LOCUS       NM_181384               1310 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus TNF superfamily member 9 (Tnfsf9), mRNA.
ACCESSION   NM_181384
VERSION     NM_181384.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian tumor necrosis factor
            ligand genes
  JOURNAL   Immunogenetics 68 (2), 125-132 (2016)
   PUBMED   26646413
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Ye,J.X., Zhang,Y.T., Zhang,X.G., Ren,D.M. and Chen,W.C.
  TITLE     Recombinant attenuated Salmonella harboring 4-1BB ligand gene
            enhances cellular immunity
  JOURNAL   Vaccine 27 (11), 1717-1723 (2009)
   PUBMED   19187795
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Shao,Z., Sun,F., Koh,D.R. and Schwarz,H.
  TITLE     Characterisation of soluble murine CD137 and its association with
            systemic lupus
  JOURNAL   Mol Immunol 45 (15), 3990-3999 (2008)
   PUBMED   18640726
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Tan,J.X., Chen,W.C., Zhang,X.G. and Zhang,G.B.
  TITLE     [The change of immunoactivity of dendritic cells induced by
            recombinant rat 4-1BBL]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24 (8), 764-766 (2008)
   PUBMED   18687212
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   Zhang,N., Sadun,R.E., Arias,R.S., Flanagan,M.L., Sachsman,S.M.,
            Nien,Y.C., Khawli,L.A., Hu,P. and Epstein,A.L.
  TITLE     Targeted and untargeted CD137L fusion proteins for the
            immunotherapy of experimental solid tumors
  JOURNAL   Clin Cancer Res 13 (9), 2758-2767 (2007)
   PUBMED   17460060
REFERENCE   6  (bases 1 to 1310)
  AUTHORS   Dimberg,J., Hugander,A. and Wagsater,D.
  TITLE     Expression of CD137 and CD137 ligand in colorectal cancer patients
  JOURNAL   Oncol Rep 15 (5), 1197-1200 (2006)
   PUBMED   16596186
REFERENCE   7  (bases 1 to 1310)
  AUTHORS   Dong,Q.M., Ma,L.J., Zhang,G.B., Wu,Y.F., Shen,J.Y., Chen,Y.,
            Chen,Y.J., Pu,X.K., Hang,S.Y. and Zhang,X.G.
  TITLE     Cloning, structural organization and chromosomal mapping of rat
            costimulatory molecule 4-1BBL
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 37 (10), 694-701 (2005)
   PUBMED   16215637
REFERENCE   8  (bases 1 to 1310)
  AUTHORS   Salih,H.R., Schmetzer,H.M., Burke,C., Starling,G.C., Dunn,R.,
            Pelka-Fleischer,R., Nuessler,V. and Kiener,P.A.
  TITLE     Soluble CD137 (4-1BB) ligand is released following leukocyte
            activation and is found in sera of patients with hematological
            malignancies
  JOURNAL   J Immunol 167 (7), 4059-4066 (2001)
   PUBMED   11564827
REFERENCE   9  (bases 1 to 1310)
  AUTHORS   Guinn,B.A., DeBenedette,M.A., Watts,T.H. and Berinstein,N.L.
  TITLE     4-1BBL cooperates with B7-1 and B7-2 in converting a B cell
            lymphoma cell line into a long-lasting antitumor vaccine
  JOURNAL   J Immunol 162 (8), 5003-5010 (1999)
   PUBMED   10202049
REFERENCE   10 (bases 1 to 1310)
  AUTHORS   Goodwin,R.G., Din,W.S., Davis-Smith,T., Anderson,D.M., Gimpel,S.D.,
            Sato,T.A., Maliszewski,C.R., Brannan,C.I., Copeland,N.G.,
            Jenkins,N.A. et al.
