LOCUS       NM_001108826            2867 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TNFAIP3 interacting protein 1 (Tnip1), mRNA.
ACCESSION   NM_001108826 XM_001073849 XM_343894
VERSION     NM_001108826.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Van Quickelberghe,E., De Sutter,D., van Loo,G., Eyckerman,S. and
            Gevaert,K.
  TITLE     A protein-protein interaction map of the TNF-induced NF-kappaB
            signal transduction pathway
  JOURNAL   Sci Data 5, 180289 (2018)
   PUBMED   30561431
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Zhou,J., Wu,R., High,A.A., Slaughter,C.A., Finkelstein,D.,
            Rehg,J.E., Redecke,V. and Hacker,H.
  TITLE     A20-binding inhibitor of NF-kappaB (ABIN1) controls Toll-like
            receptor-mediated CCAAT/enhancer-binding protein beta activation
            and protects from inflammatory disease
  JOURNAL   Proc Natl Acad Sci U S A 108 (44), E998-E1006 (2011)
   PUBMED   22011580
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   Ashida,H., Kim,M., Schmidt-Supprian,M., Ma,A., Ogawa,M. and
            Sasakawa,C.
  TITLE     A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to
            dampen the host NF-kappaB-mediated inflammatory response
  JOURNAL   Nat Cell Biol 12 (1), 66-73 (2010)
   PUBMED   20010814
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Wagner,S., Carpentier,I., Rogov,V., Kreike,M., Ikeda,F., Lohr,F.,
            Wu,C.J., Ashwell,J.D., Dotsch,V., Dikic,I. and Beyaert,R.
  TITLE     Ubiquitin binding mediates the NF-kappaB inhibitory potential of
            ABIN proteins
  JOURNAL   Oncogene 27 (26), 3739-3745 (2008)
   PUBMED   18212736
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Wang,H.B., Wang,J.T., Zhang,L., Geng,Z.H., Xu,W.L., Xu,T., Huo,Y.,
            Zhu,X., Plow,E.F., Chen,M. and Geng,J.G.
  TITLE     P-selectin primes leukocyte integrin activation during inflammation
  JOURNAL   Nat Immunol 8 (8), 882-892 (2007)
   PUBMED   17632516
  REMARK    Erratum:[Nat Immunol. 2014 Mar;15(3):305]
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Mauro,C., Pacifico,F., Lavorgna,A., Mellone,S., Iannetti,A.,
            Acquaviva,R., Formisano,S., Vito,P. and Leonardi,A.
  TITLE     ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in
            inhibiting NF-kappaB
  JOURNAL   J Biol Chem 281 (27), 18482-18488 (2006)
   PUBMED   16684768
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Zhang,S., Fukushi,M., Hashimoto,S., Gao,C., Huang,L., Fukuyo,Y.,
            Nakajima,T., Amagasa,T., Enomoto,S., Koike,K., Miura,O.,
            Yamamoto,N. and Tsuchida,N.
  TITLE     A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear
            signaling
  JOURNAL   Biochem Biophys Res Commun 297 (1), 17-23 (2002)
   PUBMED   12220502
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Heyninck,K., De Valck,D., Vanden Berghe,W., Van Criekinge,W.,
            Contreras,R., Fiers,W., Haegeman,G. and Beyaert,R.
  TITLE     The zinc finger protein A20 inhibits TNF-induced
            NF-kappaB-dependent gene expression by interfering with an RIP- or
            TRAF2-mediated transactivation signal and directly binds to a novel
            NF-kappaB-inhibiting protein ABIN
  JOURNAL   J Cell Biol 145 (7), 1471-1482 (1999)
   PUBMED   10385526
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Fukushi,M., Dixon,J., Kimura,T., Tsurutani,N., Dixon,M.J. and
            Yamamoto,N.
  TITLE     Identification and cloning of a novel cellular protein Naf1,
            Nef-associated factor 1, that increases cell surface CD4 expression
  JOURNAL   FEBS Lett 442 (1), 83-88 (1999)
   PUBMED   9923610
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001073849.1, XM_343894.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2867
                     /gene="Tnip1"
                     /note="TNFAIP3 interacting protein 1"
                     /db_xref="GeneID:363599"
                     /db_xref="RGD:1309380"
     exon            1..80
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            81..131
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..306
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2117
                     /gene="Tnip1"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 1"
                     /protein_id="NP_001102296.1"
                     /db_xref="GeneID:363599"
                     /db_xref="RGD:1309380"
                     /translation="MEGRGPYRIYDPGGSTPLGEEVSAAFDRLVEENTRLKGKIQGIK
                     MLGELLEESQMEASRLRQKAEALVRDSELPPPPPAPSLVSFDPLAELTGQDTKVQAHP
                     TTTTTTTTTTTTTTIGNSMEKSVSASKPPSNGASSDFEVVPPEEQSSPETGHHSRNVM
                     ELGSPPPEDGNLMLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQ
                     RTSILQTLCEQLRQENEALKAKLDKSLEQRDQAAERLREENTELKRLLMNSNCKEGLC
                     GQPSSPKTEGAGKKGVAGQQQASMTASKVPEAGAFGTAEKKVKLLEQQRMELLEVNKQ
                     WDQHFRTMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEME
