LOCUS       NM_017144                829 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus troponin I3, cardiac type (Tnni3), mRNA.
ACCESSION   NM_017144
VERSION     NM_017144.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 829)
  AUTHORS   Bodi,B., Olah,A., Martha,L., Toth,A., Radovits,T., Merkely,B. and
            Papp,Z.
  TITLE     Exercise-induced alterations of myocardial sarcomere dynamics are
            associated with hypophosphorylation of cardiac troponin I
  JOURNAL   Rev Cardiovasc Med 22 (4), 1079-1085 (2021)
   PUBMED   34957754
  REMARK    GeneRIF: Exercise-induced alterations of myocardial sarcomere
            dynamics are associated with hypophosphorylation of cardiac
            troponin I.
REFERENCE   2  (bases 1 to 829)
  AUTHORS   Kachooei,E., Cordina,N.M., Potluri,P.R., Guse,J.A., McCamey,D. and
            Brown,L.J.
  TITLE     Phosphorylation of Troponin I finely controls the positioning of
            Troponin for the optimal regulation of cardiac muscle contraction
  JOURNAL   J Mol Cell Cardiol 150, 44-53 (2021)
   PUBMED   33080242
  REMARK    GeneRIF: Phosphorylation of Troponin I finely controls the
            positioning of Troponin for the optimal regulation of cardiac
            muscle contraction.
REFERENCE   3  (bases 1 to 829)
  AUTHORS   Yang,B., Zhao,H. and Dong,R.
  TITLE     MiR-449 improves cardiac function by regulating HDAC1 and cTnI
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (24), 12827-12835 (2020)
   PUBMED   33378032
  REMARK    GeneRIF: MiR-449 improves cardiac function by regulating HDAC1 and
            cTnI.
REFERENCE   4  (bases 1 to 829)
  AUTHORS   Yuan,J.Q., Yuan,Y., Pan,S.S. and Cai,K.
  TITLE     Altered expression levels of autophagy-associated proteins during
            exercise preconditioning indicate the involvement of autophagy in
            cardioprotection against exercise-induced myocardial injury
  JOURNAL   J Physiol Sci 70 (1), 10 (2020)
   PUBMED   32066368
  REMARK    GeneRIF: Altered expression levels of autophagy-associated proteins
            during exercise preconditioning indicate the involvement of
            autophagy in cardioprotection against exercise-induced myocardial
            injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 829)
  AUTHORS   Yang,S., Li,H. and Chen,L.
  TITLE     MicroRNA-140 attenuates myocardial ischemia-reperfusion injury
            through suppressing mitochondria-mediated apoptosis by targeting
            YES1
  JOURNAL   J Cell Biochem 120 (3), 3813-3821 (2019)
   PUBMED   30259997
REFERENCE   6  (bases 1 to 829)
  AUTHORS   Murphy,A.M., Thompson,W.R., Peng,L.F. and Jones,L. 2nd.
  TITLE     Regulation of the rat cardiac troponin I gene by the transcription
            factor GATA-4
  JOURNAL   Biochem J 322 (Pt 2) (Pt 2), 393-401 (1997)
   PUBMED   9065755
REFERENCE   7  (bases 1 to 829)
  AUTHORS   al-Hillawi,E., Minchin,S.D. and Trayer,I.P.
  TITLE     Overexpression of human cardiac troponin-I and troponin-C in
            Escherichia coli and their purification and characterisation. Two
            point mutations allow high-level expression of troponin-I
  JOURNAL   Eur J Biochem 225 (3), 1195-1201 (1994)
   PUBMED   7957210
REFERENCE   8  (bases 1 to 829)
  AUTHORS   Ausoni,S., De Nardi,C., Moretti,P., Gorza,L. and Schiaffino,S.
  TITLE     Developmental expression of rat cardiac troponin I mRNA
  JOURNAL   Development 112 (4), 1041-1051 (1991)
   PUBMED   1935696
REFERENCE   9  (bases 1 to 829)
  AUTHORS   Martin,A.F. and Orlowski,J.
  TITLE     Molecular cloning and developmental expression of the rat
            cardiac-specific isoform of troponin I
  JOURNAL   J Mol Cell Cardiol 23 (5), 583-588 (1991)
   PUBMED   1886137
REFERENCE   10 (bases 1 to 829)
  AUTHORS   Murphy,A.M., Jones,L. 2nd, Sims,H.F. and Strauss,A.W.
  TITLE     Molecular cloning of rat cardiac troponin I and analysis of
            troponin I isoform expression in developing rat heart
  JOURNAL   Biochemistry 30 (3), 707-712 (1991)
   PUBMED   1988058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X58499.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017144.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X58499.1, CK358716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-829               X58499.1           2-830
FEATURES             Location/Qualifiers
     source          1..829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..829
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /note="troponin I3, cardiac type"
                     /db_xref="GeneID:29248"
                     /db_xref="RGD:62052"
     exon            1..115
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..740
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /note="cardiac troponin I; troponin 1, type 3; troponin I
                     type 3 (cardiac)"
                     /codon_start=1
                     /product="troponin I, cardiac muscle"
                     /protein_id="NP_058840.1"
                     /db_xref="GeneID:29248"
                     /db_xref="RGD:62052"
                     /translation="MADESSDAAGEPQPAPAPVRRRSSANYRAYATEPHAKKKSKISA
                     SRKLQLKTLMLQIAKQEMEREAEERRGEKGRVLSTRCQPLVLDGLGFEELQDLCRQLH
                     ARVDKVDEERYDVEAKVTKNITEIADLTQKIYDLRGKFKRPTLRRVRISADAMMQALL
                     GTRAKESLDLRAHLKQVKKEDIEKENREVGDWRKNIDALSGMEGRKKKFEG"
     exon            116..128
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     exon            129..215
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     exon            216..257
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     exon            258..389
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     exon            390..479
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     exon            480..656
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     exon            657..804
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      802
                     /gene="Tnni3"
                     /gene_synonym="cTNI; TnI"
ORIGIN      
        1 gcttgagcag cacagagggg acccaaccct ccaaggtcac cagggacacc cttctaagac
       61 cctccaggaa tctgcaatcc cattctctac ctctggagat cagcatggcg gatgagagca
      121 gcgatgcggc tggggaaccc cagccggcgc ctgctcctgt ccgacgtcgc tcctcggcca
      181 actaccgagc ctatgccacc gagccacatg ccaagaaaaa gtctaagatc tccgcctcca
      241 gaaaacttca gttgaagact ctgatgctgc agattgcgaa gcaggagatg gagcgtgagg
      301 cagaggagcg acgtggagag aagggccgcg ttctgagcac gcgttgccag cccttggtgt
      361 tggatgggct gggctttgaa gagcttcagg acctatgccg gcagcttcac gctcgtgtgg
      421 acaaagtgga tgaagagaga tacgacgtgg aagcaaaagt caccaagaac atcactgaga
      481 ttgcagatct gacccagaag atctatgacc tgcgtggcaa gtttaagcgg cccactctcc
      541 gaagagtgag aatctcagca gatgccatga tgcaggcact actggggacc cgggccaagg
      601 aatccttgga cctgagggcc cacctcaagc aggtgaagaa ggaggacatt gagaaggaaa
      661 accgggaggt gggagactgg cgcaagaata tcgatgcact aagtggaatg gaaggccgaa
      721 agaaaaagtt tgagggctga gcccatggct ctcacactgt gctctgaagg gcatctctga
      781 ggaataaatt tctttaaact ggaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
