LOCUS       NM_001106084            4575 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus tankyrase (Tnks), mRNA.
ACCESSION   NM_001106084 XM_001059294 XM_224923
VERSION     NM_001106084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4575)
  AUTHORS   Accialini,P., Irusta,G., Bechis,A., Bas,D., Parborell,F.,
            Abramovich,D. and Tesone,M.
  TITLE     Tankyrase inhibition regulates corpus luteum development and luteal
            function in gonadotropin-treated rats
  JOURNAL   Mol Reprod Dev 84 (8), 719-730 (2017)
   PUBMED   28628258
  REMARK    GeneRIF: Studied role of tankyrase and effect of tankyrase
            inhibitor XAV939 on corpus luteum development , luteal function,
            and Wnt/beta-catenin signaling in gonadotropin-treated prepubertal
            rats.
REFERENCE   2  (bases 1 to 4575)
  AUTHORS   Ramamoorthy,M. and Smith,S.
  TITLE     Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control
            Recombination in ALT Cancer Cells
  JOURNAL   Cancer Cell 28 (3), 357-369 (2015)
   PUBMED   26373281
REFERENCE   3  (bases 1 to 4575)
  AUTHORS   Kulak,O., Chen,H., Holohan,B., Wu,X., He,H., Borek,D.,
            Otwinowski,Z., Yamaguchi,K., Garofalo,L.A., Ma,Z., Wright,W.,
            Chen,C., Shay,J.W., Zhang,X. and Lum,L.
  TITLE     Disruption of Wnt/beta-Catenin Signaling and Telomeric Shortening
            Are Inextricable Consequences of Tankyrase Inhibition in Human
            Cells
  JOURNAL   Mol Cell Biol 35 (14), 2425-2435 (2015)
   PUBMED   25939383
REFERENCE   4  (bases 1 to 4575)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   5  (bases 1 to 4575)
  AUTHORS   Zhong,L., Yeh,T.Y., Hao,J., Pourtabatabaei,N., Mahata,S.K.,
            Shao,J., Chessler,S.D. and Chi,N.W.
  TITLE     Nutritional energy stimulates NAD+ production to promote
            tankyrase-mediated PARsylation in insulinoma cells
  JOURNAL   PLoS One 10 (4), e0122948 (2015)
   PUBMED   25876076
  REMARK    GeneRIF: tankyrase-mediated PARsylation is promoted by nutritional
            energy stimulated NAD+ in insulinoma cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4575)
  AUTHORS   Ye,J.Z. and de Lange,T.
  TITLE     TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length
            control complex
  JOURNAL   Nat Genet 36 (6), 618-623 (2004)
   PUBMED   15133513
REFERENCE   7  (bases 1 to 4575)
  AUTHORS   Chang,W., Dynek,J.N. and Smith,S.
  TITLE     TRF1 is degraded by ubiquitin-mediated proteolysis after release
            from telomeres
  JOURNAL   Genes Dev 17 (11), 1328-1333 (2003)
   PUBMED   12782650
REFERENCE   8  (bases 1 to 4575)
  AUTHORS   Seimiya,H. and Smith,S.
  TITLE     The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains
            multiple binding sites for telomeric repeat binding factor 1 (TRF1)
            and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)
  JOURNAL   J Biol Chem 277 (16), 14116-14126 (2002)
   PUBMED   11854288
REFERENCE   9  (bases 1 to 4575)
  AUTHORS   Cook,B.D., Dynek,J.N., Chang,W., Shostak,G. and Smith,S.
  TITLE     Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2
            at human telomeres
  JOURNAL   Mol Cell Biol 22 (1), 332-342 (2002)
   PUBMED   11739745
REFERENCE   10 (bases 1 to 4575)
  AUTHORS   Smith,S., Giriat,I., Schmitt,A. and de Lange,T.
