LOCUS       NM_012676               1098 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus troponin T2, cardiac type (Tnnt2), transcript
            variant 1, mRNA.
ACCESSION   NM_012676
VERSION     NM_012676.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Liu,Y., Liao,W., Wan,L., Xiang,T. and Zhang,W.
  TITLE     Correlation Between Relative Nasopharyngeal Virus RNA Load and
            Lymphocyte Count Disease Severity in Patients with COVID-19
  JOURNAL   Viral Immunol 34 (5), 330-335 (2021)
   PUBMED   32297828
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   Yamaguchi,M., Kimura,M., Ohno,T., Nakahara,N., Akiyama,N.,
            Takemori,S. and Yagi,N.
  TITLE     Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic
            Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray
            Diffraction and Mechanical Study of Cardiac Skinned Fibers
  JOURNAL   Int J Mol Sci 21 (10), 3520 (2020)
   PUBMED   32429250
  REMARK    GeneRIF: Crossbridge Recruitment Capacity of Wild-Type and
            Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by
            X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1098)
  AUTHORS   Muslimovic,A., Friden,V., Tenstad,O., Starnberg,K., Nystrom,S.,
            Wesen,E., Esbjorner,E.K., Granholm,K., Lindahl,B. and Hammarsten,O.
  TITLE     The Liver and Kidneys mediate clearance of cardiac troponin in the
            rat
  JOURNAL   Sci Rep 10 (1), 6791 (2020)
   PUBMED   32322013
  REMARK    GeneRIF: The Liver and Kidneys mediate clearance of cardiac
            troponin in the rat.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1098)
  AUTHORS   Wijnker,P.J., Li,Y., Zhang,P., Foster,D.B., dos Remedios,C., Van
            Eyk,J.E., Stienen,G.J., Murphy,A.M. and van der Velden,J.
  TITLE     A novel phosphorylation site, Serine 199, in the C-terminus of
            cardiac troponin I regulates calcium sensitivity and susceptibility
            to calpain-induced proteolysis
  JOURNAL   J Mol Cell Cardiol 82, 93-103 (2015)
   PUBMED   25771144
REFERENCE   5  (bases 1 to 1098)
  AUTHORS   Hao,J., Galindo,C.L., Tran,T.L. and Sawyer,D.B.
  TITLE     Neuregulin-1beta induces embryonic stem cell cardiomyogenesis via
            ErbB3/ErbB2 receptors
  JOURNAL   Biochem J 458 (2), 335-341 (2014)
   PUBMED   24364879
REFERENCE   6  (bases 1 to 1098)
  AUTHORS   Watkins,H., McKenna,W.J., Thierfelder,L., Suk,H.J., Anan,R.,
            O'Donoghue,A., Spirito,P., Matsumori,A., Moravec,C.S., Seidman,J.G.
            et al.
  TITLE     Mutations in the genes for cardiac troponin T and alpha-tropomyosin
            in hypertrophic cardiomyopathy
  JOURNAL   N Engl J Med 332 (16), 1058-1064 (1995)
   PUBMED   7898523
REFERENCE   7  (bases 1 to 1098)
  AUTHORS   Thierfelder,L., Watkins,H., MacRae,C., Lamas,R., McKenna,W.,
            Vosberg,H.P., Seidman,J.G. and Seidman,C.E.
  TITLE     Alpha-tropomyosin and cardiac troponin T mutations cause familial
            hypertrophic cardiomyopathy: a disease of the sarcomere
  JOURNAL   Cell 77 (5), 701-712 (1994)
   PUBMED   8205619
REFERENCE   8  (bases 1 to 1098)
  AUTHORS   Jin,J.P., Huang,Q.Q., Yeh,H.I. and Lin,J.J.
  TITLE     Complete nucleotide sequence and structural organization of rat
            cardiac troponin T gene. A single gene generates embryonic and
            adult isoforms via developmentally regulated alternative splicing
  JOURNAL   J Mol Biol 227 (4), 1269-1276 (1992)
   PUBMED   1433301
REFERENCE   9  (bases 1 to 1098)
  AUTHORS   Solaro,R.J., el-Saleh,S.C. and Kentish,J.C.
  TITLE     Ca2+, pH and the regulation of cardiac myofilament force and ATPase
            activity
  JOURNAL   Mol Cell Biochem 89 (2), 163-167 (1989)
   PUBMED   2530435
REFERENCE   10 (bases 1 to 1098)
  AUTHORS   Jin,J.P. and Lin,J.J.
