LOCUS       NM_013045               6456 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tenascin R (Tnr), mRNA.
ACCESSION   NM_013045
VERSION     NM_013045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6456)
  AUTHORS   Cowley,A.W. Jr., Moreno,C., Jacob,H.J., Peterson,C.B., Stingo,F.C.,
            Ahn,K.W., Liu,P., Vannucci,M., Laud,P.W., Reddy,P., Lazar,J.,
            Evans,L., Yang,C., Kurth,T. and Liang,M.
  TITLE     Characterization of biological pathways associated with a 1.37 Mbp
            genomic region protective of hypertension in Dahl S rats
  JOURNAL   Physiol Genomics 46 (11), 398-410 (2014)
   PUBMED   24714719
REFERENCE   2  (bases 1 to 6456)
  AUTHORS   Lysakowski,A., Gaboyard-Niay,S., Calin-Jageman,I., Chatlani,S.,
            Price,S.D. and Eatock,R.A.
  TITLE     Molecular microdomains in a sensory terminal, the vestibular calyx
            ending
  JOURNAL   J Neurosci 31 (27), 10101-10114 (2011)
   PUBMED   21734302
REFERENCE   3  (bases 1 to 6456)
  AUTHORS   Czopka,T., Von Holst,A., Schmidt,G., Ffrench-Constant,C. and
            Faissner,A.
  TITLE     Tenascin C and tenascin R similarly prevent the formation of myelin
            membranes in a RhoA-dependent manner, but antagonistically regulate
            the expression of myelin basic protein via a separate pathway
  JOURNAL   Glia 57 (16), 1790-1801 (2009)
   PUBMED   19459213
  REMARK    GeneRIF: Compared tenascin C and tenascin R in oligodendrocyte
            differentiation. Tnc and Tnr play antagonistic roles for
            differentiation and comparably inhibit morphologic maturation.
            conclude that independent molecular pathways regulate these
            processes.
REFERENCE   4  (bases 1 to 6456)
  AUTHORS   Bekku,Y., Rauch,U., Ninomiya,Y. and Oohashi,T.
  TITLE     Brevican distinctively assembles extracellular components at the
            large diameter nodes of Ranvier in the CNS
  JOURNAL   J Neurochem 108 (5), 1266-1276 (2009)
   PUBMED   19141078
REFERENCE   5  (bases 1 to 6456)
  AUTHORS   Liao,H., Huang,W., Schachner,M., Guan,Y., Guo,J., Yan,J., Qin,J.,
            Bai,X. and Zhang,L.
  TITLE     Beta 1 integrin-mediated effects of tenascin-R domains EGFL and
            FN6-8 on neural stem/progenitor cell proliferation and
            differentiation in vitro
  JOURNAL   J Biol Chem 283 (41), 27927-27936 (2008)
   PUBMED   18658130
  REMARK    GeneRIF: Beta 1 integrin-mediated effects of tenascin-R domains
            EGFL and FN6-8 on neural stem/progenitor cell proliferation and
            differentiation in vitro
REFERENCE   6  (bases 1 to 6456)
  AUTHORS   Xiao,Z.C., Bartsch,U., Margolis,R.K., Rougon,G., Montag,D. and
            Schachner,M.
  TITLE     Isolation of a tenascin-R binding protein from mouse brain
            membranes. A phosphacan-related chondroitin sulfate proteoglycan
  JOURNAL   J Biol Chem 272 (51), 32092-32101 (1997)
   PUBMED   9405406
REFERENCE   7  (bases 1 to 6456)
  AUTHORS   Aspberg,A., Miura,R., Bourdoulous,S., Shimonaka,M., Heinegard,D.,
            Schachner,M., Ruoslahti,E. and Yamaguchi,Y.
  TITLE     The C-type lectin domains of lecticans, a family of aggregating
            chondroitin sulfate proteoglycans, bind tenascin-R by
            protein-protein interactions independent of carbohydrate moiety
  JOURNAL   Proc Natl Acad Sci U S A 94 (19), 10116-10121 (1997)
   PUBMED   9294172
REFERENCE   8  (bases 1 to 6456)
  AUTHORS   Xiao,Z.C., Taylor,J., Montag,D., Rougon,G. and Schachner,M.