  TITLE     Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
  JOURNAL   Science 282 (5393), 1484-1487 (1998)
   PUBMED   9822378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Oct 27, 2010 this sequence version replaced NM_001106084.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32852.1,
                                           SRR26643298.71781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-668               JAXUCZ010000016.1  63928329-63928996
            669-893             JAXUCZ010000016.1  63954068-63954292
            894-989             JAXUCZ010000016.1  63974928-63975023
            990-1026            JAXUCZ010000016.1  64006540-64006576
            1027-1102           JAXUCZ010000016.1  64007317-64007392
            1103-1197           JAXUCZ010000016.1  64023232-64023326
            1198-1264           JAXUCZ010000016.1  64024827-64024893
            1265-1451           JAXUCZ010000016.1  64025039-64025225
            1452-1573           JAXUCZ010000016.1  64029547-64029668
            1574-1665           JAXUCZ010000016.1  64031061-64031152
            1666-1744           JAXUCZ010000016.1  64031495-64031573
            1745-1916           JAXUCZ010000016.1  64036335-64036506
            1917-1996           JAXUCZ010000016.1  64040769-64040848
            1997-2142           JAXUCZ010000016.1  64042190-64042335
            2143-2308           JAXUCZ010000016.1  64044602-64044767
            2309-2528           JAXUCZ010000016.1  64046224-64046443
            2529-2638           JAXUCZ010000016.1  64048738-64048847
            2639-2827           JAXUCZ010000016.1  64051090-64051278
            2828-3065           JAXUCZ010000016.1  64051629-64051866
            3066-3148           JAXUCZ010000016.1  64053091-64053173
            3149-3269           JAXUCZ010000016.1  64056482-64056602
            3270-3367           JAXUCZ010000016.1  64057642-64057739
            3368-3442           JAXUCZ010000016.1  64059379-64059453
            3443-3548           JAXUCZ010000016.1  64060480-64060585
            3549-3735           JAXUCZ010000016.1  64060858-64061044
            3736-3892           JAXUCZ010000016.1  64064636-64064792
            3893-4575           JAXUCZ010000016.1  64068812-64069494
FEATURES             Location/Qualifiers
     source          1..4575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..4575
                     /gene="Tnks"
                     /note="tankyrase"
                     /db_xref="GeneID:290794"
                     /db_xref="RGD:1308784"
     exon            1..668
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3979
                     /gene="Tnks"
                     /EC_number="2.4.2.30"
                     /note="tankyrase-1; tankyrase, TRF1-interacting
                     ankyrin-related ADP-ribose polymerase"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase tankyrase-1"
                     /protein_id="NP_001099554.2"
                     /db_xref="GeneID:290794"
                     /db_xref="RGD:1308784"
                     /translation="MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPT
                     PASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAATAAAPAASA
                     AVGVAPSPAGGGGNNSASSTSSPTSSSSSSPSSPGSSIAESPEAAGVGSTATLGPGAA
                     GLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGR
                     KDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL
                     HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAAR
                     SGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG
                     LVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGAD
                     PTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQ
                     PQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV
                     LHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEA
                     VQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAA
                     GYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK
