LOCUS       NM_001008336            4250 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2), mRNA.
ACCESSION   NM_001008336 XM_221379
VERSION     NM_001008336.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4250)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4250)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4250)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4250)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4250)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4250)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4250)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4250)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4250)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4250)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085825.1.
            
            On Dec 16, 2004 this sequence version replaced XM_221379.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4250
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..279
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..460
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..3420
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="ACK-1; tyrosine kinase non-receptor protein 2;
                     activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1"
                     /protein_id="NP_001008337.1"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNE
                     DLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRQEAEFPSHHSQSTFRKPS
                     PTPGGLAGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCL
                     KPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLR
                     KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA
                     LPQNDGHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGL
                     NGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD
                     MRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLS
                     AQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPTQ
                     HLGRMKKPTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKAGRSSGG
                     EVTLIDFGEEPVAPTPRPCAPSLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVVDW
                     DARPLPPPPAYDDVAQDEDDFEVCSINSTLVSAGLPTGPSQGETNYAFVPEQAQLPPA
                     LEDNLFLPPQGGGQPPSSAQTAEIFQALQQECMRQLQVPTGQLTPSPTPGGDDKPQVP
                     PRVPIPPRPTRPRVGLSPAPLGEEEASRWPGPSSPPRVPPREPLSPQGSRTPSPLVPP
                     GSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGRKVSS
                     THYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPSTPAPAAPTATVRPMPQ
                     AAPDPKANFSTNNSNPGAQPPSLRASARLPQRGCPGDGQEAARPADKVQMLQAMVHGV
                     TTEECQAALRSHSWSIQRAAQYLKVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCHLL
                     GSCGPAHHKR"
     exon            461..531
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..753
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..906
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1184
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1311
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1458
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1553
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1748
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1840
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..3189
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3285
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3413
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3414..4225
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccccagcg ggagagggat tccaagaggg acacagaacc cgcaggcgca gacgacgaag
       61 gaggtggtaa tctgcaagct gccttactgg catcggggtt gctctagtgc caagaggaat
      121 gcaggaagat gtaggggctt ggggagcaga agagcgctgt gaacctgacc tttggaagcc
      181 attgctggag ggtaggcagt ggcctgcaag atcctctctg ctacctcaag tctgagcatc
      241 cttgaagcag tgtctgcctg gggagagctg aaaactcaga ggctggggag cagcagcatg
      301 cagccggagg agggaacagg ctggctgctg gagctgctgt ctgaggtgca gctacaacag
      361 tatttcctga ggctccgaga tgacctcaac attacccgcc tgtctcattt tgagtatgtc
      421 aaaaacgaag acctggaaaa gattggcatg ggccggcctg gccagaggcg gctatgggag
      481 gctgtgaaga ggaggaaggc catgtgcaaa cgcaagtcat ggatgagcaa ggtgttcagt
      541 ggaaagcggc aggaggctga gttcccttcc catcactctc agagcacctt ccggaagccc
      601 tcccccaccc cagggggcct ggcaggggag gggaccctgc agagcctcac ctgcctcatt
