LOCUS       NM_017184                822 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus troponin I1, slow skeletal type (Tnni1), mRNA.
ACCESSION   NM_017184
VERSION     NM_017184.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 822)
  AUTHORS   Lin,Y.H., Schmidt,W., Fritz,K.S., Jeong,M.Y., Cammarato,A.,
            Foster,D.B., Biesiadecki,B.J., McKinsey,T.A. and Woulfe,K.C.
  TITLE     Site-specific acetyl-mimetic modification of cardiac troponin I
            modulates myofilament relaxation and calcium sensitivity
  JOURNAL   J Mol Cell Cardiol 139, 135-147 (2020)
   PUBMED   31981571
  REMARK    GeneRIF: Site-specific acetyl-mimetic modification of cardiac
            troponin I modulates myofilament relaxation and calcium
            sensitivity.
REFERENCE   2  (bases 1 to 822)
  AUTHORS   Liu,W., Kuang,H., Xia,Y., Pope,Z.C., Wang,Z., Tang,C. and Yin,D.
  TITLE     Regular aerobic exercise-ameliorated troponin I carbonylation to
            mitigate aged rat soleus muscle functional recession
  JOURNAL   Exp Physiol 104 (5), 715-728 (2019)
   PUBMED   30820991
  REMARK    GeneRIF: regular aerobic exercise appeared to have antioxidant
            effects in the muscle that reduced TNNI1 slow carbonylation and
            promoted Ca(2+) /calmodulin-dependent protein kinase IIalpha and
            TNNI1 expression for skeletal muscle contraction regulation
REFERENCE   3  (bases 1 to 822)
  AUTHORS   Potluri,P.R., Chamoun,J., Cooke,J.A., Badr,M., Guse,J.A., Rayes,R.,
            Cordina,N.M., McCamey,D., Fajer,P.G. and Brown,L.J.
  TITLE     The concerted movement of the switch region of Troponin I in
            cardiac muscle thin filaments as tracked by conventional and pulsed
            (DEER) EPR
  JOURNAL   J Struct Biol 200 (3), 376-387 (2017)
   PUBMED   28864299
  REMARK    GeneRIF: Troponin I interaction with calcium and Troponin C in
            cardiac muscle
REFERENCE   4  (bases 1 to 822)
  AUTHORS   Cheng,Y., Rao,V., Tu,A.Y., Lindert,S., Wang,D., Oxenford,L.,
            McCulloch,A.D., McCammon,J.A. and Regnier,M.
  TITLE     Troponin I Mutations R146G and R21C Alter Cardiac Troponin
            Function, Contractile Properties, and Modulation by Protein Kinase
            A (PKA)-mediated Phosphorylation
  JOURNAL   J Biol Chem 290 (46), 27749-27766 (2015)
   PUBMED   26391394
  REMARK    GeneRIF: these results suggest that cTnI(R146G) and cTnI(R21C)
            blunt PKA modulation of activation and relaxation kinetics by
            prohibiting cardiac-specific N-terminal interaction with the cTnI
            inhibitory peptide.
REFERENCE   5  (bases 1 to 822)
  AUTHORS   Christopher,B., Pizarro,G.O., Nicholson,B., Yuen,S., Hoit,B.D. and
            Ogut,O.
  TITLE     Reduced force production during low blood flow to the heart
            correlates with altered troponin I phosphorylation
  JOURNAL   J Muscle Res Cell Motil 30 (3-4), 111-123 (2009)
   PUBMED   19507043
  REMARK    GeneRIF: These findings suggest that altered TnI function, due to
            changes in the distribution of phosphorylated sites, is an early
            contributor to reduced contractility of the heart.
REFERENCE   6  (bases 1 to 822)
  AUTHORS   Takimoto,E., Soergel,D.G., Janssen,P.M., Stull,L.B., Kass,D.A. and
            Murphy,A.M.
  TITLE     Frequency- and afterload-dependent cardiac modulation in vivo by
            troponin I with constitutively active protein kinase A
            phosphorylation sites
  JOURNAL   Circ Res 94 (4), 496-504 (2004)
   PUBMED   14726477
  REMARK    GeneRIF: A novel role is described for cardiac TnI PKA
            phosphorylation in the rate-dependent enhancement of systolic &
            diastolic function in vivo & afterload sensitivity of relaxation.
            This has implications for cardiac failure.
REFERENCE   7  (bases 1 to 822)
  AUTHORS   Westfall,M.V. and Borton,A.R.
