LOCUS       NM_001037351             736 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus troponin C2, fast skeletal type (Tnnc2), mRNA.
ACCESSION   NM_001037351 XM_215935
VERSION     NM_001037351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 736)
  AUTHORS   Schaub MC and Heizmann CW.
  TITLE     Calcium, troponin, calmodulin, S100 proteins: from myocardial
            basics to new therapeutic strategies
  JOURNAL   Biochem Biophys Res Commun 369 (1), 247-264 (2008)
   PUBMED   17964289
  REMARK    Review article
REFERENCE   2  (bases 1 to 736)
  AUTHORS   Robinson P, Lipscomb S, Preston LC, Altin E, Watkins H, Ashley CC
            and Redwood CS.
  TITLE     Mutations in fast skeletal troponin I, troponin T, and
            beta-tropomyosin that cause distal arthrogryposis all increase
            contractile function
  JOURNAL   FASEB J 21 (3), 896-905 (2007)
   PUBMED   17194691
REFERENCE   3  (bases 1 to 736)
  AUTHORS   Gallon CE, Tschirgi ML and Chandra M.
  TITLE     Differences in myofilament calcium sensitivity in rat psoas fibers
            reconstituted with troponin T isoforms containing the alpha- and
            beta-exons
  JOURNAL   Arch Biochem Biophys 456 (2), 127-134 (2006)
   PUBMED   16839517
REFERENCE   4  (bases 1 to 736)
  AUTHORS   Garfinkel,L.I., Periasamy,M. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of cDNA sequences corresponding to
            myosin light chains 1, 2, and 3, troponin-C, troponin-T,
            alpha-tropomyosin, and alpha-actin
  JOURNAL   J Biol Chem 257 (18), 11078-11086 (1982)
   PUBMED   6179945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ217974.1 and FQ218048.1.
            
            On Mar 2, 2016 this sequence version replaced NM_001037351.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217974.1, FQ218048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               FQ217974.1         1-318
            319-736             FQ218048.1         320-737
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..736
                     /gene="Tnnc2"
                     /note="troponin C2, fast skeletal type"
                     /db_xref="GeneID:296369"
                     /db_xref="RGD:1311973"
     exon            1..96
                     /gene="Tnnc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..576
                     /gene="Tnnc2"
                     /note="skeletal troponin C; troponin C type 2 (fast)"
                     /codon_start=1
                     /product="troponin C, skeletal muscle"
                     /protein_id="NP_001032428.1"
                     /db_xref="GeneID:296369"
                     /db_xref="RGD:1311973"
                     /translation="MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVM
                     RMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRI
                     FDRNADGYIDAEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
                     "
     exon            97..148
                     /gene="Tnnc2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..292
                     /gene="Tnnc2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..407
                     /gene="Tnnc2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..544
                     /gene="Tnnc2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..716
                     /gene="Tnnc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatcctgaa ggctagagag atctggggca cctttgggtg gtggagtgcg gaggagagga
       61 cccacagcag aggagtccca gtcaccagca accatgacgg accaacaggc tgaggccagg
      121 tcctacctca gcgaggagat gatcgctgag ttcaaggctg cctttgacat gtttgatgct
      181 gatggtggtg gggacatcag cgttaaagag ctgggtaccg tgatgaggat gctagggcag
      241 acacccacca aagaggaact ggacgccatc atcgaggagg tggacgagga tggcagcggt
      301 accatcgact ttgaagagtt cttggtcatg atggtgcgcc agatgaaaga ggatgcgaaa
      361 gggaagagcg aagaggaact ggctgagtgt ttccgcatct ttgacaggaa cgcagacggt
      421 tacattgatg ccgaggagct ggctgagatt ttccgggctt ctggggagca tgtgacagac
      481 gaggagatcg aatccctgat gaaggatggt gataagaaca acgatggccg cattgacttc
      541 gacgagtttc tgaagatgat ggagggcgtt cagtaaggag ctggtcttcg tgttcatcca
      601 gactgcaggt cccctgggcg tgggcaactc catccttgcc tccttgccct accagggaaa
      661 ggctgctcct ttgggctctg tggctggaag gaataaaagc agacaatgta aagctgaaaa
      721 aaaaaaaaaa aaaaaa
//