  TITLE     Distinct effects of recombinant tenascin-R domains in neuronal cell
            functions and identification of the domain interacting with the
            neuronal recognition molecule F3/11
  JOURNAL   Eur J Neurosci 8 (4), 766-782 (1996)
   PUBMED   9081628
REFERENCE   9  (bases 1 to 6456)
  AUTHORS   Schachner,M., Taylor,J., Bartsch,U. and Pesheva,P.
  TITLE     The perplexing multifunctionality of janusin, a tenascin-related
            molecule
  JOURNAL   Perspect Dev Neurobiol 2 (1), 33-41 (1994)
   PUBMED   7530142
  REMARK    Review article
REFERENCE   10 (bases 1 to 6456)
  AUTHORS   Fuss,B., Wintergerst,E.S., Bartsch,U. and Schachner,M.
  TITLE     Molecular characterization and in situ mRNA localization of the
            neural recognition molecule J1-160/180: a modular structure similar
            to tenascin
  JOURNAL   J Cell Biol 120 (5), 1237-1249 (1993)
   PUBMED   7679676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 22, 2020 this sequence version replaced NM_013045.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z18630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               JAXUCZ010000013.1  74625026-74625682
            658-1134            JAXUCZ010000013.1  74627147-74627623
            1135-1398           JAXUCZ010000013.1  74633576-74633839
            1399-1514           JAXUCZ010000013.1  74636558-74636673
            1515-1665           JAXUCZ010000013.1  74638927-74639077
            1666-1935           JAXUCZ010000013.1  74642925-74643194
            1936-2121           JAXUCZ010000013.1  74648915-74649100
            2122-2211           JAXUCZ010000013.1  74659827-74659916
            2212-2475           JAXUCZ010000013.1  74661143-74661406
            2476-2745           JAXUCZ010000013.1  74662070-74662339
            2746-2865           JAXUCZ010000013.1  74663463-74663582
            2866-3012           JAXUCZ010000013.1  74664502-74664648
            3013-3132           JAXUCZ010000013.1  74667213-74667332
            3133-3276           JAXUCZ010000013.1  74669856-74669999
            3277-3407           JAXUCZ010000013.1  74670594-74670724
            3408-3540           JAXUCZ010000013.1  74671623-74671755
            3541-3692           JAXUCZ010000013.1  74686979-74687130
            3693-3789           JAXUCZ010000013.1  74688833-74688929
            3790-3951           JAXUCZ010000013.1  74693493-74693654
            3952-4115           JAXUCZ010000013.1  74697887-74698050
            4116-6456           JAXUCZ010000013.1  74698744-74701084
FEATURES             Location/Qualifiers
     source          1..6456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..6456
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /note="tenascin R"
                     /db_xref="GeneID:25567"
                     /db_xref="RGD:3886"
     exon            1..657
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..4235
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /note="TN-R; tenascin R (restrictin, janusin); neural
                     recognition molecule J1-160/180; Tenascin-R (Restrictin,
                     janusin, J1-160/180)"
                     /codon_start=1
                     /product="tenascin-R precursor"
                     /protein_id="NP_037177.2"
                     /db_xref="GeneID:25567"
                     /db_xref="RGD:3886"
                     /translation="MGIEGETVVLKNMLIGVNLILLGSMLKPSECRLEVTTERVQRQT
                     VEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDVSAEDDTLAEYT
                     GQTSDHESQVTFTHKINLPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNTNCC
                     QESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQ
                     CICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQC
                     ANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVTPPEDLRV
                     AGISDRSIELEWDGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYN
                     ISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFT
                     PKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPT
                     QILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRP
                     GSRYEVSISAVRGTNESDASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEY
                     KVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNA
                     RTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYT
                     LTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPS
                     PPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPI
                     VGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFDYYRVSYRPTQVGRLDSSVVPNT
                     VTEFTITRLYPATEYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQ
                     WKAPMGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPLVS
                     GTIATNFSTLLDPPANLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVD
                     AEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTTGGRVFSHPQDCAQHLMNGD
                     TLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNL
                     EDEFWLGLDNIHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKLRIGGYNG
                     TAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQG
                     INWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF"
     exon            658..1134
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1398
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1514
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1665
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1935
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2121
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2211
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2475
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2745
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2865
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3012
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3132
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3276
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3407
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3540
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3692
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3789
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..3951
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4115
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
     exon            4116..6456
                     /gene="Tnr"
                     /gene_synonym="J1NRM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacatctgcc tgtgtgtgtt ctagctttac agagtgagag ctatagtggc ccagcacaag
       61 ttttcaagat tatatgaacc cttgttttct cttgcagatt cctataactc catgttggct
      121 actaccaaaa gctcttgaac caagctctgg ctaagaagat ggggatcgaa ggggaaacag
      181 tagtcttgaa gaacatgctc attggtgtaa acctgatcct gttgggatcc atgctcaagc
      241 cttctgaatg ccggctggaa gtgactacag aaagggtcca gagacaaact gtggaggagg
      301 aaggaggggc ttccagctac aacacatcca gcaaggaaca gcctatggtc tttaaccatg
      361 tgtataacat caacgtgcca ctcgaaagcc tctgctcctc ggggctggag gcctcagctg
      421 agcaggacgt gagtgccgaa gatgatactc tggcagaata cacaggccaa acctcagacc
      481 atgaaagcca ggtcaccttc acccacaaga tcaacctccc caaaaaagcc tgcccatgtg
      541 caagctctgc ccaggtactg caggaactgt tgagccgaat cgagatgctg gagagggagg
