LOCUS       NM_134388                944 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus troponin T1, slow skeletal type (Tnnt1),
            transcript variant 1, mRNA.
ACCESSION   NM_134388
VERSION     NM_134388.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 944)
  AUTHORS   Tsika,R.W., Schramm,C., Simmer,G., Fitzsimons,D.P., Moss,R.L. and
            Ji,J.
  TITLE     Overexpression of TEAD-1 in transgenic mouse striated muscles
            produces a slower skeletal muscle contractile phenotype
  JOURNAL   J Biol Chem 283 (52), 36154-36167 (2008)
   PUBMED   18978355
REFERENCE   2  (bases 1 to 944)
  AUTHORS   Pinto,J.R., Parvatiyar,M.S., Jones,M.A., Liang,J. and Potter,J.D.
  TITLE     A troponin T mutation that causes infantile restrictive
            cardiomyopathy increases Ca2+ sensitivity of force development and
            impairs the inhibitory properties of troponin
  JOURNAL   J Biol Chem 283 (4), 2156-2166 (2008)
   PUBMED   18032382
REFERENCE   3  (bases 1 to 944)
  AUTHORS   Brotto,M.A., Biesiadecki,B.J., Brotto,L.S., Nosek,T.M. and Jin,J.P.
  TITLE     Coupled expression of troponin T and troponin I isoforms in single
            skeletal muscle fibers correlates with contractility
  JOURNAL   Am J Physiol Cell Physiol 290 (2), C567-C576 (2006)
   PUBMED   16192301
REFERENCE   4  (bases 1 to 944)
  AUTHORS   Kischel,P., Bastide,B., Muller,M., Dubail,F., Offredi,F., Jin,J.P.,
            Mounier,Y. and Martial,J.
  TITLE     Expression and functional properties of four slow skeletal troponin
            T isoforms in rat muscles
  JOURNAL   Am J Physiol Cell Physiol 289 (2), C437-C443 (2005)
   PUBMED   15788488
REFERENCE   5  (bases 1 to 944)
  AUTHORS   Wang,X., Huang,Q.Q., Breckenridge,M.T., Chen,A., Crawford,T.O.,
            Morton,D.H. and Jin,J.P.
  TITLE     Cellular fate of truncated slow skeletal muscle troponin T produced
            by Glu180 nonsense mutation in amish nemaline myopathy
  JOURNAL   J Biol Chem 280 (14), 13241-13249 (2005)
   PUBMED   15665378
REFERENCE   6  (bases 1 to 944)
  AUTHORS   Johnston,J.J., Kelley,R.I., Crawford,T.O., Morton,D.H.,
            Agarwala,R., Koch,T., Schaffer,A.A., Francomano,C.A. and
            Biesecker,L.G.
  TITLE     A novel nemaline myopathy in the Amish caused by a mutation in
            troponin T1
  JOURNAL   Am J Hum Genet 67 (4), 814-821 (2000)
   PUBMED   10952871
REFERENCE   7  (bases 1 to 944)
  AUTHORS   Gahlmann,R., Troutt,A.B., Wade,R.P., Gunning,P. and Kedes,L.
  TITLE     Alternative splicing generates variants in important functional
            domains of human slow skeletal troponin T
  JOURNAL   J Biol Chem 262 (33), 16122-16126 (1987)
   PUBMED   2824479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and AY334079.1.
            
            On Mar 27, 2013 this sequence version replaced NM_134388.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF399874.1, AY334079.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760386, SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  78349035-78349079
            46-56               JAXUCZ010000001.1  78350777-78350787
            57-842              AY334079.1         1-786
            843-944             JAXUCZ010000001.1  78359293-78359394
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..944
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /note="troponin T1, slow skeletal type"
                     /db_xref="GeneID:171409"
                     /db_xref="RGD:621852"
     exon            1..45
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            46..88
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..842
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /note="isoform 1 is encoded by transcript variant 1;
                     troponin T, slow skeletal muscle; slow skeletal muscle
                     troponin T; troponin T1, skeletal, slow; troponin T type 1
                     (skeletal, slow)"
                     /codon_start=1
                     /product="troponin T, slow skeletal muscle isoform 1"
                     /protein_id="NP_599215.2"
                     /db_xref="GeneID:171409"
                     /db_xref="RGD:621852"
                     /translation="MSDTEEQEYEEEQAEDEEAVEEEAPEEPEPVAEREEERPKPSRP
                     VVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRI
                     ERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF
                     GGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLES
                     EKFDLMEKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK"
     exon            89..102
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            103..126
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            127..159
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            160..181
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            182..245
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            246..362
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            363..440
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            441..554
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            555..664
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            665..755
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            756..796
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            797..944
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcctca gactccctct acagcatctg tggacccagc cttaggttac tccaggatgt
       61 cagacaccga agaacaagaa tatgaggagg aacaggcaga agatgaggaa gcagtggagg
      121 aagaagcccc cgaggagccg gagccggtgg cagagcgaga agaagagcgc cccaaaccca
      181 gccgtcctgt ggttcctcct ttgattcctc cgaagattcc agaaggggag cgtgtggact
      241 ttgatgacat tcaccggaag cgcatggaga aagacttact ggagctgcag acgctcatcg
      301 atgtgcactt tgagcagcgg aaaaaggaag aggaggaact cattgcgcta aaagaccgta
      361 ttgagaggcg tcgcgcagag agagctgagc aacagcgctt cagaacagaa aaggagcgag
      421 aacgccaggc caagctggcg gaggagaaga tgcggaagga ggaggaggag gcaaagaaga
      481 gagcagagga tgacgccaaa aagaagaagg ttctgtccaa catgggggct cattttgggg
      541 gctacctggt caaggcagaa cagaagcgtg ggaagcgaca gactggtcgg gagatgaaac
      601 tcaggatcct gtctgagagg aaaaagccct tgaacatcga ctacatgggg gaggaccagc
      661 tccgggagaa ggcccaggag ctgtcagaat ggatccacca gctggaatcg gagaaatttg
      721 acctgatgga gaaattgaag caacagaaat atgagatcaa tgtgctgtac aaccgcatca
      781 gtcatgccca gaaattccga aagggggctg ggaagggtcg agttggaggc cgctggaagt
      841 gagactgcca ggacatgtcc cattgtgtgg agcccaggag ccaccagagt gtgtcccatc
      901 tgtaactcaa aataaagggt cccctggcat ctgttcaagt tctt
//