                     FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALL
                     DAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLERGADVNAQ
                     DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA
                     HGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPAST
                     PSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGL
                     EHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLT
                     FHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNK
                     KLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYF
                     AENSSKSNQYVYGIGGGTGCPTHKDRSCYVCHRQMLFCRVTLGKSFLQFSTMKMAHAP
                     PGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT"
     exon            669..893
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            894..989
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1026
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1102
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1197
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1264
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1451
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1573
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1665
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1744
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1916
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1996
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2142
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2308
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2528
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2638
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2827
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3065
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3148
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3269
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3367
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3442
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3548
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3735
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3892
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4575
                     /gene="Tnks"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgacagta cgggggagtg ggaagatggc ggcgtcgcgt cgctctcagc atcatcacca
       61 ccatcatcag caacagctcc agcccgcccc aggggcttcg gctccgccac cgccacctcc
      121 cccgccgctc agcccgggct tggccccggg acctaccccg gcctctccca cggccggcgg
      181 cctggcgccc ttcgcctccc cgcggcacgg cctggcgctg ccggaggggg atggcagccg
      241 ggacccgccc gacaggccgc gatctccgga cccggtggac ggcgcggtct gcacggtggc
      301 tgctacggcc gcggccccgg cagcttccgc cgccgtcggg gtcgctccca gcccagccgg
      361 cggcggcggt aacaactccg cgtcgtccac ttcttcgcct acttcttctt cgtcttcctc
      421 tccgtcctcc cctggctcga gcatagcgga gagtcccgaa gccgccggag ttggctccac
      481 agcaactttg ggacccgggg cggcgggcct tggcccgggg gtcccagccg tgagtggggc
      541 cctgcgggag ctgctggagg cttgtcgaaa tggggacgtg tcccgggtga agaggttggt
      601 ggacgcagcg aacgtgaatg caaaggacat ggccggccga aagtcttctc ccctgcactt
      661 cgcagcaggt tttggaagga aggatgttgt agaacacttg ctgcagatgg gtgccaatgt
      721 ccatgcccgt gacgatgggg gtctcatccc acttcataac gcctgttctt ttggccatgc
      781 ggaggttgtg agtctgttac tgtgtcaagg agcagatccg aatgccagag ataactggaa
      841 ctatacgcct ctgcatgaag ctgccattaa agggaagatc gacgtttgca ttgtgctgct
      901 gcagcacgga gctgatccaa acatccggaa caccgatggg aaatcggctc tggacctggc
      961 agatccttca gcaaaggctg tcctcacagg tgaatacaaa aaggacgaac tcctagaagc
     1021 tgctaggagt ggtaatgaag aaaaactaat ggctttactg actcctctaa atgtgaattg
     1081 ccatgccagt gatgggcgaa agtctactcc gttacacctg gccgcgggct acaacagagt
     1141 gcggatagtt cagctgctgc tacagcacgg agctgatgtc cacgcaaaag acaaaggcgg
     1201 gcttgtacct cttcataatg catgctcata cggacactat gaggtcacag agctgctgtt
     1261 aaagcatggc gcttgtgtca acgctatgga tctgtggcag ttcaccccgc tgcatgaagc
     1321 cgcttccaag aaccgcgtcg aagtctgttc tttgttactt agtcatggtg ctgatccaac