  TITLE     Isolation and characterization of cDNA clones encoding embryonic
            and adult isoforms of rat cardiac troponin T
  JOURNAL   J Biol Chem 264 (24), 14471-14477 (1989)
   PUBMED   2760070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 10, 2023 this sequence version replaced NM_012676.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26051.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000013.1  49824059-49824096
            39-49               JAXUCZ010000013.1  49825052-49825062
            50-79               JAXUCZ010000013.1  49827551-49827580
            80-166              JAXUCZ010000013.1  49829733-49829819
            167-202             JAXUCZ010000013.1  49830094-49830129
            203-236             JAXUCZ010000013.1  49830921-49830954
            237-300             JAXUCZ010000013.1  49831861-49831924
            301-417             JAXUCZ010000013.1  49832122-49832238
            418-495             JAXUCZ010000013.1  49833407-49833484
            496-606             JAXUCZ010000013.1  49833956-49834066
            607-612             JAXUCZ010000013.1  49835221-49835226
            613-722             JAXUCZ010000013.1  49835550-49835659
            723-813             JAXUCZ010000013.1  49836199-49836289
            814-854             JAXUCZ010000013.1  49836551-49836591
            855-1098            JAXUCZ010000013.1  49836882-49837125
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1098
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /note="troponin T2, cardiac type"
                     /db_xref="GeneID:24837"
                     /db_xref="RGD:3882"
     CDS             1..900
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     troponin T, cardiac muscle; cardiac troponin T2; cTnT;
                     tnTc; cardiac muscle troponin T; troponin T type 2
                     (cardiac); Troponin T cardiac"
                     /codon_start=1
                     /product="troponin T, cardiac muscle isoform 1"
                     /protein_id="NP_036808.1"
                     /db_xref="GeneID:24837"
                     /db_xref="RGD:3882"
                     /translation="MSDAEEEVVEYEEEQEEEDWSEEEEDEQEEAVEEEDGEAEPDPE
                     GEAEAEEDKAEEVGPDEEARDAEDGPVEDSKPKPSRLFMPNLVPPKIPDGERVDFDDI
                     HRKRMEKDLNELQTLIEAHFENRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKER
                     QNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKAQTERKSGKRQTEREK
                     KKKILAERRKVLAIDHLNEDQLREKAKELWQSIHNLEAEKFDLQEKFKQQKYEINVLR
                     NRINDNQKVSKTRGKAKVTGRWK"
     exon            1..38
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            39..49
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            50..79
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            80..166
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            167..202
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..236
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            237..300
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            301..417
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..495
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..606
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..612
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            613..722
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..813
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..854
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1098
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctgacg ccgaggaaga ggtggtggag tacgaggagg aacaggaaga ggaagactgg
       61 agcgaagaag aggaagacga gcaagaggag gcagtggagg aggaggatgg tgaggccgag
      121 cctgatcccg agggtgaggc agaggcagag gaggacaagg cagaagaggt tggtcctgat
      181 gaagaagcca gagatgctga agatggtcca gtagaggact ccaaacccaa gcccagcagg
      241 ctcttcatgc ccaacttggt gccacccaag atccctgacg gagagagagt ggactttgat
      301 gacatccaca ggaagcgcat ggagaaggac ctgaacgagc tgcagactct gatcgaggct
      361 cacttcgaga acaggaagaa ggaggaagag gagctcattt ctctcaaaga caggatcgaa
      421 aagcgtcggg cagagcgggc tgaacagcag cgtattcgca atgaacgaga gaaggaaagg
      481 cagaaccgcc tggctgaaga gagggcccgg cgtgaggagg aggagaacag gaggaaggct
      541 gaagatgagg cccggaagaa gaaggctctg tccaacatga tgcattttgg agggtacatc
      601 cagaaggctc agacagagcg gaagagtggg aagagacaga cagagcgaga gaagaagaag
      661 aagattctgg cagagaggag gaaggtgctg gccatcgacc acctgaatga agaccagctg
      721 agagagaagg ccaaggagct atggcagagt atccacaacc tggaggccga gaagttcgac
      781 ctgcaggaaa agttcaagca gcagaaatac gaaatcaacg ttctgcgaaa caggatcaac
      841 gacaaccaga aagtctccaa aactcgtggg aaggccaaag tcaccgggcg ttggaaatag
      901 atggaactgt gttcgacaaa gctctgctcc ttgcctgtgc ccttgccctg tgaatcccag
      961 ctctaggtct tgccaggcac ccgatgcaga ctcctgtctg gaaagtagga gctgacctag
     1021 ctagaagcca gtactctgcc tgacccctat gcccacacca cgtcaggaat aaaaagccag
     1081 cacattgtgc acatggaa
//
