LOCUS       NM_181769               2982 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TNNI3 interacting kinase (Tnni3k), mRNA.
ACCESSION   NM_181769
VERSION     NM_181769.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2982)
  AUTHORS   Theis,J.L., Zimmermann,M.T., Larsen,B.T., Rybakova,I.N., Long,P.A.,
            Evans,J.M., Middha,S., de Andrade,M., Moss,R.L., Wieben,E.D.,
            Michels,V.V. and Olson,T.M.
  TITLE     TNNI3K mutation in familial syndrome of conduction system disease,
            atrial tachyarrhythmia and dilated cardiomyopathy
  JOURNAL   Hum Mol Genet 23 (21), 5793-5804 (2014)
   PUBMED   24925317
REFERENCE   2  (bases 1 to 2982)
  AUTHORS   Wang,H., Wang,L., Song,L., Zhang,Y.W., Ye,J., Xu,R.X., Shi,N. and
            Meng,X.M.
  TITLE     TNNI3K is a novel mediator of myofilament function and
            phosphorylates cardiac troponin I
  JOURNAL   Braz J Med Biol Res 46 (2), 128-137 (2013)
   PUBMED   23369981
  REMARK    GeneRIF: TNNI3K may be a novel mediator of cardiac troponin I
            phosphorylation and contribute to the regulation of cardiac
            myofilament contraction function.
REFERENCE   3  (bases 1 to 2982)
  AUTHORS   Wang,X., Wang,J., Su,M., Wang,C., Chen,J., Wang,H., Song,L.,
            Zou,Y., Zhang,L., Zhang,Y. and Hui,R.
  TITLE     TNNI3K, a cardiac-specific kinase, promotes physiological cardiac
            hypertrophy in transgenic mice
  JOURNAL   PLoS One 8 (3), e58570 (2013)
   PUBMED   23472207
  REMARK    GeneRIF: TNNI3K promotes a concentric hypertrophy with enhancement
            of cardiac function via regulating the phosphorylation of cTnI
REFERENCE   4  (bases 1 to 2982)
  AUTHORS   Lodder,E.M., Scicluna,B.P., Milano,A., Sun,A.Y., Tang,H.,
            Remme,C.A., Moerland,P.D., Tanck,M.W., Pitt,G.S., Marchuk,D.A. and
            Bezzina,C.R.
  TITLE     Dissection of a quantitative trait locus for PR interval duration
            identifies Tnni3k as a novel modulator of cardiac conduction
  JOURNAL   PLoS Genet 8 (12), e1003113 (2012)
   PUBMED   23236294
REFERENCE   5  (bases 1 to 2982)
  AUTHORS   Feng,Y., Liu,D.Q., Wang,Z., Liu,Z., Cao,H.Q., Wang,L.Y., Shi,N. and
            Meng,X.M.
  TITLE     AOP-1 interacts with cardiac-specific protein kinase TNNI3K and
            down-regulates its kinase activity
  JOURNAL   Biochemistry (Mosc) 72 (11), 1199-1204 (2007)
   PUBMED   18205602
REFERENCE   6  (bases 1 to 2982)
  AUTHORS   Zhao,Y., Meng,X.M., Wei,Y.J., Zhao,X.W., Liu,D.Q., Cao,H.Q.,
            Liew,C.C. and Ding,J.F.
  TITLE     Cloning and characterization of a novel cardiac-specific kinase
            that interacts specifically with cardiac troponin I
  JOURNAL   J Mol Med (Berl) 81 (5), 297-304 (2003)
   PUBMED   12721663
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY303692.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY303692.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..2982
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /note="TNNI3 interacting kinase"
                     /db_xref="GeneID:295531"
                     /db_xref="RGD:727908"
     exon            1..83
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2551
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /EC_number="2.7.11.1"
                     /note="cardiac ankyrin repeat kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TNNI3K"
                     /protein_id="NP_861434.1"
                     /db_xref="GeneID:295531"
                     /db_xref="RGD:727908"
                     /translation="MGNYKSRPTQTCSDEWKKKVSESYAIIIERLEDNLQIKENEFQE
                     LRHIFGSDEAFSEVSLNYRTERGLSLLHLCCVCGGNKSHIRALMLKGLRPSRLTRNGF
                     PALHLAVYKDSPELITSLLHSGADVQQVGYGGLTALHIAAIAGHPEAAEVLLQHGANV
                     NVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKL
                     LVEEGSKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHL
                     ACYNGNFEVAKEIVQVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNIN
                     HRGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEK
                     GHDAIVTLLKHYKRPQEELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRA
                     ELPSRFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCR
                     EVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII
                     AVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQ
                     PGNLRWMAPEVFTQCTRYTIKADVFSYSLCLWELLTGEIPFAHLKPAAAAADMAYHHI
                     RPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVSKLEECLCNVELMSPASSNSSGSL
                     SPSSSSDCLLSRGGPGRSHVAALRSRFELEYALNARSYAGWSQSVGTHSNPGLSLEEM
                     NRSTQYSTVDKYGYVSDPMSLTHLHSRQDDSNFEDSN"
     exon            84..192
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            193..278
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            279..376
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            377..487
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            488..586
