LOCUS       NM_017057                559 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus transition protein 2 (Tnp2), mRNA.
ACCESSION   NM_017057
VERSION     NM_017057.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 559)
  AUTHORS   Barral,S., Morozumi,Y., Tanaka,H., Montellier,E., Govin,J., de
            Dieuleveult,M., Charbonnier,G., Coute,Y., Puthier,D., Buchou,T.,
            Boussouar,F., Urahama,T., Fenaille,F., Curtet,S., Hery,P.,
            Fernandez-Nunez,N., Shiota,H., Gerard,M., Rousseaux,S.,
            Kurumizaka,H. and Khochbin,S.
  TITLE     Histone Variant H2A.L.2 Guides Transition Protein-Dependent
            Protamine Assembly in Male Germ Cells
  JOURNAL   Mol Cell 66 (1), 89-101 (2017)
   PUBMED   28366643
REFERENCE   2  (bases 1 to 559)
  AUTHORS   Pradeepa,M.M., Nikhil,G., Hari Kishore,A., Bharath,G.N., Kundu,T.K.
            and Rao,M.R.
  TITLE     Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters
            its DNA condensation property and interaction with putative histone
            chaperone NPM3
  JOURNAL   J Biol Chem 284 (43), 29956-29967 (2009)
   PUBMED   19710011
  REMARK    GeneRIF: Acetylation of transition protein 2 (TP2) by KAT3B (p300)
            alters its DNA condensation property and interaction with putative
            histone chaperone NPM3.
REFERENCE   3  (bases 1 to 559)
  AUTHORS   Kolthur-Seetharam,U., Pradeepa,M.M., Gupta,N., Narayanaswamy,R. and
            Rao,M.R.
  TITLE     Spatiotemporal organization of AT- and GC-rich DNA and their
            association with transition proteins TP1 and TP2 in rat condensing
            spermatids
  JOURNAL   J Histochem Cytochem 57 (10), 951-962 (2009)
   PUBMED   19506090
  REMARK    GeneRIF: TP1 and TP2 may have concerted functional roles during
            chromatin remodeling in mammalian spermiogenesis.
REFERENCE   4  (bases 1 to 559)
  AUTHORS   Kleene,K.C. and Bagarova,J.
  TITLE     Comparative genomics reveals gene-specific and shared regulatory
            sequences in the spermatid-expressed mammalian Odf1, Prm1, Prm2,
            Tnp1, and Tnp2 genes
  JOURNAL   Genomics 92 (2), 101-106 (2008)
   PUBMED   18562159
REFERENCE   5  (bases 1 to 559)
  AUTHORS   Pradeepa,M.M., Manjunatha,S., Sathish,V., Agrawal,S. and Rao,M.R.
  TITLE     Involvement of importin-4 in the transport of transition protein 2
            into the spermatid nucleus
  JOURNAL   Mol Cell Biol 28 (13), 4331-4341 (2008)
   PUBMED   17682055
  REMARK    GeneRIF: A detailed analysis to characterize the molecular
            components underlying the nuclear translocation of TP2, was carried
            out.
REFERENCE   6  (bases 1 to 559)
  AUTHORS   Kundu,T.K. and Rao,M.R.
  TITLE     Characterization of the zinc-metalloprotein nature of rat
            spermatidal protein TP2
  JOURNAL   FEBS Lett 351 (1), 6-10 (1994)
   PUBMED   8076694
REFERENCE   7  (bases 1 to 559)
  AUTHORS   Keime,S., Heitland,K., Kumm,S., Schlosser,M., Hroch,N., Holtz,W.
            and Engel,W.
  TITLE     Characterization of four genes encoding basic proteins of the
            porcine spermatid nucleus and close linkage of three of them
  JOURNAL   Biol Chem Hoppe Seyler 373 (5), 261-270 (1992)
   PUBMED   1627265
REFERENCE   8  (bases 1 to 559)
  AUTHORS   Baskaran,R. and Rao,M.R.
  TITLE     Mammalian spermatid specific protein, TP2, is a zinc metalloprotein
            with two finger motifs
  JOURNAL   Biochem Biophys Res Commun 179 (3), 1491-1499 (1991)
   PUBMED   1930189
REFERENCE   9  (bases 1 to 559)
  AUTHORS   Luerssen,H., Maier,W.M., Hoyer-Fender,S. and Engel,W.
  TITLE     The nucleotide sequence of rat transition protein 2 (TP2) cDNA
  JOURNAL   Nucleic Acids Res 17 (9), 3585 (1989)
   PUBMED   2726489
REFERENCE   10 (bases 1 to 559)
  AUTHORS   Cole,K.D. and Kistler,W.S.
  TITLE     Nuclear transition protein 2 (TP2) of mammalian spermatids has a
            very basic carboxyl terminal domain
  JOURNAL   Biochem Biophys Res Commun 147 (1), 437-442 (1987)
   PUBMED   3307778
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078849.1.
            
            On Aug 8, 2004 this sequence version replaced NM_017057.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078849.1, X14776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..559
                     /gene="Tnp2"
                     /note="transition protein 2"
                     /db_xref="GeneID:24840"
                     /db_xref="RGD:3885"
     exon            1..382
                     /gene="Tnp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..399
                     /gene="Tnp2"
                     /note="haploid expressed, male germcell specific,
                     chromatin binding; TP2; TP-2"
                     /codon_start=1
                     /product="nuclear transition protein 2"
                     /protein_id="NP_058753.2"
                     /db_xref="GeneID:24840"
                     /db_xref="RGD:3885"
                     /translation="MDTKMQSLPTTHPHPHSSSRPQSHTNNQCACSHHCRSCSQAGHP
                     SSSSSPSSGPPTKHPKTPMHSRYSPSRPSHRGSCPKNRKTLEGKVSKRKAVRRRKRTH
                     RAKRRSSGRRYK"
     exon            383..536
                     /gene="Tnp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgggaga agaggaggag gaggaagtct ctgcccctcc gagtgtggcc tcccatggac
       61 accaagatgc agagccttcc caccactcat ccccacccgc acagctcctc tcggcctcaa
      121 agtcacacca ataaccagtg tgcctgcagc caccactgcc ggagctgcag ccaagcaggc
      181 cacccgagct ccagttccag ccccagctct ggcccgccga cgaagcaccc caaaacaccc
      241 atgcactctc gttactcacc ttcaagaccc agccaccgcg gcagctgccc caagaacagg
      301 aagaccttgg aagggaaagt gagcaagaga aaggcggtca ggaggcggaa gcggactcac
      361 agagctaaga ggcgtagctc aggacgaaga tacaagtgac acactccagg atgttcctgt
      421 gtccatttga tcccaaaagg agatagccat cactagggga atgttgggat gacagtacag
      481 gaacatgtca ctgcagcaat ttctatgcaa catggattaa agcttgtacc ctggaaaaaa
      541 aaaaaaaaaa aaaaaaaaa
//
