LOCUS       NM_001106422            4523 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus TRAF2 and NCK interacting kinase (Tnik), mRNA.
ACCESSION   NM_001106422 XM_001057689 XM_001057754 XM_001057818 XM_001057870
            XM_001057921 XM_001057983 XM_001058039 XM_001058101 XM_001058162
            XM_001058228 XM_001058287 XM_001058359 XM_215530
VERSION     NM_001106422.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4523)
  AUTHORS   Masuda,M., Uno,Y., Ohbayashi,N., Ohata,H., Mimata,A.,
            Kukimoto-Niino,M., Moriyama,H., Kashimoto,S., Inoue,T., Goto,N.,
            Okamoto,K., Shirouzu,M., Sawa,M. and Yamada,T.
  TITLE     TNIK inhibition abrogates colorectal cancer stemness
  JOURNAL   Nat Commun 7, 12586 (2016)
   PUBMED   27562646
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4523)
  AUTHORS   Takahashi,H., Ishikawa,T., Ishiguro,M., Okazaki,S., Mogushi,K.,
            Kobayashi,H., Iida,S., Mizushima,H., Tanaka,H., Uetake,H. and
            Sugihara,K.
  TITLE     Prognostic significance of Traf2- and Nck- interacting kinase
            (TNIK) in colorectal cancer
  JOURNAL   BMC Cancer 15, 794 (2015)
   PUBMED   26499327
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4523)
  AUTHORS   Jin,J., Jung,H.Y., Wang,Y., Xie,J., Yeom,Y.I., Jang,J.J. and
            Lee,K.B.
  TITLE     Nuclear expression of phosphorylated TRAF2- and NCK-interacting
            kinase in hepatocellular carcinoma is associated with poor
            prognosis
  JOURNAL   Pathol Res Pract 210 (10), 621-627 (2014)
   PUBMED   25160513
REFERENCE   4  (bases 1 to 4523)
  AUTHORS   Fennell,D.A., Myrand,S.P., Nguyen,T.S., Ferry,D., Kerr,K.M.,
            Maxwell,P., Moore,S.D., Visseren-Grul,C., Das,M. and Nicolson,M.C.
  TITLE     Association between gene expression profiles and clinical outcome
            of pemetrexed-based treatment in patients with advanced
            non-squamous non-small cell lung cancer: exploratory results from a
            phase II study
  JOURNAL   PLoS One 9 (9), e107455 (2014)
   PUBMED   25250715
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4523)
  AUTHORS   Coba,M.P., Komiyama,N.H., Nithianantharajah,J., Kopanitsa,M.V.,
            Indersmitten,T., Skene,N.G., Tuck,E.J., Fricker,D.G.,
            Elsegood,K.A., Stanford,L.E., Afinowi,N.O., Saksida,L.M.,
            Bussey,T.J., O'Dell,T.J. and Grant,S.G.
  TITLE     TNiK is required for postsynaptic and nuclear signaling pathways
            and cognitive function
  JOURNAL   J Neurosci 32 (40), 13987-13999 (2012)
   PUBMED   23035106
REFERENCE   6  (bases 1 to 4523)
  AUTHORS   Kawabe,H., Neeb,A., Dimova,K., Young,S.M. Jr., Takeda,M.,
            Katsurabayashi,S., Mitkovski,M., Malakhova,O.A., Zhang,D.E.,
            Umikawa,M., Kariya,K., Goebbels,S., Nave,K.A., Rosenmund,C.,
            Jahn,O., Rhee,J. and Brose,N.
  TITLE     Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls
            neurite development
  JOURNAL   Neuron 65 (3), 358-372 (2010)
   PUBMED   20159449
REFERENCE   7  (bases 1 to 4523)
  AUTHORS   Mahmoudi,T., Li,V.S., Ng,S.S., Taouatas,N., Vries,R.G.,
            Mohammed,S., Heck,A.J. and Clevers,H.
