggcg tacacaagta
    12361 gatttgtttt caacaagaaa tggcctaggg caggggagac tatcttgacc agacactgca
    12421 gagctcagca ttgttcttca tggtgacaga cttacctttc cacaggaggg gaaagaccag
    12481 gtatacgttc ataagccaga agtgttctat tttaaataag gaagagatag tatttcccta
    12541 gagcgttata tgcctccctt agttttcaca gtatgagtca gtgtgctgga aacaaactcc
    12601 caataacagt tgacccattt ccagtcagta tcaggaagtt gggatgacct cttcaaaaag
    12661 ggaaatccct tcttcatata tctccctccc ttcttcctgg cttcctggac cttctggtgg
    12721 acatgctttt cttgggccac tgaaagggta acccactccc ggaggttgta aagggacttt
    12781 aggcagatgg agcagcctta ctttctgtga ctggccttac cgtgggaaaa ggtggtagaa
    12841 tgctgaatgt gtatgccaaa aacaaaaggg ggtatttatg caaaacaaaa ccaacccttg
    12901 ggaatccttc aagaggtcac ataccttgta aaggtaggat gttcgctcac caagtgatgg
    12961 cttttagcat gaaacttctt tttgctagaa gtttggggtt atgttacaat gcttgtgttt
    13021 aaaacactac tccccttaat tctttccaag gaatctctta agtgtagtac ttctgaatgt
    13081 gcctttgtcg gcccagagac caactgcggt ctgtcagagg gtctcctggt agccccaggg
    13141 acagctgttg gattttcatg agcacccatt ttgcacagtg tgagttgtgt ggaagggatt
    13201 ctgggtcttg gaccaggagg tcataagcca ggccatggcc cagcttaatt ccactgtagt
    13261 cagctgtcta catctgcatt ccttagtgtg ttctctctct ctctctctct ctctctctct
    13321 ctctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttctcgc gctataagca
    13381 ctagagaatt ggaattagaa aacggtgatt ttgtgatcca ttcattcttg tgaagaaggc
    13441 atttctggct ttgtgctgca gaaggtgctt tttttttttt tttctttaaa ccctctctgc
    13501 cttagaaggt catgatttcc caaatgcaag tcacatcaat gttgctattt ctgtgaacag
    13561 ggtatttatt gcacacaaag gaaaggtttt gaaagaattg aaactggtgt ttaaaaaaga
    13621 agaaacctct gaaatcccat tgtagttttt gagaactgtt gtagttaaac ttgaaaatct
    13681 ataatctttt catgtttcat gtttgttttc aatgacccca cctcctctgc tacccccagt
    13741 cttctaaaga agcgtccagt gaatgccaag gaccctgtcc accatcctta gtgccccccc
    13801 caggaaagtg ctccctagat tccttcagct tcattaggga agacaaaggg aggcctcact
    13861 cactcctctc attgccttgg gatgtattat tatgcaaatg tgaatttaac tagaggttgt
    13921 tggatttgtt ttgggggggg gtggttttgt tttgtttttt tccaaaaaaa aaaaaaaaaa
    13981 aaaaagtcca aatgtggtca tccttcctcc attttatatc ctgaatttgt aactatgcat
    14041 tttctgaaag ggggaaggca gggaaagaag cctgtttgtg tccttatgta ttcaagtttc
    14101 tgtgtccatg gattccccat gtctgggaag ggaagaaaag aagaagagaa ggctctcgcc
    14161 aggtcagcag agttagggcg agagggacct ctcagacccc accctcgggc aggtctgatt
    14221 gccaagcaaa attgggggcg gggtctgcca tgcctgtcta tcgttatggt gcaggattct
    14281 tgatactggc catgcagtgt taatctaagg cagctgtgga agctcacagg ctccagtatt
    14341 ctctgaactc agaacccttt caagctcagg aaaccatgcc acactctgct gacctgagag
    14401 ttcatcctct ccttttacat ttctttgttt tcagtcattg tgtagggtac cattcctaat
    14461 tatgagctga gaaagagggc tgttctcttc catgtctgct atccctgatc tctgattccc
    14521 ttgcctgtac tgagctggtg gtgtggtgag tcgtgggaca ctggaaggct ttctttcaca
    14581 ctttctctgt tgttacaatt cctgtataga gttggaccat ggaaagtcat agcgcctgca
    14641 tcgctctggt ctaggcatta ttacagcacg tactatggaa gccagagttg ctcagcctgc
    14701 tgtcagtgtt tcccacccag caacctctgt tacgttcaca gtactgtaat gagtgacaga
    14761 cttgaccaca gtctctttgt gtctgtgttg gggctacaca gacatgatcg tatcagggtt
    14821 ccaatctgtt caattgcctt taaacaaaag caaaacagca gcaagaaaat cctgatgttt
    14881 caagtgtctg acacaaaatg atacctcatg gtatatttcc cctgcaatgt aaacccttca
