LOCUS       NM_017056                439 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus transition protein 1 (Tnp1), mRNA.
ACCESSION   NM_017056
VERSION     NM_017056.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Barral,S., Morozumi,Y., Tanaka,H., Montellier,E., Govin,J., de
            Dieuleveult,M., Charbonnier,G., Coute,Y., Puthier,D., Buchou,T.,
            Boussouar,F., Urahama,T., Fenaille,F., Curtet,S., Hery,P.,
            Fernandez-Nunez,N., Shiota,H., Gerard,M., Rousseaux,S.,
            Kurumizaka,H. and Khochbin,S.
  TITLE     Histone Variant H2A.L.2 Guides Transition Protein-Dependent
            Protamine Assembly in Male Germ Cells
  JOURNAL   Mol Cell 66 (1), 89-101 (2017)
   PUBMED   28366643
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Kolthur-Seetharam,U., Pradeepa,M.M., Gupta,N., Narayanaswamy,R. and
            Rao,M.R.
  TITLE     Spatiotemporal organization of AT- and GC-rich DNA and their
            association with transition proteins TP1 and TP2 in rat condensing
            spermatids
  JOURNAL   J Histochem Cytochem 57 (10), 951-962 (2009)
   PUBMED   19506090
  REMARK    GeneRIF: TP1 and TP2 may have concerted functional roles during
            chromatin remodeling in mammalian spermiogenesis.
REFERENCE   3  (bases 1 to 439)
  AUTHORS   Govin,J., Escoffier,E., Rousseaux,S., Kuhn,L., Ferro,M.,
            Thevenon,J., Catena,R., Davidson,I., Garin,J., Khochbin,S. and
            Caron,C.
  TITLE     Pericentric heterochromatin reprogramming by new histone variants
            during mouse spermiogenesis
  JOURNAL   J Cell Biol 176 (3), 283-294 (2007)
   PUBMED   17261847
REFERENCE   4  (bases 1 to 439)
  AUTHORS   Shirley,C.R., Hayashi,S., Mounsey,S., Yanagimachi,R. and
            Meistrich,M.L.
  TITLE     Abnormalities and reduced reproductive potential of sperm from
            Tnp1- and Tnp2-null double mutant mice
  JOURNAL   Biol Reprod 71 (4), 1220-1229 (2004)
   PUBMED   15189834
REFERENCE   5  (bases 1 to 439)
  AUTHORS   Zhao,M., Shirley,C.R., Mounsey,S. and Meistrich,M.L.
  TITLE     Nucleoprotein transitions during spermiogenesis in mice with
            transition nuclear protein Tnp1 and Tnp2 mutations
  JOURNAL   Biol Reprod 71 (3), 1016-1025 (2004)
   PUBMED   15163613
REFERENCE   6  (bases 1 to 439)
  AUTHORS   Keime,S., Heitland,K., Kumm,S., Schlosser,M., Hroch,N., Holtz,W.
            and Engel,W.
  TITLE     Characterization of four genes encoding basic proteins of the
            porcine spermatid nucleus and close linkage of three of them
  JOURNAL   Biol Chem Hoppe Seyler 373 (5), 261-270 (1992)
   PUBMED   1627265
REFERENCE   7  (bases 1 to 439)
  AUTHORS   Heidaran,M.A., Kozak,C.A. and Kistler,W.S.
  TITLE     Nucleotide sequence of the Stp-1 gene coding for rat spermatid
            nuclear transition protein 1 (TP1): homology with protamine P1 and
            assignment of the mouse Stp-1 gene to chromosome 1
  JOURNAL   Gene 75 (1), 39-46 (1989)
   PUBMED   2524424
REFERENCE   8  (bases 1 to 439)
  AUTHORS   Heidaran,M.A. and Kistler,W.S.
  TITLE     Isolation of a cDNA clone for transition protein 1 (TP1), a major
            chromosomal protein of mammalian spermatids
  JOURNAL   Gene 54 (2-3), 281-284 (1987)
   PUBMED   2820847
REFERENCE   9  (bases 1 to 439)
  AUTHORS   Kistler,W.S., Noyes,C., Hsu,R. and Heinrikson,R.L.
  TITLE     The amino acid sequence of a testis-specific basic protein that is
            associated with spermatogenesis
  JOURNAL   J Biol Chem 250 (5), 1847-1853 (1975)
   PUBMED   1112834
REFERENCE   10 (bases 1 to 439)
  AUTHORS   Kistler,W.S., Noyes,C. and Heinrikson,R.L.
  TITLE     Partial structural analysis of a highly basic low molecular weight
            protein from rat testis
  JOURNAL   Biochem Biophys Res Commun 57 (2), 341-347 (1974)
   PUBMED   4829397
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078850.1.
            
            On Aug 23, 2004 this sequence version replaced NM_017056.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078850.1, M17096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..439
                     /gene="Tnp1"
                     /note="transition protein 1"
                     /db_xref="GeneID:24839"
                     /db_xref="RGD:3884"
     exon            1..156
                     /gene="Tnp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..185
                     /gene="Tnp1"
                     /note="TP-1; STP-1; testis-specific basic protein"
                     /codon_start=1
                     /product="spermatid nuclear transition protein 1"
                     /protein_id="NP_058752.1"
                     /db_xref="GeneID:24839"
                     /db_xref="RGD:3884"
                     /translation="MSTSRKLKTHGMRRGKNRAPHKGVKRGGSKRKYRKSSLKSRKRG
                     DDASRNYRSHL"
     exon            157..412
                     /gene="Tnp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttggcaga aattacaatg tcgaccagcc gcaaactaaa gactcatggc atgaggagag
       61 gcaagaaccg agctcctcac aagggcgtca agagaggagg aagcaagaga aaataccgga
      121 agagcagcct gaagagtagg aaacggggcg atgatgcaag tcgcaattac cgatcccact
      181 tgtaatgcgg caatgagctc tagcctggtg gtcttcaaac tacaccaggc agcaacaaga
      241 catcagaggg ggactgccag agagatctga agttagacca aagccagaga aagatcctat
      301 cagagtgggt aaaatgccag ttgtgacgaa attcggaatg tatatgttgg ctgtttctcc
      361 ccaacatctc aataacaatt ttgaaaacaa aataaaattg tgaaaactga aaaaaaaaaa
      421 aaaaaaaaaa aaaaaaaaa
//
