LOCUS       NM_145765               6002 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus TNF superfamily member 15 (Tnfsf15), mRNA.
ACCESSION   NM_145765
VERSION     NM_145765.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6002)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian tumor necrosis factor
            ligand genes
  JOURNAL   Immunogenetics 68 (2), 125-132 (2016)
   PUBMED   26646413
REFERENCE   2  (bases 1 to 6002)
  AUTHORS   Bi,M.C., Song,X.J., Shi,H., Xue,W.X., Xu,C.L. and Song,E.
  TITLE     Effect of atorvastatin on diabetic rat endothelial cells and
            retinal lesions
  JOURNAL   Genet Mol Res 14 (2), 5462-5467 (2015)
   PUBMED   26125742
  REMARK    GeneRIF: Expression in control and blank groups was similar at 3
            and 6 months. Atorvastatin can inhibit VEGI and vascular
            endothelial growth factor expression to protect rats from diabetic
            retinopathy
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6002)
  AUTHORS   Sagsoz,H. and Ketani,M.A.
  TITLE     The role of estrogen receptors, erbB receptors, vascular
            endothelial growth factor and its receptors, and vascular
            endothelial growth inhibitor in the development of the rat mammary
            gland
  JOURNAL   Growth Factors 28 (6), 379-393 (2010)
   PUBMED   20572782
  REMARK    GeneRIF: examined the mammary gland during pregnancy, lactation,
            and involution periods; identified the localization and
            distribution of VEGI (TNFSF15)
REFERENCE   4  (bases 1 to 6002)
  AUTHORS   Migone,T.S., Zhang,J., Luo,X., Zhuang,L., Chen,C., Hu,B.,
            Hong,J.S., Perry,J.W., Chen,S.F., Zhou,J.X., Cho,Y.H., Ullrich,S.,
            Kanakaraj,P., Carrell,J., Boyd,E., Olsen,H.S., Hu,G., Pukac,L.,
            Liu,D., Ni,J., Kim,S., Gentz,R., Feng,P., Moore,P.A., Ruben,S.M.
            and Wei,P.
  TITLE     TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T
            cell costimulator
  JOURNAL   Immunity 16 (3), 479-492 (2002)
   PUBMED   11911831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 13, 2022 this sequence version replaced NM_145765.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LN874406.1, AF520787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000005.1  82171408-82171658   c
            252-294             JAXUCZ010000005.1  82160302-82160344   c
            295-333             JAXUCZ010000005.1  82159283-82159321   c
            334-6002            JAXUCZ010000005.1  82150376-82156044   c
FEATURES             Location/Qualifiers
     source          1..6002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6002
                     /gene="Tnfsf15"
                     /gene_synonym="Tnlg1b"
                     /note="TNF superfamily member 15"
                     /db_xref="GeneID:252878"
                     /db_xref="RGD:628735"
     exon            1..251
                     /gene="Tnfsf15"
                     /gene_synonym="Tnlg1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..788
