LOCUS       NM_001270664            1047 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus troponin T3, fast skeletal type (Tnnt3),
            transcript variant 11, mRNA.
ACCESSION   NM_001270664
VERSION     NM_001270664.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Schilder,R.J., Kimball,S.R., Marden,J.H. and Jefferson,L.S.
  TITLE     Body weight-dependent troponin T alternative splicing is
            evolutionarily conserved from insects to mammals and is partially
            impaired in skeletal muscle of obese rats
  JOURNAL   J Exp Biol 214 (Pt 9), 1523-1532 (2011)
   PUBMED   21490260
  REMARK    GeneRIF: Weight-dependent quantitative variation in Tnnt3
            alternative splicing appears to be an evolutionarily conserved
            feature of skeletal muscle.
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Robinson,P., Lipscomb,S., Preston,L.C., Altin,E., Watkins,H.,
            Ashley,C.C. and Redwood,C.S.
  TITLE     Mutations in fast skeletal troponin I, troponin T, and
            beta-tropomyosin that cause distal arthrogryposis all increase
            contractile function
  JOURNAL   FASEB J 21 (3), 896-905 (2007)
   PUBMED   17194691
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Gallon,C.E., Tschirgi,M.L. and Chandra,M.
  TITLE     Differences in myofilament calcium sensitivity in rat psoas fibers
            reconstituted with troponin T isoforms containing the alpha- and
            beta-exons
  JOURNAL   Arch Biochem Biophys 456 (2), 127-134 (2006)
   PUBMED   16839517
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   Brotto,M.A., Biesiadecki,B.J., Brotto,L.S., Nosek,T.M. and Jin,J.P.
  TITLE     Coupled expression of troponin T and troponin I isoforms in single
            skeletal muscle fibers correlates with contractility
  JOURNAL   Am J Physiol Cell Physiol 290 (2), C567-C576 (2006)
   PUBMED   16192301
REFERENCE   5  (bases 1 to 1047)
  AUTHORS   Mukhopadhyay,S., Langsetmo,K., Stafford,W.F. 3rd, Henry,G.D.,
            Baleja,J.D. and Sarkar,S.
  TITLE     Identification of a region of fast skeletal troponin T required for
            stabilization of the coiled-coil formation with troponin I
  JOURNAL   J Biol Chem 280 (1), 538-547 (2005)
   PUBMED   15507453
REFERENCE   6  (bases 1 to 1047)
  AUTHORS   Behrens,O., Wedeking-Schohl,H., Mesrogli,M., Degenhardt,F. and
            Schneider,J.
  TITLE     [Doppler ultrasound in monitoring twin pregnancies with early
            discordant growth]
  JOURNAL   Z Geburtshilfe Perinatol 196 (5), 209-212 (1992)
   PUBMED   1299083
REFERENCE   7  (bases 1 to 1047)
  AUTHORS   Breitbart,R.E. and Nadal-Ginard,B.
  TITLE     Complete nucleotide sequence of the fast skeletal troponin T gene.
            Alternatively spliced exons exhibit unusual interspecies divergence
  JOURNAL   J Mol Biol 188 (3), 313-324 (1986)
   PUBMED   3735424
REFERENCE   8  (bases 1 to 1047)
  AUTHORS   Breitbart,R.E., Nguyen,H.T., Medford,R.M., Destree,A.T., Mahdavi,V.
            and Nadal-Ginard,B.
  TITLE     Intricate combinatorial patterns of exon splicing generate multiple
            regulated troponin T isoforms from a single gene
  JOURNAL   Cell 41 (1), 67-82 (1985)
   PUBMED   2986851
REFERENCE   9  (bases 1 to 1047)
  AUTHORS   Medford,R.M., Nguyen,H.T., Destree,A.T., Summers,E. and
            Nadal-Ginard,B.
  TITLE     A novel mechanism of alternative RNA splicing for the
            developmentally regulated generation of troponin T isoforms from a
            single gene
  JOURNAL   Cell 38 (2), 409-421 (1984)
   PUBMED   6205765
REFERENCE   10 (bases 1 to 1047)
  AUTHORS   Garfinkel,L.I., Periasamy,M. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of cDNA sequences corresponding to
            myosin light chains 1, 2, and 3, troponin-C, troponin-T,
            alpha-tropomyosin, and alpha-actin
  JOURNAL   J Biol Chem 257 (18), 11078-11086 (1982)
   PUBMED   6179945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and CB612473.1.