  TITLE     The kinase TNIK is an essential activator of Wnt target genes
  JOURNAL   EMBO J 28 (21), 3329-3340 (2009)
   PUBMED   19816403
REFERENCE   8  (bases 1 to 4523)
  AUTHORS   Uechi,Y., Bayarjargal,M., Umikawa,M., Oshiro,M., Takei,K.,
            Yamashiro,Y., Asato,T., Endo,S., Misaki,R., Taguchi,T. and
            Kariya,K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   9  (bases 1 to 4523)
  AUTHORS   Taira,K., Umikawa,M., Takei,K., Myagmar,B.E., Shinzato,M.,
            Machida,N., Uezato,H., Nonaka,S. and Kariya,K.
  TITLE     The Traf2- and Nck-interacting kinase as a putative effector of
            Rap2 to regulate actin cytoskeleton
  JOURNAL   J Biol Chem 279 (47), 49488-49496 (2004)
   PUBMED   15342639
REFERENCE   10 (bases 1 to 4523)
  AUTHORS   Fu,C.A., Shen,M., Huang,B.C., Lasaga,J., Payan,D.G. and Luo,Y.
  TITLE     TNIK, a novel member of the germinal center kinase family that
            activates the c-Jun N-terminal kinase pathway and regulates the
            cytoskeleton
  JOURNAL   J Biol Chem 274 (43), 30729-30737 (1999)
   PUBMED   10521462
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473961.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_001058228.1, XM_001058359.1, XM_001058287.1, XM_001057689.1,
            XM_001057754.1, XM_001058162.1, XM_001057818.1, XM_001057870.1,
            XM_001058101.1, XM_001057921.1, XM_001057983.1, XM_001058039.1,
            XM_215530.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4523
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..4523
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /note="TRAF2 and NCK interacting kinase"
                     /db_xref="GeneID:294917"
                     /db_xref="RGD:1561817"
     exon            1..424
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..4432
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="TRAF2 and NCK-interacting protein kinase"
                     /protein_id="NP_001099892.1"
                     /db_xref="GeneID:294917"
                     /db_xref="RGD:1561817"
                     /translation="MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRH
                     VKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLW
                     LVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVL
                     LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWS
                     LGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHGQ
                     RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND
                     SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQ
                     KRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQ
                     LEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ
                     EQRPLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPP
                     RSESFSISGVQPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQE
                     ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPA
                     LARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQP
                     SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPSKVKPEESRDIPRPSRPADLTA
                     LAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI
                     PTGAPGKNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNG
                     FAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDTGAEYGMGSSTKASFTPFVDPR
                     VYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPE
                     IRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEG
                     LNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYER
                     IKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSH
                     TGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGR
