LOCUS       NM_001106587            4158 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus transportin 3 (Tnpo3), mRNA.
ACCESSION   NM_001106587 XM_001064267 XM_216112
VERSION     NM_001106587.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Rodriguez-Mora S, De Wit F, Garcia-Perez J, Bermejo M,
            Lopez-Huertas MR, Mateos E, Marti P, Rocha S, Vigon L, Christ F,
            Debyser Z, Vilchez JJ, Coiras M and Alcami J.
  TITLE     The mutation of Transportin 3 gene that causes limb girdle muscular
            dystrophy 1F induces protection against HIV-1 infection
  JOURNAL   PLoS Pathog 15 (8), e1007958 (2019)
   PUBMED   31465518
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4158)
  AUTHORS   Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov
            P and Engelman AN.
  TITLE     Differential role for phosphorylation in alternative
            polyadenylation function versus nuclear import of SR-like protein
            CPSF6
  JOURNAL   Nucleic Acids Res 47 (9), 4663-4683 (2019)
   PUBMED   30916345
REFERENCE   3  (bases 1 to 4158)
  AUTHORS   Vihola A, Palmio J, Danielsson O, Penttila S, Louiselle D, Pittman
            S, Weihl C and Udd B.
  TITLE     Novel mutation in TNPO3 causes congenital limb-girdle myopathy with
            slow progression
  JOURNAL   Neurol Genet 5 (3), e337 (2019)
   PUBMED   31192305
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4158)
  AUTHORS   Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Oztop I, Lee K, Pye
            VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A
            and Cherepanov P.
  TITLE     Structural basis for nuclear import of splicing factors by human
            Transportin 3
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2728-2733 (2014)
   PUBMED   24449914
REFERENCE   5  (bases 1 to 4158)
  AUTHORS   Taltynov O, Demeulemeester J, Christ F, De Houwer S, Tsirkone VG,
            Gerard M, Weeks SD, Strelkov SV and Debyser Z.
  TITLE     Interaction of transportin-SR2 with Ras-related nuclear protein
            (Ran) GTPase
  JOURNAL   J Biol Chem 288 (35), 25603-25613 (2013)
   PUBMED   23878195
REFERENCE   6  (bases 1 to 4158)
  AUTHORS   Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng
            L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP and
            Kvaratskhelia M.
  TITLE     Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3
            or TRN-SR2)
  JOURNAL   J Biol Chem 287 (41), 34044-34058 (2012)
   PUBMED   22872640
REFERENCE   7  (bases 1 to 4158)
  AUTHORS   Lai MC, Kuo HW, Chang WC and Tarn WY.
  TITLE     A novel splicing regulator shares a nuclear import pathway with SR
            proteins
  JOURNAL   EMBO J 22 (6), 1359-1369 (2003)
   PUBMED   12628928
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216112.4, XM_001064267.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY724521.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..4158
                     /gene="Tnpo3"
                     /note="transportin 3"
                     /db_xref="GeneID:296954"
                     /db_xref="RGD:1308938"
     exon            1..469
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..3121
                     /gene="Tnpo3"
                     /codon_start=1
                     /product="transportin-3"
                     /protein_id="NP_001100057.1"
                     /db_xref="GeneID:296954"
                     /db_xref="RGD:1308938"
                     /translation="MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAW
                     EISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP
                     VIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLR
                     IGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNF
                     MANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTL
                     ETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHP
                     QYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLEPDHEGVPEE
                     TDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKS
                     VDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMK
                     GLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTA
                     LVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNP
                     IVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQ
                     PLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQN
                     GLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANSSVMRF
                     LRDLIHTGVANDHEEDFEVRKELIGQVMDQLGQQLVSQLLHTCCFCLPPYTLPDVAEV
                     LWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWA
                     LRDFTRLFR"
     exon            470..670
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..744
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..901
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1045
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1221
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1360
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1507
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1615
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1707
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1847
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2039
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2131
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2208
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2269
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2410
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2527
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2622
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2779
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2947
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3060
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3157
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..4158
                     /gene="Tnpo3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttcgctgc gtggtttgtg tcatgcggag gtaggccttt gagagcaagg cgggaggtgt
       61 ggaagcaaga acccgcatcc ggactctaga gtctgggatt ctggcgggaa gacaagacaa
      121 aaaggagcca ggaacctgaa aacgacctat ccgctgtttc cgagggggca acttccacga
      181 ggaaccccac cccccccacc ccttccctgg taacggccag aaaagaggag atggcgccag
      241 tcagggagcg gctgtggccg agacagtgag gacgcttgaa ggcagagcaa gcggaagcct
      301 tgggagaagt atcggactct tcgctgtcat cgccgccgct tccaccacca tggaaggagc
      361 caagccaacc ttgcagctcg tgtaccaggc ggtgcaggcg ctttaccacg acccagatcc
      421 cagcggaaag gagcgcgcct cgttttggct tggggagctg caacgttcgg ttcatgcgtg
      481 ggagatttct gatcaattgt tacagatccg acaggatgtg gaatcatgct atttcgctgc
      541 ccagaccatg aaaatgaaga ttcagacctc attttatgag cttcccacag actcccatgc
      601 ttctttaagg gactcattgc taactcatat tcagaacttg aaagacttgt cacctgtcat
      661 tgtaacacag ctggctttag caatagcaga ccttgcccta cagatgcctt cttggaaggg
      721 atgcgtacaa acattggtag aaaaatatag caatgatgta acttctttgc cttttttgct
      781 ggaaatcctt acagtgttac ctgaagaagt acacagtcgt tccttgcgga ttggagccaa
      841 caggcgcaca gaaattatag aagacttagc cttctactct agtacagtgg tttctttatt
      901 gatgacatgt gtagagaaag caggaactga cgagaagatg cttatgaagg tcttccgatg
      961 tttgggaagt tggtttaact tgggagtttt ggacagtaac ttcatggcta ataataagtt
     1021 attagcactc ctttttgagg ttttgcaaca agataagacc tcatctaacc tacacgaagc
     1081 tgcttctgac tgtgtgtgct ccgctctcta tgctattgaa aatgtagaga ctaacttgcc
