LOCUS       NM_001277261             908 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus troponin T1, slow skeletal type (Tnnt1),
            transcript variant 3, mRNA.
ACCESSION   NM_001277261
VERSION     NM_001277261.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 908)
  AUTHORS   Tsika,R.W., Schramm,C., Simmer,G., Fitzsimons,D.P., Moss,R.L. and
            Ji,J.
  TITLE     Overexpression of TEAD-1 in transgenic mouse striated muscles
            produces a slower skeletal muscle contractile phenotype
  JOURNAL   J Biol Chem 283 (52), 36154-36167 (2008)
   PUBMED   18978355
REFERENCE   2  (bases 1 to 908)
  AUTHORS   Pinto,J.R., Parvatiyar,M.S., Jones,M.A., Liang,J. and Potter,J.D.
  TITLE     A troponin T mutation that causes infantile restrictive
            cardiomyopathy increases Ca2+ sensitivity of force development and
            impairs the inhibitory properties of troponin
  JOURNAL   J Biol Chem 283 (4), 2156-2166 (2008)
   PUBMED   18032382
REFERENCE   3  (bases 1 to 908)
  AUTHORS   Brotto,M.A., Biesiadecki,B.J., Brotto,L.S., Nosek,T.M. and Jin,J.P.
  TITLE     Coupled expression of troponin T and troponin I isoforms in single
            skeletal muscle fibers correlates with contractility
  JOURNAL   Am J Physiol Cell Physiol 290 (2), C567-C576 (2006)
   PUBMED   16192301
REFERENCE   4  (bases 1 to 908)
  AUTHORS   Kischel,P., Bastide,B., Muller,M., Dubail,F., Offredi,F., Jin,J.P.,
            Mounier,Y. and Martial,J.
  TITLE     Expression and functional properties of four slow skeletal troponin
            T isoforms in rat muscles
  JOURNAL   Am J Physiol Cell Physiol 289 (2), C437-C443 (2005)
   PUBMED   15788488
REFERENCE   5  (bases 1 to 908)
  AUTHORS   Wang,X., Huang,Q.Q., Breckenridge,M.T., Chen,A., Crawford,T.O.,
            Morton,D.H. and Jin,J.P.
  TITLE     Cellular fate of truncated slow skeletal muscle troponin T produced
            by Glu180 nonsense mutation in amish nemaline myopathy
  JOURNAL   J Biol Chem 280 (14), 13241-13249 (2005)
   PUBMED   15665378
REFERENCE   6  (bases 1 to 908)
  AUTHORS   Johnston,J.J., Kelley,R.I., Crawford,T.O., Morton,D.H.,
            Agarwala,R., Koch,T., Schaffer,A.A., Francomano,C.A. and
            Biesecker,L.G.
  TITLE     A novel nemaline myopathy in the Amish caused by a mutation in
            troponin T1
  JOURNAL   Am J Hum Genet 67 (4), 814-821 (2000)
   PUBMED   10952871
REFERENCE   7  (bases 1 to 908)
  AUTHORS   Gahlmann,R., Troutt,A.B., Wade,R.P., Gunning,P. and Kedes,L.
  TITLE     Alternative splicing generates variants in important functional
            domains of human slow skeletal troponin T
  JOURNAL   J Biol Chem 262 (33), 16122-16126 (1987)
   PUBMED   2824479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and AY334082.1.
            
            On Mar 28, 2013 this sequence version replaced NM_001277261.1.
            
            Transcript Variant: This variant (3) lacks an exon and uses an
            alternate splice site in the coding region, compared to variant 1.
            The encoded isoform (3) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY334082.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760386, SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  78349035-78349079
            46-56               JAXUCZ010000001.1  78350777-78350787
            57-806              AY334082.1         1-750
            807-908             JAXUCZ010000001.1  78359293-78359394
FEATURES             Location/Qualifiers
     source          1..908
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..908
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /note="troponin T1, slow skeletal type"
                     /db_xref="GeneID:171409"
                     /db_xref="RGD:621852"
     exon            1..45
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            46..88
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..806
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /note="isoform 3 is encoded by transcript variant 3;
                     troponin T, slow skeletal muscle; slow skeletal muscle
                     troponin T; troponin T1, skeletal, slow; troponin T type 1
                     (skeletal, slow)"
                     /codon_start=1
                     /product="troponin T, slow skeletal muscle isoform 3"
                     /protein_id="NP_001264190.1"
                     /db_xref="GeneID:171409"
                     /db_xref="RGD:621852"
                     /translation="MSDTEEQEYEEEQAEDEEAVEEEEERPKPSRPVVPPLIPPKIPE
                     GERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQQR
                     FRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRG
                     KRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQQ
                     KYEINVLYNRISHAQKFRKGAGKGRVGGRWK"
     exon            89..102
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            103..126
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            127..145
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            146..209
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            210..326
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            327..404
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            405..518
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            519..628
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            629..719
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            720..760
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            761..908
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcctca gactccctct acagcatctg tggacccagc cttaggttac tccaggatgt
       61 cagacaccga agaacaagaa tatgaggagg aacaggcaga agatgaggaa gcagtggagg
      121 aagaagaaga gcgccccaaa cccagccgtc ctgtggttcc tcctttgatt cctccgaaga
      181 ttccagaagg ggagcgtgtg gactttgatg acattcaccg gaagcgcatg gagaaagact
      241 tactggagct gcagacgctc atcgatgtgc actttgagca gcggaaaaag gaagaggagg
      301 aactcattgc gctaaaagac cgtattgaga ggcgtcgcgc agagagagct gagcaacagc
      361 gcttcagaac agaaaaggag cgagaacgcc aggccaagct ggcggaggag aagatgcgga
      421 aggaggagga ggaggcaaag aagagagcag aggatgacgc caaaaagaag aaggttctgt
      481 ccaacatggg ggctcatttt gggggctacc tggtcaaggc agaacagaag cgtgggaagc
      541 gacagactgg tcgggagatg aaactcagga tcctgtctga gaggaaaaag cccttgaaca
      601 tcgactacat gggggaggac cagctccggg agaaggccca ggagctgtca gaatggatcc
      661 accagctgga atcggagaaa tttgacctga tggagaaatt gaagcaacag aaatatgaga
      721 tcaatgtgct gtacaaccgc atcagtcatg cccagaaatt ccgaaagggg gctgggaagg
      781 gtcgagttgg aggccgctgg aagtgagact gccaggacat gtcccattgt gtggagccca
      841 ggagccacca gagtgtgtcc catctgtaac tcaaaataaa gggtcccctg gcatctgttc
      901 aagttctt
//
