LOCUS       NM_001034105             918 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus troponin C1, slow skeletal and cardiac type
            (Tnnc1), mRNA.
ACCESSION   NM_001034105 XM_214266
VERSION     NM_001034105.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Vetter,A.D., Houang,E.M., Sell,J.J., Thompson,B.R., Sham,Y.Y. and
            Metzger,J.M.
  TITLE     TnI Structural Interface with the N-Terminal Lobe of TnC as a
            Determinant of Cardiac Contractility
  JOURNAL   Biophys J 114 (7), 1646-1656 (2018)
   PUBMED   29642034
  REMARK    GeneRIF: TnI Structural Interface with the N-Terminal Lobe of TnC
            as a Determinant of Cardiac Contractility
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Potluri,P.R., Chamoun,J., Cooke,J.A., Badr,M., Guse,J.A., Rayes,R.,
            Cordina,N.M., McCamey,D., Fajer,P.G. and Brown,L.J.
  TITLE     The concerted movement of the switch region of Troponin I in
            cardiac muscle thin filaments as tracked by conventional and pulsed
            (DEER) EPR
  JOURNAL   J Struct Biol 200 (3), 376-387 (2017)
   PUBMED   28864299
  REMARK    GeneRIF: Troponin C interaction with Troponin I in cardiac muscle
REFERENCE   3  (bases 1 to 918)
  AUTHORS   Li,K.L., Ghashghaee,N.B., Solaro,R.J. and Dong,W.
  TITLE     Sarcomere length dependent effects on the interaction between cTnC
            and cTnI in skinned papillary muscle strips
  JOURNAL   Arch Biochem Biophys 601, 69-79 (2016)
   PUBMED   26944554
  REMARK    GeneRIF: the interaction between cTnC and cTnI in skinned papillary
            muscle strips is dependent on sarcomere length
REFERENCE   4  (bases 1 to 918)
  AUTHORS   Pineda-Sanabria,S.E., Robertson,I.M., Sun,Y.B., Irving,M. and
            Sykes,B.D.
  TITLE     Probing the mechanism of cardiovascular drugs using a covalent
            levosimendan analog
  JOURNAL   J Mol Cell Cardiol 92, 174-184 (2016)
   PUBMED   26853943
  REMARK    GeneRIF: These findings provide new insights into the in vivo
            mechanism of Ca(2+) sensitization and demonstrate that directly
            targeting cTnC has significant potential in cardiovascular therapy.
REFERENCE   5  (bases 1 to 918)
  AUTHORS   Wijnker,P.J., Li,Y., Zhang,P., Foster,D.B., dos Remedios,C., Van
            Eyk,J.E., Stienen,G.J., Murphy,A.M. and van der Velden,J.
  TITLE     A novel phosphorylation site, Serine 199, in the C-terminus of
            cardiac troponin I regulates calcium sensitivity and susceptibility
            to calpain-induced proteolysis
  JOURNAL   J Mol Cell Cardiol 82, 93-103 (2015)
   PUBMED   25771144
REFERENCE   6  (bases 1 to 918)
  AUTHORS   Huynh,Q., Butters,C.A., Leiden,J.M. and Tobacman,L.S.
  TITLE     Effects of cardiac thin filament Ca2+: statistical mechanical
            analysis of a troponin C site II mutant
  JOURNAL   Biophys J 70 (3), 1447-1455 (1996)
   PUBMED   8785301
REFERENCE   7  (bases 1 to 918)
  AUTHORS   Dong,W., Rosenfeld,S.S., Wang,C.K., Gordon,A.M. and Cheung,H.C.
  TITLE     Kinetic studies of calcium binding to the regulatory site of
            troponin C from cardiac muscle
  JOURNAL   J Biol Chem 271 (2), 688-694 (1996)
   PUBMED   8557674
REFERENCE   8  (bases 1 to 918)
  AUTHORS   al-Hillawi,E., Minchin,S.D. and Trayer,I.P.
