LOCUS       NM_001394684            1887 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus TNFAIP3 interacting protein 2 (Tnip2), transcript
            variant 1, mRNA.
ACCESSION   NM_001394684 XM_006251255
VERSION     NM_001394684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Fu,J., Wu,C., Xu,G., Zhang,J., Chen,J., Chen,C., Hong,H., Xue,P.,
            Jiang,J., Huang,J., Ji,C. and Cui,Z.
  TITLE     Protective effect of TNIP2 on the inflammatory response of
            microglia after spinal cord injury in rats
  JOURNAL   Neuropeptides 101, 102351 (2023)
   PUBMED   37329819
  REMARK    GeneRIF: Protective effect of TNIP2 on the inflammatory response of
            microglia after spinal cord injury in rats.
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Gong,H., Sheng,X., Xue,J. and Zhu,D.
  TITLE     Expression and role of TNIP2 in multiple organ dysfunction syndrome
            following severe trauma
  JOURNAL   Mol Med Rep 19 (4), 2906-2912 (2019)
   PUBMED   30720079
  REMARK    GeneRIF: the data indicated that TNIP2 is significantly decreased
            in MODS following severe trauma, and it plays a protective role in
            MODS development by inhibiting the inflammation response and
            oxidative stress by preventing NFkappaB activation.
REFERENCE   3  (bases 1 to 1887)
  AUTHORS   Leotoing,L., Chereau,F., Baron,S., Hube,F., Valencia,H.J.,
            Bordereaux,D., Demmers,J.A., Strouboulis,J. and Baud,V.
  TITLE     A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2
            (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase
            alpha (IKKalpha)-mediated NF-kappaB transcriptional activity
  JOURNAL   J Biol Chem 286 (37), 32277-32288 (2011)
   PUBMED   21784860
REFERENCE   4  (bases 1 to 1887)
  AUTHORS   Wagner,S., Carpentier,I., Rogov,V., Kreike,M., Ikeda,F., Lohr,F.,
            Wu,C.J., Ashwell,J.D., Dotsch,V., Dikic,I. and Beyaert,R.
  TITLE     Ubiquitin binding mediates the NF-kappaB inhibitory potential of
            ABIN proteins
  JOURNAL   Oncogene 27 (26), 3739-3745 (2008)
   PUBMED   18212736
REFERENCE   5  (bases 1 to 1887)
  AUTHORS   Papoutsopoulou,S., Symons,A., Tharmalingham,T., Belich,M.P.,
            Kaiser,F., Kioussis,D., O'Garra,A., Tybulewicz,V. and Ley,S.C.
  TITLE     ABIN-2 is required for optimal activation of Erk MAP kinase in
            innate immune responses
  JOURNAL   Nat Immunol 7 (6), 606-615 (2006)
   PUBMED   16633345
REFERENCE   6  (bases 1 to 1887)
  AUTHORS   Tadros,A., Hughes,D.P., Dunmore,B.J. and Brindle,N.P.
  TITLE     ABIN-2 protects endothelial cells from death and has a role in the
            antiapoptotic effect of angiopoietin-1
  JOURNAL   Blood 102 (13), 4407-4409 (2003)
   PUBMED   12933576
REFERENCE   7  (bases 1 to 1887)
  AUTHORS   Chien,C.Y., Liu,W.K., Chou,C.K. and Su,J.Y.
  TITLE     The A20-binding protein ABIN-2 exerts unexpected function in
            mediating transcriptional coactivation
  JOURNAL   FEBS Lett 543 (1-3), 55-60 (2003)
   PUBMED   12753905
REFERENCE   8  (bases 1 to 1887)
  AUTHORS   Van Huffel,S., Delaei,F., Heyninck,K., De Valck,D. and Beyaert,R.