  TITLE     Molecular cloning of a ligand for the inducible T cell gene 4-1BB:
            a member of an emerging family of cytokines with homology to tumor
            necrosis factor
  JOURNAL   Eur J Immunol 23 (10), 2631-2641 (1993)
   PUBMED   8405064
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_181384.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY259541.1, LN874412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               JAXUCZ010000009.1  2031011-2031527
            518-554             JAXUCZ010000009.1  2031866-2031902
            555-1310            JAXUCZ010000009.1  2032590-2033345
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1310
                     /gene="Tnfsf9"
                     /gene_synonym="Tnlg5a"
                     /note="TNF superfamily member 9"
                     /db_xref="GeneID:353218"
                     /db_xref="RGD:727974"
     exon            1..517
                     /gene="Tnfsf9"
                     /gene_synonym="Tnlg5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1018
                     /gene="Tnfsf9"
                     /gene_synonym="Tnlg5a"
                     /note="costimulatory molecule; tumor necrosis factor
                     (ligand) superfamily, member 9; tumor necrosis factor
                     ligand 5a; tumor necrosis factor superfamily member 9"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     9"
                     /protein_id="NP_852049.1"
                     /db_xref="GeneID:353218"
                     /db_xref="RGD:727974"
                     /translation="MDQHALDVGGTVDAGHPPGTAQPPDAAFLRDTGLPSDAAFLVDT
                     VRLTEAALPTDAACPAVNVRDPEAAWPPALNFCSRHPRLYCLGGLVLLLLVACVPIFI
                     RILPQPALTITTSPDLDTGENTADQVTPVSHIGCANTTQQGFPVFAKLLAKNQASLSN
                     TTLNWHSQEGAGSSYLSRGLRYEEDKKELVVDSPGLYYVFLELKLSPTSINTGRKVQG
                     WVSLVLQAKPQVDHLDSLALTVELFPCSMEDKLVDRSWNRLLRLKAGHRLSVDLRAYL
                     HGAQDAYRDWELSHANTTSFGLFLVKPDPPQG"
     exon            518..554
                     /gene="Tnfsf9"
                     /gene_synonym="Tnlg5a"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1310
                     /gene="Tnfsf9"
                     /gene_synonym="Tnlg5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcggctgc cctccctccc ctccccggaa aaggcgcctc cgtagcctat aaagcgtggg
       61 cactggcggg agatgtgcac tgcccgaggc aatggaccag cacgcacttg atgttggggg
      121 gaccgtggat gccggacatc caccaggtac tgcgcagccc ccggatgcgg cgttcctcag
      181 agataccggg ctcccttcgg atgctgcgtt cctggtagat actgtgcgcc tcacagaagc
      241 tgcgctgccc acggatgctg cgtgccctgc ggttaatgtt cgggatcctg aggccgcgtg
      301 gccgccggcc ctgaactttt gttcccgcca cccgaggctt tactgcctag gcggcttggt
      361 gttgctgctc ctggtcgcct gtgtccctat cttcatccgc atcctacctc agcccgcgct
      421 cacaatcacc acctcgcctg acctggatac cggagagaat actgcagacc aggtcacccc
      481 tgtttcccac attggctgcg ccaacactac acaacagggt tttcccgtgt tcgccaagct
      541 actggctaaa aaccaagcat cgctgagtaa cacgactctg aactggcaca gccaggaggg
      601 agctgggagc tcatacctgt ctcgaggtct gaggtacgag gaggacaaaa aggagttggt
      661 ggtggacagt cctgggctct actacgtgtt cttggaactg aagctcagtc caacgtccat
      721 aaacacaggc cgcaaggtgc agggctgggt ctcccttgtt ttgcaagcaa agcctcaggt
      781 agatcacctt gacagcttgg ccctgacagt ggaattgttc ccttgctcca tggaggacaa
      841 attagtggat cgttcctgga atcgtctgtt gcgcctgaag gctggtcacc gcctcagtgt
      901 ggatctgagg gcctatctgc atggagccca ggatgcatac agagactggg agctgtctca
      961 tgccaacacc accagctttg gactcttcct tgtgaaacct gacccccctc agggatgagt
     1021 tcttacccac gtgacattgc acatgggtgc tctagccacc cttcttgtga cccctggacg
     1081 ctaagacccc aagctgctat atttcatggg gcctaggcag tccttcctcc aggactttcc
     1141 tcttgtcttt aactggactc agtatttatt gtgagcatag ctcagacaag actttatata
     1201 attcactgga cagcattagt aactgctggg cagctgctag aaatcaaagg ttcccaaatc
     1261 aaactttata tttatattaa taagtaaaaa ataaatgtat ttgtaaataa
//