                     /gene="Tnfsf15"
                     /gene_synonym="Tnlg1b"
                     /note="tumor necrosis factor ligand 1b; tumor necrosis
                     factor (ligand) superfamily, member 15; TNF ligand-related
                     molecule 1; vascular endothelial cell growth inhibitor;
                     tumor necrosis factor superfamily member 15"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     15"
                     /protein_id="NP_665708.1"
                     /db_xref="GeneID:252878"
                     /db_xref="RGD:628735"
                     /translation="MAEELGLGFGEAVPVEMLPEGCRHRREARTGLAARSKACLALTC
                     CLLSFPILAGLSTLLMTGQLRIPGKDCMFPTVTEERSAPSAQPVYTPSRDKPKAHLTI
                     MRQTPVPHLKNELAALHWENNLGMAFTKNRMNYTNKFLVIPESGDYFIYSQITFRGTT
                     SECGDISRVRRPKKPDSITVVITKVADSYPEPAHLLTGTKSVCEISSNWFQPIYLGAM
                     FSLEEGDRLMVNVSDISLVDYTKEDKTFFGAFLI"
     exon            252..294
                     /gene="Tnfsf15"
                     /gene_synonym="Tnlg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            295..333
                     /gene="Tnfsf15"
                     /gene_synonym="Tnlg1b"
                     /inference="alignment:Splign:2.1.0"
     exon            334..6002
                     /gene="Tnfsf15"
                     /gene_synonym="Tnlg1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagaagta tccccaagac agcagaagca tggcagagga gctggggctg ggctttgggg
       61 aagcagtccc agtggaaatg ctgccggaag gctgccggca caggcgagag gccaggaccg
      121 ggctagcagc caggagcaaa gcctgtttgg ctctcacctg ctgcctgtta tcatttccca
      181 tcctcgcagg acttagcacc ctcctgatga ctggccagct ccggatcccc ggaaaagact
      241 gtatgtttcc gactgtgaca gaagagaggt ctgccccttc agcacaacca gtttacacac
      301 cttccagaga caagccaaaa gcccacctga caattatgag acaaactcct gtaccacatc
      361 tgaaaaatga actggctgct ctacactggg agaataacct agggatggcc ttcaccaaga
      421 accgaatgaa ctacaccaac aaattcctgg tgatcccaga gtcaggagac tatttcatct
      481 actcccagat cacattccga ggaaccacat ctgagtgtgg tgacatcagc agggtgagac
      541 ggccaaaaaa gccagactcc atcactgtgg ttatcaccaa ggtagcagac agctaccctg
      601 agcctgccca cctccttaca gggaccaagt ctgtgtgtga aataagcagc aactggtttc
      661 agcccatcta ccttggggcc atgttctcct tggaagaagg ggacaggctg atggtaaatg
      721 tcagtgacat ctccttggtg gattacacaa aagaagataa aactttcttt ggagccttct
      781 tgatatgagg aggaagcaac catcattcca cggggttttc ctgccttcta cttcccaatt
      841 tcctttgctt atatggaact ataaacaggg gctttagagg gatcagggat agggaacagt
      901 ggtttagcta tataatttag gaacccaaag ttgatcctta tatgccttat ggactgaaat
      961 agtaaatgaa gaactcagaa cagctcctgg ttgatagaga cctgctgggt tttaaaaatt
     1021 caaacaccca tcatccaatg gcacaaatct actggtctca cggtgccctc tgtcctagac
     1081 ctctctgaac cagcagttca gttatagctg aatttgataa taaacttact tcagtccaag
     1141 agttaaggac agaatgcaaa gaaagtctga gaaaacgatt taattcctcc agaggcaaaa
     1201 gtcttttgtt tgcatttcaa cattcttttg tgcctaacct aaaaactaag aaagaaagaa