  TITLE     Overexpression of human cardiac troponin-I and troponin-C in
            Escherichia coli and their purification and characterisation. Two
            point mutations allow high-level expression of troponin-I
  JOURNAL   Eur J Biochem 225 (3), 1195-1201 (1994)
   PUBMED   7957210
REFERENCE   9  (bases 1 to 918)
  AUTHORS   Berlin,J.R., Bassani,J.W. and Bers,D.M.
  TITLE     Intrinsic cytosolic calcium buffering properties of single rat
            cardiac myocytes
  JOURNAL   Biophys J 67 (4), 1775-1787 (1994)
   PUBMED   7819510
REFERENCE   10 (bases 1 to 918)
  AUTHORS   Thierfelder,L., Watkins,H., MacRae,C., Lamas,R., McKenna,W.,
            Vosberg,H.P., Seidman,J.G. and Seidman,C.E.
  TITLE     Alpha-tropomyosin and cardiac troponin T mutations cause familial
            hypertrophic cardiomyopathy: a disease of the sarcomere
  JOURNAL   Cell 77 (5), 701-712 (1994)
   PUBMED   8205619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 30, 2022 this sequence version replaced NM_001034105.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM107778.1, CR753959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000016.1  6408607-6408668
            63-93               JAXUCZ010000016.1  6410056-6410086
            94-240              JAXUCZ010000016.1  6410312-6410458
            241-355             JAXUCZ010000016.1  6410799-6410913
            356-492             JAXUCZ010000016.1  6411422-6411558
            493-918             JAXUCZ010000016.1  6411645-6412070
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..918
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /note="troponin C1, slow skeletal and cardiac type"
                     /db_xref="GeneID:290561"
                     /db_xref="RGD:1309921"
     exon            1..62
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..524
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /note="troponin C, cardiac/slow skeletal; troponin C type
                     1 (slow)"
                     /codon_start=1
                     /product="troponin C, slow skeletal and cardiac muscles"
                     /protein_id="NP_001029277.1"
                     /db_xref="GeneID:290561"
                     /db_xref="RGD:1309921"
                     /translation="MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKV
                     MRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFR
                     MFDKNADGYIDLDELKMMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGV
                     E"
     exon            63..93
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            94..240
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            241..355
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            356..492
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            493..918
                     /gene="Tnnc1"
                     /gene_synonym="Tncc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaacccca gtagcctgtc ccctgagctg ccaccagcat ggatgacatc tacaaagcag
       61 cggtagagca gttgacagaa gaacagaaga atgagttcaa ggctgccttc gatatctttg
      121 tcctgggcgc ggaggatggc tgcatcagca ccaaggagct gggcaaggtg atgaggatgc
      181 tgggacagaa ccccacacct gaggagctgc aggagatgat cgacgaggta gacgaggatg
      241 gcagtggcac agtggacttc gacgagttcc ttgtcatgat ggttcggtgc atgaaggatg
      301 acagcaaagg gaagtctgag gaggagctgt cggatctctt ccgcatgttt gacaaaaacg
      361 ctgatggcta cattgacttg gatgaactga agatgatgct gcaggccaca ggtgagacca
      421 tcacggaaga tgacatcgaa gagctcatga aggacggtga caagaacaac gatggccgaa
      481 tcgactatga cgagttcctg gagttcatga agggcgtgga gtagacactg gctttgcaca
      541 gagttgccca tgcctgttct cctaatccag ccggaccccg tgataggagt gcacccgggt
      601 tctctagact ctctgaacct ggttgtgtcc ttgaagcttt ggctcttctg gactctccct
      661 gttcccgtcc caggggacac aaataaatcc tctctccttg gaggcctggt atcttgctct
      721 gattttcctg gggtcacagt cttttctcag ggttccctcc tgcttgatga caccatccct
      781 gtattctgac tgttcagctt accttctgcc agaggacttt ggttaggtca gagaaatctt
      841 gctttgcacc ccatcgatga ctaggccctg ctgtagcccc agagcctgca ttttaacaag
      901 ctcctggagt cctcgaaa
//