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            587..725
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            726..870
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            871..975
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1070
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1220
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1307
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1364
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1457
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1515
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1710
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1815
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1868
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1921
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2054
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2164
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2224
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2394
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2474
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2982
                     /gene="Tnni3k"
                     /gene_synonym="Cark"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagggca gcagcacagg agaaaagcaa agacttcttt aaaatgggga attacaaatc
       61 cagaccaaca cagacttgtt ctgatgaatg gaagaagaaa gttagtgaat cttacgctat
      121 tatcatagaa aggctggagg ataacctgca gatcaaagaa aatgaatttc aagaactaag
      181 gcacatcttt ggctctgatg aagccttcag tgaagtcagt ttaaattacc gcacagagcg
      241 tggcctgtcc ctgctacacc tctgctgtgt ctgtggcggc aacaagtcac atatccgtgc
      301 ccttatgtta aaagggctcc gtccatccag actgacgaga aatgggtttc cagctctgca
      361 cctggccgtt tacaaggaca gcccggaact tatcacttca ctgttgcaca gcggagcaga
      421 tgttcagcaa gtgggatacg gtggcctcac agccctccac atagctgcaa tagctggaca
      481 cccagaggct gcagaagtgc tgctacaaca tggggccaat gtgaatgttc aagatgccgt
      541 cttcttcacc ccactgcaca ttgcagccta ctatgggcac gagcaggtaa ccagtgtcct
      601 tttgaagttt ggtgctgatg tcaatgtaag cggtgaagtt ggggacaggc ctctgcacct
      661 ggcctctgca aagggcttct tcaacattgt gaaactcctg gtagaagaag ggagcaaagc
      721 agatgtgaac gctcaggaca atgaagacca cgtccctctg cacttctgtt ctcgatttgg
      781 acaccacaat atagtgagct acctgctcca gagtgactta gaggtccagc ctcacgtcat
      841 taacatctat ggtgacactc ctttgcacct ggcatgctac aatggaaatt ttgaagttgc
      901 caaggaaatt gtccaggtaa caggaactga aagtctgact aaggaaaaca tcttcagcga
      961 gacagctttt cacagtgctt gtacctatgg caagaacatt gacctggtca aatttcttct
     1021 tgatcagaat gctgtgaaca ttaaccaccg aggaagagat gggcacacag gattgcactc
     1081 tgcttgctac cacggccata tccgcctggt tcagttccta cttgataatg gtgcagatat
     1141 gaatcttgtc gcttgtgatc ccagcaggtc tagtggtgaa aaagatgagc agacatgttt
     1201 gatgtgggct tacgagaaag gacatgatgc cattgttaca ctcctgaagc actacaagag
     1261 accccaggag gagctgccat gtaacgaata ttcccagcct ggaggagatg gctcctatgt
     1321 gtctgttcct tcccccttgg gcaagattaa aagcatgaca aaagagaagg cagatgttct
     1381 cctcctgagg gctgaactac cctcccgctt ccatctccaa ctctccgaaa tcgagttcca
     1441 cgagattatc ggctcgggtt cctttgggaa agtctataaa gggcgatgca gaaataaaat
     1501 agtggcgatc aaacgatacc gagccaacac ctactgctcc aagtcagacg tggatatgtt
     1561 ttgccgagag gtgtccattc tctgccagct caaccacccc tgcgtggttc agtttgtggg
     1621 tgcctgcctg gatgacccca gtcagtttgc cattgtcact cagtacattt caggaggctc
     1681 cctgttctcc ctgcttcatg aacagaagag aattcttgac ttgcagtcta aattaatcat
     1741 tgcggtagac gttgccaagg gcatggagta cctgcacagc ttgacccagc caatcataca
     1801 ccgcgacctg aacagccaca atattctgct ctatgaggat ggccatgctg tggtggcaga
     1861 ttttggagaa tcaagatttc tgcagtccct ggatgaagac aacatgacaa agcagccagg
     1921 gaacctgcgc tggatggccc ctgaggtgtt cacacagtgc acgagataca ccatcaaggc
     1981 tgatgtcttc agttactccc tgtgtctgtg ggagctcctc actggagaaa ttccattcgc
     2041 tcatctcaag ccagccgctg cagcagcaga tatggcgtat caccacatca gaccgcccat
     2101 cggctattcc atccccaagc ccatctcatc cctgctgata cggggctgga atgcatgtcc
     2161 tgaaggacga ccagagttct ctgaagtcgt tagcaaactg gaggagtgcc tatgcaatgt
     2221 ggagctcatg tctccagcat caagtaacag cagtggctct ctgtcacctt cctcttcttc
     2281 cgattgcctg ctgagccggg gagggcctgg ccggagccac gtggcagcct tacggagccg
     2341 ttttgagttg gagtatgccc taaatgcaag gtcctatgct gggtggtccc aaagtgttgg
     2401 aacacactct aatccgggcc tgtctttgga ggagatgaat aggagcaccc agtattcaac
     2461 tgttgacaaa tacggctatg tgtctgatcc catgagcctg acgcaccttc actcccgcca
     2521 agacgacagc aactttgagg acagcaactg acaggtctgg catacaccta aggggcgtct
     2581 ccccatcagg ctgacagcag tgattttacc catggcaggc ttgcttccaa ttataacgcc
     2641 ctgccctctg aggtttcttc aaatcgtctt gcttattcta agctcgttta attcccttct
     2701 acaggacagg ctttgactca tgccaagcct gaagtgtcaa agagcagata cagaatgtgc
     2761 atgaggaatt gttcttagtt tgatatttaa agcccttaat tgcctggggc tggggttcaa
     2821 atctgtgtag atagctgggt tgacccttat gtatttgtag accaaactgt gtgggcttgt
     2881 gtttgagggt ctcctgttgg gtttcttaaa aacaagctgg ctgatttatc tcctgttgcc
     2941 tttgttgtta cttctgtgat taaagtctct tcggtgatct ag
//