     1261 acaacaacaa caacaaaaaa aaaaaaaacc caaagaaaca aagaaatgaa gaaaaacaaa
     1321 gaaaagacaa aaagaaaagg aaaggaaaaa gaaaagaact ggtattttca cgaatattct
     1381 ccaaaaagga aatggttttc tgctgtgccg gagcaagctc acctttcttc tgaatgcatt
     1441 ctttaatatc caaacatgcc agtaggaatt ccacatgcac atggaacata gaacactttt
     1501 attgttgtga gaccgtgttt cttgagtacc tactctgctc tgggcactca gtccacagga
     1561 ccatgaagag aaagtcaaat ttacttaaaa actaaatgaa ttctcaatgc atacttccta
     1621 atcaactacc actcagaatg ttccaaagac taacttcaag tcagccatca aggtgatttg
     1681 caagtaatgg tgcttgttat caagcctgag accccgagtt tgacttccca gaacccaaaa
     1741 gctggaagga gagaactgac tcccacaagc tatcctcaac cctcacacaa atgccatggc
     1801 atgcatatac taactaaata aataaatgtt aaagcaaagt ttaaagaaaa atttcaagtc
     1861 atgcaagaca gcgttcctga aaatgttctc tctgttgctg tccagggtag gctagccagc
     1921 tgatagagac actgaaggaa attagagaca gatatctggt ggaatggacc actgtatgaa
     1981 cacttgattc atgccaggat tcaatgtact tattctccga caaccaacaa agtgtcaatc
     2041 atcaaatctg gagaagtcta tctggatctg ctctcaagtt tggtttgcag ctttaaatga
     2101 agaatgctgt atgggtattt ttgccttaaa atattcaaag ggatttaaat atggaattaa
     2161 ttaaccaacc cagacaaagc ctcttcttgg aggagaactt ggaggatgag gtcctactgt
     2221 gcttccttgg tttcatttct ttagtgtggt tttctaatac taacagagat aagagggggt
     2281 gaccatggtc ttttagctgc ttgactggtc tgttcagcaa aaatttattc atttttcaag
     2341 accaaatgag gccattagaa gaaggcacat taacttcatg catttgatat aatgtgacct
     2401 attgtgtgac ctttacaaga tcaataatat tttaacagtg atgcttgatt ccatgaccaa
     2461 attcaacatc ccaccaggtg aataaaacgt gggtgtgaac tgtggtcagt tccttccaat
     2521 tccacatctc tgttagaagt gctcatgtga tggcagatgc cacaaaggag tcggatggta
     2581 aacttggccc caaataactg ctgagccatc tgctaggaaa aattagtagt gctgggtagt
     2641 gtggctccct cacaaccact ggtagagtag tagtagctga acaaaatttg ttgtgtaata
     2701 atttgttaca aaattcatct ccactgccta ccaaacctag gttgtataat atctaacttc
     2761 tgctaagctg gcttacattg gtccttttgc tgtcttcaac ttcttgaaaa aggcctcagt
     2821 gagaacacag ggaaaagtga ggtcaccccc acccctgttc ttcatagggg aaaatcacac
     2881 ctgaaagaag ctgggcagac ttggtgacca ggaggaagag gtattgctta ggtctaaaac
     2941 cctgagagta atgttcattg gtcaattaag gatgctttgt caatgactcc agtctggctc
     3001 cgaggtcaga aaggagagtg agatgctctc tctgcccacg tttatcttcc gggtgcatga
     3061 gaacactgag caacatagag ttatgggaaa agacttgccc aaaagcagtc agggtgaccc
     3121 ggtcacctcc tccactaaac ccaagctttg tgccaacacc cttcaaagct gcccagaagt
     3181 gatctagatg gcttggaaat ttatccaaga caggaatttc ctgatatcca aaggtgcttg
     3241 aggctttgtc cctgacatat tggactcaaa ccagcatttc catagcaaac aggagcatga
     3301 tgggtttttt ttttaatcaa aatggaaaaa atagttttaa gaatacgtga tggagtcaat
     3361 ggcatacatc tgtaatccca gccgatggga gtctgagcca ggaggattgt catgagtttg
     3421 aggagagcct gggctaaatt gtgattttca agaaagccta gtctacaaaa caagaccttg
     3481 ctttaattaa aaaaaaaaaa aagaagaaga agaccacagg ctggtcctta gagataaggt
     3541 aatatattca tggatttgga tcaggaggta tatgttttgg aaaatagtta atttagcgag