    14941 ctcccccttt cttgacatct gtgagctatt ctttataaaa taaggatgtg taaataccgg
    15001 ataagtcttt gaaacatttt ctttgctgtg aaaatagccc taaaatatga tgtttgcatg
    15061 ttaagctgtc agaagtttca gatctgaatt cttttcttgt tgatgaagaa aaaagcaaag
    15121 cagtccggtg gaatggcttt gggtttgtgg tttggttatt ctctcctggt gttccttctc
    15181 cctgcagtac agggcagcag accagtggct acccctgccc taactaacac catctatccc
    15241 agcaccaagg ccccgggtag gggatgggga gatctgaatt tctctcttcc atatatgatg
    15301 cagggacttc aagaaggttt tgtacccagg acctcaagac cttgacttct ctttgacttc
    15361 tctgtcctgt gtgtgcgtgt gtgcgtgtgt gcgtgtgtgc gtgtgtgtgt gagcatgtga
    15421 aatgtgtgcg tgcacgtgca tgtgcatgtg tgttttcaca tatacacact tgctctttag
    15481 tgtgattctt taatccccag tggagattag tccctgattt tgcagtctgt ccagtggcat
    15541 tttcagcaat gctctggaaa tgtatttctt acttagaagg aaattcagct taaagctgac
    15601 attcttagac attcttgttg acacatgctg cttgtgagga cgctgacaga tgctgccctc
    15661 ctagaccttg ggctccctcg aaacagagta gaagactccc acttttatct cattttaact
    15721 caaatccata tgtgttaaga agctgttgtc aaaagtgctt tccctgatct gtttagtgac
    15781 gacttccttt gagggaggaa tatggatgaa actgatagac atcccttgcc catcttctga
    15841 ctggcactgt aaccttgcat tttacttctg ttgtttgtct ggaggtcctt gcttatcagt
    15901 gtgctttctc ccatcgctgg ggttctgcct gcccttgttt ccctctctga tgttcccaaa
    15961 gggctttgct gatgtctgca cctctttcct ggggcattcc cctactatac cctttgcaca
    16021 caccagtgac caaagtgtat gcagtggtct caacacgaca tcaaatggtg cacgcacctc
    16081 tagtgtgctc tcacatgtgc acaagattct gcacccttgg ccttaacttc agcacgactt
    16141 aaggtgcagg aacattttta acaggtttaa aaataaactt ctctgggagg gaaaataaag
    16201 cagatccaag cgctccccac tatctgcttg caactcattc tgcatctgac ccagcccagc
    16261 cctgttttgc aaccaaaacc aacaacaaaa agcaacctaa ggagaggttt ctggactgtt
    16321 ttatctttct ccctttcgat ggaggtacaa atgctgcttt gggttccata atcctagggg
    16381 gctatgttta cacagtgaaa ttaattctac caaatcagga aacagtaagt agtgaaagac
    16441 ccttcagtaa gaaatcacag aggctgaacc agaggtgaga ggacctaggg atgtggcaga
    16501 agtggaggga gatcctattt aaccctttgt gacaccaggg tcacctcctc tctgctctct
    16561 ttggccctcc ttaccccttt aatcaaaagg ttcagagaaa gacaccagaa aaaggctgaa
    16621 gttttaagag gcagctttcc aactttgcac acaaatgaaa ggtaccatga aagtcctctc
    16681 gtctgaaaca ctcggcagaa acaacctgtg caaaggtcag accgctgcac atgtcgatgc
    16741 tctctgcaag ttacctataa gtgttttgtt tgcttatact tgaaatcact tttacaatat
    16801 tattttggtg gctttctttt ctctcttctg atgggcaact gaaaatgcag gtgacaagtt
    16861 ttaaggatgt ttgaggggag aaaaggaagg atgtggcatt gtctttttta acctagaggt
    16921 tcagtcagac tcccgtatgg taaagttgct catcttactg gtttaacatg gacacagaaa
    16981 ctaggcactt tggtggttca cttgcacggc aggccgaccc cctttctata ttttatttta
    17041 cttttttagt atagtggtac ttaaaatcac tggttcactt aaaaaaaaaa acaaaatgtt
    17101 aaactctact aatgtacaaa taagctgaaa agttgcattt tatgtgtatt tttgccatag
    17161 caggtactgt atttctcatg ctggatttca aagtatatat atatacatat atatatatac
    17221 atatatatat atatatatca aaaacaagca aaactgaagg gtggtgtttt ctcagattgt
    17281 gacaggttga gtggtaagga ataaagtcgt agtcatttca ttaaaactga gagatgatgt
    17341 aatgcatata taagagtttt ttgaagggtt ttttgggctt ttaaacagct tattttgttt
    17401 ttgtttagtt tttattttat tttattttgg aaagatatga ttgtattatg tgcaactcag
    17461 ttgcttacat tataactaca aaatattttt gagttcctgg aaaaaaagaa aaaagactaa
    17521 taaatgtgtt tggctgctaa gca
//