     1381 cttggtcaat tgccatggca aaagtgctgt ggatatggct cccactcctg agctccggga
     1441 aagactgaca tatgaattta aaggccattc tttactacaa gctgccagag aagcagacct
     1501 ggccaaagtg aagaaaacac ttgctttgga aatcattaac ttcaagcagc cacagtctca
     1561 tgaaactgcc ttgcattgtg ctgtggcctc cttgcatccc aaacgaaagc aggtggcaga
     1621 actgctactt aggaagggcg ccaatgtcaa tgaaaaaaac aaggacttca tgactccttt
     1681 gcatgttgca gctgaaagag ctcataatga cgtcatggag gttctgcata agcatggagc
     1741 aaagatgaac gcgctggaca gtctaggtca gactgctttg cacagagctg ccttggctgg
     1801 ccacctgcag acctgccgcc tcctgctgag ttacggctct gacccttcca tcatctccct
     1861 gcaaggcttc acagccgcgc agatggggaa cgaagcggtg cagcagattc tgagcgagag
     1921 tactcctatc cgcacttctg atgtggacta tcgactctta gaggcatcga aagctggtga
     1981 cttggaaact gtgaagcaac tgtgcagccc gcagaatgtg aactgcagag atctggaggg
     2041 ccgccattcc actcccttac acttcgctgc aggctacaac cgtgtgtctg tcgtcgagta
     2101 ccttctacat catggagctg atgtccatgc caaagacaaa gggggcttgg ttccccttca
     2161 caatgcctgc tcctatggac actacgaggt agctgagctc ttggtgaggc acggggcttc
     2221 tgtcaacgtg gcggacttgt ggaaatttac ccctctccat gaagccgcag ccaagggaaa
     2281 atatgagatc tgcaaactcc ttctaaaaca tggagcagat ccaactaaga agaacagaga
     2341 tggaaacaca cccctagatc tggtcaaaga aggagacaca gatattcagg acctactgag
     2401 gggggatgct gccctgttgg atgctgccaa gaagggctgc ctggccagag tgcagaagct
     2461 ttgtactcca gagaacatca actgccgaga cacccagggc agaaactcaa ctcctctcca
     2521 cctggcagcg ggctataata acctggaagt agccgagtac ctgctagagc gcggcgctga
     2581 tgtgaacgcc caggacaaag gaggtttaat tccactccac aacgcagcgt cttatgggca
     2641 tgttgatata gcagcattac tgataaagta caacacgtgt gtaaacgcaa cggataagtg
     2701 ggccttcact cccctccacg aagcagccca gaaggggagg acacagttgt gtgccctact
     2761 cctagcacat ggcgcagacc caaccatgaa gaaccaggag ggtcagacac ctttagacct
     2821 ggcaacggct gatgacatcc gagctttgct gatagatgcc atgccccctg aggccttacc
     2881 tacctgtttt aaacctcagg caactgtagt tagtgcctct ctgatctcac cagcgtccac
     2941 cccgtcctgc ctctctgctg ccagcagcat agataacctc actggcccgt tagcagagct
     3001 ggctgtagga ggagcctcca atgcggggga tggtgctgcg ggtgcagaaa ggaaggaagg
     3061 agaagttgcg ggtcttgaca tgaatatcag ccaattcctt aaaagccttg gccttgagca
     3121 ccttcgggac atctttgaaa cagagcagat cacgttagat gtgctggccg atatgggtca
     3181 tgaggaactg aaagaaatag gcatcaatgc ctatggacac cgccacaagt taatcaaggg
     3241 cgttgaaaga ctcttaggtg gacaacaagg aaccaatccg tatctgacct ttcactgtgt
     3301 gaatcaggga actattttac tagatcttgc tccagaagat aaagaatacc aatcagtaga
     3361 agaagagatg cagagtacta ttcgggagca cagagatggc gggaatgctg gtggcatctt
     3421 caacagatac aatgtcattc gaattcagaa agttgtaaac aagaagctga gggagcggtt
     3481 ttgtcacaga caaaaggagg tgtctgagga gaaccacaac catcacaatg agcgcatgct
     3541 gttccacggt tcccctttca ttaatgccat tattcataaa gggtttgatg agcggcacgc
     3601 atacattgga gggatgtttg gagctgggat ttactttgcc gaaaactctt ccaaaagcaa
     3661 tcagtatgtt tatggaattg gaggaggaac aggctgcccc acacacaaag ataggtcatg
     3721 ttacgtatgt cacagacaaa tgcttttctg tagagtgacc cttggaaagt cttttctgca
     3781 attcagcacc atgaaaatgg cccatgcgcc tccaggacat cactcagtca tcggtagacc
     3841 aagtgtcaat gggctggcgt atgctgaata tgtcatctac agaggggaac aggcatatcc
     3901 agaatatctc atcacctacc agatcatgaa gccggaagcc ccttcccaga ctgcaacggc
     3961 agcagagcag aagacctagt gattgcccct ggtaaaggcc agagtgattc aaacctgcaa
     4021 ctggattaca gtggattgct tccaacaaaa aaaatcaata ttctctaaat cccaacagcc
     4081 aagaaataag ctgtttgtct tttataaagc attgctagag tgaccctgcg gagtgagtcc
     4141 ccaagcacat tcacctgccc tggtcccctt gaggaaatgg ctaccaggcg gccttgacca
     4201 tgtctcaggc cgttttcatt gcagttaccc atttctgaag caagatgctt tgctcaagat
     4261 gtagagatgg gaaaagagaa tatgctggct tacacgttct tggttcatac actacatttt
     4321 cttcgttgtg ttggcacatg gataacagac acatgtgatg ggcttatttt ttaattttgc
     4381 caaacatatt tgttgatgct tcttgttctt gttgttgttg tcgtcgtcat tattgttact
     4441 ttgaaaatga gccagagtct tcctgggata ttttgcacag agtcacactg actaaaatca
     4501 ttagcgatgc agccgaagct tctggctaga cactggtcca gtgtccccgt tgtcagattt
     4561 tgtatctctg cttct
//