      601 tgtcagtgct gcgagaccag tgcaacacca actgctgtca ggaaagtgct gccacaggac
      661 aactggacta tgtccctcac tgcagcggcc atggcaactt tagcttcgag tcctgtggct
      721 gcatctgcaa tgaaggctgg tttggcaaga actgctcaga gccctactgc ccattgggct
      781 gctccagtcg gggtgtatgt gtcgatggcc agtgcatttg tgacagtgaa tacagcggag
      841 atgactgttc agagctccgg tgcccaacag actgcagttc ccgagggctc tgtgtggatg
      901 gggaatgtgt ctgtgaagag ccctacacag gcgaggactg cagggagctg cgttgccctg
      961 gggactgttc agggaagggg caatgtgcca atggtacctg cctgtgccaa gagggctatg
     1021 ctggtgagga ctgcagtcag cgacggtgtc tgaatgcttg cagtgggcga ggtcactgcc
     1081 aggaggggct ctgcatctgt gaggagggct accagggccc tgactgctca gcagttaccc
     1141 ctccagagga cttgcgagtg gctggtatca gcgacaggtc cattgagctg gaatgggacg
     1201 ggccgatggc agtgacggaa tatgtgatct cttaccagcc gacggccctg gggggccttc
     1261 agctccagca gcgggtgcct ggagattgga gtggtgtcac catcacggag ctggagccag
     1321 gtctcaccta caacatcagc gtctacgctg tcattagcaa catcctcagc cttcccatca
     1381 ctgccaaggt ggccactcat ctttctactc ctcaagggct acagttcaag acgatcacag
     1441 agaccaccgt ggaagtgcag tgggagccct tctctttctc cttcgatggg tgggagatca
     1501 gcttcactcc aaagaacaat gaaggagggg tgatagctca gctccccagc gatgttacgt
     1561 cctttaacca aacgggactg aaacctgggg aggagtacat tgtgaatgtt gtagcactaa
     1621 aggaacaagc ccggagccct ccgacctctg ccagcgtctc cactgtcatt gacgggccca
     1681 cacagatcct ggttcgagat gtctctgata ctgtggcctt tgtggaatgg accccacctc
     1741 gagccaaagt tgatttcatt ctattaaaat atggcttggt gggtggcgaa ggtgggaaga
     1801 ctaccttccg gctgcagcct ccccttagcc agtactcagt gcaagccctt agacctggct
     1861 cccgctacga ggtgtccatc agcgcagtcc gggggaccaa tgaaagtgat gcctcaagca
     1921 cccagtttac aacagaaatt gatgctccca agaatttgcg agtgggttcc cggacagcaa
     1981 ctagccttga cctcgaatgg gataacagcg aggctgaagc tcaggagtac aaggttgtgt
     2041 acagcaccct agccggggag cagtaccatg aagtgctggt acccaaaggc attggtccaa
     2101 ctaccaagac taccctcaca gatctggttc caggcacaga atatggagtt ggaatatctg
     2161 cggtaatgaa ctcgaaacaa agcattcccg ctaccatgaa tgccaggact gagcttgaca
     2221 gtccccgaga cctcatggta acagcctcct cagagacctc tatctctctc atctggacga
     2281 aggccagtgg tcctattgat cactatcgaa ttacttttac tccatcttct gggatctcct
     2341 cagaagtcac tgtgcctagg gataggactt catatacact gacagatcta gagcctggag
     2401 cagaatacat catctccatt actgctgaga ggggtcggca gcagagcctg gagtctactg
     2461 tggatgcctt cacaggcttc cgccctatct cccacttgca cttttctcat gtgacctcct
     2521 ccagtgtcaa catcacctgg agtgacccat ctcccccagc agacagactc attctgaact
     2581 acagccccag ggatgaagag gaggagatga tggaggttct cttggatgcc accaagaggc
     2641 acgccgtcct aatgggtcta cagccagcca ctgaatatat agtgaatctc gtagctgtcc
     2701 atgggacagt aacctctgaa cccatagtgg gttctatcac tacaggaatt gatcctccca
     2761 aaaacatcac aattagcaac gtgactaagg actccctgac agtttcctgg agccctcctg
     2821 ttgcgccttt tgattactac cgagtatcct atcgacccac ccaagtggga cggctggaca
     2881 gctctgtcgt gcccaacact gtgacagagt tcacaatcac caggctctat ccagctactg
     2941 aatatgaaat aagcctcaac agtgtacgcg gcagggagga gagtgaacgc atctgcaccc
     3001 tggtgcacac agccatggat agccccatgg atctaattgc taccaacatc acgccaacag
     3061 aagccctgct ccagtggaag gcacccatgg gtgaagtgga aaattatgtc attgtcctca
     3121 cccactttgc catggctgga gagaccatcc tggttgatgg ggtcagtgaa gaattccagc
     3181 ttgtagacct gcttcctagg acccactaca ctgtcaccat gtatgctacc agtggacctc
     3241 tcgtgagtgg caccatcgcc accaacttct ccaccctcct ggaccctccc gccaacctga
     3301 cagccagtga agtcaccagg caaagcgcac tgatctcctg gcagccaccc agagctgcga
     3361 ttgaaaacta tgtcttgaca tacaagtcca ccgatggaag ccgcaaggag ctgattgtgg
     3421 atgctgagga cacctggatc cgactggagg gcctgtcgga gaacacagac tacacagtgc
     3481 tcctgcaggc agctcaggag gccacaagga gcagcctcac ctctactatc tttaccacag
