LOCUS       NM_001398596            2071 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus TNF superfamily member 18 (Tnfsf18), mRNA.
ACCESSION   NM_001398596 XM_008769705
VERSION     NM_001398596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2071)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian tumor necrosis factor
            ligand genes
  JOURNAL   Immunogenetics 68 (2), 125-132 (2016)
   PUBMED   26646413
REFERENCE   2  (bases 1 to 2071)
  AUTHORS   Liao,G., van Driel,B., Magelky,E., O'Keeffe,M.S., de Waal
            Malefyt,R., Engel,P., Herzog,R.W., Mizoguchi,E., Bhan,A.K. and
            Terhorst,C.
  TITLE     Glucocorticoid-induced TNF receptor family-related protein ligand
            regulates the migration of monocytes to the inflamed intestine
  JOURNAL   FASEB J 28 (1), 474-484 (2014)
   PUBMED   24107315
REFERENCE   3  (bases 1 to 2071)
  AUTHORS   Lacal,P.M., Petrillo,M.G., Ruffini,F., Muzi,A., Bianchini,R.,
            Ronchetti,S., Migliorati,G., Riccardi,C., Graziani,G. and
            Nocentini,G.
  TITLE     Glucocorticoid-induced tumor necrosis factor receptor
            family-related ligand triggering upregulates vascular cell adhesion
            molecule-1 and intercellular adhesion molecule-1 and promotes
            leukocyte adhesion
  JOURNAL   J Pharmacol Exp Ther 347 (1), 164-172 (2013)
   PUBMED   23892569
REFERENCE   4  (bases 1 to 2071)
  AUTHORS   Zhou,Z., Song,X., Berezov,A., Zhang,G., Li,Y., Zhang,H., Murali,R.,
            Li,B. and Greene,M.I.
  TITLE     Human glucocorticoid-induced TNF receptor ligand regulates its
            signaling activity through multiple oligomerization states
  JOURNAL   Proc Natl Acad Sci U S A 105 (14), 5465-5470 (2008)
   PUBMED   18378892
REFERENCE   5  (bases 1 to 2071)
  AUTHORS   Chattopadhyay,K., Ramagopal,U.A., Brenowitz,M., Nathenson,S.G. and
            Almo,S.C.
  TITLE     Evolution of GITRL immune function: murine GITRL exhibits unique
            structural and biochemical properties within the TNF superfamily
  JOURNAL   Proc Natl Acad Sci U S A 105 (2), 635-640 (2008)
   PUBMED   18182486
REFERENCE   6  (bases 1 to 2071)
  AUTHORS   Zhou,Z., Tone,Y., Song,X., Furuuchi,K., Lear,J.D., Waldmann,H.,
            Tone,M., Greene,M.I. and Murali,R.
  TITLE     Structural basis for ligand-mediated mouse GITR activation
  JOURNAL   Proc Natl Acad Sci U S A 105 (2), 641-645 (2008)
   PUBMED   18178614
REFERENCE   7  (bases 1 to 2071)
  AUTHORS   Chattopadhyay,K., Ramagopal,U.A., Mukhopadhaya,A.,
            Malashkevich,V.N., Dilorenzo,T.P., Brenowitz,M., Nathenson,S.G. and
            Almo,S.C.
  TITLE     Assembly and structural properties of glucocorticoid-induced TNF
            receptor ligand: Implications for function
  JOURNAL   Proc Natl Acad Sci U S A 104 (49), 19452-19457 (2007)
   PUBMED   18040044
REFERENCE   8  (bases 1 to 2071)
  AUTHORS   Tone,M., Tone,Y., Adams,E., Yates,S.F., Frewin,M.R., Cobbold,S.P.
            and Waldmann,H.
  TITLE     Mouse glucocorticoid-induced tumor necrosis factor receptor ligand
            is costimulatory for T cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15059-15064 (2003)
   PUBMED   14608036
REFERENCE   9  (bases 1 to 2071)
  AUTHORS   Yu,K.Y., Kim,H.S., Song,S.Y., Min,S.S., Jeong,J.J. and Youn,B.S.