     3601 aatgctgtct caaaggttgc ttaactcaaa tcaagtctat aaatatttac ctagtacttg
     3661 cttgccctga agacagagac ataaattatt ttagtctcag atccattcgt tctaacagat
     3721 tggcatctcc atcatctgtg gagcttttaa tcactctggt tgtattagct aattaattag
     3781 ctaacttgag acacactgat actttcttat tatgaacatg ggtgcatttg acaaagaaca
     3841 atcattaaca aaatggtttg aatttccact taagtggttt tcttttttct ttttcttttt
     3901 ctttttttta aaaaaaaaaa caaactagct aatcaagggc agtttcccat aaatcaatgc
     3961 ccaggggagt gtcaggatac agtgccctgt ggtgagagcc agcattgaga caacattctc
     4021 aaagagactg ttatttactg gcctcaaatt ctgacatgaa cacctttgaa aatgttagga
     4081 ctttatggac agcctagagg tgctttgaaa agtctatgtt cacagcaaaa ggcataatca
     4141 gcatgcagaa taggtcactt gaatttttac cttagctgtt tttacatctg tttcacagaa
     4201 cacaaattcc taggctgtaa tctctaaggt ggatttgttg attttctaag gtacagtggg
     4261 gaaaaaggaa agtgtacttg taccatgttg tttctcagtg catgtcagaa tctactcaac
     4321 agagaacatg ccagagcctt ggattcattc tgctacaagc tacatcactc caagggaaat
     4381 ttcaagtttg tgcctgtcaa ctactctgga ttgtggaagc cccacgagtt cactgtgcac
     4441 aaggcacagc cattgccagc tctctcttgc atggtatttc tctcaagctc tgactcaatc
     4501 aggtttccat gattgtgaca ttgggaatta attgctaaag caggtttatt tatattctgt
     4561 cccttgcaaa atatatgcag atatgtctgg cctcaaaatc ccctgctttt attagtgctt
     4621 agagaatact gggcgtgttt tgctgttttc agtcgtattt tatttaagct tgcagtattg
     4681 tcctgaatat tagcagtgtt ccaagatatt gcctgctagc ctctggctag tttactagca
     4741 gtgacagtat tagatcagag cgtctgtatt catgccttgc actattctac tactgttaaa
     4801 acttcccggg ctccgtaaca cacttacccc cagctcttcc atctacccat cttgtagata
     4861 tagcttgtga ggagactcac aagtttcttt taatggaata gccagaattc tactcttggc
     4921 aagtggcact caatttgatt cagttaaagg agaaattgaa gtcagaaata tctttgagta
     4981 ttcatggggc aacgtagaag agcaaggaga ctgcttacac atggtggtca catctctggt
     5041 ttcatcccta aaaccaattt tctgacccta aatagatttt tttcttgtag ctttagggat
     5101 tatttttctt gtagtctctg gaaagggtca agcaaaaaga aagctttgtg gaaaccattg
     5161 catcatggag gtcatgggag gggttaatcc aaagaattcc ttctccaaat ctatagccat
     5221 gtggccaccc tttggtggac ttctatttga tcatgacaaa actgagagcc ctgcccagag
     5281 ttcagtggtt cccaaagaac tagaagagta atctgttccc tcaccaactc taggggcttg
     5341 gcctgtagag aaaaatgtca cgggatttta aagttaacat gagctgccat ccaaacttat
     5401 gtctcttcaa gaatgaagaa acacaggcta ggagagggaa cctatgaagc ctggtgttga
     5461 gcagtagctc gatggtgtct tgaggctaaa actagacttc ctacccctga ccacactcaa
     5521 cagcctttca atttgatcca tggattgttt agtagttttt tattttattt tattttgagc
     5581 acctgtcaca cccagttact gtcatgccaa gagggtccat aacaggcaag tcctactctg
     5641 ctgtgcgcac acaagatgaa ggaggctcac agtagtaagt aaacagataa gcaaacttat
     5701 gtgattttcg tcttaaagtc attaagacac acctcgtgcc cctcttttgt ttcagagggt
     5761 atacaggctg aacagatgta ggtgttcgcc tgattttatt gataagcccc atgtgctttc
     5821 attggttgta tgttttatgt taaaacgtca catcaccatg gtaaaaatgc atattgtatg
     5881 ttgttgggta tataattaac tagtacgcat cccatgtatg aattctaatg tctgtaaatg
     5941 aaaaattata tatgttaaca tatgtaatgg ttgtaattta ataaactgac actgaaggct
     6001 ac
//