     3541 ggggccgggt gttctctcat cctcaagact gtgcccagca cttgatgaat ggagacactc
     3601 tgagtggagt ttacaccatc ttcctcaatg gggagttaag ccacaagttg caagtatact
     3661 gcgatatgac cacagatggg ggcggctgga ttgttttcca gagacggcaa aatggccaaa
     3721 ctgatttttt ccggaaatgg gcagattacc gtgttggctt tgggaatctg gaggatgagt
     3781 tttggctagg gctagacaac atccacagga taacagccca gggccgctat gagctgcgtg
     3841 tggatatgcg ggatggacag gaggccgtct ttgcctacta tgacaagttc gctgtggagg
     3901 acagcagaag cctgtacaag ctccgtatag gaggctacaa tggcactgca ggagactccc
     3961 ttagctatca ccagggacgt cctttctcca ctgaggacag agacaatgat gttgcagtca
     4021 ccaactgtgc catgtcatac aagggtgctt ggtggtataa gaactgccac cggaccaacc
     4081 tcaacgggaa gtatggggag tccaggcaca gtcaggggat caactggtac cattggaaag
     4141 gccatgaatt ctccatcccc tttgtagaaa tgaagatgag gccctacatc catcgtctca
     4201 cagccgggag gaaacggcga gccttgaaat tctgagcact gggcagccag ccatcagcca
     4261 aacgatcttt tctgtcattt gtttgtattt tataatatga gacaaggggg gaggggcaac
     4321 agtaatgtgc ttcacaacat attcagacta tctgaaggaa gcaggaatca gttaggtacc
     4381 atctgctcct aatttctgct gccttggagc ctgactctca ggctacatgc tccctgctaa
     4441 ccagtcctgc ctgatcaccc ccctcttttc tcacacagga ggaaaactgg ggagttaaaa
     4501 caaaaacagg ccatgaagta cagattatta tggtgatggg cacacacaca attttctctg
     4561 ctccctcttc tgagatacta tccaacttct aagaaatagt aatctggtca ccgctgacca
     4621 tgaccaggtg accacactat cccagagaag attcaacaag aaagcttagc caatcttctc
     4681 ttaagaggaa agatacccac cacactctgg cacaacagcc caagttcact tcaatgggct
     4741 aaagattctc ccattctgac acttaacttt taggaagagt ggcctctctt ccagcccccg
     4801 cccctccact agatcctata gacctaccaa cccaactatt gtttagaact ccagttacca
     4861 aagcttgtct gatcctggcc ctggatcaca taagagctgt gccctgagtg tcataagcta
     4921 ttgtcatgga ataactttct ttggtggtga gacttgggga agggaattgt ttctagcaca
     4981 tttgcaccag gcattgacaa aggacaggag tagaaatgaa ggcacctacc agggagtccg
     5041 taggtcccat tggaatctga ccttgtttag tgctacttcg tacatttatg atctgattta
     5101 ccatggactc ctttctctga ttcctagctg aaggtctcta gttctttatc cagccaggct
     5161 ctcctcagtg gaagtggctt cataagaatc aggggggaaa tttgtctgag ccattcccct
     5221 gactgattac cctgggagga gacagaatat ttgtccagga cttttgtttg tttgctttga
     5281 tcctgtagta aacagaactg accccctcaa tgaggtgaga tcatgagaaa cattttccat
     5341 ctccctctgt tatcctgctt tgagaagaaa aatgaaaagt gccagaggaa attgcattta
     5401 gaactccaaa ggtgagagga gtgatctccc cgccccccac atgatttgat ttttaagccc
     5461 tggagaactg gaggctatag aagccatgac ctttcagctt ctcctcaaat aaaaaacaag
     5521 ccagtcttcc ctgcagcaaa ctctgccaag cttctcaact gccttctccc tgtctttctg
     5581 tccgctccca tctctgagga cccagtgtgt gctatagggc ctgtggctac catctagggt
     5641 gtcttatacc tgtgccaacc atttcctgaa caagttggca tcttgaaata gaaatagcta
     5701 ccatttaatc aaactttgag caagaagcaa tagtcctcct gggctgatga tcacctgctt
     5761 agcatcatga cattggagtt agcttgccat tttctgtaac ctcccccatt tttgtgatgc
     5821 agacccagtg acctattcaa ggccaaaaac gcagatggag ttttcacttt ttaatccatc
     5881 atggacttca aacagctaag agagggagga agaaagggaa gcctataggt tatataaaat
     5941 ttaactagat gtaggccaac catgcagaac cagaggtaag cgctttcaaa ggacttgagg
     6001 gctgtgatac agggccacct cagacaccat gacagctaca agtccttgat ggatttgttc
     6061 aaatctctgg gactcggttt cctcacctag ttgaattaga gtttagacca aaagaatttc
     6121 taatgctcct ttaggtttaa cagtcaataa tgtttatctg tgataggaaa gcagaatcaa
     6181 agttggcctt ggtgagccat cataattaag gaaaagccag aatctttgtg aaggagatgg
     6241 ggaaagggaa ggaaagaaag aagggaggaa agagactgac tcagaactct ctgtgtctct
     6301 catacacaca cacacacaca cacacacaca cacacacaca cacacacaca caccccaaaa
     6361 acaatgctaa aagaagctga agtcattatg tctacaaaag cagagccaag gacctgggtg
     6421 tggctgaaca gcccacctca tcaagggagc cgaaat
//