  TITLE     Identification of a ligand for glucocorticoid-induced tumor
            necrosis factor receptor constitutively expressed in dendritic
            cells
  JOURNAL   Biochem Biophys Res Commun 310 (2), 433-438 (2003)
   PUBMED   14521928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 20, 2021 this sequence version replaced XM_008769705.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2282956.1,
                                           SRR21887623.1808397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000013.1  76366853-76367034
            183-216             JAXUCZ010000013.1  76372234-76372267
            217-2071            JAXUCZ010000013.1  76374754-76376608
FEATURES             Location/Qualifiers
     source          1..2071
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2071
                     /gene="Tnfsf18"
                     /gene_synonym="Tnlg2a"
                     /note="TNF superfamily member 18"
                     /db_xref="GeneID:364031"
                     /db_xref="RGD:1305066"
     exon            1..182
                     /gene="Tnfsf18"
                     /gene_synonym="Tnlg2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..569
                     /gene="Tnfsf18"
                     /gene_synonym="Tnlg2a"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     18; tumor necrosis factor ligand 2a; tumor necrosis factor
                     superfamily member 18"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     18"
                     /protein_id="NP_001385525.1"
                     /db_xref="GeneID:364031"
                     /db_xref="RGD:1305066"
                     /translation="MEEMPLSESSPRGTERLRKPWLFCIVALLLMLFCTLGTLIYTSL
                     KPTAKEPCMVKFELLSSKWQMTAPEPHCVNMTSDGMLEILQNGVYLIYGQVIPVDKEY
                     IKDNAPFVVQIVKKNHALQTLTNDFKILPIGGIYELNAGDTIYLEFNSEDHIQKSNTY
                     WGIILMPDLSFIS"
     exon            183..216
                     /gene="Tnfsf18"
                     /gene_synonym="Tnlg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            217..2071
                     /gene="Tnfsf18"
                     /gene_synonym="Tnlg2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgctttg cacgctctca tccctccaga gaatgagttc taacctcatg gaggaaatgc
       61 ctttgagcga gtcaagtcct cgagggacag agaggctcag gaagccatgg ctcttctgca
      121 tagttgctct gttgctgatg ctgttctgta ccttgggtac actgatctat acttcactca
      181 agccaactgc caaagagccc tgcatggtta agtttgaact attatcctca aaatggcaaa
      241 tgacagctcc tgaacctcac tgtgtgaata tgacatctga tgggatgctg gagatacttc
      301 agaatggcgt gtatttaatc tatggccaag tgattcctgt tgataaggaa tacataaaag
      361 acaatgcccc ctttgtagta cagatagtta aaaaaaacca tgccctacaa actctaacaa
      421 acgattttaa aatcttacct ataggaggga tttatgaact gaatgctgga gataccatat
      481 atttggagtt caactctgaa gaccatattc agaaaagtaa tacatactgg gggatcattt
      541 taatgccaga tctctcattc atctcctaga gattgggttt ggtcttctca tcttcttcag
      601 tgtatccaga gatgctggtg ggtgggctgg agggggttga ttgctagcaa tgtacacagt
      661 ttgtgagggc ttacaaatca acacagagcc tcttggcata taaaagttta accctcatat
      721 ctgtctgaag aggactcagc aaatgagccg catccctaat gttgggtctg caagtgcact
      781 tgcacaatct atgataaatg gaatatgggc agcagaagac agaaaccctt ccaaagactg
      841 tttgcccaac cttgatcctt gggtagaatg aagtcctgtt tctgtggaag tctttcttgg
      901 cttgcaaaaa gggtgtaggg gcagtagctt ggcctttttt tccatcataa tttccttgag
      961 ttgttttacc ttaatccctt caaactcaca ccatctgaga gcctcctaat taaaagttgt
     1021 cagaatggtg gggtggccaa gacatgccaa caacaccttt ctttagaggt ggtgttctta
     1081 aaggacagag aacattacaa agcctatagg gacagaggtc aagatggcat gaaatggaat
     1141 tgatctggga aatttttttt attttgttat tctcaggatg caggttcatt ttgaactttc
     1201 ccctatgcct tcgttgctct tgtgtgtatg tgtgtataaa tgctgaaaac agtaaaatga
     1261 gagtttgcac cagtactcac tagattcaac accagaagtg ggtacttctc tggctgtctt
     1321 acacaacgat agcaaatttt tggttggtgt tccttaactt gcaattataa ctgttttctt
     1381 gcaccacaca ataatgctat gatgttagtc gggtagatat ttttgggaaa ataattgcac
     1441 agtgagaaca tggatagatg aatcctaaga ctcttacctc aactcacaac tcacaatgaa
     1501 ttaagtgagt ggtgttcttc attatgccat tcgcatggtc tctgctttga aactggtgtt
     1561 tctaccatca caagataaat ctctaaaatg gaataagttc aactctgaag tggacgcatc
     1621 gactttactc caaggtggcc agaatgaagc tacaagaaag ccattctttt accagcagac
     1681 attttcctct tcttgcccag agtaagaaga tccaggatac tgttggagga gtccatcgca
     1741 ctccggcatg ctgacttttg aaaacaataa tgaacatttg tgttcagagt ttggactctg
     1801 ttaaatttag ccagcttgtg agttcttgtt gaaaagtatt tttaaaaatt tacaatattt
     1861 ataggtattt gtgaaaagct atatagtgat attttatata aaactaattt aaaaatattt
     1921 ttattacatg taacaaaaat acttatgata ggctattcta tttcttcttt tttttaaatg
     1981 agtacttgct gaattgccat agtgtacaaa gactcttgtg tctgcatatc ttctcaggaa
     2041 attaaaatta tatcatatgt atttatgaaa a
//