  TITLE     Role of troponin I phosphorylation in protein kinase C-mediated
            enhanced contractile performance of rat myocytes
  JOURNAL   J Biol Chem 278 (36), 33694-33700 (2003)
   PUBMED   12815045
  REMARK    GeneRIF: troponin I phosphorylation has a role in protein kinase
            C-mediated enhanced contractile performance of myocytes
REFERENCE   8  (bases 1 to 822)
  AUTHORS   Metzger,J.M., Michele,D.E., Rust,E.M., Borton,A.R. and
            Westfall,M.V.
  TITLE     Sarcomere thin filament regulatory isoforms. Evidence of a dominant
            effect of slow skeletal troponin I on cardiac contraction
  JOURNAL   J Biol Chem 278 (15), 13118-13123 (2003)
   PUBMED   12551900
REFERENCE   9  (bases 1 to 822)
  AUTHORS   Huang,X., Pi,Y., Lee,K.J., Henkel,A.S., Gregg,R.G., Powers,P.A. and
            Walker,J.W.
  TITLE     Cardiac troponin I gene knockout: a mouse model of myocardial
            troponin I deficiency
  JOURNAL   Circ Res 84 (1), 1-8 (1999)
   PUBMED   9915769
REFERENCE   10 (bases 1 to 822)
  AUTHORS   Koppe,R.I., Hallauer,P.L., Karpati,G. and Hastings,K.E.
  TITLE     cDNA clone and expression analysis of rodent fast and slow skeletal
            muscle troponin I mRNAs
  JOURNAL   J Biol Chem 264 (24), 14327-14333 (1989)
   PUBMED   2760067
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017184.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04993.1, BF525158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                JAXUCZ010000013.1  49781529-49781553
            26-55               JAXUCZ010000013.1  49784766-49784795
            56-59               JAXUCZ010000013.1  49785490-49785493
            60-101              JAXUCZ010000013.1  49787394-49787435
            102-233             JAXUCZ010000013.1  49787901-49788032
            234-323             JAXUCZ010000013.1  49789943-49790032
            324-500             JAXUCZ010000013.1  49791065-49791241
            501-822             JAXUCZ010000013.1  49792024-49792345
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..822
                     /gene="Tnni1"
                     /note="troponin I1, slow skeletal type"
                     /db_xref="GeneID:29388"
                     /db_xref="RGD:621765"
     exon            1..25
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            26..55
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..608
                     /gene="Tnni1"
                     /note="troponin I, skeletal, slow 1; troponin I type 1
                     (skeletal, slow)"
                     /codon_start=1
                     /product="troponin I, slow skeletal muscle"
                     /protein_id="NP_058880.2"
                     /db_xref="GeneID:29388"
                     /db_xref="RGD:621765"
                     /translation="MPEVERKSKITASRKLMLKSLMLAKAKECWEQEHEEREAEKVRY
                     LSERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVL
                     DLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGD
                     WRKNVEAMSGMEGRKKMFDAAKSPTSQ"
     exon            56..59
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..101
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..233
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..323
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..500
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..822
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcatctgc acaggacacc aacaggtgct gccttgttac caccatgccg gaagttgaga
       61 ggaaatctaa gatcactgcc tcccgtaaac tcatgctgaa gagcctgatg ctagccaagg
      121 ccaaggagtg ctgggagcag gagcacgagg agcgagaggc tgagaaggtg cgttacctct
      181 cggagcgcat ccctacgctg cagacccgcg gtctttccct cagcgccctt caggacttat
      241 gccgagagct ccatgccaag gtggaggtgg tggatgagga gcgctatgat atcgaagcca
      301 aatgcctcca caacacgaga gagatcaagg acctgaagct gaaggtgctg gacctccgtg
      361 ggaagttcaa gcgtccaccc ctgcgccggg tccgtgtctc agccgacgcc atgctccgag
      421 ccctactggg ttccaaacac aaggtgtcca tggatctgcg ggccaacctc aagtctgtga
      481 agaaagaaga cacagaaaag gagcggccag tggaggtggg agactggagg aagaacgtgg
      541 aggccatgtc tggcatggaa ggccgcaaga agatgttcga tgctgccaag tccccaacct
      601 cgcagtagag gtgcttagag tgctcttctt ggtgcccctc agaatcttgg ggcactcagg
      661 agaagggatg ggaggctgac ccaacgtaca gaactcttag gagtcagctc tcttgggttc
      721 aagcctactg cagtgtcttc agacactggg cacagcatgc ctgtgtcagg tctttttttg
      781 ctgttgttgt tccctcatca ataaaacttg ggcttgtatg tg
//
