LOCUS       NM_017185                679 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus troponin I2, fast skeletal type (Tnni2), mRNA.
ACCESSION   NM_017185
VERSION     NM_017185.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 679)
  AUTHORS   Potluri,P.R., Chamoun,J., Cooke,J.A., Badr,M., Guse,J.A., Rayes,R.,
            Cordina,N.M., McCamey,D., Fajer,P.G. and Brown,L.J.
  TITLE     The concerted movement of the switch region of Troponin I in
            cardiac muscle thin filaments as tracked by conventional and pulsed
            (DEER) EPR
  JOURNAL   J Struct Biol 200 (3), 376-387 (2017)
   PUBMED   28864299
  REMARK    GeneRIF: Troponin I interaction with calcium and Troponin C in
            cardiac muscle
REFERENCE   2  (bases 1 to 679)
  AUTHORS   James,R.S., Walter,I. and Seebacher,F.
  TITLE     Variation in expression of calcium-handling proteins is associated
            with inter-individual differences in mechanical performance of rat
            (Rattus norvegicus) skeletal muscle
  JOURNAL   J Exp Biol 214 (Pt 21), 3542-3548 (2011)
   PUBMED   21993782
REFERENCE   3  (bases 1 to 679)
  AUTHORS   Fedorova,M., Todorovsky,T., Kuleva,N. and Hoffmann,R.
  TITLE     Quantitative evaluation of tryptophan oxidation in actin and
            troponin I from skeletal muscles using a rat model of acute
            oxidative stress
  JOURNAL   Proteomics 10 (14), 2692-2700 (2010)
   PUBMED   20455213
  REMARK    GeneRIF: The effects of reactive oxygen species on tryptophan
            residues in alpha skeletal actin and troponin I, was investigated.
REFERENCE   4  (bases 1 to 679)
  AUTHORS   Li,Y., Chen,B., Chen,J., Lou,G., Chen,S. and Zhou,D.
  TITLE     Fast skeletal muscle troponin I is a co-activator of estrogen
            receptor-related receptor alpha
  JOURNAL   Biochem Biophys Res Commun 369 (4), 1034-1040 (2008)
   PUBMED   18331830
REFERENCE   5  (bases 1 to 679)
  AUTHORS   Robinson,P., Lipscomb,S., Preston,L.C., Altin,E., Watkins,H.,
            Ashley,C.C. and Redwood,C.S.
  TITLE     Mutations in fast skeletal troponin I, troponin T, and
            beta-tropomyosin that cause distal arthrogryposis all increase
            contractile function
  JOURNAL   FASEB J 21 (3), 896-905 (2007)
   PUBMED   17194691
REFERENCE   6  (bases 1 to 679)
  AUTHORS   Brotto,M.A., Biesiadecki,B.J., Brotto,L.S., Nosek,T.M. and Jin,J.P.
  TITLE     Coupled expression of troponin T and troponin I isoforms in single
            skeletal muscle fibers correlates with contractility
  JOURNAL   Am J Physiol Cell Physiol 290 (2), C567-C576 (2006)
   PUBMED   16192301
REFERENCE   7  (bases 1 to 679)
  AUTHORS   Simpson,J.A., Van Eyk,J. and Iscoe,S.
  TITLE     Respiratory muscle injury, fatigue and serum skeletal troponin I in
            rat
  JOURNAL   J Physiol 554 (Pt 3), 891-903 (2004)
   PUBMED   14673191
  REMARK    GeneRIF: Release of fast sTnI consistent with load-induced injury
            of fast glycolytic fibres of inspiratory muscles, probably
            diaphragm. May provide insights into molecular basis of respiratory
            muscle dysfunction.  Marker of respiratory muscle fatigue.
REFERENCE   8  (bases 1 to 679)
  AUTHORS   Sung,S.S., Brassington,A.M., Grannatt,K., Rutherford,A.,
            Whitby,F.G., Krakowiak,P.A., Jorde,L.B., Carey,J.C. and Bamshad,M.
  TITLE     Mutations in genes encoding fast-twitch contractile proteins cause
            distal arthrogryposis syndromes
  JOURNAL   Am J Hum Genet 72 (3), 681-690 (2003)
   PUBMED   12592607
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M73701.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M73701.1, FQ215644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..679
                     /gene="Tnni2"
                     /note="troponin I2, fast skeletal type"
                     /db_xref="GeneID:29389"
                     /db_xref="RGD:62050"
     exon            1..11
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
     exon            12..41
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..582
                     /gene="Tnni2"
                     /note="troponin I, skeletal, fast 2; troponin 1, type 2;
                     troponin I type 2 (skeletal, fast)"
                     /codon_start=1
                     /product="troponin I, fast skeletal muscle"
                     /protein_id="NP_058881.1"
                     /db_xref="GeneID:29389"
                     /db_xref="RGD:62050"
                     /translation="MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRRESEKQNY
                     LSEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVKVQKSSKELEDMNQKLFD
                     LRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGD
                     WRKNIEEKSGMEGRKKMFESES"
     exon            42..48
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
     exon            49..90
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..219
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
     exon            220..309
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..486
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..679
                     /gene="Tnni2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaatcta ggctcagagc ttgagatctc aagatgggag atgaggagaa gcgcaacagg
       61 gccatcacgg cccggagaca gcacctgaag agtgtgatgc tccagatcgc ggccacagag
      121 ctggagaaag aggaaagccg ccgcgaatcc gagaagcaga actacctgtc agaacactgc
      181 ccgcctctgc acatcccagg ctccatgtct gaagtgcagg aactctgcaa acaactgcat
      241 gcgaagatcg atgcggctga agaggagaaa tatgacatgg aggtgaaggt gcagaagagc
      301 agcaaggagc tggaagacat gaaccagaag ctatttgacc tgaggggcaa gttcaagagg
      361 cccccactcc ggagggtgcg tatgtcagct gacgccatgc tgaaggcgct gctgggctct
      421 aagcacaagg tgtgcatgga cctgagagcc aacctgaagc aggtcaagaa ggaagacact
      481 gagaaggagc gggacctgcg tgacgtgggt gactggagga agaatattga ggagaagtct
      541 ggcatggagg gtcggaagaa gatgtttgag tctgagtcct aactgcctac ttccccagtc
      601 ccaccctacc attggggaag cacctaacat ccagtctgga gtacttggcc tcactccaat
      661 aaaggattcg catcccttc
//