                     ITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
                     ERNDKVNPFQLCFSVCILRDHQVPVKPSFSFILT"
     exon            425..490
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            491..547
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            548..673
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            674..784
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            785..875
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1006
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1061
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1140
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1316
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1383
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1588
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1699
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1786
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1975
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2140
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2380
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2487
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2651
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2749
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2934
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3064
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3229
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3341
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3512
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3656
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3791
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3892
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4042
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4202
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4523
                     /gene="Tnik"
                     /gene_synonym="RGD1561817"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggagttga tatgtctcat tataacagcc aatgcagccg ccatccacgc acaagcaaag
       61 aagcatgtcc catttaaata cacccacgca gccccagcgc ccttagccga tcagggcgcg
      121 cagcccacac gcaccgcggc tccgggcttg gagatccgcg caggtcgggc tccgggatcc
      181 cgcggatcga cgctctcgga agatcgggat cggactcttg ttggggcccg ggtgggcggg
      241 ggaggctggg ccccgggcct ctctggcgga cagccgcatg aggacgcgag cgaaatagac
      301 cagggtggaa ttgccaagga agacgcttcg gggtggtttt ggtccatttc tcccgcgaag
      361 agtcgacatg gcgagcgact ccccagctcg cagcctggat gaaatcgatc tctccgccct
      421 gagggaccct gcagggatct ttgagttggt ggaacttgtc ggaaatggta catatggcca
      481 agtttataag ggtcgtcatg tcaaaacagg ccagcttgct gccattaagg ttatggacgt
      541 cacaggggat gaagaggaag aaatcaaaca agaaattaac atgttgaaga aatattctca
      601 tcacaggaac attgctacat actacggtgc ttttatcaaa aagaaccctc cgggcatgga
      661 tgaccaacta tggttggtta tggagttctg tggtgctggc tctgtcactg acctgatcaa
      721 gaacacgaaa ggcaacacat tgaaagagga gtggattgca tacatctgca gggagatctt
      781 acggggcctg agtcacctgc accagcacaa agtgattcat cgggatatta aaggacagaa
      841 tgtcttgctg actgaaaatg cagaagttaa gctagtggat tttggcgtga gtgcccagct
      901 tgaccgaaca gtgggcagga ggaacacgtt catcgggacc ccctactgga tggcacccga
      961 agtcattgcc tgtgatgaga acccagatgc cacgtatgat ttcaagagtg acttgtggtc
     1021 tttgggaatc accgccattg agatggcaga aggtgccccc cccctctgtg atatgcatcc
     1081 catgagagcg ctcttcctca tcccacggaa ccccgcacct cgcctcaagt ctaagaagtg
     1141 gtcaaaaaaa ttccagtcat ttatcgagag ctgcttggta aagaatcacg gccagcggcc
     1201 agccacagaa cagttgatga agcacccatt catacgagac cagcctaatg agaggcaggt
     1261 ccgcatccag ctgaaggacc acattgatcg aacaaagaag aagcgaggag aaaaagatga
     1321 gactgagtat gaatacagtg gaagtgagga agaagaggaa gagaacgact ctggggaacc
     1381 cagctccatt ctgaacctac caggagagtc aacactgcga cgggacttcc tgagactgca
