LOCUS       NM_022290               1336 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus tenomodulin (Tnmd), mRNA.
ACCESSION   NM_022290
VERSION     NM_022290.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Xu,P., Zhang,B., Deng,B., Luo,Q. and Song,G.
  TITLE     Mechanical stretch facilitates tenomodulin expression to induce
            tenocyte migration via MAPK signaling pathway
  JOURNAL   Arch Biochem Biophys 734, 109486 (2023)
   PUBMED   36513131
  REMARK    GeneRIF: Mechanical stretch facilitates tenomodulin expression to
            induce tenocyte migration via MAPK signaling pathway.
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Xu,P., Deng,B., Zhang,B., Luo,Q. and Song,G.
  TITLE     Stretch-Induced Tenomodulin Expression Promotes Tenocyte Migration
            via F-Actin and Chromatin Remodeling
  JOURNAL   Int J Mol Sci 22 (9), 4928 (2021)
   PUBMED   34066472
  REMARK    GeneRIF: Stretch-Induced Tenomodulin Expression Promotes Tenocyte
            Migration via F-Actin and Chromatin Remodeling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Chen,C.H., Lin,Y.H., Chen,C.H., Wang,Y.H., Yeh,M.L., Cheng,T.L. and
            Wang,C.Z.
  TITLE     Transforming growth factor beta 1 mediates the low-frequency
            vertical vibration enhanced production of tenomodulin and type I
            collagen in rat Achilles tendon
  JOURNAL   PLoS One 13 (10), e0205258 (2018)
   PUBMED   30307981
  REMARK    GeneRIF: Study in Sprague-Dawley rats demonstrated that 10 Hz
            vertical vibration stimulated the anabolic effect of tenocytes and
            the stiffness of intact Achilles tendons by increasing the
            expression of TGF-beta1, which was followed by an increased
            expression of tenomodulin and type I collagen that then improved
            Achilles tendon stiffness via mechano-transduction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Kishimoto,Y., Ohkawara,B., Sakai,T., Ito,M., Masuda,A.,
            Ishiguro,N., Shukunami,C., Docheva,D. and Ohno,K.
  TITLE     Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and
            Tnmd in tendon-derived cells
  JOURNAL   PLoS One 12 (7), e0182051 (2017)
   PUBMED   28750046
  REMARK    GeneRIF: Wnt/beta-catenin decreased Mkx and Tnmd expressions
            without suppressing Scx expression in Scx-programmed tendon
            progenitors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Lee,J.Y., Zhou,Z., Taub,P.J., Ramcharan,M., Li,Y., Akinbiyi,T.,
            Maharam,E.R., Leong,D.J., Laudier,D.M., Ruike,T., Torina,P.J.,
            Zaidi,M., Majeska,R.J., Schaffler,M.B., Flatow,E.L. and Sun,H.B.
  TITLE     BMP-12 treatment of adult mesenchymal stem cells in vitro augments
            tendon-like tissue formation and defect repair in vivo
  JOURNAL   PLoS One 6 (3), e17531 (2011)
   PUBMED   21412429
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Watahiki,J., Yamaguchi,T., Enomoto,A., Irie,T., Yoshie,K.,
            Tachikawa,T. and Maki,K.
  TITLE     Identification of differentially expressed genes in mandibular
            condylar and tibial growth cartilages using laser microdissection
            and fluorescent differential display: chondromodulin-I (ChM-1) and
            tenomodulin (TeM) are differentially expressed in mandibular
            condylar and other growth cartilages
  JOURNAL   Bone 42 (6), 1053-1060 (2008)
   PUBMED   18337200
  REMARK    GeneRIF: Data show that chondromodulin-I (ChM-1) and tenomodulin
            (TeM) are differentially expressed in mandibular condylar and other
            growth cartilages.
REFERENCE   7  (bases 1 to 1336)
  AUTHORS   Pisani,D.F., Pierson,P.M., Massoudi,A., Leclerc,L., Chopard,A.,
            Marini,J.F. and Dechesne,C.A.
  TITLE     Myodulin is a novel potential angiogenic factor in skeletal muscle
  JOURNAL   Exp Cell Res 292 (1), 40-50 (2004)
   PUBMED   14720505
REFERENCE   8  (bases 1 to 1336)
  AUTHORS   Oshima,Y., Shukunami,C., Honda,J., Nishida,K., Tashiro,F.,
            Miyazaki,J., Hiraki,Y. and Tano,Y.
