LOCUS       NM_001107012            2055 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 1 (Tnk1), mRNA.
ACCESSION   NM_001107012 XM_001079627 XM_220614
VERSION     NM_001107012.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Hoare K, Hoare S, Smith OM, Kalmaz G, Small D and Stratford May W.
  TITLE     Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
  JOURNAL   Oncogene 22 (23), 3562-3577 (2003)
   PUBMED   12789265
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Felschow DM, Civin CI and Hoehn GT.
  TITLE     Characterization of the tyrosine kinase Tnk1 and its binding with
            phospholipase C-gamma1
  JOURNAL   Biochem Biophys Res Commun 273 (1), 294-301 (2000)
   PUBMED   10873601
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220614.4, XM_001079627.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2055
                     /gene="Tnk1"
                     /note="tyrosine kinase, non-receptor, 1"
                     /db_xref="GeneID:303247"
                     /db_xref="RGD:1310113"
     exon            1..214
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2055
                     /gene="Tnk1"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="non-receptor tyrosine-protein kinase TNK1"
                     /protein_id="NP_001100482.1"
                     /db_xref="GeneID:303247"
                     /db_xref="RGD:1310113"
                     /translation="MLPEASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPE
                     DLDNLGMGRPAQRRLTEALKRYRSGVKSKNWVYKILGGFAPEQKEIPPYSDSLPHLHE
                     PEGGLKCLIPEGAVCRGELLGSGCFGVVHQGLWTLPGGQSIPVAVKSLRVGPEGPMGT
                     ELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPMPPLP
                     VTLLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRKIKVADFGLVRPLGGARGR
                     YVMGGPRPIPYAWCAPESLRQGAFSAASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQ
                     RLEKDRARLPKPALCSRALYSLALRCWAPHPADRPTFSNLEGLLQEAWLSEGRCVREV
                     TEPGALRMEPGDPITIIEGSPDTTTWKGQNGRTLKVGNFPASAVTLADLGGSPVTHPV
                     HRGSPARGEKYRGGTDGDREKAVLQDLPPARNQRRKVPLQRMKGISKSLESVLSLGPR
                     PAGGGSSPPELRRGCTRAWPQGLADLPPRPPDLPPRPPIICSSQPIQPHRVRPKREPL
                     HNHCTGAPGSSKVTIPPGGPLSDSEWQRKIVEVELSVHGVTYQECQMALRTMGGDVAS
                     AIRNLKVDQLFHLSNRSRADCRRILEHHHWDLSAASRYVLARS"
     exon            215..285
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..477
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..633
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..917
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1191
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1286
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1451
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1531
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1845
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1941
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2055
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctatccatt taaagcagac tgccgtcctc cggagaggtc taaccccaga catgctcccc
       61 gaagccagtt ccctgtggct ccttcggctg ctccgggacg tccagctggc ccagttctac
      121 cggcccatcc ttgaggaact caacgtcact cggccagaac attttgactt tgtaaggcct
      181 gaggacctgg acaaccttgg catgggcagg cctgcccaac gaagacttac tgaagccctg
      241 aagaggtacc gttcgggggt caagtctaag aactgggtgt acaagatact tgggggtttt
      301 gctcctgaac agaaggagat ccctccatac tcagacagtc ttccacacct ccatgagcca
      361 gaggggggac tcaagtgtct gattccagag ggtgctgtgt gcagagggga actgctgggt
      421 tcaggctgct ttggtgttgt acatcaaggg ctatggacac tacccggtgg tcaaagtatc
      481 ccagtggctg tcaagtccct ccgtgtgggt cccgagggtc cgatgggcac agaactggga
      541 gacttcctgc gggaagtgtc tgtcatgatg aaactggagc acccacatgt gctgcgcctg
      601 catggcctcg tactgggcca gcctctacag atggtgatgg aacttgcgcc actgggttcc
      661 ctgcatgcgc gcctgactgc cccagcaccg atgcccccac tgcctgtaac cctactgtgc
      721 ctttttctgc gtcagttggc aggagccatg gcgtacttgg ggtcctgtgg gttagtgcac
      781 agggatcttg ctacccgtaa cctcctgcta gcctcacctc ggaagatcaa ggtggctgat
      841 tttggactgg tgcggccact gggcggcgcc cgaggtcgct acgttatggg tgggccccgt
      901 cccatcccct atgcctggtg cgctcctgag agcctacgcc agggagcctt ctcggctgcc
      961 tccgacgtgt ggatgtttgg cgtgacactc tgggaaatgt tttctggagg cgaggaaccc
     1021 tgggcaggtg ttccaccata tctcatccta cagcggctgg agaaggaccg agccaggctg
     1081 ccaaagcctg ccctctgttc cagggccctc tactcccttg ccttgcgttg ctgggcccct
     1141 catcctgcag accggcctac cttttccaat ctggaaggac tgcttcaaga ggcttggctc
     1201 tctgaggggc gctgtgtgag ggaggtcaca gagccaggtg ctttgcggat ggagcccggt
     1261 gaccccatca ctatcattga gggcagccca gacaccacaa cctggaaggg acagaatggt
     1321 cgcaccctca aagtgggcaa ctttccggct tcagcagtga cactagcaga cttgggggga
     1381 tccccagtca cccatccagt ccacagaggt tcccctgccc gtggagagaa atacagaggg
     1441 ggcacagatg gggacaggga gaaggcagtg ttacaagacc tacccccggc acggaaccag
     1501 agaaggaagg tgcccctgca gaggatgaaa ggcatttcca agagtctgga gtcagttctg
     1561 tccctgggcc ctagacccgc aggaggtggt tcaagccctc cagaacttcg acgaggatgt
     1621 actagagctt ggcctcaagg actcgcagac ctccctccac gcccaccaga cctgcctcca
     1681 cgcccaccca tcatctgctc ctctcagccc atccagcccc acagagtccg gcccaaaaga
     1741 gaacccttac ataatcactg cactggagcg cctgggtcca gcaaagtcac tatcccccct
     1801 ggaggtccct tatcagactc ggagtggcag aggaagattg tagaggtaga gctgagtgtg
     1861 catggcgtca cctaccagga gtgccaaatg gcactcagaa ccatgggggg agatgtggct
     1921 tctgctatcc ggaacctcaa ggtagaccag ctcttccacc tcagtaaccg gtccagagca
     1981 gattgtcgtc gcattctgga gcatcaccac tgggacctgt cagcagccag tcgctacgtc
     2041 ctggcccggt cctga
//