     1441 gctggccaac aaggagcgct cagaggccct gcggcgccaa cagctggagc agcagcagag
     1501 ggagaatgaa gaacataaga ggcagctact ggctgagcgc cagaagcgca tcgaggagca
     1561 gaaggagcag aggcggaggc tggaggagca acaaaggcga gaaaaggagc ttcggaagca
     1621 gcaggagcgg gaacagcgcc ggcactatga ggagcagatg cgccgggagg aggagaggag
     1681 gcgcgcagaa cacgaacagg agtacatcag gcgacagcta gaagaagagc aaaggcagtt
     1741 agaaatctta cagcagcagc tactgcatga gcaagctcta cttctggaat ataagcgcaa
     1801 acaactggaa gaacagagac aagcagaaag actgcagcgg cagctaaagc aagagcggga
     1861 ctatctggtt tccctccagc accagcggca ggagcagagg cccctggaga agaagccatt
     1921 gtaccattac aaggagggca tgagtcctag tgagaagcct gcctgggcca aggaggtgga
     1981 agaacgctca agactcaacc gacagagttc acctgccatg cctcacaagg ttgccaacag
     2041 gatctcagac cccaacctac ccccaagatc agagtccttc agcattagtg gggttcagcc
     2101 tgctcggaca cccccaatgc tcagacctgt tgatccccag atcccgcagc tggtagccgt
     2161 caaatcccag ggacctgcct tgaccgcctc ccagtcagtg catgagcaac ccacaaaagg
     2221 cctgtctggg ttccaggagg ctctgaatgt gacctctcac cgggtcgaga tgccacgcca
     2281 gaactcggat cccacctcgg aaaaccctcc tctccccacg cgcattgaga agtttgaccg
     2341 aagctcttgg ttacgacagg aagaagacat tccaccaaag gtgcctcaaa gaacaacttc
     2401 tatatcccca gcactagcca gaaagaattc ccctgggaat ggcagtgctt taggcccaag
     2461 actcggatct cagcctatca gagcaagcaa ccctgatctc cgcaggacag agccagtcct
     2521 ggagagctcc ttgcagcgga ccagcagtgg cagttcttcc agctccagca ctcccagctc
     2581 ccagcccagc tctcaaggag gctctcagcc tgggtcacaa gcaggatcta gtgaacgaac
     2641 cagagttcgg gccaacagta agtcagaagg atcgcccgtg ctcccccatg agccttccaa
     2701 ggtgaaacca gaagaatcca gagacatccc acggcccagc cggccagctg atctgacggc
     2761 gttagccaaa gaattaagag aactccggat tgaagaaaca aaccgcccac tgaagaaagt
     2821 gactgattac tcttcctcca gcgaggagtc agagagcagt gaggaagaag aggaggatgg
     2881 agagagtgag acgcacgatg ggacagtggc tgtcagtgac atacccagac taatacccac
     2941 gggtgctcca gggaagaatg agcagtacaa catggggatg gtcggcacac atgggctgga
     3001 gacttcgcat gcagatacct ttggcggcag catttcaaga gaaggaacct tgatgatcag
     3061 agagacggct gaagagaaga agcgatctgg ccacagtgac agtaatggct tcgcaggtca
     3121 catcaatctc ccagaccttg tgcagcagag ccattcgcca gctgggactc ccactgaggg
     3181 cctgggccgt gtctccactc attcccagga gatggacact ggagctgaat atggtatggg
     3241 aagcagcacc aaagcctcct tcaccccctt cgtggaccct agagtgtacc agacatcgcc
     3301 cactgatgaa gatgaagagg atgatgagtc ttcggctgct gccctgttta ctagcgaact
     3361 tcttaggcaa gaacaggcca aactcaatga agcgaggaag atttcagtgg taaatgtgaa
     3421 cccaacgaac attcgccctc acagtgacac accggaaatc agaaaataca agaaacgatt
     3481 caattccgaa atactctgtg cagctctgtg gggtgtgaac cttctggtgg ggactgaaaa
     3541 tggcctgatg cttttggaca gaagcggcca aggcaaagtc tacaacctca tcaaccggag
     3601 gcgatttcag cagatggacg tgctagaagg actaaacgtt cttgtcacga tatcaggaaa
     3661 gaagaataag ctccgggtgt actatctctc gtggttaaga aacagaatcc tgcacaatga
     3721 cccagaagta gaaaagaagc agggttggat caccgtcgga gacttggaag gctgtatcca
     3781 ttacaaagtt gttaaatatg aaaggatcaa gttcttggtg attgccttaa agaatgcagt
     3841 agagatatac gcatgggcgc ctaaacctta tcataagttc atggcattta agtcttttgc
     3901 agatcttcag cataagcctc tgctcgttga cctcacagta gaagaaggtc aaaggttaaa
     3961 ggtcattttt ggctcacaca ctggtttcca tgtaattgat gttgactctg gaaactccta
     4021 cgatatctat ataccatccc atattcaggg taatatcact cctcacgcta tcgtcatctt
     4081 gcctaaaaca gacggaatgg agatgcttgt ctgctatgag gatgaggggg tgtatgtgaa
     4141 cacctatggc cggatcacta aggatgtggt gctccaatgg ggagaaatgc ccacatctgt
     4201 ggcctacatt cattccaatc agataatggg ctggggcgag aaagctattg agatccggtc
     4261 agtggaaaca ggacatttgg atggagtgtt tatgcataaa cgagctcaaa ggttaaagtt
     4321 tctatgtgaa agaaatgata aggtaaatcc gtttcaactt tgctttagtg tttgcatttt
     4381 aagagaccac caggtacctg tgaaaccttc attttccttt atactgactt gagtcacatc
     4441 tgtgttcaag gatcaatgac aatcttgaaa tggcattact tggtttgatt catgtgaaca
     4501 ttcagaatct atgactcatg cat
//