            
            Transcript Variant: This variant (11) lacks two alternate in-frame
            exons compared to variant 1. The resulting isoform (11) has the
            same N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215694.1, FQ215316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  207082014-207082069
            57-147              CB612473.1         6-96
            148-192             CB612473.1         115-159
            193-560             CB612473.1         175-542
            561-566             JAXUCZ010000001.1  207095167-207095172
            567-676             JAXUCZ010000001.1  207095279-207095388
            677-767             JAXUCZ010000001.1  207095499-207095589
            768-808             JAXUCZ010000001.1  207097313-207097353
            809-1047            JAXUCZ010000001.1  207098776-207099014
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1047
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /note="troponin T3, fast skeletal type"
                     /db_xref="GeneID:24838"
                     /db_xref="RGD:3883"
     exon            1..98
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            99..133
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..863
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /note="isoform 11 is encoded by transcript variant 11;
                     troponin T, fast skeletal muscle; fTnT; tnTf; fast
                     skeletal muscle troponin T; troponin T type 3 (skeletal,
                     fast); troponin T3, skeletal, fast"
                     /codon_start=1
                     /product="troponin T, fast skeletal muscle isoform 11"
                     /protein_id="NP_001257593.1"
                     /db_xref="GeneID:24838"
                     /db_xref="RGD:3883"
                     /translation="MSDEETEQVEEEAQEEEVQEEAPEPEEKPRPKLTAPKIPEGEKV
                     DFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRAERAEQQRIRAE
                     KERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQT
                     AREMKKKILAERRKPLNIDHLSDDKLRDKAKELWDTLYQLETDKFEFGEKLKRQKYDI
                     TTLRSRIDQAQKHSKKAGATAKGKVGGRWK"
     exon            134..147
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            148..165
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            166..180
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            181..192
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            193..211
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            212..257
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            258..374
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            375..452
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            453..566
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            567..676
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            677..767
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            768..808
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1047
                     /gene="Tnnt3"
                     /gene_synonym="Tnt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgtcact ataacatgaa ggggtgaggc cgttggacag tgcctgctgc tggtcctgtc
       61 cacaaggagc ccccaacctt tctcagactc aactgcagac acaacccacc gccactatgt
      121 ctgacgagga aactgaacaa gttgaggagg aggcccagga ggaagaagtc caggaggaag
      181 ccccggaacc agaggagaaa ccaagaccca aacttactgc tcctaagatc ccggaaggag
      241 agaaagtaga cttcgatgat atccagaaga agcgtcagaa caaggacctc atggagctcc
      301 aggccctcat tgacagccac tttgaagcta gaaagaaaga agaagaggag ctaattgcac
      361 ttaaggaaag aattgaaaag cgccgtgcag agagggctga gcagcaaagg attcgcgctg
      421 agaaggagcg ggagcgccag aacagactgg cggaggagaa ggccagaaga gaggaggaag
      481 atgccaagag gagagctgaa gatgacttga agaagaaaaa ggctctgtcc tctatgggtg
      541 ccaactacag cagctacctg gccaaggctg accagaagag aggcaagaaa cagacagccc
      601 gggaaatgaa aaagaagatt cttgctgaaa ggcgcaaacc tctgaacatt gaccatctta
      661 gtgatgataa gctgagggac aaggccaagg aactctggga taccttgtac caactggaga
      721 ctgacaaatt tgagtttggg gagaagctga aacgtcagaa atacgatatt accaccctca
      781 ggagccgcat tgaccaagcc cagaagcaca gcaagaaggc cggtgccaca gccaagggca
      841 aagtcggcgg gcgctggaag taaacgagcc aagaggtgcc ctgcagcaga gaccatcaac
      901 cctgactctt gccagggtcc cttattccag ctctgtattc tccaaccctc atgcccaggc
      961 acttttggga actcagggcc caccctgctg caatgtcctc gccctctggg gtctagaaat
     1021 aaagttatca gactcccctc tactgtc
//
