LOCUS       NM_001277260             941 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus troponin T1, slow skeletal type (Tnnt1),
            transcript variant 2, mRNA.
ACCESSION   NM_001277260
VERSION     NM_001277260.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 941)
  AUTHORS   Tsika,R.W., Schramm,C., Simmer,G., Fitzsimons,D.P., Moss,R.L. and
            Ji,J.
  TITLE     Overexpression of TEAD-1 in transgenic mouse striated muscles
            produces a slower skeletal muscle contractile phenotype
  JOURNAL   J Biol Chem 283 (52), 36154-36167 (2008)
   PUBMED   18978355
REFERENCE   2  (bases 1 to 941)
  AUTHORS   Pinto,J.R., Parvatiyar,M.S., Jones,M.A., Liang,J. and Potter,J.D.
  TITLE     A troponin T mutation that causes infantile restrictive
            cardiomyopathy increases Ca2+ sensitivity of force development and
            impairs the inhibitory properties of troponin
  JOURNAL   J Biol Chem 283 (4), 2156-2166 (2008)
   PUBMED   18032382
REFERENCE   3  (bases 1 to 941)
  AUTHORS   Brotto,M.A., Biesiadecki,B.J., Brotto,L.S., Nosek,T.M. and Jin,J.P.
  TITLE     Coupled expression of troponin T and troponin I isoforms in single
            skeletal muscle fibers correlates with contractility
  JOURNAL   Am J Physiol Cell Physiol 290 (2), C567-C576 (2006)
   PUBMED   16192301
REFERENCE   4  (bases 1 to 941)
  AUTHORS   Kischel,P., Bastide,B., Muller,M., Dubail,F., Offredi,F., Jin,J.P.,
            Mounier,Y. and Martial,J.
  TITLE     Expression and functional properties of four slow skeletal troponin
            T isoforms in rat muscles
  JOURNAL   Am J Physiol Cell Physiol 289 (2), C437-C443 (2005)
   PUBMED   15788488
REFERENCE   5  (bases 1 to 941)
  AUTHORS   Wang,X., Huang,Q.Q., Breckenridge,M.T., Chen,A., Crawford,T.O.,
            Morton,D.H. and Jin,J.P.
  TITLE     Cellular fate of truncated slow skeletal muscle troponin T produced
            by Glu180 nonsense mutation in amish nemaline myopathy
  JOURNAL   J Biol Chem 280 (14), 13241-13249 (2005)
   PUBMED   15665378
REFERENCE   6  (bases 1 to 941)
  AUTHORS   Johnston,J.J., Kelley,R.I., Crawford,T.O., Morton,D.H.,
            Agarwala,R., Koch,T., Schaffer,A.A., Francomano,C.A. and
            Biesecker,L.G.
  TITLE     A novel nemaline myopathy in the Amish caused by a mutation in
            troponin T1
  JOURNAL   Am J Hum Genet 67 (4), 814-821 (2000)
   PUBMED   10952871
REFERENCE   7  (bases 1 to 941)
  AUTHORS   Gahlmann,R., Troutt,A.B., Wade,R.P., Gunning,P. and Kedes,L.
  TITLE     Alternative splicing generates variants in important functional
            domains of human slow skeletal troponin T
  JOURNAL   J Biol Chem 262 (33), 16122-16126 (1987)
   PUBMED   2824479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and AY334080.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region, compared to variant 1. The encoded isoform
            (2) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  78349035-78349079
            46-56               JAXUCZ010000001.1  78350777-78350787
            57-839              AY334080.1         1-783
            840-941             JAXUCZ010000001.1  78359293-78359394
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..941
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /note="troponin T1, slow skeletal type"
                     /db_xref="GeneID:171409"
                     /db_xref="RGD:621852"
     exon            1..45
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            46..88
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..839
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /note="isoform 2 is encoded by transcript variant 2;
                     troponin T, slow skeletal muscle; slow skeletal muscle
                     troponin T; troponin T1, skeletal, slow; troponin T type 1
                     (skeletal, slow)"
                     /codon_start=1
                     /product="troponin T, slow skeletal muscle isoform 2"
                     /protein_id="NP_001264189.1"
                     /db_xref="GeneID:171409"
                     /db_xref="RGD:621852"
                     /translation="MSDTEEQEYEEEQAEDEEAVEEEAPEEPEPVAEREERPKPSRPV
                     VPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIE
                     RRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFG
                     GYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESE
                     KFDLMEKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK"
     exon            89..102
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            103..126
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            127..159
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            160..178
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            179..242
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            243..359
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            360..437
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            438..551
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            552..661
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            662..752
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            753..793
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
     exon            794..941
                     /gene="Tnnt1"
                     /gene_synonym="Fang2; sTnT; tnTs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcctca gactccctct acagcatctg tggacccagc cttaggttac tccaggatgt
       61 cagacaccga agaacaagaa tatgaggagg aacaggcaga agatgaggaa gcagtggagg
      121 aagaagcccc cgaggagccg gagccggtgg cagagcgaga agagcgcccc aaacccagcc
      181 gtcctgtggt tcctcctttg attcctccga agattccaga aggggagcgt gtggactttg
      241 atgacattca ccggaagcgc atggagaaag acttactgga gctgcagacg ctcatcgatg
      301 tgcactttga gcagcggaaa aaggaagagg aggaactcat tgcgctaaaa gaccgtattg
      361 agaggcgtcg cgcagagaga gctgagcaac agcgcttcag aacagaaaag gagcgagaac
      421 gccaggccaa gctggcggag gagaagatgc ggaaggagga ggaggaggca aagaagagag
      481 cagaggatga cgccaaaaag aagaaggttc tgtccaacat gggggctcat tttgggggct
      541 acctggtcaa ggcagaacag aagcgtggga agcgacagac tggtcgggag atgaaactca
      601 ggatcctgtc tgagaggaaa aagcccttga acatcgacta catgggggag gaccagctcc
      661 gggagaaggc ccaggagctg tcagaatgga tccaccagct ggaatcggag aaatttgacc
      721 tgatggagaa attgaagcaa cagaaatatg agatcaatgt gctgtacaac cgcatcagtc
      781 atgcccagaa attccgaaag ggggctggga agggtcgagt tggaggccgc tggaagtgag
      841 actgccagga catgtcccat tgtgtggagc ccaggagcca ccagagtgtg tcccatctgt
      901 aactcaaaat aaagggtccc ctggcatctg ttcaagttct t
//