  TITLE     Expression and localization of tenomodulin, a transmembrane type
            chondromodulin-I-related angiogenesis inhibitor, in mouse eyes
  JOURNAL   Invest Ophthalmol Vis Sci 44 (5), 1814-1823 (2003)
   PUBMED   12714610
REFERENCE   9  (bases 1 to 1336)
  AUTHORS   Yamana,K., Wada,H., Takahashi,Y., Sato,H., Kasahara,Y. and
            Kiyoki,M.
  TITLE     Molecular cloning and characterization of CHM1L, a novel membrane
            molecule similar to chondromodulin-I
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1101-1106 (2001)
   PUBMED   11162640
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF191769.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF191769.1, AB055423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..1336
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /note="tenomodulin"
                     /db_xref="GeneID:64104"
                     /db_xref="RGD:620938"
     exon            1..265
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1171
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /note="teM; rTeM; rChM1L; chondromodulin-I-like protein;
                     chondromodulin-1-like protein; myodulin"
                     /codon_start=1
                     /product="tenomodulin"
                     /protein_id="NP_071626.1"
                     /db_xref="GeneID:64104"
                     /db_xref="RGD:620938"
                     /translation="MAKNPPENCEGCHILNAEALKSKKIRKSLKICGLVFGILALTLI
                     VLFWGSKHFWPEVSKKTYGMEHTFYSNGEKKKISMEIDPITRTEIFRSGNGTDETLEV
                     HDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAE
                     KPIENRDFLKNSKILEICDNVTMYWINPTLIAVSELQDFEEDGEDLHFPTSEKKGIDQ
                     NEQWVVPQVKVEKTRRTRQASEEDLPVNDYTENGIEFDPMLDERGYCCIYCRRGNRYC
                     RRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV"
     exon            266..397
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            398..538
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            539..640
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            641..794
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            795..961
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1334
                     /gene="Tnmd"
                     /gene_synonym="ChM1L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgcacaga agttatatac atatatgggt atatctatgt aacaaatcgt agcacgggag
       61 ccccctgggc tccctccggc tctggtatga catatttgag ccatataaat tcagcttctc
      121 ctctggcatc tgttagccga ctcacttgca actccacctc agcagtggtc tctcagtcct
      181 ctcaaagcaa ggaaagagca ctgtgtgctg ggagaccatg gcaaagaatc ctccagagaa
      241 ctgtgagggc tgtcacattc taaatgcaga agctctgaaa tctaagaaga tacgtaaatc
      301 actgaagatt tgtggactag tgtttggtat cctggcctta actctaattg tcctgttttg
      361 ggggagcaaa cacttctggc ccgaggtatc caagaagacc tatggcatgg agcacacttt
      421 ctacagcaat ggcgagaaga agaagatttc catggaaatt gatcccataa ccagaacaga
      481 aatattcaga agtggaaatg gcaccgatga aacattggaa gtccatgact ttaaaaacgg
      541 atacactggc atctactttg taggtcttca aaaatgcttt attaaaactc aaatcaaagt
      601 gattcctgaa ttttctgaac cagaagagga aatagatgag aatgaagaaa ttactacaac
      661 gttctttgaa cagtcagtga tttgggttcc tgcagaaaag cctattgaaa acagagactt
      721 cctgaaaaat tctaaaattc tggagatttg cgacaatgtg actatgtact ggatcaatcc
      781 cactctaata gcagtttcag aattacagga ctttgaggag gatggtgaag atcttcactt
      841 tcctaccagc gaaaaaaaag ggattgacca gaatgagcaa tgggtggtcc cacaagtgaa
      901 ggtggagaag acccgccgca ccagacaagc aagcgaggaa gaccttcctg ttaatgacta
      961 tactgaaaat ggaatcgaat ttgatcccat gctggatgag agaggttact gttgtattta
     1021 ctgccgtcga ggcaaccgct actgccgcag ggtctgtgaa cctttactag gctactaccc
     1081 atacccctac tgctaccaag gaggtcgagt catctgtcgt gtcatcatgc cttgcaactg
     1141 gtgggtggcc cgcatgcttg ggagagtcta ataggaagtt tgagtccaaa tgcttaacct
     1201 tttgttagcc aacatataat taatgcatgc tactccatga atttctgcat ttgcctccaa
     1261 gtagcctatc ctccagaatt atttgtagga tattcctctc ttcgtgttct aataaacgtc
     1321 tacatcatca tcaaaa
//