      661 ggggagaaag acctgcgcct gctggagaag ctgggagatg gctcctttgg cgtggtgcgc
      721 aggggtgaat gggatgcccc tgcagggaag acggtgagtg tggccgtgaa gtgcctgaaa
      781 cctgatgtgc tgagccagcc cgaggccatg gacgacttca tccgggaggt caatgccatg
      841 cattcgctag accaccgaaa cctcattcgc ttgtacggtg tggtgctcac accacccatg
      901 aagatggtga cagagctggc ccctctggga tccttgttgg accggctacg taaacaccaa
      961 ggtcatttcc tcttggggac gctgagtcgc tatgccgtgc aggtggctga gggcatgggc
     1021 tacctggagt ccaagcgctt cattcaccga gacctggctg ctcgaaatct gcttttggcc
     1081 acccgtgacc tggtcaagat tggggacttt ggactgatgc gagctctgcc ccagaatgat
     1141 ggccactatg tcatgcaaga acatcgcaag gtgccctttg cctggtgtgc ccctgagagc
     1201 ctgaagacac ggactttctc ccatgccagt gacacctgga tgtttggggt cacactgtgg
     1261 gagatgttta cgtatggcca ggagccctgg attggcctca atggcagcca gatcctgcat
     1321 aagattgaca aggaagggga gcgcctgccc cggcctgagg actgccccca agacatctac
     1381 aatgtcatgg tccagtgctg ggcccacaag ccagaggaca gacccacatt tgtggccctt
     1441 cgggacttcc tgctggaggc tcagcctaca gacatgcggg cccttcagga cttcgaggag
     1501 ccggacaagc tgcacatcca gatgaacgac gtcattactg tcattgaggg aagggctgag
     1561 aactactggt ggcgtggtca gaacacacgg acgctgtgtg tgggaccctt ccctcgaaat
     1621 gtggtgacct ctgtggctgg cctgtcagcc caggacatca gccagcctct acagaatagc
     1681 ttcattcaca cagggcatgg cgacagtgac ccccgccact gctgggggtt ccctgacagg
     1741 atcgatgaac tgtacctggg aaaccccatg gacccccctg acctgctgag tgtggaactg
     1801 agcacctcgc gacccaccca gcatttagga cggatgaaaa agccaacata tgaccctgtg
     1861 agtgaggacc cagaccccct gtccagcgac ttcaagagac ttggcctgag gaagccagcc
     1921 ctgccccgag ggctctggct ggcaaagccc tcagcccggg tgccaggcac caaggcaggc
     1981 cgcagcagtg ggggtgaggt cacactcatc gacttcggcg aggagcctgt agccccaacc
     2041 ccacggccct gtgcaccttc cttggcacag ttggccatgg atgcctgctc cctgctggac
     2101 aagacaccac cacagagccc cacacgggca ctgccacgac ctttacatcc tacacctgtg
     2161 gtggactggg acgctcgccc gctgcccccg ccccctgcct acgatgatgt ggcccaagat
     2221 gaggatgact tcgaggtgtg ctctatcaac agcaccctag tgagtgcagg cctccctacc
     2281 gggcctagcc aaggcgagac caattatgcg tttgtacctg agcaggccca gctgccccct
     2341 gccctggagg ataacctgtt cctgccaccg cagggtggag gccagccacc cagctcagcc
     2401 cagactgcag agattttcca ggcactgcag caggagtgta tgcggcagct acaggtcccc
     2461 actggccagc tgaccccgtc ccctacccca ggaggtgatg acaagcccca ggtgccaccc
     2521 cgggtaccta ttccccctcg gcccacacgt ccacgtgtgg gactatctcc agctccctta
     2581 ggtgaggaag aggcaagtcg gtggcctgga ccctcctccc ctccccgagt gcctccccgg
     2641 gaacccctgt ctcctcaagg gtcgaggacc ccaagccccc tagtaccacc tggcagctcc
     2701 ccactaccgc atcggctctc gagctcacct ggaaagacca tgcccaccac ccagagcttt
     2761 gcctcagacc ctaagtacgc cactccacaa gtgatccagg ctcctggccc acgggctggc
     2821 ccctgcatcc tgcccattgt ccgtgatggc aggaaggtca gcagcaccca ctattacctg
     2881 ctgccagagc gccctcccta cctcgagcgc taccagcgct tcctgaggga ggcccagagc
     2941 cccgaggagc cggccgccct gcccgttccc ccactgctgc ccccgcctag cactccagcc
     3001 cctgccgccc ccactgccac cgtccgacct atgcctcagg ctgccccaga cccaaaggcc
     3061 aacttctcca ccaataacag caacccaggg gcgcagccac catccctgag ggccagtgca
     3121 cggctgccgc agaggggctg cccaggggat gggcaagagg ctgcccggcc agcagacaaa
     3181 gtccagatgc tgcaggccat ggtgcatggg gtgaccacag aggagtgcca ggcggccctg
     3241 aggagccaca gctggagtat tcagagggct gcccagtatc tgaaggtgga gcagctcttt
     3301 gggctgggtc ttcggccacg ggtggagtgc cacaaagtgc tagagatgtt cgactggaac
     3361 ctagagcaag ccggctgtca ccttctgggg tcctgtggcc ctgcccacca caaacgctga
     3421 tggttgactg gagagcaatg gtctgcccta agagaacctc ttgaacctgt ctgtgggaca
     3481 agggtgggga gatgccctgc ctcaggcctg gaggacccac aactgcctgc ggctcccagt
     3541 ggacagtgag acccaggcag caggaggctg ggagcctcac cttgcccacc tcgctcaccc
     3601 acccagcgct gttctgcaca ccttggttca gccctcagtg ccccaaccaa gaggtgggaa
     3661 gttccaagcc ttgtgaaggc aagacaggaa gctgcctggc aggccctgtg tgtgacctgc
     3721 ctttggcccc agaccaaggc tgggctggtg gctagagtgt gccccaggct ttccctgggg
     3781 gattagactg agaggaagcc aggcttgact tggacaagaa ggatgtgttg gccacacaga
     3841 agggtgggcc agcacccaac aggccctcct caggaccagg cccctttcca gggaacccct
     3901 gtaggaatgt ggagtgttgg acagaatgtg acctgtggct tcactgtgaa ctcgggcttg
     3961 gctggtctta gatcttgtag ctgtaaacag cctgaagtgg ctcagaaaca gaagaggcgc
     4021 caggatcttc tctggcaggg accagggccc caggccccgg gtgtggaggg agaccccagc
     4081 ggcaccagta cttgtcctgt ttgatgcctg ttcctcccct gtgtccattt gatgtgttcc
     4141 catcgcctct gttgccaaag ctgctgtccc agccatggat atctgcttct tccagagaaa
     4201 taaagtctgt ttctatttta cgtcaaaaaa aaaaaaaaaa aaaaaaaaaa
//