     1141 attggccatg cagctttttc agggcgtcct gacactggag actgcctatc atatggctgt
     1201 ggcacgggaa gatttagaca aagttctgaa ttactgccgt atcttcaccg aactatgtga
     1261 aacttttctg gaaaaaattg tctgtactcc aggccaaggt ctgggagatc ttcgaacttt
     1321 ggaattgctt cttatctgcg caggccaccc tcagtatgag gtagtagaaa tttcctttaa
     1381 cttttggtac cggctaggag aacatttata caaaaccaat gatgaagtta ttcacagcat
     1441 cttcaaagca tatattcaga ggctgcttca tgccttggct cgacactgcc agttggaacc
     1501 agaccatgaa ggagttcctg aagagactga tgactttggg gagtttcgaa tgagagtgtc
     1561 agacctggtg aaggacttga ttttcttgat tggatctatg gagtgctttg ctcagttgta
     1621 ctctactctg aaggaaggca atccaccctg ggaggtgaca gaagcggtcc tctttatcat
     1681 ggctgctata gcaaagagtg ttgatccgga gaacaatcct acactcgtgg aggtactgga
     1741 gggagttgtc catctcccag agactgtgca cacagctgtg cgctacacca gcattgagtt
     1801 ggttggtgaa atgagtgaag tggtggaccg aaatcctcag tttctggatc ctgtattggg
     1861 ctatttgatg aaaggcctgt gtgaaaagcc tctggcttct gctgcagcca aagccattca
     1921 taacatttgt tccgtttgtc gggatcatat ggctcagcac tttaatggac tcctagaaat
     1981 tgcccactcc cttgattctt tcatgttgtc tcctgaagcc gctgtgggtt tgctaaaagg
     2041 aacagctctt gtcctagcaa gactaccttt ggataagatc actgaatgtc ttagtgagtt
     2101 atgttctgtt caggttatgg cattgaaaaa gctgttgtct caggagccca gcaatggcat
     2161 ttcttcagat cccactgtct tcttagatcg cctggcagta atatttagac acaccaatcc
     2221 tattgtagaa aatggacaga ctcatccatg ccaaaaagtc atccaggaaa tatggccagt
     2281 tttgtctgag actctgaata agcatcgagc tgacaatcgg attgtagagc gttgttgtag
     2341 atgcctgcgc tttgcggttc gctgtgtagg caaaggatct gcagccctgt tacagccact
     2401 agtcacacag atggtgaatg tgtaccatgt acatcagcat tcctgtttcc tgtatcttgg
     2461 cagtatactt gtggatgagt acggcatgga ggaaggctgt cggcagggat tattagacat
     2521 gctccaggcg ctatgcattc ccacctttca gctcctagaa cagcagaatg gcctccagaa
     2581 tcaccccgac actgtagatg acctgttcag gttagccacc cgatttattc agcgaagccc
     2641 tgtcaccttg ctgaggagcc aggtggttat cccgatctta cagtgggcca tcgcgtctac
     2701 caccttggat caccgagatg ccaattccag tgtcatgagg ttcctgcgag acctcatcca
     2761 cacaggagta gcaaatgatc atgaagaaga ctttgaagtg cggaaggaac taattggaca
     2821 ggtgatggac cagcttgggc agcagcttgt aagccagttg ctacacacgt gctgcttctg
     2881 ccttccccct tacaccctac ccgatgtggc tgaagtgctc tgggagatca tgcaggttga
     2941 cagaccgact ttctgtcggt ggctagagaa ttccttgaaa ggtttgccaa aggagacaac
     3001 ggtgggagct gtcacagtga cacataaaca acttacagat ttccacaagc aagtcactag
     3061 tgctgaggaa tgtaagcaag tttgctgggc cttgcgagac ttcaccaggt tgtttcgata
     3121 gctcaagctc acactcctgc actgtgcctg tcatcaggaa tgtctttttt cattagaaga
     3181 caggaagaaa acaacccaga ctgtgtccca caatcagaaa cctccgttgt ggcagagggg
     3241 ccttcacgac caccatacca tcccgccaca cagggagaga cttcaccctc caaggcatcc
     3301 taaggagtcc ctgtttgggg tgtgaggggg aaacagcgcg cggtatttaa ggatggctac
     3361 agcctgtccg gcgtggtggg agggaactag tttcctggtg aacttctttc taaaaggaaa
     3421 aataatttaa ggaaagttaa aaaaaaaaaa aaaaagaaag aaagaaaaga aaagaaaatt
     3481 ttttaaaaag gaaagctgag atgaaaccag aactgaaatt cgcactggca gcagaagatg
     3541 cacacacatg acagacacac acatgacaga cacacaccag catgcagtgc acacggagac
     3601 atggcagtga gagctgtctg agacagaccc ttaccttagg gaaacgaggg aatagcgtct
     3661 gctctccttc ctttaaacac aggtgaacag aggaaacgct ctccccaatt cctccacctt
     3721 tagagccgcc cagacaagga gcctgttgtg cttatatcat ggttagggat ggtagtcaga
     3781 accagccaag gtgacccaac cctgatccta tcgagttgct aagtccactc cagtccacac
     3841 gtcttcgtca tcagctttgg ggagaaaagc caaacctggg gagggcggag aggacaaatg
     3901 tgtagtaaac ctttccctct ctctctctct tttcttctct ctctctctct ctctctctct
     3961 ctctctctct cttctctccc tcttgattat tcatccacaa atatggggtg ggaggggatt
     4021 aaaaagaggg caagagtatg aagggaatgt atttacaggg ctacctgtat tttgctaaaa
     4081 aagtgtgaaa attaattgcc ttcaagggca ctgttctgtc ctgtgtgtgg ccatcttatg
     4141 aataaatcaa cagcacca
//
