LOCUS       NM_001415762            1160 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus troponin T2, cardiac type (Tnnt2), transcript
            variant 2, mRNA.
ACCESSION   NM_001415762 XM_006249833
VERSION     NM_001415762.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1160)
  AUTHORS   Liu,Y., Liao,W., Wan,L., Xiang,T. and Zhang,W.
  TITLE     Correlation Between Relative Nasopharyngeal Virus RNA Load and
            Lymphocyte Count Disease Severity in Patients with COVID-19
  JOURNAL   Viral Immunol 34 (5), 330-335 (2021)
   PUBMED   32297828
REFERENCE   2  (bases 1 to 1160)
  AUTHORS   Yamaguchi,M., Kimura,M., Ohno,T., Nakahara,N., Akiyama,N.,
            Takemori,S. and Yagi,N.
  TITLE     Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic
            Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray
            Diffraction and Mechanical Study of Cardiac Skinned Fibers
  JOURNAL   Int J Mol Sci 21 (10), 3520 (2020)
   PUBMED   32429250
  REMARK    GeneRIF: Crossbridge Recruitment Capacity of Wild-Type and
            Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by
            X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1160)
  AUTHORS   Muslimovic,A., Friden,V., Tenstad,O., Starnberg,K., Nystrom,S.,
            Wesen,E., Esbjorner,E.K., Granholm,K., Lindahl,B. and Hammarsten,O.
  TITLE     The Liver and Kidneys mediate clearance of cardiac troponin in the
            rat
  JOURNAL   Sci Rep 10 (1), 6791 (2020)
   PUBMED   32322013
  REMARK    GeneRIF: The Liver and Kidneys mediate clearance of cardiac
            troponin in the rat.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1160)
  AUTHORS   Wijnker,P.J., Li,Y., Zhang,P., Foster,D.B., dos Remedios,C., Van
            Eyk,J.E., Stienen,G.J., Murphy,A.M. and van der Velden,J.
  TITLE     A novel phosphorylation site, Serine 199, in the C-terminus of
            cardiac troponin I regulates calcium sensitivity and susceptibility
            to calpain-induced proteolysis
  JOURNAL   J Mol Cell Cardiol 82, 93-103 (2015)
   PUBMED   25771144
REFERENCE   5  (bases 1 to 1160)
  AUTHORS   Hao,J., Galindo,C.L., Tran,T.L. and Sawyer,D.B.
  TITLE     Neuregulin-1beta induces embryonic stem cell cardiomyogenesis via
            ErbB3/ErbB2 receptors
  JOURNAL   Biochem J 458 (2), 335-341 (2014)
   PUBMED   24364879
REFERENCE   6  (bases 1 to 1160)
  AUTHORS   Watkins,H., McKenna,W.J., Thierfelder,L., Suk,H.J., Anan,R.,
            O'Donoghue,A., Spirito,P., Matsumori,A., Moravec,C.S., Seidman,J.G.
            et al.
  TITLE     Mutations in the genes for cardiac troponin T and alpha-tropomyosin
            in hypertrophic cardiomyopathy
  JOURNAL   N Engl J Med 332 (16), 1058-1064 (1995)
   PUBMED   7898523
REFERENCE   7  (bases 1 to 1160)
  AUTHORS   Thierfelder,L., Watkins,H., MacRae,C., Lamas,R., McKenna,W.,
            Vosberg,H.P., Seidman,J.G. and Seidman,C.E.
  TITLE     Alpha-tropomyosin and cardiac troponin T mutations cause familial
            hypertrophic cardiomyopathy: a disease of the sarcomere
  JOURNAL   Cell 77 (5), 701-712 (1994)
   PUBMED   8205619
REFERENCE   8  (bases 1 to 1160)
  AUTHORS   Jin,J.P., Huang,Q.Q., Yeh,H.I. and Lin,J.J.
  TITLE     Complete nucleotide sequence and structural organization of rat
            cardiac troponin T gene. A single gene generates embryonic and
            adult isoforms via developmentally regulated alternative splicing
  JOURNAL   J Mol Biol 227 (4), 1269-1276 (1992)
   PUBMED   1433301
REFERENCE   9  (bases 1 to 1160)
  AUTHORS   Solaro,R.J., el-Saleh,S.C. and Kentish,J.C.
  TITLE     Ca2+, pH and the regulation of cardiac myofilament force and ATPase
            activity
  JOURNAL   Mol Cell Biochem 89 (2), 163-167 (1989)
   PUBMED   2530435
REFERENCE   10 (bases 1 to 1160)
  AUTHORS   Jin,J.P. and Lin,J.J.