                     ETDKEQLTTEAKELRQKVKYLQDQLSPLMRQREYQEKEIQRLNKALEEALSIQASPSS
                     PPAAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQ
                     VEKLQAQVTLTTAQLRTLKEEEKAKEALKQQKRKAKASGERYHVEPHPEHLCGAYPYA
                     YPPMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRNQN
                     SQVMDPPPDRPAEPESADNDCDGPQ"
     exon            307..444
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..566
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..647
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..839
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..934
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1058
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1148
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1214
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1346
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1475
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1607
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1733
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1799
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1991
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2082
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2867
                     /gene="Tnip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagggacg catggccaca ctcactgggc acatcttcag atcgcctcgt gcttcctccg
       61 gtgagtgacc tgggctgaag gtgacagaga aaggcagata tctctgagtt caaggccagc
      121 ctgatctatt actaggtggc catcacggca ggggttgagc caccctcatg gaagggagag
      181 gaccctaccg gatctacgac ccagggggca gcacgcctct gggagaggag gtgtccgcag
      241 cttttgaccg tctagtggag gagaatactc ggctgaaggg aaaaatacaa gggataaaga
      301 tgttaggaga gcttctggag gaatctcaaa tggaagcgtc cagactccgg cagaaggcgg
      361 aggcgctggt cagggacagc gagctgcctc caccaccacc tgctccctcc ttggtctcct
      421 ttgatcccct ggctgagctc acaggacagg atacaaaggt tcaggcacat cctactacta
      481 ccaccaccac caccaccacc accaccacca ccaccattgg aaactccatg gagaagtcag
      541 tgtcagcctc caagcctcca tccaatggcg cctcctctga ctttgaagtg gtccctcctg
      601 aggagcagag ttcacctgaa actggccacc actctaggaa cgtgatggag ctggggtccc
      661 cacccccaga ggacggcaat ctgatgctcc acctgcagcg cctggagacc accctgagtg
      721 tgtgtgcaga ggaaccagat cacagccagc tcttcaccca cctgggccgc atggccctcg
      781 agttcaacag gttggcctcc aaagtgcata aaaatgagca acgtacctcc atcctgcaga
      841 ccttatgtga gcagctgcgc caggagaatg aagccctgaa ggccaagctg gacaagagcc
      901 tggaacagcg ggatcaggct gctgagaggc tgcgggagga aaacacggag ctcaagagac
      961 tgttgatgaa cagcaactgc aaagagggac tctgtgggca gcccagctcc ccaaagacag
     1021 agggtgctgg caagaagggc gtggctggac agcagcaggc cagtatgacg gcaagtaagg
     1081 tccctgaagc aggggccttc ggtacagctg agaagaaggt gaagttgctg gaacagcagc
     1141 gcatggagct gctggaagtg aacaagcagt gggaccagca tttccggacc atgaagcaac
     1201 agtatgagca gaagatcaca gagcttcgcc agaagctggt ggacctgcag aaacaggtga
     1261 ctgagctgga ggctgagcgc gagcagaagc agcgtgactt tgaccggaaa ctcctcctgg
     1321 ctaaatctaa gattgagatg gaagagactg acaaggaaca gctgacaaca gaggccaagg
     1381 aacttcgcca gaaggtcaag tacctgcagg atcagctgag cccacttatg aggcaacgag
     1441 aataccagga aaaggagatc cagcggctca acaaggccct ggaggaggcc ctcagcatcc
     1501 aggcctctcc ctcatcccca cctgcagctt ttgggagccc agaaggggtc gggggccatc
     1561 tgaggaagca ggaactggtg acgcagaatg agctattgaa acagcaggta aagatctttg
     1621 aagaggactt ccagagggaa cggagtgacc gtgagcgcat gaacgaagag aaggaggagc
     1681 tgaagaagca ggtggagaag ctgcaggccc aggtcaccct gaccactgcc cagctcagaa
     1741 cactcaaaga ggaggagaag gccaaggaag ccctcaaaca acagaagagg aaggcaaagg
     1801 cctcaggaga gcgctaccat gtggaacccc accctgagca cctttgtggc gcctatccct
     1861 atgcctaccc acccatgcca gccatggtac ctcaccatgc atacaaggac tggtcccaga
     1921 tccgataccc tccaccccct gtgcccatgg agcacccgcc cccacacccc aactctcgtc
     1981 tcttccatct gccagagtac acctggcgtc caccctgtgc aggaattcgg aatcagaact
     2041 ctcaagtgat ggacccgccc ccagacaggc ctgcagagcc agagtctgca gacaatgact
     2101 gtgacgggcc ccagtgagac tgcagcgggt cacttggttc tgccttcatc tttcagagcc
     2161 agctgacctc agattgccaa aagtgtaaag gccatgtgca tgttcagtgt gacccaagcc
     2221 ttggcagaac agaggctggg aggggcagat ggccacatcc ccagccaagc tctagctgtt
     2281 tacaagacta ggaagaatct acccgtgagg cctccaccag gttcttctgg atgcagccag
     2341 gagaaactca acaccctgcc tcttgccaag accaggaggc ctcacctggc tttgacctgc
     2401 catctgttgc cgaggccact ggcttccatc ctaagagtgg ggtgcaacaa gaccccttcc
     2461 tctcagaacc tcaaagactt ggttccaggc tctccagaga ccacacccag ttcgtgtgca
     2521 tgtgctgttt ttgcttcaag ctcagtagca ggacctgccc tgcaccccct gctccttacc
     2581 cctctgtgag gagttaggga agagggcttt gtctctagag cagaagagaa caacgggatg
     2641 gcctgatgct gtcatgctct ccactgcacc tgtgtcggcc tcctgagagc caccatgatc
     2701 tggaatgaag gccacaccag ccaggtctgc taaagggccc cagactgaag atgacctcag
     2761 cccccacagt tatgtctatg gtgccagagg tctgtattaa ggtagctgct gttactaggc
     2821 agctgtttgc acaaatcttg gacataaatc caacttgagg atctaca
//