  TITLE     Identification of a novel A20-binding inhibitor of nuclear
            factor-kappa B activation termed ABIN-2
  JOURNAL   J Biol Chem 276 (32), 30216-30223 (2001)
   PUBMED   11390377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Apr 30, 2021 this sequence version replaced XM_006251255.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1338445.1,
                                           SRR26643296.33291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               JAXUCZ010000014.1  80452936-80453278
            344-634             JAXUCZ010000014.1  80461808-80462098
            635-724             JAXUCZ010000014.1  80464603-80464692
            725-973             JAXUCZ010000014.1  80466665-80466913
            974-1093            JAXUCZ010000014.1  80467107-80467226
            1094-1887           JAXUCZ010000014.1  80469348-80470141
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1887
                     /gene="Tnip2"
                     /note="TNFAIP3 interacting protein 2"
                     /db_xref="GeneID:305451"
                     /db_xref="RGD:1307717"
     exon            1..343
                     /gene="Tnip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1357
                     /gene="Tnip2"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 2"
                     /protein_id="NP_001381613.1"
                     /db_xref="GeneID:305451"
                     /db_xref="RGD:1307717"
                     /translation="MSSGDARSGRQDEAPSAASALCGLYHEAGQQLQLLKDQLAARDA
                     LIASLRTRLAALEGHTAPSLVDALLDQVERFREQLRRQEDGASESQLRQEVERLTECL
                     EEKEREMQQLMSQPQHEQEKEVVLLRRSVVEKEKARAASDILCRSLTDETHQLRRTLA
                     ATAHMCQHLAKCLDERQRVQGDAGEKSPAELEHTSRDTSGQSVIKKLQEENRLLKQKV
                     IHVEDLNAKWQRYDASRDEYVKGLHAQLKRRQVPLEPELMKKEISRLNRQLEEKISDC
                     AEAKQELAAVKMARDTALERVQMLEQQILAYKDDFKSERADRERAHSRIQELEEKVMS
                     LMYQVSQRQDSREPGPCRIHTGSKTAKYLEMDALEHVAPGGWRPESRSQQMEPSAEGG
                     HVCTTQRGQGDLQCPHCLRCFSDEQGEAFLRHLSECCQ"
     exon            344..634
                     /gene="Tnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..724
                     /gene="Tnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..973
                     /gene="Tnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1093
                     /gene="Tnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1887
                     /gene="Tnip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttatcgct cccgcagcct agagaagttg gagacgccca agtccccacg gaaggcccac
       61 agctatgtcg tctggggacg caaggtctgg tagacaggac gaggccccga gcgcggcctc
      121 agcgctctgt ggcctgtacc acgaggcagg ccagcaacta cagctcctga aggatcagct
      181 ggctgcgcgt gacgccctta tcgcgagcct ccgcacccgc ctcgcggctc tggaagggca
      241 cacggcacca tcacttgtgg acgcacttct ggatcaggtg gagcgcttcc gtgagcagct
      301 gcggcgacag gaggatggtg cctcggagtc ccaactgcgg caggaagttg aaagacttac
      361 tgagtgtcta gaagaaaaag agagggagat gcagcagctg atgagccagc ctcagcatga
      421 gcaagagaag gaggtggtct tgcttcggag aagtgtggta gagaaggaaa aagccagggc
      481 ggccagtgac attctgtgcc gctccttgac tgatgagacc caccaactgc gcaggacatt
      541 ggctgccact gcccacatgt gccaacatct ggccaaatgt ctggatgagc gacaacgtgt
      601 gcagggagac gctggggaga aaagccctgc tgagctagag catacaagca gggatacctc
      661 tggccagagt gttattaaga agttacagga agaaaatcga ctgttaaaac agaaggtgat
      721 tcatgtggaa gacctcaatg ccaagtggca gcgttatgat gcaagtaggg atgaatacgt
      781 gaaggggtta catgcacagc tgaagaggcg gcaggttcct cttgagcctg agcttatgaa
      841 gaaggagatt tcccggctta acagacagtt ggaggagaaa ataagtgact gtgccgaagc
      901 aaaacaggag ctggcagccg tgaagatggc ccgggacact gcgctggagc gagtgcagat
      961 gctggagcag cagattcttg cttacaagga tgacttcaaa tcagaaaggg cagatcggga
     1021 acgagctcat agtaggattc aggagctgga ggaaaaggtc atgtccttga tgtaccaagt
     1081 ttcccagaga caggactccc gggagccagg accctgtcgg attcatacgg ggagcaaaac
     1141 tgccaagtac ttagagatgg atgcactgga gcatgtggcg ccgggcggct ggaggcctga
     1201 gtctaggtcc caacagatgg aaccttctgc agagggtggg catgtctgta caacccagag
     1261 aggtcagggt gatcttcagt gtcctcattg cctgcggtgt ttcagtgatg agcaaggcga
     1321 ggcattcctc aggcaccttt ctgagtgctg ccaatgagcc agagacacca tgcctgtgtg
     1381 acccatgacc agcaactcag tgtgttgcat tctcctgaga tctagggccc aaataggcag
     1441 ggtcactggt cagagggaac tattgacaga gcaggaggaa gagatggggt caggggcatc
     1501 aagctggatg cttgtggaac atctcatgcg gaatctggac cgagctgtca attcaaagct
     1561 gcaagctatc tgttgtggga gtattctgac ttgcttgcac ctaaagttgt gctacttgct
     1621 ggaaggggaa gttgctgtgg gagcagcgtg tcctctctcc agggtggtag ctccatcctg
     1681 ttgagtaggt aggtgtctta ttccctgact ggtctgtgag cactacagtt acatggtaca
     1741 ctagaacctt cccaaacaca gcagagccac acagctgtat ccagtaccat caccttgcaa
     1801 gaacacttgt atttccaaag ggaatgcacc tttatttcct aatcatttac ttttataata
     1861 aatggattta ctactgtgct gctctga
//