  TITLE     Isolation and characterization of cDNA clones encoding embryonic
            and adult isoforms of rat cardiac troponin T
  JOURNAL   J Biol Chem 264 (24), 14471-14477 (1989)
   PUBMED   2760070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 29, 2022 this sequence version replaced XM_006249833.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161855.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN11044071,
                                           SAMN16418986 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000013.1  49819123-49819180
            59-106              JAXUCZ010000013.1  49824049-49824096
            107-117             JAXUCZ010000013.1  49825052-49825062
            118-147             JAXUCZ010000013.1  49827551-49827580
            148-234             JAXUCZ010000013.1  49829733-49829819
            235-270             JAXUCZ010000013.1  49830094-49830129
            271-304             JAXUCZ010000013.1  49830921-49830954
            305-368             JAXUCZ010000013.1  49831861-49831924
            369-485             JAXUCZ010000013.1  49832122-49832238
            486-563             JAXUCZ010000013.1  49833407-49833484
            564-674             JAXUCZ010000013.1  49833956-49834066
            675-784             JAXUCZ010000013.1  49835550-49835659
            785-875             JAXUCZ010000013.1  49836199-49836289
            876-916             JAXUCZ010000013.1  49836551-49836591
            917-1160            JAXUCZ010000013.1  49836882-49837125
FEATURES             Location/Qualifiers
     source          1..1160
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1160
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /note="troponin T2, cardiac type"
                     /db_xref="GeneID:24837"
                     /db_xref="RGD:3882"
     exon            1..58
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            59..106
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..962
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     troponin T, cardiac muscle; cardiac troponin T2; cTnT;
                     tnTc; cardiac muscle troponin T; troponin T type 2
                     (cardiac); Troponin T cardiac"
                     /codon_start=1
                     /product="troponin T, cardiac muscle isoform 2"
                     /protein_id="NP_001402691.1"
                     /db_xref="GeneID:24837"
                     /db_xref="RGD:3882"
                     /translation="MSDAEEEVVEYEEEQEEEDWSEEEEDEQEEAVEEEDGEAEPDPE
                     GEAEAEEDKAEEVGPDEEARDAEDGPVEDSKPKPSRLFMPNLVPPKIPDGERVDFDDI
                     HRKRMEKDLNELQTLIEAHFENRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKER
                     QNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKK
                     KILAERRKVLAIDHLNEDQLREKAKELWQSIHNLEAEKFDLQEKFKQQKYEINVLRNR
                     INDNQKVSKTRGKAKVTGRWK"
     exon            107..117
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            118..147
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            148..234
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            235..270
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..304
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            305..368
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..485
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            486..563
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..674
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            675..784
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..875
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..916
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1160
                     /gene="Tnnt2"
                     /gene_synonym="Ctt; CTTG; RATCTTG; Tnnt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctgct gaggctgagc agacacctca agtcctgagt gcaggtccct gttcagagaa
       61 cggagaacat gtctgacgcc gaggaagagg tggtggagta cgaggaggaa caggaagagg
      121 aagactggag cgaagaagag gaagacgagc aagaggaggc agtggaggag gaggatggtg
      181 aggccgagcc tgatcccgag ggtgaggcag aggcagagga ggacaaggca gaagaggttg
      241 gtcctgatga agaagccaga gatgctgaag atggtccagt agaggactcc aaacccaagc
      301 ccagcaggct cttcatgccc aacttggtgc cacccaagat ccctgacgga gagagagtgg
      361 actttgatga catccacagg aagcgcatgg agaaggacct gaacgagctg cagactctga
      421 tcgaggctca cttcgagaac aggaagaagg aggaagagga gctcatttct ctcaaagaca
      481 ggatcgaaaa gcgtcgggca gagcgggctg aacagcagcg tattcgcaat gaacgagaga
      541 aggaaaggca gaaccgcctg gctgaagaga gggcccggcg tgaggaggag gagaacagga
      601 ggaaggctga agatgaggcc cggaagaaga aggctctgtc caacatgatg cattttggag
      661 ggtacatcca gaagacagag cggaagagtg ggaagagaca gacagagcga gagaagaaga
      721 agaagattct ggcagagagg aggaaggtgc tggccatcga ccacctgaat gaagaccagc
      781 tgagagagaa ggccaaggag ctatggcaga gtatccacaa cctggaggcc gagaagttcg
      841 acctgcagga aaagttcaag cagcagaaat acgaaatcaa cgttctgcga aacaggatca
      901 acgacaacca gaaagtctcc aaaactcgtg ggaaggccaa agtcaccggg cgttggaaat
      961 agatggaact gtgttcgaca aagctctgct ccttgcctgt gcccttgccc tgtgaatccc
     1021 agctctaggt cttgccaggc acccgatgca gactcctgtc tggaaagtag gagctgacct
     1081 agctagaagc cagtactctg cctgacccct atgcccacac cacgtcagga ataaaaagcc
     1141 agcacattgt gcacatggaa
//
